A small-molecule inhibitor of deubiquitinating enzyme USP14 inhibits Dengue virus replication.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Virus Research

• Publication date

  2012-04-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.virusres.2012.01.009PMID 22306365
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Host-microbe interactions: ever increasing complexity.

  2011cited by this paper
• Exploitation of cellular pathways by Dengue virus.

  2011cited by this paper
• Use of a tandem affinity purification assay to detect interactions between West Nile and dengue viral proteins and proteins of the mosquito vector.

  2011cited by this paper
• Appraising the Roles of CBLL1 and the Ubiquitin/Proteasome System for Flavivirus Entry and Replication

  2010cited by this paper
• Enhancement of Proteasome Activity by a Small-Molecule Inhibitor of Usp14

  2010cited by this paper
• Ubiquitin-like protein conjugation and the ubiquitin–proteasome system as drug targets

  2010cited by this paper
• The therapeutic potential of deubiquitinating enzyme inhibitors.

  2010cited by this paper
• The ubiquitin-proteasome pathway is important for dengue virus infection in primary human endothelial cells.

  2010cited by this paper
• Dengue: a continuing global threat

  2010cited by this paper
• Ubiquitin: same molecule, different degradation pathways.

  2010cited by this paper
• Identification of Cellular Proteome Modifications in Response to West Nile Virus Infection*

  2009cited by this paper
• Targeting proteins for degradation.

  2009cited by this paper
• Discovery of Insect and Human Dengue Virus Host Factors

  2009cited by this paper
• Recognition and processing of ubiquitin-protein conjugates by the proteasome.

  2009cited by this paper
• West Nile virus genome amplification requires the functional activities of the proteasome

  2008cited by this paper
• RNA interference screen for human genes associated with West Nile virus infection

  2008cited by this paper
• Targeting ubiquitin specific proteases for drug discovery.

  2008cited by this paper
• West Nile virus.

  2007cited by this paper
• Host Gene Expression Profiling of Dengue Virus Infection in Cell Lines and Patients

  2007cited by this paper
• The ubiquitin-proteasome pathway in viral infections.

  2006cited by this paper
• Targeting of host-cell ubiquitin pathways by viruses.

  2005cited by this paper
• The ubiquitin‐proteasome pathway is required for the function of the viral VP16 transcriptional activation domain

  2004cited by this paper
• Proteasome inhibition reduces coxsackievirus B3 replication in murine cardiomyocytes.

  2003cited by this paper
• The Ubiquitin‐Vacuolar Protein Sorting System is Selectively Required During Entry of Influenza Virus into Host Cells

  2003cited by this paper
• Viruses and the 26S proteasome: hacking into destruction.

  2003cited by this paper
• Polyubiquitination is required for US11-dependent movement of MHC class I heavy chain from endoplasmic reticulum into cytosol.

  2001cited by this paper
• Ubiquitination is essential for human cytomegalovirus US11-mediated dislocation of MHC class I molecules from the endoplasmic reticulum to the cytosol.

  2001cited by this paper
• Ubiquitin is part of the retrovirus budding machinery.

  2000cited by this paper
• A role for ubiquitin ligase recruitment in retrovirus release.

  2000cited by this paper
• Proteasome inhibition interferes with gag polyprotein processing, release, and maturation of HIV-1 and HIV-2.

  2000cited by this paper
• Inhibition of ubiquitin/proteasome-dependent protein degradation by the Gly-Ala repeat domain of the Epstein-Barr virus nuclear antigen 1.

  1997cited by this paper
• The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53.

  1993cited by this paper

• AKT and DUBs: a bidirectional relationship

  2025cites this paper
• Regulation of ubiquitination and antiviral activity of Cactin by deubiquitinase Usp14 in Drosophila

  2024cites this paper
• The endoplasmic reticulum (ER): a crucial cellular hub in flavivirus infection and potential target site for antiviral interventions

  2024cites this paper
• Activation of the 20S proteasome core particle prevents cell death induced by oxygen- and glucose deprivation in cultured cortical neurons

  2024cites this paper
• Unraveling role of ubiquitination in drug resistance of gynecological cancer.

