Drug-Lipid A Interactions on the Escherichia coli ABC Transporter MsbA

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Journal of Bacteriology

• Publication date

  2005-09-15

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1128/JB.187.18.6363-6369.2005PMID 16159769PMCID PMC1236644
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A critical role of a carboxylate in proton conduction by the ATP‐binding cassette multidrug transporter LmrA

  2005cited by this paper
• P-Glycoprotein Substrate Binding Domains Are Located at the Transmembrane Domain/Transmembrane Domain Interfaces: A Combined Photoaffinity Labeling-Protein Homology Modeling Approach

  2005cited by this paper
• Lipopolysaccharide Transport to the Bacterial Outer Membrane in Spheroplasts*

  2005cited by this paper
• Structure of the ABC Transporter MsbA in Complex with ADP·Vanadate and Lipopolysaccharide

  2005cited by this paper
• Biogenesis of the Gram-negative bacterial outer membrane.

  2004cited by this paper
• Biogenesis of the gram-negative bacterial outer membrane.

  2004cited by this paper
• Reversible Transport by the ATP-binding Cassette Multidrug Export Pump LmrA

  2004cited by this paper
• A Three-Dimensional Model for the Substrate Binding Domain of the Multidrug ATP Binding Cassette Transporter LmrA

  2004cited by this paper
• Biosynthesis, transport, and modification of lipid A.

  2004cited by this paper
• An ABC transporter with a secondary-active multidrug translocator domain

  2003cited by this paper
• The ATP Binding Cassette Multidrug Transporter LmrA and Lipid Transporter MsbA Have Overlapping Substrate Specificities*

  2003influential reference
• CHAPTER 5 – SUBSTRATE-BINDING SITES IN ABC TRANSPORTERS

  2003cited by this paper
• Structure of MsbA from Vibrio cholera: a multidrug resistance ABC transporter homolog in a closed conformation.

  2003cited by this paper
• Molecular Basis of Bacterial Outer Membrane Permeability Revisited

  2003cited by this paper
• Translocation of Phospholipids Is Facilitated by a Subset of Membrane-spanning Proteins of the Bacterial Cytoplasmic Membrane*

  2003cited by this paper
• ABC proteins : from bacteria to man

  2003cited by this paper
• Structure of MsbA from E. coli: a homolog of the multidrug resistance ATP binding cassette (ABC) transporters.

  2001cited by this paper
• Molecular basis of multidrug transport by ATP-binding cassette transporters: a proposed two-cylinder engine model.

  2001cited by this paper
• An Escherichia coli Mutant Defective in Lipid Export*

  2001cited by this paper
• Innate immunity.

  2000cited by this paper
• Communication between multiple drug binding sites on P-glycoprotein.

  2000influential reference
• The homodimeric ATP‐binding cassette transporter LmrA mediates multidrug transport by an alternating two‐site (two‐cylinder engine) mechanism

  2000cited by this paper
• Topology and transport of membrane lipids in bacteria.

  2000cited by this paper
• MDR3 P-glycoprotein, a Phosphatidylcholine Translocase, Transports Several Cytotoxic Drugs and Directly Interacts with Drugs as Judged by Interference with Nucleotide Trapping*

  2000cited by this paper
• The secondary multidrug transporter LmrP contains multiple drug interaction sites.

  1999cited by this paper
• Brownian ratchets: molecular separations in lipid bilayers supported on patterned arrays.

  1999cited by this paper
• The purified and functionally reconstituted multidrug transporter LmrA of Lactococcus lactis mediates the transbilayer movement of specific fluorescent phospholipids.

  1999cited by this paper
• Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene.

  1998cited by this paper
• Function of Escherichia coli MsbA, an Essential ABC Family Transporter, in Lipid A and Phospholipid Biosynthesis*

  1998cited by this paper
• A bacterial antibiotic-resistance gene that complements the human multidrug-resistance P-glycoprotein gene

  1998influential reference
• Molecular basis for membrane phospholipid diversity: why are there so many lipids?

  1997cited by this paper
• The multi‐drug resistance reversal agent SR33557 and modulation of vinca alkaloid binding to P‐glycoprotein by an allosteric interaction

  1997cited by this paper
• Controlled gene expression systems for Lactococcus lactis with the food-grade inducer nisin

  1996influential reference
• Innate immunity.

  1996cited by this paper
• Co-operative, competitive and non-competitive interactions between modulators of P-glycoprotein.

