A Grand Challenge. 2. Phenotypic Profiling of a Natural Product Library on Parkinson's Patient-Derived Cells.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Journal of Natural Products

• Publication date

  2016-07-22

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1021/acs.jnatprod.6b00258PMID 27447544
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A Grand Challenge: Unbiased Phenotypic Function of Metabolites from Jaspis splendens against Parkinson's Disease.

  2016cited by this paper
• The re-emergence of natural products for drug discovery in the genomics era

  2015cited by this paper
• Connecting phenotype and chemotype: high-content discovery strategies for natural products research.

  2015cited by this paper
• NMR Fingerprints of the Drug-like Natural-Product Space Identify Iotrochotazine A: A Chemical Probe to Study Parkinson’s Disease**

  2014cited by this paper
• The Vps35 D620N Mutation Linked to Parkinson's Disease Disrupts the Cargo Sorting Function of Retromer

  2014cited by this paper
• "Function-first" lead discovery: mode of action profiling of natural product libraries using image-based screening.

  2013cited by this paper
• Multiplex Cytological Profiling Assay to Measure Diverse Cellular States

  2013cited by this paper
• Drug-like properties: guiding principles for the design of natural product libraries.

  2012cited by this paper
• α-Synuclein in Parkinson's disease.

  2012cited by this paper
• Seven alkaloids and their antibacterial activity from Hypecoum erectum L.

  2011cited by this paper
• VPS35 mutations in Parkinson disease.

  2011cited by this paper
• Autophagosome Formation during Varicella-Zoster Virus Infection following Endoplasmic Reticulum Stress and the Unfolded Protein Response

  2011cited by this paper
• NRF2 Activation Restores Disease Related Metabolic Deficiencies in Olfactory Neurosphere-Derived Cells from Patients with Sporadic Parkinson's Disease

  2011cited by this paper
• Disease-specific, neurosphere-derived cells as models for brain disorders

  2010cited by this paper
• Identification of Internalizing Human Single-Chain Antibodies Targeting Brain Tumor Sphere Cells

  2010cited by this paper
• Lysosomal accumulation of mTOR is enhanced by rapamycin

  2010cited by this paper
• When is Chemical Similarity Significant? The Statistical Distribution of Chemical Similarity Scores and Its Extreme Values

  2010cited by this paper
• The nuclear protein Waharan is required for endosomal-lysosomal trafficking in Drosophila

  2010cited by this paper
• Binding of Guanylyl Cyclase Activating Protein 1 (GCAP1) to Retinal Guanylyl Cyclase (RetGC1)

  2008cited by this paper
• An Unbiased Cell Morphology–Based Screen for New, Biologically Active Small Molecules

  2005cited by this paper
• The evolving role of natural products in drug discovery

  2005cited by this paper
• Protein structure similarity clustering and natural product structure as guiding principles in drug discovery.

  2005cited by this paper
• Disruptive effect of chloroquine on lysosomes in cultured rat hepatocytes.

  2005cited by this paper
• Compound library development guided by protein structure similarity clustering and natural product structure.

  2004cited by this paper
• Multidimensional Drug Profiling By Automated Microscopy

  2004cited by this paper
• Chemical space and biology

  2004cited by this paper
• High-Content Profiling of Drug-Drug Interactions: Cellular Targets Involved in the Modulation of Microtubule Drug Action by the Antifungal Ketoconazole

  2003cited by this paper
• Mitochondrial Complex I Inhibitor Rotenone Induces Apoptosis through Enhancing Mitochondrial Reactive Oxygen Species Production*

  2003cited by this paper
• Anti-tumour activity of Digitalis purpurea L. subsp. heywoodii.

  2003cited by this paper
• From protein domains to drug candidates-natural products as guiding principles in the design and synthesis of compound libraries.

  2002cited by this paper
• High glucose‐induced oxidative stress and mitochondrial dysfunction in neurons

  2002cited by this paper
• Endosomal Localization of the Autoantigen EEA1 Is Mediated by a Zinc-binding FYVE Finger*

  1996cited by this paper
• How does taxol stabilize microtubules?

  1995cited by this paper
• Effects of the microtubule depolymerizing and stabilizing agents Nocodazole and taxol on glucose-induced insulin secretion from hamster islet tumor (HIT) cells.

  1994cited by this paper
• Pharmacokinetics and antiarrhythmic efficacy of intravenous ajmaline in ventricular arrhythmia of acute onset

  1989cited by this paper
• The lysosomal proton pump is electrogenic.

  1983cited by this paper
• Colchicine-induced changes in the cytoskeleton of the golden-mantled ground squirrel (Spermophilus lateralis) Sertoli cells.

  1983cited by this paper
• Action of cytochalasin D on cytoskeletal networks

  1982cited by this paper

• Phytochemical investigation of Asarum sieboldii var. seoulense and the phenotypic profiles of its constituents against a Parkinson's Disease olfactory cell line.

  2023cites this paper
• Meeting the Challenge 2: Identification of Potential Chemical Probes for Parkinson's Disease from Ligusticum chuanxiong Hort Using Cytological Profiling.

  2022cites this paper
• Phlegmacaritones A and B, a Pair of Serratane-Related Triterpenoid Epimers with an Unprecedented Carbon Skeleton from Phlegmariurus carinatus.

  2022cites this paper
• Analyzing Olfactory Neuron Precursors Non-Invasively Isolated through NADH FLIM as a Potential Tool to Study Oxidative Stress in Alzheimer’s Disease

  2021cites this paper
• A Grand Challenge. 3. Unbiased Phenotypic Function of Metabolites from Australia Plants Gloriosa superba and Alangium villosum against Parkinson's Disease.

  2020cites this paper
• Image-based profiling for drug discovery: due for a machine-learning upgrade?

  2020cites this paper
• Is it time for artificial intelligence to predict the function of natural products based on 2D-structure.

  2019cites this paper
• Design and Synthesis of Natural Product Inspired Libraries Based on the Three-Dimensional (3D) Cedrane Scaffold: Toward the Exploration of 3D Biological Space.

  2018cites this paper
• Mini Review APPLICATION OF IMAGE-BASED HIGH CONTENT ANALYSIS FOR THE SCREENING OF BIOACTIVE NATURAL-PRODUCTS

  2018cites this paper
• Screening and identification of novel biologically active natural compounds

  2017cites this paper
• Data-analysis strategies for image-based cell profiling

  2017cites this paper
• Meeting the Challenge: Using Cytological Profiling to Discover Chemical Probes from Traditional Chinese Medicines against Parkinson's Disease.

  2016cites this paper