Paced Electrogram Fractionation Analysis of Arrhythmogenic Tendency in ΔKPQ Scn5a Mice

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Cardiovascular Electrophysiology

• Publication date

  2005-12-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1111/j.1540-8167.2005.00200.xPMID 16403066
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Inherited and acquired vulnerability to ventricular arrhythmias: cardiac Na+ and K+ channels.

  2005influential reference
• Association of long QT syndrome loci and cardiac events among patients treated with beta-blockers.

  2004cited by this paper
• Association of Long QT Syndrome Loci and Cardiac Events Among Patients Treated With β-Blockers

  2004cited by this paper
• Spatial Dispersion of Repolarization is a Key Factor in the Arrhythmogenicity of Long QT Syndrome

  2004cited by this paper
• Effect of pacing and mexiletine on dispersion of repolarisation and arrhythmias in DeltaKPQ SCN5A (long QT3) mice.

  2003cited by this paper
• Sudden Death in Noncoronary Heart Disease Is Associated With Delayed Paced Ventricular Activation

  2003cited by this paper
• Cellular mechanisms underlying the long QT syndrome.

  2003cited by this paper
• Electrogram prolongation and nifedipine‐suppressible ventricular arrhythmias in mice following targeted disruption of KCNE1

  2003cited by this paper
• Cellular mechanisms underlying the long QT syndrome.

  2002cited by this paper
• Cardiac Nitric Oxide Synthase 1 Regulates Basal and &bgr;-Adrenergic Contractility in Murine Ventricular Myocytes

  2002cited by this paper
• Slowed conduction and ventricular tachycardia after targeted disruption of the cardiac sodium channel gene Scn5a

  2002cited by this paper
• Abrupt rate accelerations or premature beats cause life-threatening arrhythmias in mice with long-QT3 syndrome

  2001cited by this paper
• Phase 2 Early Afterdepolarization as a Trigger of Polymorphic Ventricular Tachycardia in Acquired Long-QT Syndrome: Direct Evidence From Intracellular Recordings in the Intact Left Ventricular Wall

  2001cited by this paper
• Effectiveness and limitations of beta-blocker therapy in congenital long-QT syndrome.

  2001cited by this paper
• Possible Bradycardic Mode of Death and Successful Pacemaker Treatment in a Large Family with Features of Long QT Syndrome Type 3 and Brugada Syndrome

  2001cited by this paper
• Homozygous SCN5A Mutation in Long-QT Syndrome With Functional Two-to-One Atrioventricular Block

  2001cited by this paper
• Altered atrial, atrioventricular, and ventricular conduction in patients with the long QT syndrome caused by the DeltaKPQ SCN5A sodium channel gene mutation.

  2001cited by this paper
• Mechanism of Ventricular Arrhythmias in the Long QT Syndrome: On Hermeneutics

  2001cited by this paper
• Effectiveness and limitations of beta-blocker therapy in congenital long-QT syndrome.

  2000cited by this paper
• Paced ventricular electrogram fractionation and sudden death in hypertrophic cardiomyopathy and other non-coronary heart diseases.

  2000cited by this paper
• Spectrum of Mutations in Long-QT Syndrome Genes: KVLQT1, HERG, SCN5A, KCNE1, and KCNE2

  2000cited by this paper
• Differential effects of beta-adrenergic agonists and antagonists in LQT1, LQT2 and LQT3 models of the long QT syndrome.

  2000cited by this paper
• The long-QT syndrome.

  2000influential reference
• Sodium channel abnormalities are infrequent in patients with long QT syndrome: identification of two novel SCN5A mutations.

  1999cited by this paper
• Voltage-gated ion channels and hereditary disease.

  1999influential reference
• Control of L‐type calcium current during the action potential of guinea‐pig ventricular myocytes

  1998cited by this paper
• Management of Patients with the Hereditary Long QT Syndrome

  1998cited by this paper
• Sodium Channel Block With Mexiletine Is Effective in Reducing Dispersion of Repolarization and Preventing Torsade de Pointes in LQT2 and LQT3 Models of the Long-QT Syndrome

  1997cited by this paper
• Electrophysiological mechanism of the characteristic electrocardiographic morphology of torsade de pointes tachyarrhythmias in the long-QT syndrome: detailed analysis of ventricular tridimensional activation patterns.

  1997cited by this paper
• Sodium channel block with mexiletine is effective in reducing dispersion of repolarization and preventing torsade des pointes in LQT2 and LQT3 models of the long-QT syndrome.

  1997cited by this paper
• Differential response to Na+ channel blockade, beta-adrenergic stimulation, and rapid pacing in a cellular model mimicking the SCN5A and HERG defects present in the long-QT syndrome.

  1996cited by this paper
• Characterization of human cardiac Na+ channel mutations in the congenital long QT syndrome.

  1996cited by this paper
• Multiple mechanisms of Na+ channel--linked long-QT syndrome.

