Apoptosis and efferocytosis in mouse models of atherosclerosis.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Current Drug Targets

• Publication date

  2007-11-30

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.2174/138945007783220623PMID 18220705
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Enhanced Immune System Activation and Arterial Inflammation Accelerates Atherosclerosis in Lupus-Prone Mice

  2007cited by this paper
• The Emerging Role of Vascular Smooth Muscle Cell Apoptosis in Atherosclerosis and Plaque Stability

  2007cited by this paper
• Monocyte/Macrophage Suppression in CD11b Diphtheria Toxin Receptor Transgenic Mice Differentially Affects Atherogenesis and Established Plaques

  2007cited by this paper
• Putative murine models of plaque rupture.

  2007cited by this paper
• ApoE−/−Fas−/− C57BL/6 mice: a novel murine model simultaneously exhibits lupus nephritis, atherosclerosis, and osteopenia Published, JLR Papers in Press, January 26, 2007.

  2007cited by this paper
• Complement C1q reduces early atherosclerosis in low-density lipoprotein receptor-deficient mice.

  2007cited by this paper
• Potent free radical scavenger, edaravone, suppresses oxidative stress-induced endothelial damage and early atherosclerosis.

  2007cited by this paper
• Phagocytosis in atherosclerosis: Molecular mechanisms and implications for plaque progression and stability.

  2007cited by this paper
• Morphological characteristics of coronary atherosclerosis in diabetes mellitus.

  2006cited by this paper
• Hyperhomocysteinemia inhibits post-injury reendothelialization in mice.

  2006cited by this paper
• Monocyte accumulation in mouse atherogenesis is progressive and proportional to extent of disease

  2006cited by this paper
• Systemic Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand Delivery Shows Antiatherosclerotic Activity in Apolipoprotein E–Null Diabetic Mice

  2006cited by this paper
• Macrophage insulin receptor deficiency increases ER stress-induced apoptosis and necrotic core formation in advanced atherosclerotic lesions.

  2006cited by this paper
• Burying the dead: the impact of failed apoptotic cell removal (efferocytosis) on chronic inflammatory lung disease.

  2006cited by this paper
• The Unfolded Protein Response Is an Important Regulator of Inflammatory Genes in Endothelial Cells

  2006cited by this paper
• High-Density Lipoproteins Enhance Progenitor-Mediated Endothelium Repair in Mice

  2006cited by this paper
• Combinatorial pattern recognition receptor signaling alters the balance of life and death in macrophages

  2006cited by this paper
• Apoptosis of vascular smooth muscle cells induces features of plaque vulnerability in atherosclerosis

  2006cited by this paper
• A role for the apoptosis inhibitory factor AIM/Spalpha/Api6 in atherosclerosis development.

  2005cited by this paper
• Increased vulnerability of pre-existing atherosclerosis in ApoE-deficient mice following adenovirus-mediated Fas ligand gene transfer.

  2005cited by this paper
• Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor

  2005cited by this paper
• Fat apoptosis through targeted activation of caspase 8: a new mouse model of inducible and reversible lipoatrophy

  2005cited by this paper
• Activation of the Unfolded Protein Response Occurs at All Stages of Atherosclerotic Lesion Development in Apolipoprotein E–Deficient Mice

  2005cited by this paper
• Transglutaminase 2 in the balance of cell death and survival

  2005cited by this paper
• Leukocyte Transglutaminase 2 Expression Limits Atherosclerotic Lesion Size

  2005cited by this paper
• Consequences and Therapeutic Implications of Macrophage Apoptosis in Atherosclerosis: The Importance of Lesion Stage and Phagocytic Efficiency

  2005cited by this paper
• Macrophage expression of active MMP-9 induces acute plaque disruption in apoE-deficient mice.

  2005cited by this paper
• Impaired Clearance of Apoptotic Cells Promotes Synergy between Atherogenesis and Autoimmune Disease

  2004cited by this paper
• Apolipoprotein E Modulates Clearance of Apoptotic Bodies In Vitro and In Vivo, Resulting in a Systemic Proinflammatory State in Apolipoprotein E-Deficient Mice1

  2004cited by this paper
• Reduced Macrophage Apoptosis Is Associated With Accelerated Atherosclerosis in Low-Density Lipoprotein Receptor–Null Mice

  2004cited by this paper
• Autoimmune Disease and Impaired Uptake of Apoptotic Cells in MFG-E8-Deficient Mice

  2004cited by this paper
• Emigration of monocyte-derived cells from atherosclerotic lesions characterizes regressive, but not progressive, plaques.