  1996cited by this paper
• Multidrug resistance mediated by a bacterial homolog of the human multidrug transporter MDR1.

  1996cited by this paper
• The essential Escherichia coli msbA gene, a multicopy suppressor of null mutations in the htrB gene, is related to the universally conserved family of ATP‐dependent translocators

  1993cited by this paper
• The lipid A biosynthesis mutation lpxA2 of Escherichia coli results in drastic antibiotic supersusceptibility

  1992cited by this paper
• Sequencing, mutational analysis, and transcriptional regulation of the Escherichia coli htrB gene

  1991cited by this paper
• A mutant of Escherichia coli defective in the first step of endotoxin biosynthesis.

  1990cited by this paper
• Biosynthesis and function of phospholipids in Escherichia coli.

  1990cited by this paper
• LSU Digital Commons LSU Digital Commons ATPase activity of the MsbA lipid flippase of Escherichia coli ATPase activity of the MsbA lipid flippase of Escherichia coli

  year unknowncited by this paper

• Antibiotic resistance characterization, virulence factors and molecular characteristics of Bacillus species isolated from probiotic preparations in China.

  2024cites this paper
• Molecular mechanisms of tigecycline-resistance among Enterobacterales

  2024cites this paper
• The inactivation of tolC sensitizes Escherichia coli to perturbations in lipopolysaccharide transport

  2024cites this paper
• Probing the allosteric NBD-TMD crosstalk in the ABC transporter MsbA by solid-state NMR

  2024cites this paper
• The culmination of multidrug-resistant efflux pumps vs. meager antibiotic arsenal era: Urgent need for an improved new generation of EPIs

  2023cites this paper
• Identification of a muropeptide precursor transporter from gut microbiota and its role in preventing intestinal inflammation

  2023cites this paper
• The ABC transporter MsbA adopts the wide inward-open conformation in E. coli cells

  2022cites this paper
• Differential dynamics and direct interaction of bound ligands with lipids in multidrug transporter ABCG2

  2022cites this paper
• Comparative genomics analysis of the multidrug-resistant Aeromonas hydrophila MX16A providing insights into antibiotic resistance genes

  2022cites this paper
• Effects of Verapamil and Two Bisbenzylisoquinolines, Curine and Guattegaumerine Extracted from Isolona hexaloba, on the Inhibition of ABC Transporters from Pseudomonas aeruginosa

  2022cites this paper
• Lactococcus lactis, an Attractive Cell Factory for the Expression of Functional Membrane Proteins

  2022cites this paper
• MsbA: an ABC transporter paradigm.

  2021cites this paper
• Engineered MATE multidrug transporters reveal two functionally distinct ion-coupling pathways in NorM from Vibrio cholerae

  2021cites this paper
• The Whole Is Bigger than the Sum of Its Parts: Drug Transport in the Context of Two Membranes with Active Efflux.

  2021cites this paper
• Myristic Acid Inhibits the Activity of the Bacterial ABC Transporter BmrA

  2021influential citation
• Energetics of lipid transport by the ABC transporter MsbA is lipid dependent

  2021cites this paper
• Cloning and Functional Characterization of Putative Escherichia coli ABC Multidrug Efflux Transporter YddA

  2020influential citation
• Acinetobacter baumannii Efflux Pumps and Antibiotic Resistance

  2020cites this paper
• Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) CLOSED AND OPEN STATE CHANNEL MODELS

  2020cites this paper
• Structural Insights into the Lipid A Transport Pathway in MsbA.

  2019cites this paper
• Antibiotic Resistance Mediated by the MacB ABC Transporter Family: A Structural and Functional Perspective

  2018cites this paper
• MlaEMlaE MlaFMlaF MlaD ATP ADP + Pi ATP ADP + Pi MlaC a Mla system b Lol system OmpC ? ? ? ?

  2018cites this paper
• Study of ABC Membrane Transporters in Single Live Cells

  2018influential citation
• Structure and function of LptD in some Gram-negative bacteria

  2017cites this paper
• The effect of drug binding on specific sites in transmembrane helices 4 and 6 of the ABC exporter MsbA studied by DNP-enhanced solid-state NMR.

