The Antifungal Polyketide Ambruticin Targets the HOG Pathway

ABSTRACT The polyketide ambruticin is an attractive candidate for drug development as an antifungal agent, but its mechanism of action has not yet been elucidated. Here we present evidence that ambruticin exerts its effect by targeting HOG, the osmotic stress control pathway, through Hik1, a group III histidine kinase.

• Publication year

  2007

• Venue

  Antimicrobial Agents and Chemotherapy

• Publication date

  2007-08-13

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1128/AAC.00369-07PMID 17698623PMCID PMC2043265
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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