Genetic vs. pharmacological inactivation of COMT influences cannabinoid-induced expression of schizophrenia-related phenotypes.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  International Journal of Neuropsychopharmacology

• Publication date

  2012-10-01

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1017/S1461145711001581PMID 22074909
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2010influential reference
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  2009cited by this paper
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  2009cited by this paper
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  2009cited by this paper
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  2009cited by this paper
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  2009cited by this paper
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  2008cited by this paper
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  2008cited by this paper
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  2007cited by this paper
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  2004cited by this paper
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  2003cited by this paper
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  2002influential reference
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  1998influential reference

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  2020cites this paper
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  2019influential citation
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  2019cites this paper
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