  2024cites this paper
• West Nile Virus Subgenomic RNAs Modulate Gene Expression in a Neuronal Cell Line

  2024cites this paper
• Host-Driven Ubiquitination Events in Vector-Transmitted RNA Virus Infections as Options for Broad-Spectrum Therapeutic Intervention Strategies

  2024cites this paper
• Inhibitors of the Ubiquitin-Mediated Signaling Pathway Exhibit Broad-Spectrum Antiviral Activities against New World Alphaviruses

  2023cites this paper
• RGS2 promotes estradiol biosynthesis by trophoblasts during human pregnancy

  2023cites this paper
• Deubiquitinating Enzyme Inhibitors Block Chikungunya Virus Replication

  2023influential citation
• Inhibitors of Deubiquitinating Enzymes Interfere with the SARS-CoV-2 Papain-like Protease and Block Virus Replication In Vitro

  2022cites this paper
• Proteasomal deubiquitylase activity enhances cell surface recycling of the epidermal growth factor receptor in non-small cell lung cancer

  2022cites this paper
• Inhibiting UCH-L5: Rational Design of a Cyclic Ubiquitin-Based Peptide Inhibitor

  2022cites this paper
• The Role of Deubiquitinases in Virus Replication and Host Innate Immune Response

  2022cites this paper
• USP14: Structure, Function, and Target Inhibition

  2022cites this paper
• Inhibition of USP14 influences alphaherpesvirus proliferation by degrading viral VP16 protein via ER stress-triggered selective autophagy

  2021cites this paper
• Novel Antiviral Strategies Against Emerging Arbovirus Infections

  2021cites this paper
• Grouper ubiquitin-specific protease 14 promotes iridovirus replication through negatively regulating interferon response.

  2020cites this paper
• The Functional Deubiquitinating Enzymes in Control of Innate Antiviral Immunity

  2020cites this paper
• USP14 negatively regulates RIG-I-mediated IL-6 and TNF-α production by inhibiting NF-κB activation.

  2020cites this paper
• Ubiquitin‐specific protease 14 is a new therapeutic target for the treatment of diseases

  2020influential citation
• The deubiquitylase USP2 maintains ErbB2 abundance via counteracting endocytic degradation and represents a therapeutic target in ErbB2-positive breast cancer

  2020cites this paper
• Assay Systems for Profiling Deubiquitinating Activity

  2020cites this paper
• Recent advances in antiviral drug development towards dengue virus.

  2020cites this paper
• Proteasome, a Promising Therapeutic Target for Multiple Diseases Beyond Cancer

  2020cites this paper
• USP49 potently stabilizes APOBEC3G protein by removing ubiquitin and inhibits HIV-1 replication

  2019cites this paper
• Emerging role of ubiquitin-specific protease 14 in oncogenesis and development of tumor: Therapeutic implication.

  2019cites this paper
• Flaviviruses Exploit the Lipid Droplet Protein AUP1 to Trigger Lipophagy and Drive Virus Production.

  2018cites this paper
• Biochemistry and Molecular Biology of Flaviviruses.

  2018cites this paper
• Characterization and structure‐activity relationship analysis of a class of antiviral compounds that directly bind dengue virus capsid protein and are incorporated into virions

  2018cites this paper
• USP14 promotes K63‐linked RIG‐I deubiquitination and suppresses antiviral immune responses

  2018cites this paper
• An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons

  2017cites this paper
• Ubiquitin-specific protease 14 regulates LPS-induced inflammation by increasing ERK1/2 phosphorylation and NF-κB activation

  2017cites this paper
• Analysis of the miRNA profile in C6/36 cells persistently infected with dengue virus type 2.

  2017cites this paper
• Inhibitors of Deubiquitinating Enzymes Block HIV-1 Replication and Augment the Presentation of Gag-Derived MHC-I Epitopes

  2017cites this paper
• Interferon, viruses and drug discovery

  2017influential citation
• Decision for cell fate: deubiquitinating enzymes in cell cycle checkpoint

  2016cites this paper
• A novel mosquito ubiquitin targets viral envelope protein for degradation and reduces virion production during dengue virus infection

  2016cites this paper
• Manipulation of viral infection by deubiquitinating enzymes: new players in host-virus interactions.

