In search of Flavivirus inhibitors part 2: tritylated, diphenylmethylated and other alkylated nucleoside analogues.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  European journal of medicinal chemistry

• Publication date

  2014-04-09

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.ejmech.2014.02.011PMID 24583349
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Fluorine in medicinal chemistry.

  2015cited by this paper
• Dengue and dengue hemorrhagic fever.

  2014cited by this paper
• A Straightforward Diphenylmethyl Protection Method and Deprotection of Some Pyrimidine Nucleosides

  2013cited by this paper
• In search of flavivirus inhibitors: evaluation of different tritylated nucleoside analogues.

  2013influential reference
• 3',5'Di-O-trityluridine inhibits in vitro flavivirus replication.

  2013cited by this paper
• The global distribution and burden of dengue

  2013cited by this paper
• Favipiravir (T-705), a novel viral RNA polymerase inhibitor.

  2013cited by this paper
• Ivermectin is a potent inhibitor of flavivirus replication specifically targeting NS3 helicase activity: new prospects for an old drug.

  2012cited by this paper
• Chemoenzymatic Synthesis of 3′‐O‐Acetal‐Protected 2′‐Deoxynucleosides as Building Blocks for Nucleic Acid Chemistry

  2010cited by this paper
• Fluorine in medicinal chemistry.

  2008cited by this paper
• The many roles for fluorine in medicinal chemistry.

  2008cited by this paper
• Intradermally Administered Yellow Fever Vaccine at Reduced Dose Induces a Protective Immune Response: A Randomized Controlled Non-Inferiority Trial

  2008cited by this paper
• Yellow fever: epidemiology and prevention.

  2007cited by this paper
• Fluorine in Pharmaceuticals: Looking Beyond Intuition

  2007cited by this paper
• Synthesis and pharmacokinetics of valopicitabine (NM283), an efficient prodrug of the potent anti-HCV agent 2'-C-methylcytidine.

  2006cited by this paper
• Yellow fever vaccine-associated viscerotropic disease (YEL-AVD) and corticosteroid therapy: eleven United States cases, 1996-2004.

  2006cited by this paper
• Synthesis of N3-substituted uridine and related pyrimidine nucleosides and their antinociceptive effects in mice.

  2005cited by this paper
• Fluorine in Medicinal Chemistry

  2004cited by this paper
• 5-Fluorouracil: mechanisms of action and clinical strategies

  2003cited by this paper
• Dengue: an update.

  2002cited by this paper
• Modified nucleosides for treatment of viral infections and abnormal cellular proliferation

  2001cited by this paper
• Dengue and Dengue Hemorrhagic Fever

  1998cited by this paper
• Convenient Intermediates for the Preparation of C-4 Modified Derivatives of Pyrimidine Nucleosides.

  1997influential reference
• The dengue viruses

  1990cited by this paper
• Flavivirus genome organization, expression, and replication.

  1990cited by this paper
• Pathogenesis of dengue: challenges to molecular biology.

  1988cited by this paper
• Flavivirus replication strategy.

  1987influential reference
• The 9-fluorenylmethyloxycarbonyl(fmoc) Group As a 5'-o Base Labile Protecting Group in Solid Supported Oligonucleotide Synthesis

  1987cited by this paper
• [Yellow fever (epidemiology and prevention)].

  1983cited by this paper
• Stereochemical control as a function of protecting-group participation in 2-deoxy-D-erythro-pentofuranosyl nucleosides☆

  1981cited by this paper
• Two-Stage Synthesis of 3′-O-Tritylthymidine via Hydrolysis of 3′, 5′-Di-O-tritylthymidine; Comparison with Alternative Methods

  1980cited by this paper
• 4'-Substituted nucleosides. 5. Hydroxymethylation of nucleoside 5'-aldehydes

  1979cited by this paper
• Dengue Viruses

  1977cited by this paper
• Reaction of diazoalkanes with 1-substituted 2, 4-dioxopyrimidines. Formation of O2, N-3 and O4-alkyl products.

