Role of 12-lipoxygenase in regulation of ovarian cancer cell proliferation and survival

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Cancer Chemotherapy and Pharmacology

• Publication date

  2011-03-29

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s00280-011-1595-yPMID 21442472
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cancer Statistics, 2010

  2010cited by this paper
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  2010cited by this paper
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• PI-3-K and AKT: Onto the mitochondria.

  2009cited by this paper
• Tumour cell survival signalling by the ERK1/2 pathway

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• 15-Lipoxygenase-1 in Colorectal Cancer: A Review

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• Dual roles of the MAPK/ERK1/2 cell signaling pathway after stroke

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• Comparative Analysis of Peritoneum and Tumor Eicosanoids and Pathways in Advanced Ovarian Cancer

  2007cited by this paper
• Non-steroidal anti-inflammatory drugs to potentiate chemotherapy effects: from lab to clinic.

  2007cited by this paper
• Inhibition of 12-lipoxygenase during baicalein-induced human lung nonsmall carcinoma H460 cell apoptosis.

  2007influential reference
• A coding polymorphism in the 12-lipoxygenase gene is associated to essential hypertension and urinary 12(S)-HETE.

  2006cited by this paper
• Specific monocyte adhesion to endothelial cells induced by oxidized phospholipids involves activation of cPLA2 and lipoxygenase Published, JLR Papers in Press, February 5, 2006.

  2006cited by this paper
• What are cyclooxygenases and lipoxygenases doing in the driver's seat of carcinogenesis?

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• 9L Gliosarcoma Cell Proliferation and Tumor Growth in Rats Are Suppressed by N-Hydroxy-N′-(4-butyl-2-methylphenol) Formamidine (HET0016), a Selective Inhibitor of CYP4A

  2006cited by this paper
• The extracellular signal-regulated kinase: Multiple substrates regulate diverse cellular functions

  2006cited by this paper
• Expression of 12-lipoxygenase in human renal cell carcinoma and growth prevention by its inhibitor.

  2004cited by this paper
• PI 3-kinase, Akt and cell survival.

  2004cited by this paper
• Lipoxygenase inhibitors prevent urological cancer cell growth.

  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
• PI3K-Akt pathway: Its functions and alterations in human cancer

  2004cited by this paper
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  2002cited by this paper
• Lipoxygenase inhibitors attenuate growth of human pancreatic cancer xenografts and induce apoptosis through the mitochondrial pathway.

  2002cited by this paper
• Arachidonate 12-lipoxygenases.

  2002cited by this paper
• Cyclooxygenase, lipoxygenase and tumor angiogenesis

  2002cited by this paper
• P-450 metabolites of arachidonic acid in the control of cardiovascular function.

  2002cited by this paper
• 12-Lipoxygenase inhibition induced apoptosis in human gastric cancer cells.

  2001influential reference
• Lipoxygenase‐5 is overexpressed in prostate adenocarcinoma

  2001cited by this paper
• Prostaglandins and leukotrienes: advances in eicosanoid biology.

  2001cited by this paper
• Lipoxygenase modulation to reverse carcinogenesis.

  2001cited by this paper
• Expression, subcellular localization and putative function of platelet‐type 12‐lipoxygenase in human prostate cancer cell lines of different metastatic potential

  2000influential reference
• Signaling angiogenesis via p42/p44 MAP kinase and hypoxia.

  2000cited by this paper
• Eicosanoid regulation of angiogenesis: role of endothelial arachidonate 12-lipoxygenase.

  2000cited by this paper
• 12-lipoxygenase expression in human melanoma cell lines.

  1999cited by this paper
• The diversity of the lipoxygenase family

  1999cited by this paper
• Lipoxygenases: Occurrence, Functions, Catalysis, and Acquisition of Substrate*

  1999cited by this paper
• A 12R-lipoxygenase in human skin: mechanistic evidence, molecular cloning, and expression.

  1998cited by this paper
• Enhanced angiogenesis and growth of 12-lipoxygenase gene-transfected MCF-7 human breast cancer cells in athymic nude mice.

  1998cited by this paper
• Elevated 12-lipoxygenase mRNA expression correlates with advanced stage and poor differentiation of human prostate cancer.

  1995cited by this paper
• Endogenous 12(S)-HETE production by tumor cells and its role in metastasis.

  1994cited by this paper
• Arachidonic acid epoxides. Isolation and structure of two hydroxy epoxide intermediates in the formation of 8,11,12- and 10,11,12-trihydroxyeicosatrienoic acids.

  1983cited by this paper

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• Role of oxylipins in ovarian function and disease: A comprehensive review.

  2024cites this paper
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  2024cites this paper
• PPARγ activation modulates the balance of peritoneal macrophage populations to suppress ovarian tumor growth and tumor-induced immunosuppression

  2023cites this paper
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  2023cites this paper
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  2022cites this paper
• Biology and pharmacology of platelet-type 12-lipoxygenase in platelets, cancer cells, and their crosstalk.

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  2021cites this paper
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  2020cites this paper
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  2020cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2016cites this paper
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  2015cites this paper
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  2015cites this paper
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  2013cites this paper
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• Regulation of inflammation in cancer by eicosanoids.

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