Early-life cocaine interferes with BDNF-mediated behavioral plasticity

An important aspect of goal-directed action selection is differentiating between actions that are more or less likely to be reinforced. With repeated performance or psychostimulant exposure, however, actions can assume stimulus-elicited—or “habitual”—qualities that are resistant to change. We show that selective knockdown of prelimbic prefrontal cortical Brain-derived neurotrophic factor (Bdnf) increases sensitivity to response–outcome associations, blocking habit-like behavioral inflexibility. A history of adolescent cocaine exposure, however, occludes the “beneficial” effects of Bdnf knockdown. This finding highlights a challenge in treating addiction—that drugs of abuse may bias decision-making toward habit systems even in individuals with putative neurobiological resiliencies.

• Publication year

  2014

• Venue

  Learning & memory (Cold Spring Harbor, N.Y.)

• Publication date

  2014-05-01

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1101/lm.033290.113PMID 24737916PMCID 3994500
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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