On the rate and linearity of viability declines in Drosophila mutation-accumulation experiments: genomic mutation rates and synergistic epistasis revisited.

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Genetics

• Publication date

  2004-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1534/GENETICS.166.2.797PMID 15020469PMCID PMC1470720
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Accumulation of transposable elements in laboratory lines of Drosophila melanogaster

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• Dominance and overdominance of mildly deleterious induced mutations for fitness traits in Caenorhabditis elegans.

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• Dominance of mutations affecting viability in Drosophila melanogaster.

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• The mutational rate of Drosophila viability decline: tinkering with old data.

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• Environment dependence of mutational parameters for viability in Drosophila melanogaster.

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• The rate of mutation and the homozygous and heterozygous mutational effects for competitive viability: a long-term experiment with Drosophila melanogaster.

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• Rapid mutational declines of viability in Drosophila.

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• Estimate of the mutation rate per nucleotide in humans.

  2000cited by this paper
• On the average coefficient of dominance of deleterious spontaneous mutations.

  2000cited by this paper
• Deleterious mutations and the evolution of sex.

  2000cited by this paper
• FACTORS AFFECTING THE GENETIC LOAD IN DROSOPHILA: SYNERGISTIC EPISTASIS AND CORRELATIONS AMONG FITNESS COMPONENTS

  2000cited by this paper
• A test for epistasis among induced mutations in Caenorhabditis elegans.

  2000cited by this paper
• Little Evidence for Synergism Among Deleterious Mutations in a Nonsegmented RNA Virus

  1999cited by this paper
• PERSPECTIVE: SPONTANEOUS DELETERIOUS MUTATION

  1999cited by this paper
• New estimates of the rates and effects of mildly deleterious mutation in Drosophila melanogaster.

  1999cited by this paper
• High genomic deleterious mutation rates in hominids

  1999cited by this paper
• The mutation rate and the distribution of mutational effects of viability and fitness in Drosophila melanogaster.

  1998cited by this paper
• TEST OF INTERACTION BETWEEN GENETIC MARKERS THAT AFFECT FITNESS IN ASPERGILLUS NIGER

  1997cited by this paper
• Test of synergistic interactions among deleterious mutations in bacteria

  1997cited by this paper
• THE RATE AND EFFECTS DISTRIBUTION OF VIABILITY MUTATION IN DROSOPHILA: MINIMUM DISTANCE ESTIMATION

  1997cited by this paper
• Nature of deleterious mutation load in Drosophila.

  1996cited by this paper
• The Mathematica Book

  1996cited by this paper
• Spontaneous mutational variances and covariances for fitness-related traits in Drosophila melanogaster.

  1996cited by this paper
• Mutation and Conservation

  1995cited by this paper
• MUTATIONAL MELTDOWNS IN SEXUAL POPULATIONS

  1995cited by this paper
• A reevaluation of data from competitive tests shows high levels of heterosis in Drosophila melanogaster.

  1994cited by this paper
• Extinction risk by mutational meltdown: Synergistic effects between population regulation and genetic drift

  1994cited by this paper
• Deleterious mutations and the evolution of sexual reproduction

  1988cited by this paper
• INBREEDING DEPRESSION AND ITS EVOLUTIONARY CONSEQUENCES

  1987cited by this paper
• Spontaneous and ethyl methanesulfonate-induced mutations controlling viability in Drosophila melanogaster. II. Homozygous effect of polygenic mutations.

  1977cited by this paper
• Spontaneous and ethyl methanesulfonate-induced mutations controlling viability in Drosophila melanogaster. III. Heterozygous effect of polygenic mutations.

  1977cited by this paper
• Mutation rate and dominance of genes affecting viability in Drosophila melanogaster.

  1972influential reference
• Genetic Loads and the Cost of Natural Selection

  1970cited by this paper
• The Genetic Structure of Natural Populations of DROSOPHILA MELANOGASTER. VII Synergistic Interaction of Spontaneous Mutant Polygenes Controlling Viability.

  1969cited by this paper
• The genetic structure of natural populations

  1969cited by this paper
• The genetic structure of natural populations of Drosophila melanogaster. 8. Natural selection on the degree of dominance of viability polygenes.

  1969influential reference
• The genetic structure of natural populations of Drosophila melanogaster. V. Coupling-repulsion effect of spontaneous mutant polygenes controlling viability.

  1968influential reference
• The genetic structure of natural populations of Drosophila melanogaster. 3. Dominance effect of spontaneous mutant polygenes controlling viability in heterozygous genetic backgrounds.

  1965cited by this paper
• THE GENETIC STRUCTURE OF NATURAL POPULATIONS OF DROSOPHILA MELANOGASTER. II. OVERDOMINANCE OF SPONTANEOUS MUTANT POLYGENES CONTROLLING VIABILITY IN HOMOZYGOUS GENETIC BACKGROUND.

  1964cited by this paper
• THE GENETIC STRUCTURE OF NATURAL POPULATIONS OF DROSOPHILA MELANOGASTER. I. SPONTANEOUS MUTATION RATE OF POLYGENES CONTROLLING VIABILITY.

  1964influential reference
• THE VIABILITY OF NEAR-NORMAL IRRADIATED CHROMOSOMES

  1959cited by this paper
• Genetic structure of natural populations.