  1996cited by this paper
• Long QT syndrome patients with mutations of the SCN5A and HERG genes have differential responses to Na+ channel blockade and to increases in heart rate. Implications for gene-specific therapy.

  1995cited by this paper
• Cardiac sodium channel mutations in patients with long QT syndrome, an inherited cardiac arrhythmia.

  1995cited by this paper
• The significance of paced electrogram fractionation in hypertrophic cardiomyopathy. A prospective study.

  1995cited by this paper
• SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome.

  1995cited by this paper
• Electrophysiologic Mechanisms of the Long QT Interval Syndromes and Torsade de Pointes

  1995cited by this paper
• Molecular mechanism for an inherited cardiac arrhythmia

  1995cited by this paper
• Food intake increases the relative oral bioavailability of vanoxerine.

  1993cited by this paper
• A novel negative selection for homologous recombinants using diphtheria toxin A fragment gene.

  1993cited by this paper
• The Long QT Syndrome: Prospective Longitudinal Study of 328 Families

  1991cited by this paper
• The herpes simplex virus type 1 thymidine kinase is expressed in the testes of transgenic mice under the control of a cryptic promoter

  1991cited by this paper
• Infertility in male transgenic mice: disruption of sperm development by HSV-tk expression in postmeiotic germ cells.

  1990cited by this paper
• Early Afterdepolarizations: Mechanism of Induction and Block A Role for L‐Type Ca2+ Current

  1989cited by this paper
• Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines

  1984cited by this paper
• Untersuchungen am überlebenden Säugethierherzen

  1898cited by this paper
• Life-threatening Arrhythmias Genotype-phenotype Correlation in the Long-qt Syndrome : Gene-specific Triggers for Genotype-phenotype Correlation in the Long-qt Syndrome Gene-specific Triggers for Life-threatening Arrhythmias

  year unknowncited by this paper

• Diagnosis and Management of Congenital Long QT Syndrome in Children and Adolescents

  2024cites this paper
• Muscarinic receptor regulation of chronic pain-induced atrial fibrillation

  2022cites this paper
• Modeling incomplete penetrance in long QT syndrome type 3 through ion channel heterogeneity: an in silico population study.

  2022cites this paper
• The Genetic Puzzle of Familial Atrial Fibrillation

  2020cites this paper
• The contribution of non-coding regulatory elements to cardiovascular disease

  2020cites this paper
• ANNALS OF THE NEW YORK ACADEMY OF SCIENCES MARROW

  2020cites this paper
• University of Birmingham German Cardiac Society Working Group on Cellular Electrophysiology state-of-the-art paper

  2018cites this paper
• Transgenic Animal Models of Cardiac Channelopathies: Benefits and Limitations

  2018cites this paper
• Channelopathies in Heart Disease

  2018cites this paper
• Ageing, the autonomic nervous system and arrhythmia: From brain to heart.

  2018cites this paper
• German Cardiac Society Working Group on Cellular Electrophysiology state-of-the-art paper: impact of molecular mechanisms on clinical arrhythmia management

  2018cites this paper
• Multiple targets for flecainide action: implications for cardiac arrhythmogenesis

  2018influential citation
• Ion channels, long QT syndrome and arrhythmogenesis in ageing

  2017cites this paper
• Murine Electrophysiological Models of Cardiac Arrhythmogenesis.

  2017cites this paper
• Sodium channel biophysics, late sodium current and genetic arrhythmic syndromes

  2017cites this paper
• The effects of ageing and adrenergic challenge on electrocardiographic phenotypes in a murine model of long QT syndrome type 3

  2017cites this paper
• Atrial Anti-Arrhythmic Effects of Heptanol in Langendorff-Perfused Mouse Hearts

  2016cites this paper
• Sodium channel haploinsufficiency and structural change in ventricular arrhythmogenesis

  2016cites this paper
• Title Atrial AntiArrhythmic Effects of Heptanol in Langendorff-Perfused Mouse Hearts

  2016cites this paper
• Anti-arrhythmic effects of hypercalcemia in hyperkalemic, Langendorff-perfused mouse hearts

  2016cites this paper
• The impact of recent advances in genetics in understanding disease mechanisms underlying the long QT syndromes

  2016cites this paper
• Comparison of Gating Properties and Use-Dependent Block of Nav1.5 and Nav1.7 Channels by Anti-Arrhythmics Mexiletine and Lidocaine

  2015cites this paper
• The involvement of TRPC3 channels in sinoatrial arrhythmias

  2015cites this paper
• Measurement and interpretation of electrocardiographic QT intervals in murine hearts

  2014cites this paper
• The SCN5A Mutation A1180V is Associated With Electrocardiographic Features of LQT3

  2014cites this paper
• [Clinical polymorphisms and approaches of arrhythmias treatment in a family with δKPQ1505-1507 deletion in SCN5A gene].