  2017cites this paper
• Bacterial ABC multidrug exporters: From shared proteins motifs and features to diversity in molecular mechanisms

  2016cites this paper
• Helicobacter pylori and Antibiotic Resistance, A Continuing and Intractable Problem

  2016cites this paper
• Coupled ATPase-adenylate kinase activity in ABC transporters

  2016cites this paper
• Metagenomic mining of pathogenicity and antibiotic resistance traits across human populations worlwide

  2016cites this paper
• ATP-dependent substrate transport by the ABC transporter MsbA is proton-coupled

  2016cites this paper
• The Power of Asymmetry: Architecture and Assembly of the Gram-Negative Outer Membrane Lipid Bilayer.

  2016cites this paper
• Structures and Transport Mechanisms of the ABC Efflux Pumps

  2016cites this paper
• Antimicrobial Drug Efflux Pumps in Escherichia coli

  2016cites this paper
• The DrrAB system of Streptomyces peucetius is a Multi-Drug Transporter of Broad Substrate Specificity

  2016influential citation
• Comparative genomic approaches to understanding Achromobacter xylosoxidans

  2015cites this paper
• A subset of annular lipids is linked to the flippase activity of an ABC transporter.

  2015cites this paper
• Acinetobacter baumannii Repeatedly Evolves a Hypermutator Phenotype in Response to Tigecycline That Effectively Surveys Evolutionary Trajectories to Resistance

  2015influential citation
• The Challenge of Efflux-Mediated Antibiotic Resistance in Gram-Negative Bacteria

  2015cites this paper
• Interactions between salmonella typhimuriumand human gut bacteria

  2015cites this paper
• Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)

  2015cites this paper
• Membrane Proteins Production for Structural Analysis

  2014cites this paper
• Analysis of the structural and functional roles of coupling helices in the ATP-binding cassette transporter MsbA through enzyme assays and molecular dynamics simulations.

  2014cites this paper
• Biosynthesis and export of bacterial lipopolysaccharides.

  2014cites this paper
• The DrrAB Efflux System of Streptomyces peucetius Is a Multidrug Transporter of Broad Substrate Specificity*

  2014cites this paper
• Characterization of DrrAB Complex from Streptomyces Peucetius as A Multidrug Transporter

  2014cites this paper
• Lactococcus lactis: Recent Developments in Functional Expression of Membrane Proteins

  2014cites this paper
• Molecular Disruption of the Power Stroke in the ATP-binding Cassette Transport Protein MsbA*

  2013cites this paper
• Multidrug resistance and efflux pumps: insights from molecular dynamics simulations.

  2013cites this paper
• MacA, a Periplasmic Membrane Fusion Protein of the Macrolide Transporter MacAB-TolC, Binds Lipopolysaccharide Core Specifically and with High Affinity

  2013cites this paper
• Substrate Binding Stabilizes a Pre-translocation Intermediate in the ATP-binding Cassette Transport Protein MsbA*

  2013cites this paper
• ATP-binding Cassette Transport Protein Pre-translocation Intermediate in the Substrate Binding Stabilizes a Membrane Biology :

  2013cites this paper
• Tuning the Drug Efflux Activity of an ABC Transporter in vivo by in vitro Selected DARPin Binders

  2012cites this paper
• Proteins that bind and move lipids: MsbA and NPC1

  2012influential citation
• Asymmetry in the Homodimeric ABC Transporter MsbA Recognized by a DARPin*

  2012cites this paper
• Basic Residues R260 and K357 Affect the Conformational Dynamics of the Major Facilitator Superfamily Multidrug Transporter LmrP

  2012cites this paper
• MsbA ATP-binding cassette (ABC) transporter of E. coli: structure and possible flippase mechanism.

  2011cites this paper
• A Combined Experimental and Mathematical Approach for Molecular-based Optimization of Irinotecan Circadian Delivery

  2011cites this paper
• Approche combinée expérimentale et mathématique pour la personnalisation sur base moléculaire des thérapies anticancéreuses standards et chronomodulées. (A combined experimental and mathematical approach for molecular-based personalization of chronomodulated and standard anticancer therapies)

  2011cites this paper
• Virulence determinants, drug resistance and mobile genetic elements of Laribacter hongkongensis: a genome-wide analysis

  2011cites this paper
• Deleting two C-terminal alpha-helices is effective to crystallize the bacterial ABC transporter Escherichia coli MsbA complexed with AMP-PNP.

  2010cites this paper
• ABC exporter MsbA

  2010cites this paper
• The reconstituted Escherichia coli MsbA protein displays lipid flippase activity

  2010cites this paper
• Understanding polyspecificity of multidrug ABC transporters: closing in on the gaps in ABCB1.

