MRE 11 – RAD 50 – NBS 1 is a critical regulator of FANCD 2 stability and function during DNA double-strand break repair

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  2009

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• FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway

  2008cited by this paper
• Mechanism of replication-coupled DNA interstrand crosslink repair.

  2008influential reference
• A Glycine-Arginine Domain in Control of the Human MRE11 DNA Repair Protein

  2008cited by this paper
• A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex.

  2008cited by this paper
• FANCM and FAAP24 function in ATR-mediated checkpoint signaling independently of the Fanconi anemia core complex.

  2008cited by this paper
• Fanconi anemia is associated with a defect in the BRCA2 partner PALB2

  2007cited by this paper
• Biallelic mutations in PALB2 cause Fanconi anemia and predispose to childhood cancer

  2007cited by this paper
• Human CtIP promotes DNA end resection

  2007cited by this paper
• FANCI is a second monoubiquitinated member of the Fanconi anemia pathway

  2007cited by this paper
• Twists and turns in the function of DNA damage signaling and repair proteins by post-translational modifications.

  2007cited by this paper
• DNA Structure-Induced Recruitment and Activation of the Fanconi Anemia Pathway Protein FANCD2

  2007cited by this paper
• Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template.

  2007cited by this paper
• Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins

  2007cited by this paper
• Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair.

  2007cited by this paper
• Histone H2AX and Fanconi anemia FANCD2 function in the same pathway to maintain chromosome stability

  2007cited by this paper
• Cells deficient in the FANC/BRCA pathway are hypersensitive to plasma levels of formaldehyde.

  2007cited by this paper
• Interplay between human DNA repair proteins at a unique double‐strand break in vivo

  2006influential reference
• Activation of Fanconi Anemia Pathway in Cells with Re-Replicated DNA

  2006cited by this paper
• Structural bioinformatics Detection of a tandem BRCT in Nbs 1 and Xrs 2 with functional implications in the DNA damage response

  2006cited by this paper
• ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

  2006cited by this paper
• Purification and biochemical characterization of ataxia-telangiectasia mutated and Mre11/Rad50/Nbs1.

  2006influential reference
• ATM and ATR promote Mre11 dependent restart of collapsed replication forks and prevent accumulation of DNA breaks

  2006cited by this paper
• The WD40 Repeats of FANCL Are Required for Fanconi Anemia Core Complex Assembly*

  2006influential reference
• Arginine methylation of MRE11 by PRMT1 is required for DNA damage checkpoint control.

  2005cited by this paper
• The BRIP1 helicase functions independently of BRCA1 in the Fanconi anemia pathway for DNA crosslink repair

  2005cited by this paper
• Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair.

  2005cited by this paper
• The DNA helicase BRIP1 is defective in Fanconi anemia complementation group J

  2005cited by this paper
• Fanconi anemia (cross)linked to DNA repair.

  2005cited by this paper
• Mesoscale conformational changes in the DNA-repair complex Rad50/Mre11/Nbs1 upon binding DNA

  2005cited by this paper
• Regulated interaction of the Fanconi anemia protein, FANCD2, with chromatin.

  2005influential reference
• Direct DNA Binding Activity of the Fanconi Anemia D2 Protein*

  2005cited by this paper
• The DNA crosslink‐induced S‐phase checkpoint depends on ATR–CHK1 and ATR–NBS1–FANCD2 pathways

  2004influential reference
• ATR couples FANCD2 monoubiquitination to the DNA-damage response.

  2004cited by this paper
• FANCL Replaces BRCA1 as the Likely Ubiquitin Ligase Responsible for FANCD2 Monoubiquitination

  2004cited by this paper
• Repair Kinetics of Genomic Interstrand DNA Cross-Links: Evidence for DNA Double-Strand Break-Dependent Activation of the Fanconi Anemia/BRCA Pathway

  2004cited by this paper
• DNA replication-dependent nuclear dynamics of the Mre11 complex.

  2003cited by this paper
• Regulation of Mre11/Rad50 by Nbs1

  2003cited by this paper
• Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways.

  2002cited by this paper
• Interaction of FANCD2 and NBS1 in the DNA damage response

  2002influential reference
• DNA cross-link-dependent RAD50/MRE11/NBS1 subnuclear assembly requires the Fanconi anemia C protein.

  2002cited by this paper
• Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin.

  2002cited by this paper
• Mammalian Rad51C contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability.

  2002cited by this paper
• An Antisense Construct of Full-Length Human RAD50 cDNA Confers Sensitivity to Ionizing Radiation and Alkylating Agents on Human Cell Lines

  2002cited by this paper
• Biallelic Inactivation of BRCA2 in Fanconi Anemia

  2002cited by this paper
• Adenovirus oncoproteins inactivate the Mre11–Rad50–NBS1 DNA repair complex

  2002cited by this paper
• Fanconi anemia and DNA repair.

  2001cited by this paper
• Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway.

  2001cited by this paper
• Positional cloning of a novel Fanconi anemia gene, FANCD2.

  2001cited by this paper
• Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres

  2000cited by this paper
• Defining the Roles of Nucleotide Excision Repair and Recombination in the Repair of DNA Interstrand Cross-Links in Mammalian Cells

  2000cited by this paper
• ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

  2000cited by this paper
• DNA Replication Is Required To Elicit Cellular Responses to Psoralen-Induced DNA Interstrand Cross-Links

  2000cited by this paper
• Repair of Intermediate Structures Produced at DNA Interstrand Cross-Links in Saccharomyces cerevisiae

  2000cited by this paper
• XRCC3 promotes homology-directed repair of DNA damage in mammalian cells.

  1999cited by this paper
• The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder.

  1999cited by this paper
• Nuclear foci of mammalian recombination proteins are located at single-stranded DNA regions formed after DNA damage.

  1999cited by this paper
• The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks.

  1998cited by this paper
• Nuclease Activities in a Complex of Human Recombination and DNA Repair Factors Rad50, Mre11, and p95*

  1998cited by this paper
• Electron microscopic visualization of RecT protein and its complexes with DNA.

  1995cited by this paper
• Identification and Characterization of the Escherichia coli RecT Protein, a Protein Encoded by the recE Region That Promotes Renaturation of Homologous Single-Stranded DNA

  1993cited by this paper
• Susceptibility of Fanconi's anaemia fibroblasts to chromosome damage by carcinogens

  1976cited by this paper

• 2 directly inhibits DNA 2 nuclease at stalled replication forks and acts as a RAD 51 mediator in strand exchange

  2021cites this paper