Consumption of Soy Isoflavone Enriched Bread in Men with Prostate Cancer Is Associated with Reduced Proinflammatory Cytokines and Immunosuppressive Cells

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Cancer Prevention Research

• Publication date

  2015-08-14

• Fields of study

  Medicine

• Identifiers
  DOI 10.1158/1940-6207.CAPR-14-0464PMID 26276751PMCID PMC4633400
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Isoflavone Pharmacokinetics and Metabolism after Consumption of a Standardized Soy and Soy–Almond Bread in Men with Asymptomatic Prostate Cancer

  2015cited by this paper
• Correlation between frequencies of blood monocytic myeloid-derived suppressor cells, regulatory T cells and negative prognostic markers in patients with castration-resistant metastatic prostate cancer

  2014cited by this paper
• Chronic Inflammation in Benign Prostate Tissue Is Associated with High-Grade Prostate Cancer in the Placebo Arm of the Prostate Cancer Prevention Trial

  2014cited by this paper
• Genistein inhibits human prostate cancer cell detachment, invasion, and metastasis.

  2014cited by this paper
• Soy and soy isoflavones in prostate cancer: a systematic review and meta‐analysis of randomized controlled trials

  2014cited by this paper
• Polyphenol E Enhances the Antitumor Immune Response in Neuroblastoma by Inactivating Myeloid Suppressor Cells

  2013cited by this paper
• Effect of soy protein isolate supplementation on biochemical recurrence of prostate cancer after radical prostatectomy: a randomized trial.

  2013cited by this paper
• Design and selection of soy breads used for evaluating isoflavone bioavailability in clinical trials.

  2013cited by this paper
• Pancreatic cancer-associated stellate cells promote differentiation of myeloid-derived suppressor cells in a STAT3-dependent manner.

  2013cited by this paper
• The Interactions of Dietary Tomato Powder and Soy Germ on Prostate Carcinogenesis in the TRAMP Model

  2013cited by this paper
• Demystifying Immunotherapy in Prostate Cancer: Understanding Current and Future Treatment Strategies

  2013cited by this paper
• Regulatory T cells in the bone marrow microenvironment in patients with prostate cancer

  2012cited by this paper
• Soy isoflavones radiosensitize lung cancer while mitigating normal tissue injury.

  2011cited by this paper
• Analysis of circulating regulatory T cells in patients with metastatic prostate cancer pre- versus post-vaccination

  2011cited by this paper
• Suppression of dendritic cells' maturation and functions by daidzein, a phytoestrogen.

  2011cited by this paper
• Distinct myeloid suppressor cell subsets correlate with plasma IL-6 and IL-10 and reduced interferon-alpha signaling in CD4+ T cells from patients with GI malignancy

  2011cited by this paper
• Curcumin Induces the Differentiation of Myeloid-Derived Suppressor Cells and Inhibits Their Interaction with Cancer Cells and Related Tumor Growth

  2011cited by this paper
• Molecular mechanisms regulating myeloid-derived suppressor cell differentiation and function.

  2011cited by this paper
• Nutraceuticals and prostate cancer prevention: a current review

  2010cited by this paper
• Prostate cancer as a model for tumour immunotherapy

  2010cited by this paper
• Results of a randomized phase I dose-finding trial of several doses of isoflavones in men with localized prostate cancer: administration prior to radical prostatectomy.

  2010cited by this paper
• Sipuleucel-T immunotherapy for castration-resistant prostate cancer.

  2010cited by this paper
• Guidance from an NIH Workshop on Designing, Implementing, and Reporting Clinical Studies of Soy Interventions1–4

  2010cited by this paper
• Immunosuppressive CD14+HLA‐DRlow/− monocytes in prostate cancer

  2010cited by this paper
• Soy isoflavones and immunity.

  2008cited by this paper
• Enhanced Functionality of CD4+CD25highFoxP3+ Regulatory T Cells in the Peripheral Blood of Patients with Prostate Cancer

  2008cited by this paper
• Suppression of VEGF-mediated autocrine and paracrine interactions between prostate cancer cells and vascular endothelial cells by soy isoflavones.

  2007cited by this paper
• Control of the mean number of false discoveries, Bonferroni and stability of multiple testing

  2007cited by this paper
• The number of regulatory T cells in prostate cancer is associated with the androgen receptor and hypoxia‐inducible factor (HIF)‐2α but not HIF‐1α

  2007cited by this paper
• A Phase II Randomized, Placebo-Controlled Clinical Trial of Purified Isoflavones in Modulating Steroid Hormones in Men Diagnosed With Localized Prostate Cancer

  2007cited by this paper
• Estimated Asian Adult Soy Protein and Isoflavone Intakes

  2006cited by this paper
• Genistein suppresses antigen-specific immune responses through competition with 17beta-estradiol for estrogen receptors in ovalbumin-immunized BALB/c mice.