  1976cited by this paper
• SELECTIVE PROTECTION OF HYDROXYL GROUPS IN DEOXYNUCLEOSIDES USING ALKYLSILYL REAGENTS

  1974cited by this paper
• The alkylation of 2'-deoxyguanosine and of thymidine with diazoalkanes. Some observations on o-alkylation.

  1973cited by this paper
• Use of the -butyldimethylsilyl group for protecting the hydroxyl functions of nucleosides

  1973cited by this paper
• Studies on polynucleotides

  1965cited by this paper
• Nucleosides. XVI. Further Studies of Anhydronucleosides1

  1963cited by this paper
• Nucleosides. XI. Synthesis of 1-β-D-Arabinofuranosul-5-Fluorouracil and Related Nucleosides1

  1961cited by this paper
• Studies on Polynucleotides. I. A New and General Method for the Chemical Synthesis of the C5″-C3″ Internucleotidic Linkage. Syntheses of Deoxyribo-dinucleotides1

  1958cited by this paper
• Nucleotides part XXXII. Synthesis of a dithymidine dinucleotide containing a 3′: 5′-internucleotidic linkage

  1955cited by this paper

• Assessing the Design of Pyrimidine-Based Nucleoside Analogs Targeting Dengue and Zika RNA-Dependent RNA Polymerase: What are the Rules?

  2025cites this paper
• Selective Methylation of Nucleosides via an In Situ Generated Methyl Oxonium.

  2024cites this paper
• Elongation of N6-benzyladenosine scaffold via Pd-catalyzed C-C bond formation leads to derivatives with antiflaviviral activity.

  2023cites this paper
• Antiviral and Antimicrobial Nucleoside Derivatives: Structural Features and Mechanisms of Action

  2021cites this paper
• A systematic review of experimental evidence for antiviral effects of ivermectin and an in silico analysis of ivermectin's possible mode of action against SARS‐CoV‐2

  2021cites this paper
• Multi-sulfonated ligands on gold nanoparticles as virucidal antiviral for Dengue virus

  2020cites this paper
• Dengue drug discovery: Progress, challenges and outlook

  2019cites this paper
• Antiviral activity spectrum of phenoxazine nucleoside derivatives

  2019cites this paper
• Recent update on anti-dengue drug discovery.

  2019cites this paper
• Nucleoside analogs as a rich source of antiviral agents active against arthropod-borne flaviviruses

  2018cites this paper
• Discovery of Dengue Virus Inhibitors.

  2018cites this paper
• New tools in nucleoside toolbox of tick-borne encephalitis virus reproduction inhibitors.

  2017cites this paper
• Inhibitors compounds of the flavivirus replication process

  2017cites this paper
• Aminopurine and aminoquinazoline scaffolds for development of potential dengue virus inhibitors.

  2017cites this paper
• Independent Generation and Reactivity of Thymidine Radical Cations.

  2017cites this paper
• Antiviral and Cytostatic Evaluation of 5‐(1‐Halo‐2‐sulfonylvinyl)‐ and 5‐(2‐Furyl)uracil Nucleosides

  2017cites this paper
• Anti‐flavivirus Activity of Different Tritylated Pyrimidine and Purine Nucleoside Analogues

  2016cites this paper
• New developments in flavivirus drug discovery

  2016cites this paper
• The Reactivity of Thymine and Thymidine 5,6-Epoxides with Organometallic Reagents - A Route to Thymidine (6-4) Photoproduct Analogues.

  2016cites this paper
• Rigid amphipathic nucleosides suppress reproduction of the tick-borne encephalitis virus

  2016cites this paper
• Conjugation of Uridine with Oleanolic Acid Derivatives as Potential Antitumor Agents

  2016cites this paper
• Synthesis by microwave-assisted 1,3-dipolar cycloaddition of 1,2,3-triazole 1'-homo-3'-isoazanucleosides and evaluation of their anticancer activity.

  2015cites this paper
• In search of uracil derivatives as bioactive agents. Uracils and fused uracils: Synthesis, biological activity and applications.

  2015cites this paper
• The search for nucleoside/nucleotide analog inhibitors of dengue virus.

  2015cites this paper
• Synthesis and evaluation of imidazole-4,5- and pyrazine-2,3-dicarboxamides targeting dengue and yellow fever virus

  2014cites this paper