  2004cited by this paper
• Association of Multiple Cellular Stress Pathways With Accelerated Atherosclerosis in Hyperhomocysteinemic Apolipoprotein E-Deficient Mice

  2004cited by this paper
• Endogenous p53 Protects Vascular Smooth Muscle Cells From Apoptosis and Reduces Atherosclerosis in ApoE Knockout Mice

  2004cited by this paper
• Niemann-Pick C heterozygosity confers resistance to lesional necrosis and macrophage apoptosis in murine atherosclerosis

  2003cited by this paper
• Macrophage-Specific p53 Expression Plays a Crucial Role in Atherosclerosis Development and Plaque Remodeling

  2003cited by this paper
• Intraplaque hemorrhage and progression of coronary atheroma.

  2003cited by this paper
• The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages

  2003cited by this paper
• Circulating Progenitor Cells Regenerate Endothelium of Vein Graft Atherosclerosis, Which Is Diminished in ApoE-Deficient Mice

  2003cited by this paper
• A mechanistic role for cardiac myocyte apoptosis in heart failure.

  2003cited by this paper
• Conditional cell ablation by tight control of caspase-3 dimerization in transgenic mice

  2002cited by this paper
• Consequences of cellular cholesterol accumulation: basic concepts and physiological implications.

  2002cited by this paper
• Identification of a factor that links apoptotic cells to phagocytes

  2002cited by this paper
• Regulation of endothelial cell apoptosis in atherothrombosis

  2002cited by this paper
• C1q and Mannose Binding Lectin Engagement of Cell Surface Calreticulin and Cd91 Initiates Macropinocytosis and Uptake of Apoptotic Cells

  2001cited by this paper
• Free Cholesterol Loading of Macrophages Is Associated with Widespread Mitochondrial Dysfunction and Activation of the Mitochondrial Apoptosis Pathway*

  2001cited by this paper
• Atherosclerosis The Road Ahead

  2001cited by this paper
• Macrophage p53 Deficiency Leads to Enhanced Atherosclerosis in APOE*3-Leiden Transgenic Mice

  2001cited by this paper
• Changing concepts of atherogenesis

  2000cited by this paper
• Free Cholesterol Loading of Macrophages Induces Apoptosis Involving the Fas Pathway*

  2000cited by this paper
• Apoptosis in the atherosclerotic plaque: quantitative and qualitative aspects.

  1998cited by this paper
• Apoptosis is associated with increased cell surface tissue factor procoagulant activity.

  1996cited by this paper
• Mouse Models of Atherosclerosis

  1996cited by this paper
• Active proliferation of different cell types, including lymphocytes, in human atherosclerotic plaques.

  1995cited by this paper
• Evidence that the death of macrophage foam cells contributes to the lipid core of atheroma.

  1995cited by this paper
• Cell Toxicity Induced by Inhibition of Acyl Coenzyme A:Cholesterol Acyltransferase and Accumulation of Unesterified Cholesterol *

  1995cited by this paper
• Atherosclerosis in mice lacking apo E. Evaluation of lesional development and progression.

  1994cited by this paper
• ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree.

  1994cited by this paper
• Distribution of Circumferential Stress in Ruptured and Stable Atherosclerotic Lesions A Structural Analysis With Histopathological Correlation

  1993cited by this paper
• Transgenic mice carrying the apolipoprotein E3-Leiden gene exhibit hyperlipoproteinemia.

  1993cited by this paper
• Effects of fibrous cap thickness on peak circumferential stress in model atherosclerotic vessels.

  1992cited by this paper
• Homocysteine-induced endothelial cell injury in vitro: a model for the study of vascular injury.

  1980cited by this paper

• Mapping the evolving trend of research on efferocytosis: a comprehensive data-mining-based study

  2025cites this paper
• Redefining Macrophage Heterogeneity in Atherosclerosis: A Focus on Possible Therapeutic Implications

  2025cites this paper
• Melatonin as a treatment for atherosclerosis: focus on programmed cell death, inflammation and oxidative stress

  2025cites this paper
• Disulfiram Reduces Atherosclerosis and Enhances Efferocytosis, Autophagy, and Atheroprotective Gut Microbiota in Hyperlipidemic Mice

  2024cites this paper
• Regulation of Zfp36 by ISGF3 and MK2 restricts the expression of inflammatory cytokines during necroptosis stimulation

  2024cites this paper
• Cell death in atherosclerosis

  2024cites this paper
• Targeting Macrophages: Therapeutic Approaches in Diabetic Kidney Disease

  2024cites this paper
• Crosstalk Between Cholesterol, ABC Transporters, and PIP2 in Inflammation and Atherosclerosis.

