Effects of L-tryptophan on gastric emptying evaluated by breath test in relation to gastric accommodation evaluated by Barostat in rats.

Gastric emptying has been known to correlate the pyloric sphincter contractile function and distention-induced gastric relaxation (gastric accommodation). In the present study, the effects of L-tryptophan on the gastric emptying and accommodation were evaluated by breath test using [1-(13)C]acetic acid and Barostat study, respectively, in rats. L-Tryptophan significantly decreased Cmax and AUC120min and delayed Tmax, indicating the inhibition of gastric emptying. L-Tryptophan significantly enhanced the gastric accommodation. These findings show that L-tryptophan may inhibit the gastric emptying through the enhanced gastric accommodation. Therefore, L-tryptophan may be useful for the therapy of postprandial dyspepsia, especially for early satiety.

• Publication year

  2015

• Venue

  Journal of Pharmacological Sciences

• Publication date

  2015-02-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.jphs.2014.12.008PMID 25727962
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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