  2006cited by this paper
• CD4+CD25high T Cells Are Enriched in the Tumor and Peripheral Blood of Prostate Cancer Patients1

  2006cited by this paper
• Genistein, estrogen receptors, and the acquired immune response.

  2006cited by this paper
• Dietary intervention in prostate cancer patients: PSA response in a randomized double‐blind placebo‐controlled study

  2005cited by this paper
• Phase 1B study to improve immune responses in head and neck cancer patients using escalating doses of 25-hydroxyvitamin D3

  2004cited by this paper
• Western soy intake is too low to produce health effects.

  2004cited by this paper
• Tomato and soy polyphenols reduce insulin-like growth factor-I-stimulated rat prostate cancer cell proliferation and apoptotic resistance in vitro via inhibition of intracellular signaling pathways involving tyrosine kinase.

  2003cited by this paper
• Emerging evidence on the role of soy in reducing prostate cancer risk.

  2003cited by this paper
• The phytoestrogen genistein suppresses cell-mediated immunity in mice.

  2003cited by this paper
• Genistein and methoxychlor modulate the activity of natural killer cells and the expression of phenotypic markers by thymocytes and splenocytes in F0 and F1 generations of Sprague-Dawley rats.

  2002cited by this paper
• The phytoestrogen genistein induces thymic and immune changes: A human health concern?

  2002cited by this paper
• Genistein modulates splenic natural killer cell activity, antibody-forming cell response, and phenotypic marker expression in F(0) and F(1) generations of Sprague-Dawley rats.

  2002cited by this paper
• Genistein in the diet reduces the incidence of poorly differentiated prostatic adenocarcinoma in transgenic mice (TRAMP).

  2001cited by this paper
• Genistein modulates immune responses and increases host resistance to B16F10 tumor in adult female B6C3F1 mice.

  2001cited by this paper
• Dietary intake and bioavailability of polyphenols.

  2000cited by this paper
• Genistein inhibits growth of estrogen-independent human breast cancer cells in culture but not in athymic mice.

  2000cited by this paper
• Soybean phytochemicals inhibit the growth of transplantable human prostate carcinoma and tumor angiogenesis in mice.

  1999cited by this paper
• Genistein, a dietary-derived inhibitor of in vitro angiogenesis.

  1993cited by this paper
• Procedures for comparing samples with multiple endpoints.

  1984cited by this paper

• Antioxidant and immunomodulatory effects of the white bread supplemented with blueberry and apple peel

  2025cites this paper
• Roles of equol and the PI3K/Akt signaling pathway in the cardioprotective effects of enteral daidzein against ischemia-reperfusion injury in isolated rat hearts.

  2025cites this paper
• Deciphering the metabolic landscape of colorectal cancer through the lens of AhR-mediated intestinal inflammation

  2025cites this paper
• Role of Nutrients Regulating Myeloid Derived Suppressor Cells in Cancer: A Scoping Review

  2024cites this paper
• Chrysin Enhances Anti‐Cancer Activity of Jurkat T Cell and NK‐92 Cells Against Human Breast Cancer Cell Lines

  2024cites this paper
• The potential use of natural killer cells to treat Alzheimer's disease: Can nutrition play a role?

  2024cites this paper
• Effects of Soy Bread on Cardiovascular Risk Factor, Inflammation and Oxidative Stress in Women With Active Rheumatoid Arthritis: A Randomized Double-Blind Controlled Trial

  2024cites this paper
• The effect of dietary interventions or patterns on the cardiometabolic health of individuals treated with androgen deprivation therapy for prostate cancer: A systematic review.

  2024cites this paper
• Phytochemicals in Cancer Chemoprevention: Preclinical and Clinical Studies

  2024cites this paper
• Fortified bread with encapsulated ingredients: impacts and potential applications

  2024cites this paper
• Effect of the Fermented Soy Q-CAN® Product on Biomarkers of Inflammation and Oxidation in Adults with Cardiovascular Risk, and Canonical Correlations between the Inflammation Biomarkers and Blood Lipids

  2023cites this paper
• Targeting the prostate tumor microenvironment by plant-derived natural products.