  2023cites this paper
• Disulfiram reduces atherosclerosis and enhances efferocytosis, autophagy, and atheroprotective gut microbiota in hyperlipidemic mice

  2023cites this paper
• A bibliometric analysis of efferocytosis in cardiovascular diseases from 2001 to 2022

  2023cites this paper
• IRE1α: from the function to the potential therapeutic target in atherosclerosis

  2023cites this paper
• Anti-Oxidative, Anti-Apoptotic, and M2 Polarized DSPC Liposome Nanoparticles for Selective Treatment of Atherosclerosis

  2023cites this paper
• Coating M-CSF on plastic surface results in the generation of increased numbers of macrophages in vitro.

  2020cites this paper
• Cardiotrophin-1 Deficiency Abrogates Atherosclerosis Progression

  2020cites this paper
• Scavenging of reactive dicarbonyls with 2-hydroxybenzylamine reduces atherosclerosis in hypercholesterolemic Ldlr−/− mice

  2019cites this paper
• Reduced Levels of Testosterone Induce LDL Oxidation and Atherosclerotic Lesions Involving Inflammatory Imbalance and Reduced Macrophage Apoptosis

  2019cites this paper
• Un-JAMming atherosclerotic arteries: JAM-L as a target to attenuate plaque development.

  2019cites this paper
• Phosphorylation of LXRα impacts atherosclerosis regression by modulating monocyte/macrophage trafficking

  2018cites this paper
• Activating transcription factor 3, an early cellular adaptive responder in ischemia/reperfusion-induced injury

  2018cites this paper
• Differentiated macrophages acquire a pro-inflammatory and cell death–resistant phenotype due to increasing XIAP and p38-mediated inhibition of RipK1

  2018cites this paper
• 2016 Russell Ross Memorial Lecture in Vascular Biology: Molecular–Cellular Mechanisms in the Progression of Atherosclerosis

  2017cites this paper
• Histone deacetylase-high mobility group box-1 pathway targeted by hypaconitine suppresses the apoptosis of endothelial cells

  2017cites this paper
• Breaking a Vicious Cycle.

  2017cites this paper
• Role of Cannabinoid Receptor Type 2 (CB2) in Late Stage Atherosclerosis

  2017cites this paper
• B-cell-specific depletion of tumour necrosis factor alpha inhibits atherosclerosis development and plaque vulnerability to rupture by reducing cell death and inflammation.

  2016cites this paper
• Shear stress, arterial identity and atherosclerosis

  2015cites this paper
• Reality of a Vaccine in the Prevention and Treatment of Atherosclerosis.

  2015cites this paper
• Syndecan-1 Modulates the Motility and Resolution Responses of Macrophages

  2015cites this paper
• Macrophages in vascular inflammation – From atherosclerosis to vasculitis

  2015cites this paper
• Regulation of macrophage function related to atherosclerosis development

  2015cites this paper
• Damage associated molecular patterns and toll like receptors in inflammation mediated vascular remodeling : mechanistic insights and therapeutic potentials

  2014cites this paper
• Alpha7 Nicotinic Acetylcholine Receptor: Novel Role in Macrophage Survival and Murine Atherosclerosis

  2014cites this paper
• ACAT Inhibition Reduces the Progression of Preexisting, Advanced Atherosclerotic Mouse Lesions Without Plaque or Systemic Toxicity

  2013cites this paper
• Ephs and ephrins resurface in inflammation, immunity, and atherosclerosis.

  2013cites this paper
• Endoplasmic Reticulum Stress in the Endothelium: A Contribution to Athero-Susceptibility

  2013cites this paper
• Chapter 2 Future potential biomarkers for post-interventional restenosis and accelerated atherosclerosis

  2013cites this paper
• Serum levels of &ggr;-glutamyltransferase and progression of coronary atherosclerosis

  2013cites this paper
• Effects of exercise training and RhoA/ROCK inhibition on plaque in ApoE-/- mice.

  2013cites this paper
• The involvement of the monocytes/macrophages in chronic inflammation associated with atherosclerosis.

  2013cites this paper
• Enhancement in efferocytosis of oxidized low-density lipoprotein-induced apoptotic RAW264.7 cells through Sirt1-mediated autophagy

  2013cites this paper
• Therapeutic Strategies for Metabolic Syndrome and Lifestyle-Related Disease

  2013cites this paper
• The role of syndecan-1 in the resolution of chronic inflammatory responses

  2013cites this paper
• Future potential biomarkers for postinterventional restenosis and accelerated atherosclerosis.