  1946cited by this paper
• Unravelling the Evolutionary Advantage of Sex : a Commentary on ' Mutation–selection Balance and the Evolutionary Advantage of Sex and Recombination '

  year unknowncited by this paper

• The impact of background selection in mutation-selection-drift balance models of complex trait evolution

  2025cites this paper
• A gene-based model of fitness and its implications for genetic variation: Linkage disequilibrium

  2025cites this paper
• A gene-based model of fitness and its implications for genetic variation: linkage disequilibrium

  2025cites this paper
• Are mutations usually deleterious? A perspective on the fitness effects of mutation accumulation

  2022cites this paper
• Are there Physical Linkages between Genes that have Synergistic Fitness Effects?

  2020cites this paper
• Accelerated inbreeding depression suggests synergistic epistasis for deleterious mutations in Drosophila melanogaster

  2019cites this paper
• Fitness Effects of Spontaneous Mutations in Picoeukaryotic Marine Green Algae

  2016cites this paper
• Estimation des taux de mutation : implications pour la diversification et l'évolution du phytoplancton eucaryote

  2016cites this paper
• Accelerating Mutational Load Is Not Due to Synergistic Epistasis or Mutator Alleles in Mutation Accumulation Lines of Yeast

  2015influential citation
• Estimating the mutation load in human genomes

  2015cites this paper
• Transcriptome‐wide effects of sexual selection on the fate of new mutations

  2015cites this paper
• Causes of natural variation in fitness: Evidence from studies of Drosophila populations

  2015cites this paper
• Can Synergistic Epistasis Halt Mutation Accumulation? Results from Numerical Simulation

  2013cites this paper
• Biological Information New Perspectives (583 Pages)

  2013cites this paper
• The Nature of Variation in Mutational Properties: Context-dependent Changes in Mutation Rates and Mutational Fitness Effects

  2013cites this paper
• A characterization of adaptive mutations in yeast

  2012cites this paper
• Rates and Fitness Consequences of New Mutations in Humans

  2012cites this paper
• Inferences About the Distribution of Dominance Drawn From Yeast Gene Knockout Data

  2011cites this paper
• Transposable elements in natural populations of Drosophila melanogaster

  2010cites this paper
• I NFERENCES ABOUT THE DISTRIBUTION OF DOMINANCE DRAWN FROM YEAST 1 GENE KNOCKOUT DATA 2 3 4

  2010cites this paper
• Parasites and deleterious mutations: interactions influencing the evolutionary maintenance of sex

  2010cites this paper
• Selection, Epistasis, and Parent‐of‐Origin Effects on Deleterious Mutations across Environments in Drosophila melanogaster

  2009cites this paper
• Molecular Spectrum of Spontaneous de Novo Mutations in Male and Female Germline Cells of Drosophila melanogaster

  2009cites this paper
• Spontaneous Mutation Accumulation Studies in Evolutionary Genetics

  2009influential citation
• Direct estimation of per nucleotide and genomic deleterious mutation rates in Drosophila

  2008cites this paper
• Synergistic Fitness Interactions and a High Frequency of Beneficial Changes Among Mutations Accumulated Under Relaxed Selection in Saccharomyces cerevisiae

  2008cites this paper
• A genome-wide view of the spectrum of spontaneous mutations in yeast

  2008cites this paper
• Spontaneous mutations in diploid Saccharomyces cerevisiae: another thousand cell generations.

  2008influential citation
• THE BUILD UP OF MUTATION-SELECTION-DRIFT BALANCE IN LABORATORY DROSOPHILA POPULATIONS

  2007cites this paper
• The Dynamics of the roo Transposable Element In Mutation-Accumulation Lines and Segregating Populations of Drosophila melanogaster

  2007cites this paper
• Direct estimation of per nucleotide and genomic deleterious mutation rates in Drosophila

  2007cites this paper
• Mutational Bias for Body Size in Rhabditid Nematodes

  2007influential citation
• Increase of the Spontaneous Mutation Rate in a Long-Term Experiment With Drosophila melanogaster

  2006influential citation
• Substantial changes in the genetic basis of tadpole morphology of Rana lessonae in the presence of predators

  2006cites this paper
• Indirect mechanisms of genomic instability and the biological significance of mutations at tandem repeat loci.

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• Long live the Red Queen? examining environmental influences on host-parasite interactions in Daphnia

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• EVIDENCE FOR OVERDOMINANT SELECTION MAINTAINING X‐LINKED FITNESS VARIATION IN DROSOPHILA MELANOGASTER

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• Genomic Mutation in Lines of Arabidopsis thaliana Exposed to Ultraviolet-B Radiation

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• DELETERIOUS MUTATION IN RELATED SPECIES OF THE PLANT GENUS AMSINCKIA WITH CONTRASTING MATING SYSTEMS

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• Estimation of the rate and effects of deleterious genomic mutations in finite populations with linkage disequilibrium

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• Genetic instability of C. elegans comes naturally.

  2005cites this paper
• A measure of the within‐chromosome synergistic epistasis for Drosophila viability

  2005cites this paper
• Comparative evolutionary genetics of spontaneous mutations affecting fitness in rhabditid nematodes.

  2005cites this paper
• How Common Are Overdominant Mutations?

  2004cites this paper