  2023cites this paper
• Impact of Soybean Phytoestrogen-Rich Extract on Markers of Inflammation Markers in 4-Vinyl Cyclohexane Diepoxide-Induced Menopause in Albino Rats

  2023cites this paper
• Approaches for boosting antitumor immunity in prostate cancer therapy: A comprehensive review on drugs, products, and nanoparticles

  2023cites this paper
• Environmental toxicants and health adversities: A review on interventions of phytochemicals

  2023cites this paper
• Protective effect of daidzein on ovarian ischemia‑reperfusion injury in rats

  2022cites this paper
• Foods may modify responsiveness to cancer immune checkpoint blockers by altering both the gut microbiota and activation of estrogen receptors in immune cells

  2022cites this paper
• Impact of soybean bioactive compounds as response to diet-induced chronic inflammation: A systematic review.

  2022cites this paper
• Myeloid-Derived Suppressor Cells as Key Players and Promising Therapy Targets in Prostate Cancer

  2022cites this paper
• Nutritional quality, functional property and acceptability of maize (Zea mays) based complementary foods enriched with defatted groundnut (Arachis hypogea L.) and ginger (Zinger officinale Roscoe) powder in Wistar rats

  2022cites this paper
• Bread Enriched with Resveratrol: Influence of the Delivery Vehicles on its Bioactivity

  2022cites this paper
• Nutritional and surgical aspects in prostate disorders

  2022cites this paper
• Plant derived coumestrol phytochemical targets human skin carcinoma cells by inducing mitochondrial-mediated apoptosis, cell cycle arrest, inhibition of cell migration and invasion and modulation of m-TOR/PI3K/AKT signalling pathway

  2021cites this paper
• Natural and Synthetic Estrogens in Chronic Inflammation and Breast Cancer

  2021cites this paper
• Apple polyphenol phloretin complexed with ruthenium is capable of reprogramming the breast cancer microenvironment through modulation of PI3K/Akt/mTOR/VEGF pathways.

  2021cites this paper
• Flavonoids against non-physiologic inflammation attributed to cancer initiation, development, and progression—3PM pathways

  2021cites this paper
• The effects of twenty-four nutrients and phytonutrients on immune system function and inflammation: A narrative review

  2021influential citation
• Current Perspectives on the Beneficial Effects of Soybean Isoflavones and Their Metabolites for Humans

  2021cites this paper
• Myeloid-derived suppressor cells in cancer immunotherapy-clinical perspectives.

  2021cites this paper
• Modulation of α-synuclein fibrillation by plant metabolites, daidzein, fisetin and scopoletin under physiological conditions.

  2021cites this paper
• Genistein Reduces the Risk of Local Mammary Cancer Recurrence and Ameliorates Alterations in the Gut Microbiota in the Offspring of Obese Dams

  2021cites this paper
• Food Intake During Cancer Therapy

  2020cites this paper
• Daidzein-rich isoflavones aglycone inhibits lung cancer growth through inhibition of NF-κB signaling pathway.

  2020cites this paper
• Chemopreventive and Therapeutic Efficacy of Cinnamomum zeylanicum L. Bark in Experimental Breast Carcinoma: Mechanistic In Vivo and In Vitro Analyses

  2020cites this paper
• Changes in Nutrient and Phytochemical Composition of Processed Tigernut (Cyperus esclentus L)

  2020cites this paper
• Improvement of Aglycone Content in Soy Isoflavones Extract by Free and Immobilized Β-Glucosidase and their Effects in Lipid Accumulation

  2020cites this paper
• Reduction of inflammation in chronic pancreatitis using a soy bread intervention: A feasibility study.

  2020cites this paper
• Equol, a Blood–Brain Barrier Permeable Gut Microbial Metabolite of Dietary Isoflavone Daidzein, Exhibits Neuroprotective Effects against Neurotoxins Induced Toxicity in Human Neuroblastoma SH-SY5Y Cells and Caenorhabditis elegans

  2020cites this paper
• RENISUS Plants and Their Potential Antitumor Effects in Clinical Trials and Registered Patents

  2020cites this paper
• Can soy isoflavones plus soy protein change serum levels of interlukin‐6? A systematic review and meta‐analysis of randomized controlled trials

  2020cites this paper
• Targeting the tumor immwpune microenvironment with "nutraceuticals": From bench to clinical trials.