  2016cites this paper
• USP14 de-ubiquitinates vimentin and miR-320a modulates USP14 and vimentin to contribute to malignancy in gastric cancer cells

  2016cites this paper
• Function of Deubiquitinating Enzyme USP14 as Oncogene in Different Types of Cancer

  2016cites this paper
• The quest for host targets to combat dengue virus infections.

  2016cites this paper
• Inhibition of 19S proteasome-associated deubiquitinases by metal-containing compounds

  2015cites this paper
• MODULATION OF APOLIPOPROTEIN B-100 DEGRADATION AND SECRETION BY HEPATIC PROTEIN QUALITY CONTROL COMPONENTS

  2015cites this paper
• Overexpression of deubiquitinating enzyme USP28 promoted non-small cell lung cancer growth

  2015cites this paper
• DUBs, the regulation of cell identity and disease.

  2015cites this paper
• Targeting Proteasomal Degradation of Soluble, Misfolded Proteins

  2015cites this paper
• Stress Response Pathways in Cancer

  2015cites this paper
• Proteasomal serine hydrolases are up-regulated by and required for influenza virus infection.

  2014cites this paper
• Identification and characterization of a proteasome deubiquitinase inhibitor

  2014cites this paper
• Disassembly of Lys11 and Mixed Linkage Polyubiquitin Conjugates Provides Insights into Function of Proteasomal Deubiquitinases Rpn11 and Ubp6*

  2014cites this paper
• Deubiquitinating enzyme inhibitors and their potential in cancer therapy.

  2014cites this paper
• deubiquitinases Rpn11 and Ubp6 into function of proteasomal polyubiquitin conjugates provide insights Disassembly of Lys11- and mixed-linkage Protein Synthesis and Degradation:

  2014cites this paper
• The Ubiquitin-Proteasome System (UPS) as a Cancer Drug Target: Emerging Mechanisms and Therapeutics

  2014cites this paper
• Targeting Host Factors to Treat West Nile and Dengue Viral Infections

  2014cites this paper
• Extended ubiquitin species are protein-based DUB inhibitors

  2014cites this paper
• Revisiting dengue virus-host cell interaction: new insights into molecular and cellular virology.

  2014cites this paper
• Disassembly of Lys 11-and mixed-linkage polyubiquitin conjugates provide insights into function of proteasomal deubiquitinases Rpn 11 and Ubp

  2014cites this paper
• Toward understanding ubiquitin-modifying enzymes: from pharmacological targeting to proteomics.

  2014cites this paper
• Ubiquitin Hydrolase UCH-L1 Destabilizes mTOR Complex 1 by Antagonizing DDB1-CUL4-Mediated Ubiquitination of Raptor

  2013cites this paper
• Molecular architecture and assembly of the eukaryotic proteasome.

  2013cites this paper
• Inhibiteurs de l'usp14 utilisables en vue du traitement ou de la prévention d'infections virales

  2013cites this paper
• Over-Expression of Deubiquitinating Enzyme USP14 in Lung Adenocarcinoma Promotes Proliferation through the Accumulation of β-Catenin

  2013cites this paper
• Deubiquitinating enzymes as promising drug targets for infectious diseases.

  2013cites this paper
• Functional Studies of Deubiquitinating Enzymes

  2012cites this paper
• Recent Advances in the Discovery of Dengue Virus Inhibitors

  2012cites this paper
• Characterization of hypertonic stress-induced protein damage and the cellular mechanisms for defense and repair in C. elegans

  2012cites this paper
• Ubiquitin-Based Probes Prepared by Total Synthesis To Profile the Activity of Deubiquitinating Enzymes

  2012cites this paper
• Review Article Unraveling role of ubiquitination in drug resistance of gynecological cancer

  year unknowncites this paper