  2012cites this paper
• Adipose triglyceride lipase in immune response, inflammation, and atherosclerosis

  2012cites this paper
• Hemodialysis Removes Uremic Toxins That Alter the Biological Actions of Endothelial Cells

  2012cites this paper
• Visfatin/NAMPT: a multifaceted molecule with diverse roles in physiology and pathophysiology.

  2012cites this paper
• Macrophage proliferation and apoptosis in atherosclerosis

  2012cites this paper
• Implication des phagocytes mononucléés dans les pathologies inflammatoires chroniques : exploration d’un modèle murin d’athérosclérose et du xanthogranulome chez l’homme

  2012cites this paper
• Interference with ER stress and restoration of efferocytosis in the treatment of advanced atherosclerosis

  2012cites this paper
• Oxidative Stress as Pathogenesis of Cardiovascular Risk Associated with Metabolic Syndrome

  2011cites this paper
• Necrotic cell death in atherosclerosis

  2011cites this paper
• Etude du rôle des sous-populations monocytaires dans l'obésité et l'insulinorésistance

  2011cites this paper
• Identification of an up-regulated anti-apoptotic network in the internal thoracic artery.

  2011cites this paper
• Lack of EP4 receptors on bone marrow-derived cells enhances inflammation in atherosclerotic lesions.

  2011cites this paper
• Effects of Dyslipidemia on Invariant Natural Killer T Cell Activation

  2011cites this paper
• Efficient Phagocytosis Requires Triacylglycerol Hydrolysis by Adipose Triglyceride Lipase

  2010cites this paper
• Hoechst-IR: an imaging agent that detects necrotic tissue in vivo by binding extracellular DNA.

  2010cites this paper
• Macrophage death and defective inflammation resolution in atherosclerosis

  2010cites this paper
• Particulate air pollution, systemic oxidative stress, inflammation, and atherosclerosis

  2010cites this paper
• Control of Macrophage Activation and Function by PPARs

  2010cites this paper
• Natural Killer T Cells and Atherosclerosis: Form and Function Meet Pathogenesis

  2010cites this paper
• Control of macrophage activation and function by PPARs.

  2010cites this paper
• G2A Deficiency in Mice Promotes Macrophage Activation and Atherosclerosis

  2009cites this paper
• Macrophage Apoptosis in Atherosclerosis: Consequences on Plaque Progression and the Role of Endoplasmic Reticulum Stress

  2009cites this paper
• Brief Report: Increased Apoptosis in Advanced Atherosclerotic Lesions of Apoe−/− Mice Lacking Macrophage Bcl-2

  2009cites this paper
• Models to study atherosclerosis: a mechanistic insight.

  2009cites this paper
• The Antiangiogenic Activity of rPAI-123 Inhibits Vasa Vasorum and Growth of Atherosclerotic Plaque

  2009cites this paper
• Age-Accelerated Atherosclerosis Correlates With Failure to Upregulate Antioxidant Genes

  2009cites this paper
• Diabetes mellitus and apoptosis: inflammatory cells

  2009cites this paper
• Étude du rôle régulateur de la lamine B1 dans l’activation plaquettaire : base moléculaire de la thromboprotection chez les patients porteurs d'anticoagulant lupique et d'anti-lamine B1

  2009cites this paper
• Macrophages create an acidic extracellular hydrolytic compartment to digest aggregated lipoproteins.

  2009cites this paper
• Results Middle-Aged Mice Develop Worse Metabolic Syndrome in Response to HFD Than Young Mice

  2009cites this paper
• Effects of equol on oxidized low-density lipoprotein-induced apoptosis in endothelial cells.

  2009cites this paper
• Molecular Medicine G 2 A Deficiency in Mice Promotes Macrophage Activation and Atherosclerosis

  2009cites this paper
• Reduced apoptosis and plaque necrosis in advanced atherosclerotic lesions of Apoe-/- and Ldlr-/- mice lacking CHOP.

  2009cites this paper
• Defective Phagocytosis of Apoptotic Cells by Macrophages in Atherosclerotic Lesions of ob/ob Mice and Reversal by a Fish Oil Diet

  2009cites this paper
• Macrophage function and its impact on atherosclerotic lesion composition, progression, and stability: the good, the bad, and the ugly.

  2008cites this paper
• Metabolic syndrome: from epidemiology to systems biology

  2008cites this paper
• Macrophage Apoptosis Exerts Divergent Effects on Atherogenesis as a Function of Lesion Stage

  2008cites this paper
• Atherosclerotic plaque stability--what determines the fate of a plaque?

  2008cites this paper
• Mertk Receptor Mutation Reduces Efferocytosis Efficiency and Promotes Apoptotic Cell Accumulation and Plaque Necrosis in Atherosclerotic Lesions of Apoe−/− Mice

  2008cites this paper