IDH2 deficiency promotes mitochondrial dysfunction and cardiac hypertrophy in mice.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Free Radical Biology & Medicine

• Publication date

  2015-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.freeradbiomed.2014.12.018PMID 25557279
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Attenuated mitochondrial NADP+-dependent isocitrate dehydrogenase activity induces apoptosis and hypertrophy of H9c2 cardiomyocytes.

  2014cited by this paper
• Suppression of tumorigenesis in mitochondrial NADP(+)-dependent isocitrate dehydrogenase knock-out mice.

  2014cited by this paper
• Multiplexed immunoassays for simultaneous quantification of cardiovascular biomarkers in the model of H(G)-nitro-L-arginine methylester (L-NAME) hypertensive rat.

  2013cited by this paper
• Oxidative and nitrosative stress in the maintenance of myocardial function.

  2012cited by this paper
• Redox signaling in cardiac myocytes

  2011cited by this paper
• Phosphoinositide-3 kinase signaling in cardiac hypertrophy and heart failure.

  2011cited by this paper
• Mitochondrial Oxidative Stress Mediates Angiotensin II–Induced Cardiac Hypertrophy and G&agr;q Overexpression–Induced Heart Failure

  2011cited by this paper
• Cell metabolism: an essential link between cell growth and apoptosis.

  2011cited by this paper
• Vimentin in cancer and its potential as a molecular target for cancer therapy

  2011cited by this paper
• Therapeutic targeting of mitochondrial superoxide in hypertension

  2010cited by this paper
• Transgenic mouse models for the vital selenoenzymes cytosolic thioredoxin reductase, mitochondrial thioredoxin reductase and glutathione peroxidase 4.

  2009cited by this paper
• N-acetylcysteine prevents glucose/glucose oxidase-induced oxidative stress, mitochondrial damage and apoptosis in H9c2 cells.

  2009cited by this paper
• The use of ebselen for radioprotection in cultured cells and mice.

  2009cited by this paper
• Cancer cell killing via ROS: To increase or decrease, that is the question

  2008cited by this paper
• Differential Phosphorylation of Translation Initiation Regulators 4EBP1, S6k1, and Erk 1/2 Following Inhibition of Alcohol Metabolism in Mouse Heart

  2008cited by this paper
• Return to the fetal gene program protects the stressed heart: a strong hypothesis

  2007cited by this paper
• Simvastatin attenuates hypertrophic responses induced by cardiotrophin-1 via JAK–STAT pathway in cultured cardiomyocytes

  2006cited by this paper
• Overexpression of Mitochondrial Peroxiredoxin-3 Prevents Left Ventricular Remodeling and Failure After Myocardial Infarction in Mice

  2006cited by this paper
• Cytosolic NADPH may regulate differences in basal Nox oxidase-derived superoxide generation in bovine coronary and pulmonary arteries.

  2005cited by this paper
• Targeting an antioxidant to mitochondria decreases cardiac ischemia‐reperfusion injury

  2005cited by this paper
• Myocyte apoptosis in heart failure.

  2005cited by this paper
• Oxygen, oxidative stress, hypoxia, and heart failure.

  2005cited by this paper
• Alternative Start Sites in the Saccharomyces cerevisiae GLR1 Gene Are Responsible for Mitochondrial and Cytosolic Isoforms of Glutathione Reductase*

  2004cited by this paper
• Decreased cardiac mitochondrial NADP+-isocitrate dehydrogenase activity and expression: a marker of oxidative stress in hypertrophy development.

  2004cited by this paper
• Overexpression of Glutathione Peroxidase Prevents Left Ventricular Remodeling and Failure After Myocardial Infarction in Mice

  2004cited by this paper
• Superoxide dismutases: active sites that save, but a protein that kills.

  2004cited by this paper
• Short interfering RNA-mediated silencing of glutaredoxin 2 increases the sensitivity of HeLa cells toward doxorubicin and phenylarsine oxide.

  2004cited by this paper
• Aging of Cardiac Myocytes in Culture: Oxidative Stress, Lipofuscin Accumulation, and Mitochondrial Turnover

  2004cited by this paper
• Genetic Dissection of the Phospholipid Hydroperoxidase Activity of Yeast Gpx3 Reveals Its Functional Importance*

  2004cited by this paper
• Cardiac hypertrophy: the good, the bad, and the ugly.

  2003cited by this paper
• Glucose‐6‐Phosphate Dehydrogenase Modulates Cytosolic Redox Status and Contractile Phenotype in Adult Cardiomyocytes

  2003cited by this paper
• Bobbing along on the crest of a wave: NO ascends hamster cheek pouch arterioles.

