Developing Human Radiation Biodosimetry Models: Testing Cross-Species Conversion Approaches Using an Ex Vivo Model System

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Radiation Research

• Publication date

  2017-03-22

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1667/RR14655.1PMID 28328310PMCID PMC5996993
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Variable Selection

  2019influential reference
• The Reactome pathway Knowledgebase

  2015cited by this paper
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  2013influential reference
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  2013cited by this paper
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  2009influential reference
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