Loss of the liver X receptor LXRα/β in peripheral sensory neurons modifies energy expenditure

Peripheral neural sensory mechanisms play a crucial role in metabolic regulation but less is known about the mechanisms underlying vagal sensing itself. Recently, we identified an enrichment of liver X receptor alpha and beta (LXRα/β) in the nodose ganglia of the vagus nerve. In this study, we show mice lacking LXRα/β in peripheral sensory neurons have increased energy expenditure and weight loss when fed a Western diet (WD). Our findings suggest that the ability to metabolize and sense cholesterol and/or fatty acids in peripheral neurons is an important requirement for physiological adaptations to WDs. DOI: http://dx.doi.org/10.7554/eLife.06667.001

• Publication year

  2015

• Venue

  eLife

• Publication date

  2015-06-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.7554/eLife.06667PMID 26076474PMCID 4467361
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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