  2003cited by this paper
• Norepinephrine-induced interleukin-6 increase in rat hearts: differential signal transduction in myocytes and non-myocytes

  2003cited by this paper
• Principles of interleukin (IL)-6-type cytokine signalling and its regulation.

  2003cited by this paper
• Cytosolic NADP(+)-dependent isocitrate dehydrogenase status modulates oxidative damage to cells.

  2002cited by this paper
• Enhancement of glutathione cardioprotection by ascorbic acid in myocardial reperfusion injury.

  2002cited by this paper
• Involvement of Nuclear Factor-&kgr;B and Apoptosis Signal-Regulating Kinase 1 in G-Protein–Coupled Receptor Agonist–Induced Cardiomyocyte Hypertrophy

  2002cited by this paper
• Glutathione in defense and signaling: lessons from a small thiol.

  2002cited by this paper
• Myocardial hibernation in coronary artery disease

  2002cited by this paper
• Glutathione in Defense and Signaling

  2002cited by this paper
• Control of Mitochondrial Redox Balance and Cellular Defense against Oxidative Damage by Mitochondrial NADP+-dependent Isocitrate Dehydrogenase*

  2001cited by this paper
• Glutathione deficiency intensifies ischaemia-reperfusion induced cardiac dysfunction and oxidative stress.

  2001cited by this paper
• PPAR signaling in the control of cardiac energy metabolism.

  2000cited by this paper
• Cosubstrates involved in the reduction of cytosolic glutathione disulfide in rat heart.

  1997cited by this paper
• The cellular basis of dilated cardiomyopathy in humans.

  1995cited by this paper
• S-thiolation of individual human neutrophil proteins including actin by stimulation of the respiratory burst: evidence against a role for glutathione disulfide.

  1994cited by this paper
• Ischaemia and the myocyte cytoskeleton: review and speculation.

  1993cited by this paper
• Ferrous ion oxidation in the presence of xylenol orange for detection of lipid hydroperoxide in low density lipoprotein.

  1992cited by this paper
• Impairment of the myocardial ultrastructure and changes of the cytoskeleton in dilated cardiomyopathy.

  1991cited by this paper
• Spectrophotometric determination of oxidized and reduced pyridine nucleotides in erythrocytes using a single extraction procedure.

  1987cited by this paper
• Microtubules and desmin filaments during onset of heart hypertrophy in rat: a double immunoelectron microscope study.

  1987cited by this paper
• Assay of glutathione, glutathione disulfide, and glutathione mixed disulfides in biological samples.

  1981cited by this paper
• Obituary Notice: Percival Spencer Umfreville Pickering.

  year unknowncited by this paper

• Modulation of Ferroptosis by the Irx3–Etfa Pathway Protects Against Cardiac Hypertrophy

  2026cites this paper
• Structural variants in human congenital heart disease disrupt distal genomic regulatory contacts of developmental genes

  2026cites this paper
• Mitochondrial Dysfunction in the Development and Progression of Cardiometabolic Diseases: A Narrative Review

  2025cites this paper
• Sex-specific response to A1BG loss results in female dilated cardiomyopathy

  2025cites this paper
• IDH Mutant Cholangiocarcinoma: Pathogenesis, Management, and Future Therapies

  2025cites this paper
• SIRT3–IDH2 axis is a target of dietary fructose: implication of IDH2 as a key player in dietary carcinogen toxicity in mice colon

  2025cites this paper
• Oxidative Stress, Mitochondrial Quality Control, Autophagy, and Sirtuins in Heart Failure

  2025cites this paper
• SIRT5 desuccinylating IDH2 to alleviate oxidative stress in bovine mammary epithelial cells induced by ammonia.

  2025cites this paper
• Implications of metabolism on multi‐systems healthy aging across the lifespan

  2024cites this paper
• Jingfang Granule promotes the tricarboxylic acid cycle to improve chronic fatigue syndrome by increasing the expression of Idh1 and Idh2.

  2024cites this paper
• Integrative transcriptomic, proteomic and metabolomic analyses yields insights into muscle fiber type in cattle.