  2014cites this paper
• Ventricular arrhythmogenesis following slowed conduction in heptanol-treated, Langendorff-perfused mouse hearts

  2012cites this paper
• Altered sinoatrial node function and intra-atrial conduction in murine gain-of-function Scn5a+/ΔKPQ hearts suggest an overlap syndrome

  2012cites this paper
• The Age‐dependence of atrial arrhythmogenicity in Scn5a +/−murine hearts reflects alterations in action potential propagation and recovery

  2012cites this paper
• An Introduction to Murine Models of Atrial Fibrillation

  2012cites this paper
• Mouse Models of SCN5A-Related Cardiac Arrhythmias

  2012influential citation
• Simulation of cardiac pacemaker dysfunction arising from genetic mutations

  2012influential citation
• Spatial and temporal heterogeneities are localized to the right ventricular outflow tract in a heterozygotic Scn 5 a mouse model

  2011cites this paper
• Autonomic modulation and antiarrhythmic therapy in a model of long QT syndrome type 3

  2010cites this paper
• Spatial and temporal heterogeneities are localized to the right ventricular outflow tract in a heterozygotic Scn5a mouse model

  2010cites this paper
• Experimental Physiology –Research Paper: Atrial arrhythmogenic properties in wild‐type and Scn5a+/− murine hearts

  2010cites this paper
• Effects of flecainide and quinidine on action potential and ventricular arrhythmogenic properties in Scn3b knockout mice

  2010cites this paper
• Regional variations in action potential alternans in isolated murine Scn5a+/− hearts during dynamic pacing

  2010influential citation
• Alternans in Genetically Modified Langendorff-Perfused Murine Hearts Modeling Catecholaminergic Polymorphic Ventricular Tachycardia

  2010cites this paper
• Re-evaluating the efficacy of beta-adrenergic agonists and antagonists in long QT-3 syndrome through computational modelling.

  2009cites this paper
• Drug-induced arrhythmias and sudden cardiac death: implications for the pharmaceutical industry.

  2009cites this paper
• Human stem cells as a model for cardiac differentiation and disease

  2009cites this paper
• Atrial arrhythmogenesis in wild-type and Scn5a+/Δ murine hearts modelling LQT3 syndrome

  2009cites this paper
• Mouse models of SCN5A-related cardiac arrhythmias.

  2008cites this paper
• Scn3b knockout mice exhibit abnormal ventricular electrophysiological properties

  2008influential citation
• Arrhythmogenic substrate and its modification by nicorandil in a murine model of long QT type 3 syndrome.

  2008cites this paper
• Anti-arrhythmic effects of cyclopiazonic acid in Langendorff-perfused murine hearts.

  2008cites this paper
• Arrhythmogenic actions of the Ca2+ channel agonist FPL-64716 in Langendorff-perfused murine hearts

  2008cites this paper
• Pharmacological separation of early afterdepolarizations from arrhythmogenic substrate in ΔKPQ Scn5a murine hearts modelling human long QT 3 syndrome

  2008influential citation
• Dispersions of repolarization and ventricular arrhythmogenesis: lessons from animal models.

  2008cites this paper
• Physiological consequences of the P2328S mutation in the ryanodine receptor (RyR2) gene in genetically modified murine hearts

  2008cites this paper
• Antiarrhythmic vs. pro-arrhythmic effects depending on the intensity of adrenergic stimulation in a canine anthopleurin-A model of type-3 long QT syndrome.

  2008cites this paper
• Mouse models of human arrhythmia syndromes

  2008influential citation
• Ventricular arrhythmogenesis: insights from murine models.

  2008cites this paper
• Transient alterations in transmural repolarization gradients and arrhythmogenicity in hypokalaemic Langendorff‐perfused murine hearts

  2007cites this paper
• Effects of flecainide and quinidine on arrhythmogenic properties of Scn5a+/Δ murine hearts modelling long QT syndrome 3

  2007influential citation
• Effects of L‐type Ca2+ channel antagonism on ventricular arrhythmogenesis in murine hearts containing a modification in the Scn5a gene modelling human long QT syndrome 3

  2007cites this paper
• Effects of flecainide and quinidine on arrhythmogenic properties of Scn5a+/− murine hearts modelling the Brugada syndrome

  2007cites this paper
• A quantitative analysis of the effect of cycle length on arrhythmogenicity in hypokalaemic Langendorff-perfused murine hearts

  2007influential citation
• Genetic mutations and arrhythmia: simulation from DNA to electrocardiogram.

  2007cites this paper
• The contribution of refractoriness to arrhythmic substrate in hypokalemic Langendorff-perfused murine hearts

  2007cites this paper
• Roles and regulation of the cardiac sodium channel Na v 1.5: recent insights from experimental studies.

  2007cites this paper
• Criteria for arrhythmogenicity in genetically-modified Langendorff-perfused murine hearts modelling the congenital long QT syndrome type 3 and the Brugada syndrome

  2007influential citation
• Action Potential Alternans in LQT3 Syndrome: A Simulation Study

  2007cites this paper