  2020cites this paper
• Plant-Based Food By-Products: Prospects for Valorisation in Functional Bread Development

  2020cites this paper
• Role of Flavonoids in the Prevention of AhR-Dependent Resistance During Treatment with BRAF Inhibitors

  2020cites this paper
• AhR and Cancer: From Gene Profiling to Targeted Therapy

  2020cites this paper
• Soy-tomato enriched diet reduces inflammation and disease severity in a pre-clinical model of chronic pancreatitis

  2020cites this paper
• Rhus coriaria L. (Sumac) Demonstrates Oncostatic Activity in the Therapeutic and Preventive Model of Breast Carcinoma

  2020cites this paper
• A newfangled coordinated ruthenium phloretin complex reprogramming breast cancer microenvironment interceded by modulation of PI3K/Akt/mTOR/VEGF pathway and modifying the antioxidant status correlated with intensified apoptotic events.

  2020cites this paper
• Soy Isoflavone Supplementation Increases Long Interspersed Nucleotide Element-1 (LINE-1) Methylation in Head and Neck Squamous Cell Carcinoma

  2019cites this paper
• Soy isoflavones and their metabolites modulate cytokine-induced natural killer cell function

  2019cites this paper
• Nutritional Interventions for Treating Cancer-Related Fatigue: A Qualitative Review

  2019cites this paper
• Main Inflammatory Cells and Potentials of Anti-Inflammatory Agents in Prostate Cancer

  2019cites this paper
• Dietary Flavonoids for Immunoregulation and Cancer: Food Design for Targeting Disease

  2019cites this paper
• Modulation of regulatory T cells by natural products in cancer.

  2019cites this paper
• Engineering and Health Benefits of Fruits and Vegetables Beverages

  2019cites this paper
• Beneficial Role of Phytochemicals on Oxidative Stress and Age-Related Diseases

  2019cites this paper
• Modulation of Tumor Immunity by Medicinal Plant or Functional Food-Derived Compounds

  2019cites this paper
• Ensuring the future of functional foods

  2019cites this paper
• Effects of Phytochemical Fortification of Flour and Bread on Human Health

  2019cites this paper
• Dietary Assessment as a Means to Modulate Inflammation in Patients with Prostate Cancer

  2018cites this paper
• Towards improving the nutrition and health of the aged: the role of sprouted grains and encapsulation of bioactive compounds in functional bread - a review

  2018cites this paper
• Fermentation and germination improve nutritional value of cereals and legumes through activation of endogenous enzymes

  2018cites this paper
• A Novel Tomato-Soy Juice Induces a Dose-Response Increase in Urinary and Plasma Phytochemical Biomarkers in Men with Prostate Cancer.

  2018cites this paper
• Metabolic influence on the differentiation of suppressive myeloid cells in cancer.

  2018cites this paper
• Nutraceuticals in prostate cancer therapeutic strategies and their neo-adjuvant use in diverse populations

  2018cites this paper
• Cholesterol-Lowering Nutraceuticals Affecting Vascular Function and Cardiovascular Disease Risk

  2018cites this paper
• Soy Consumption and the Risk of Prostate Cancer: An Updated Systematic Review and Meta-Analysis

  2018cites this paper
• Targeting epithelial-mesenchymal plasticity in cancer: clinical and preclinical advances in therapy and monitoring.

  2017cites this paper
• Running title : Modulating enzymatic and chemical conversion of isoflavones Figures and Tables : 4 Figures and 2 Tables Supplemental Materials : 3 Tables

  2017cites this paper
• Modulating conversion of isoflavone glycosides to aglycones using crude beta-glycosidase extracts from almonds and processed soy.

  2017cites this paper
• Coumestrol Inhibits Proliferation and Migration of Prostate Cancer Cells by Regulating AKT, ERK1/2, and JNK MAPK Cell Signaling Cascades

  2017cites this paper
• Effects of Soy Product Intake and Interleukin Genetic Polymorphisms on Early Gastric Cancer Risk in Korea: A Case-Control Study

  2017cites this paper
• An update of research evidence on nutrition and prostate cancer.

  2017cites this paper
• Modulation of tumor microenvironment by chemopreventive natural products

  2017cites this paper
• Broad spectrum targeting of tumor vasculature by medicinal plants: An updated review

  2017cites this paper
• Anti-angiogenic Therapy in Patients with Advanced Gastric and Gastroesophageal Junction Cancer: A Systematic Review

  2017cites this paper
• Beyond the Cholesterol-Lowering Effect of Soy Protein: A Review of the Effects of Dietary Soy and Its Constituents on Risk Factors for Cardiovascular Disease

  2017cites this paper
• Isoflavones: Anti-Inflammatory Benefit and Possible Caveats

  2016influential citation
• Food-based natural products for cancer management: Is the whole greater than the sum of the parts?

  2016cites this paper
• Isoflavone Pharmacokinetics and Metabolism after Consumption of a Standardized Soy and Soy–Almond Bread in Men with Asymptomatic Prostate Cancer

  2015cites this paper