  2024cites this paper
• 25-Hydroxycholecalciferol Improves Cardiac Metabolic Adaption, Mitochondrial Biogenetics, and Redox Status to Ameliorate Pathological Remodeling and Functional Failure in Obese Chickens

  2024cites this paper
• Sex-Specific Response to A1BG Loss Results in Female Dilated Cardiomyopathy

  2024cites this paper
• Mitochondria fission accentuates oxidative stress in hyperglycemia‐induced H9c2 cardiomyoblasts in vitro by regulating fatty acid oxidation

  2024cites this paper
• Overexpression of ATP5F1A in Cardiomyocytes Promotes Cardiac Reverse Remodeling

  2024cites this paper
• Integrative analysis of transcriptome, DNA methylome, and chromatin accessibility reveals candidate therapeutic targets in hypertrophic cardiomyopathy

  2024cites this paper
• Epigenetic modulators link mitochondrial redox homeostasis to cardiac function in a sex-dependent manner

  2024cites this paper
• Effects of hindlimb unloading on the mevalonate and mechanistic target of rapamycin complex 1 signaling pathways in a fast‐twitch muscle in rats

  2024cites this paper
• Mitochondrial Dysfunction in Heart Failure: From Pathophysiological Mechanisms to Therapeutic Opportunities

  2024cites this paper
• Monogenic Disorders of ROS Production and the Primary Anti-Oxidative Defense

  2024cites this paper
• Long-term dietary n3 fatty acid prevents aging-related cardiac diastolic and vascular dysfunction.

  2023cites this paper
• Fine-mapping causal tissues and genes at disease-associated loci

  2023cites this paper
• Mitochondrial heterogeneity in diseases

  2023cites this paper
• Changes of energy metabolism in failing heart and its regulation by SIRT3

  2023cites this paper
• Mitochondria in Pathological Cardiac Hypertrophy Research and Therapy

  2022cites this paper
• The roles of NADPH and isocitrate dehydrogenase in cochlear mitochondrial antioxidant defense and aging.

  2022cites this paper
• Isocitrate dehydrogenase 3b is required for spermiogenesis but dispensable for retinal viability

  2022cites this paper
• Global profiling of protein lysine malonylation in mouse cardiac hypertrophy.

  2022cites this paper
• Mitochondrial Sirtuin-3 (SIRT3) Prevents Doxorubicin-Induced Dilated Cardiomyopathy by Modulating Protein Acetylation and Oxidative Stress

  2022cites this paper
• Epigenetic modulators link mitochondrial redox homeostasis to cardiac function

  2022cites this paper
• Reduced nicotinamide adenine dinucleotide phosphate in redox balance and diseases: a friend or foe?

  2022cites this paper
• Crucial Role of Mammalian Glutaredoxin 3 in Cardiac Energy Metabolism in Diet-induced Obese Mice Revealed by Transcriptome Analysis

  2021cites this paper
• Metabolic adaptations in cancers expressing isocitrate dehydrogenase mutations

  2021cites this paper
• SIRT5-Related Desuccinylation Modification Contributes to Quercetin-Induced Protection against Heart Failure and High-Glucose-Prompted Cardiomyocytes Injured through Regulation of Mitochondrial Quality Surveillance

  2021cites this paper
• LncRNA LncHrt preserves cardiac metabolic homeostasis and heart function by modulating the LKB1-AMPK signaling pathway

  2021cites this paper
• Hypertrophic preconditioning attenuates post-myocardial infarction injury through deacetylation of isocitrate dehydrogenase 2

  2021cites this paper
• APC/C CDH1 ubiquitinates IDH2 contributing to ROS increase in mitosis.

  2021cites this paper
• SUMOylation enhances the activity of IDH2 under oxidative stress.

  2020cites this paper
• Isocitrate dehydrogenase 2 protects mice from high-fat diet-induced metabolic stress by limiting oxidative damage to the mitochondria from brown adipose tissue

  2020cites this paper
• Metabolomics and the pig model reveal aberrant cardiac energy metabolism in metabolic syndrome

  2020cites this paper
• Isocitrate dehydrogenase 2 deficiency aggravates prolonged high-fat diet intake-induced hypertension

  2020cites this paper
• Safflor Yellow B Attenuates Ischemic Brain Injury via Downregulation of Long Noncoding AK046177 and Inhibition of MicroRNA-134 Expression in Rats

  2020cites this paper
• Mitochondrial Dysfunction and Therapeutic Targets in Auditory Neuropathy

  2020cites this paper
• SIRT1/SIRT3 Modulates Redox Homeostasis during Ischemia/Reperfusion in the Aging Heart

  2020cites this paper
• Riding the tiger – physiological and pathological effects of superoxide and hydrogen peroxide generated in the mitochondrial matrix

  2020cites this paper
• Carbendazim-resistance associated β2-tubulin substitutions increase deoxynivalenol biosynthesis by reducing the interaction between β2-tubulin and IDH3 in Fusarium graminearum

  2019cites this paper
• Hepatic Transcriptomics Reveals that Lipogenesis Is a Key Signaling Pathway in Isocitrate Dehydrogenase 2 Deficient Mice

  2019cites this paper
• Reactive oxygen species-mediated senescence is accelerated by inhibiting Cdk2 in Idh2-deficient conditions

  2019cites this paper
• IDH2 deficiency increases bone mass with reduced osteoclastogenesis by limiting RANKL expression in osteoblasts.

