Site directed mutagenesis of Drosophila flightin disrupts phosphorylation and impairs flight muscle structure and mechanics

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Journal of Muscle Research and Cell Motility

• Publication date

  2007-10-03

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s10974-007-9120-yPMID 17912596
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay.

  2007cited by this paper
• Localization of the binding site of the C-terminal domain of cardiac myosin-binding protein-C on the myosin rod.

  2007cited by this paper
• Flightin is a myosin rod binding protein

  2007cited by this paper
• Regulation of cardiac contractile function by troponin I phosphorylation.

  2005cited by this paper
• Flight muscle properties and aerodynamic performance of Drosophila expressing a flightin transgene

  2005cited by this paper
• Paramyosin phosphorylation site disruption affects indirect flight muscle stiffness and power generation in Drosophila melanogaster.

  2005cited by this paper
• Cardiac Myosin-Binding Protein-C Phosphorylation and Cardiac Function

  2005cited by this paper
• Myofilin, a protein in the thick filaments of insect muscle

  2005cited by this paper
• Overexpression of miniparamyosin causes muscle dysfunction and age-dependant myofibril degeneration in the indirect flight muscles of Drosophila melanogaster

  2004cited by this paper
• Mutations that affect flightin expression in Drosophila alter the viscoelastic properties of flight muscle fibers.

  2004cited by this paper
• Suppression of muscle hypercontraction by mutations in the myosin heavy chain gene of Drosophila melanogaster.

  2003cited by this paper
• The overall pattern of cardiac contraction depends on a spatial gradient of myosin regulatory light chain phosphorylation.

  2001cited by this paper
• Phosphopeptide sequencing by in-source decay spectrum in delayed extraction matrix-assisted laser desorption ionization time-of-flight mass spectrometry.

  2000cited by this paper
• Flightin Is Essential for Thick Filament Assembly and Sarcomere Stability in Drosophila Flight Muscles

  2000cited by this paper
• A direct screen identifies new flight muscle mutants on the Drosophila second chromosome.

  1999cited by this paper
• Assembly of thick filaments and myofibrils occurs in the absence of the myosin head

  1999cited by this paper
• The Drosophila projectin mutant, bentD, has reduced stretch activation and altered indirect flight muscle kinetics

  1999cited by this paper
• A genetic deficiency that spans the flightin gene of Drosophila melanogaster affects the ultrastructure and function of the flight muscles.

  1998cited by this paper
• Structural basis for activation of the titin kinase domain during myofibrillogenesis

  1998cited by this paper
• Mapping of a myosin-binding domain and a regulatory phosphorylation site in M-protein, a structural protein of the sarcomeric M band.

  1998influential reference
• Troponin-T is a calcium-binding protein in insect muscle: in vivo phosphorylation, muscle-specific isoforms and developmental profile in Drosophila melanogaster

  1998cited by this paper
• Phosphorylation-dependent power output of transgenic flies: an integrated study.

  1997cited by this paper
• Molecular structure of the sarcomeric M band: mapping of titin and myosin binding domains in myomesin and the identification of a potential regulatory phosphorylation site in myomesin

  1997cited by this paper
• Defects in the Drosophila myosin rod permit sarcomere assembly but cause flight muscle degeneration.

  1995cited by this paper
• Impairment of muscle function caused by mutations of phosphorylation sites in myosin regulatory light chain

  1995cited by this paper
• Multiple isoelectric variants of flightin in Drosophila stretch-activated muscles are generated by temporally regulated phosphorylations

  1994cited by this paper
• Fourier analysis of wing beat signals: assessing the effects of genetic alterations of flight muscle structure in Diptera.

  1994cited by this paper
• Transformation of Drosophila melanogaster with the wild-type myosin heavy-chain gene: rescue of mutant phenotypes and analysis of defects caused by overexpression

  1994cited by this paper
• Flightin, a novel myofibrillar protein of Drosophila stretch-activated muscles

  1993cited by this paper
• Myosin light chain phosphorylation in vertebrate striated muscle: regulation and function.

  1993cited by this paper
• In-gel digestion of proteins for internal sequence analysis after one- or two-dimensional gel electrophoresis.

  1992cited by this paper
• Structurally differentDrosophila striated muscles utilize distinct variants of Z-band-associated proteins

  1991cited by this paper
• Identification and characterization of Drosophila melanogaster paramyosin.

  1991cited by this paper
• Phosphorylated and dephosphorylated myosin light chains of Drosophila fly and larva.

  1990influential reference
• Transposition of cloned P elements into Drosophila germ line chromosomes.

  1982cited by this paper
• Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

  1970cited by this paper
• Cleavage of structural proteins during

  1970cited by this paper

• Two Forms of Thick Filament in the Flight Muscle of Drosophila melanogaster

  2024cites this paper
• Immune system modulation & virus transmission during parasitism identified by multi-species transcriptomics of a declining insect biocontrol system

  2024cites this paper
• Structure of the Flight Muscle Thick Filament from the Bumble Bee, Bombus ignitus, at 6 Å Resolution

  2022cites this paper
• Taking flight: an educational primer for use with “A novel mechanism for activation of myosin regulatory light chain by protein kinase C-delta in Drosophila”

  2022cites this paper
• A Novel Mechanism for Activation of Myosin Regulatory Light Chain by Protein Kinase C-Delta in Drosophila

  2020cites this paper
• Reductions in ATPase activity, actin sliding velocity, and myofibril stability yield muscle dysfunction in Drosophila models of myosin-based Freeman–Sheldon syndrome

  2019cites this paper
• The R249Q hypertrophic cardiomyopathy myosin mutation decreases contractility in Drosophila by impeding force production

  2019cites this paper
• Effect of the Insecticide Dinotefuran on the Ultrastructure of the Flight Muscle of Female Sogatella furcifera (Hemiptera: Delphacidae)

  2017cites this paper
• Intrinsic disorder and multiple phosphorylations constrain the evolution of the flightin N-terminal region.

  2016cites this paper
• The systematic identification of cytoskeletal genes required for Drosophila melanogaster muscle maintenance

  2014cites this paper
• An Ongoing Role for Structural Sarcomeric Components in Maintaining Drosophila melanogaster Muscle Function and Structure

  2014cites this paper
• A systematic analysis of the role of the cytoskeleton in Drosophila melanogaster muscle maintenance

  2013influential citation
• Alternative relay and converter domains tune native muscle myosin isoform function in Drosophila.

  2012cites this paper
• COOH-terminal truncation of flightin decreases myofilament lattice organization, cross-bridge binding, and power output in Drosophila indirect flight muscle.

  2011influential citation
• and power output in Drosophila indirect flight muscle binding, myofilament lattice organization, cross-bridge COOH-terminal truncation of flightin decreases

  2011cites this paper
• Flightin is necessary for length determination, structural integrity, and large bending stiffness of insect flight muscle thick filaments.

  2010cites this paper
• Development of phosphopeptide enrichment techniques for phosphoproteome analysis.

  2008cites this paper