  2010cites this paper
• Multidrug efflux pumps: The structures of prokaryotic ATP‐binding cassette transporter efflux pumps and implications for our understanding of eukaryotic P‐glycoproteins and homologues

  2010cites this paper
• Dissection of the conformational cycle of the multidrug/lipidA ABC exporter MsbA

  2010cites this paper
• Molecular basis of multidrug transport by ABC transporters.

  2009cites this paper
• The ABC transporter MsbA interacts with lipid A and amphipathic drugs at different sites

  2009cites this paper
• Nucleotide dependent packing differences in helical crystals of the ABC transporter MsbA.

  2009cites this paper
• A Multidrug ABC Transporter with a Taste for Salt

  2009cites this paper
• Mapping Daunorubicin-binding Sites in the ATP-binding Cassette Transporter MsbA Using Site-specific Quenching by Spin Labels*

  2009cites this paper
• NMR and EPR studies of membrane transporters

  2009cites this paper
• The Conformational Transition Pathway of ATP Binding Cassette Transporter MsbA Revealed by Atomistic Simulations*

  2009cites this paper
• ABC efflux pump-based resistance to chemotherapy drugs.

  2009cites this paper
• Caractérisation de 2 transporteurs ABC (“ATP-Binding Cassette”) bactériens de fonction inconnue : YheI/YheH de Bacillus subtilis et Rv1747 de Mycobacterium tuberculosis

  2008cites this paper
• Structure, Function, and Evolution of Bacterial ATP-Binding Cassette Systems

  2008cites this paper
• ATP-binding cassette transporters in Escherichia coli.

  2008cites this paper
• Multidrug transport by the ABC transporter Sav1866 from Staphylococcus aureus.

  2008cites this paper
• A symbiotic mutant of Sinorhizobium meliloti reveals a novel genetic pathway involving succinoglycan biosynthetic functions

  2008cites this paper
• Caracterización del lipopolisacárido de "Aeromonas" mesófilas

  2008cites this paper
• Functional role of transmembrane helix 6 in drug binding and transport by the ABC transporter MsbA.

  2008cites this paper
• Activity assay of membrane transport proteins.

  2008cites this paper
• Spin-labeled lipid A.

  2008cites this paper
• Functional Characterization of Escherichia coli MsbA

  2008cites this paper
• Two Proton Translocation Pathways in a Secondary Active Multidrug Transporter

  2007cites this paper
• New structure model for the ATP-binding cassette multidrug transporter LmrA.

  2007cites this paper
• Flexibility in the ABC transporter MsbA: Alternating access with a twist

  2007cites this paper
• Distribution and Physiology of ABC-Type Transporters Contributing to Multidrug Resistance in Bacteria

  2007cites this paper
• Prédiction structurale et ingénierie des assemblages macromoléculaires par bioinformatique

  2007cites this paper
• The ABC transporter Tba of Amycolatopsis balhimycina is required for efficient export of the glycopeptide antibiotic balhimycin

  2007cites this paper
• Perfiles de susceptibilidad/resistencia a antibióticos en bacterias del ácido láctico y bifidobacterias. Caracterización molecular de genes de resistencia

  2007cites this paper
• Biochemical Characterization of MsbA from Pseudomonas aeruginosa*

  2007cites this paper
• Molecular dynamics simulations of E. coli MsbA transmembrane domain: formation of a semipore structure.

  2006cites this paper
• Elucidation of the structure and molecular mechanism of the tripartite multidrug efflux pumps in the Gram-negative pathogens: Vibrio cholerae and Neisseria gonorrhoeae

  2006cites this paper
• Lipid trafficking to the outer membrane of Gram‐negative bacteria

  2006cites this paper
• New light on multidrug binding by an ATP-binding-cassette transporter.

  2006cites this paper
• Two membrane proteins from Bifidobacterium breve UCC2003 constitute an ABC-type multidrug transporter.

  2006influential citation
• Structure of the Multidrug Transporter EmrD from Escherichia coli

  2006cites this paper
• The structures of MsbA: Insight into ABC transporter‐mediated multidrug efflux

  2006cites this paper
• Identification of Nostoc punctiforme akinete‐expressed genes using differential display

  2006cites this paper
• Bmc Microbiology

  year unknowncites this paper