  2019cites this paper
• IDH2 deficiency impairs cutaneous wound healing via ROS-dependent apoptosis.

  2019cites this paper
• Activation of AK005401 aggravates acute ischemia/reperfusion mediated hippocampal injury by directly targeting YY1/FGF21

  2019cites this paper
• Reversal of heart failure in a chemogenetic model of persistent cardiac redox stress.

  2019cites this paper
• Cancer-associated mutation and beyond: The emerging biology of isocitrate dehydrogenases in human disease

  2019cites this paper
• Left Ventricular Hypertrophy: Roles of Mitochondria CYP1B1 and Melatonergic Pathways in Co-Ordinating Wider Pathophysiology

  2019cites this paper
• Mitochondrial Dysfunction and Oxidative Stress: Focusing on Cardiac Hypertrophy and Heart Failure

  2019cites this paper
• Mechanisms for the transition from physiological to pathological cardiac hypertrophy.

  2019cites this paper
• Plasma Energy-Balance Metabolites Discriminate Asymptomatic Patients with Peripheral Artery Disease

  2018cites this paper
• Mitochondrial dysfunction in pathophysiology of heart failure

  2018cites this paper
• Isocitrate dehydrogenase 2 deficiency induces endothelial inflammation via p66sh-mediated mitochondrial oxidative stress.

  2018cites this paper
• IDH2 Deficiency in Microglia Decreases the Pro-inflammatory Response via the ERK and NF-κB Pathways

  2018cites this paper
• IDH2 deficiency accelerates skin pigmentation in mice via enhancing melanogenesis

  2018cites this paper
• Disruption of IDH2 attenuates lipopolysaccharide-induced inflammation and lung injury in an α-ketoglutarate-dependent manner.

  2018cites this paper
• Isocitrate dehydrogenase 2 deficiency exacerbates dermis damage by ultraviolet-B via ΔNp63 downregulation.

  2018cites this paper
• NAD(H) and NADP(H) Redox Couples and Cellular Energy Metabolism

  2018cites this paper
• IDH2-deficient mice develop spinal deformities with aging.

  2018cites this paper
• Exogenous Gene Transmission of Isocitrate Dehydrogenase 2 Mimics Ischemic Preconditioning Protection.

  2018cites this paper
• Loss of IDH2 Accelerates Age-related Hearing Loss in Male Mice

  2018cites this paper
• Amelioration of late-onset hepatic steatosis in IDH2-deficient mice

  2017cites this paper
• Expression patterns of members of the isocitrate dehydrogenase gene family in murine inner ear

  2017cites this paper
• Idh2 Deficiency Exacerbates Acrolein-Induced Lung Injury through Mitochondrial Redox Environment Deterioration

  2017cites this paper
• Isocitrate protects DJ-1 null dopaminergic cells from oxidative stress through NADP+-dependent isocitrate dehydrogenase (IDH)

  2017cites this paper
• Increased susceptibility of IDH2-deficient mice to dextran sodium sulfate-induced colitis

  2017cites this paper
• Role of free radicals in human inflammatory diseases

  2017cites this paper
• Idh2 deficiency accelerates renal dysfunction in aged mice.

  2017cites this paper
• Translocase of Inner Membrane 50 Functions as a Novel Protective Regulator of Pathological Cardiac Hypertrophy

  2017cites this paper
• High fructose causes cardiac hypertrophy via mitochondrial signaling pathway.

  2016cites this paper
• IDH2 deficiency impairs mitochondrial function in endothelial cells and endothelium-dependent vasomotor function.

  2016cites this paper
• IDH2 deficiency promotes mitochondrial dysfunction and dopaminergic neurotoxicity: implications for Parkinson’s disease

  2016cites this paper
• Reductive carboxylation is a major metabolic pathway in the retinal pigment epithelium

  2016cites this paper
• Mitochondrial specialization revealed by single muscle fiber proteomics: focus on the Krebs cycle

  2015cites this paper
• Mitochondrion as a Target for Heart Failure Therapy- Role of Protein Lysine Acetylation.

  2015cites this paper