Ketamine Blockade of Voltage-gated Sodium Channels: Evidence for a Shared Receptor Site with Local Anesthetics

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Anesthesiology

• Publication date

  2001-12-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1097/00000542-200112000-00020PMID 11748399
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1994influential reference
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