Smac mimetic reverses resistance to TRAIL and chemotherapy in human urothelial cancer cells

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Cancer Biology & Therapy

• Publication date

  2010-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4161/cbt.10.9.13237PMID 20814238PMCID PMC3230293
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Curcumin potentiates the apoptotic effects of chemotherapeutic agents and cytokines through down-regulation of nuclear factor-κB and nuclear factor-κB–regulated gene products in IFN-α–sensitive and IFN-α–resistant human bladder cancer cells

  2007cited by this paper
• Curcumin potentiates the apoptotic effects of chemotherapeutic agents and cytokines through down-regulation of nuclear factor-kappaB and nuclear factor-kappaB-regulated gene products in IFN-alpha-sensitive and IFN-alpha-resistant human bladder cancer cells.

  2007cited by this paper
• IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis.

  2007cited by this paper
• Long-term survival results of a randomized trial comparing gemcitabine plus cisplatin, with methotrexate, vinblastine, doxorubicin, plus cisplatin in patients with bladder cancer.

  2006cited by this paper
• Neutrophil stimulation with Mycobacterium bovis bacillus Calmette-Guerin (BCG) results in the release of functional soluble TRAIL/Apo-2L.

  2005cited by this paper
• A small molecule Smac-mimic compound induces apoptosis and sensitizes TRAIL- and etoposide-induced apoptosis in breast cancer cells

  2005cited by this paper
• Apo2L/TRAIL is an indirect mediator of apoptosis induced by interferon‐α in human myeloma cells

  2005cited by this paper
• Apo2L/TRAIL is an indirect mediator of apoptosis induced by interferon-alpha in human myeloma cells.

  2005cited by this paper
• Fas Ligand and TNF-Related Apoptosis-Inducing Ligand Induction on Infiltrating Lymphocytes in Bladder Carcinoma by Bacillus Calmette-Guérin Treatment

  2005cited by this paper
• Bortezomib abolishes tumor necrosis factor-related apoptosis-inducing ligand resistance via a p21-dependent mechanism in human bladder and prostate cancer cells.

  2005cited by this paper
• X-linked inhibitor of apoptosis protein (XIAP) is a nonredundant modulator of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in human cancer cells.

  2004cited by this paper
• Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand

  2004cited by this paper
• Role of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand in Interferon-Induced Apoptosis in Human Bladder Cancer Cells

  2004cited by this paper
• Determination of diagnostic and prognostic values of urinary interleukin-8, tumor necrosis factor-alpha, and leukocyte arylsulfatase-A activity in patients with bladder cancer.

  2004cited by this paper
• Specific downregulation of bcl-2 and xIAP by RNAi enhances the effects of chemotherapeutic agents in MCF-7 human breast cancer cells

  2004cited by this paper
• Loss of XIAP protein expression by RNAi and antisense approaches sensitizes cancer cells to functionally diverse chemotherapeutics

  2004cited by this paper
• A small molecule Smac mimic potentiates TRAIL- and TNFalpha-mediated cell death.

  2004cited by this paper
• A Small Molecule Smac Mimic Potentiates TRAIL- and TNFα-Mediated Cell Death

  2004cited by this paper
• Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand: A Novel Mechanism for Bacillus Calmette-Guerin-Induced Antitumor Activity

  2004cited by this paper
• Direct activation of the apoptosis machinery as a mechanism to target cancer cells

  2003cited by this paper
• Apoptosis-targeted therapies for cancer.

  2003cited by this paper
• Synthetic Smac/DIABLO Peptides Enhance the Effects of Chemotherapeutic Agents by Binding XIAP and cIAP1 in Situ *

  2002cited by this paper
• IAP proteins: blocking the road to death's door

  2002cited by this paper
• Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo

  2002cited by this paper
• Salvage intravesical therapy with interferon-alpha 2b plus low dose bacillus Calmette-Guerin is effective in patients with superficial bladder cancer in whom bacillus Calmette-Guerin alone previously failed.

  2001cited by this paper
• Human Ovarian Cancer and Cisplatin Resistance: Possible Role of Inhibitor of Apoptosis Proteins* * This work was supported by grants from the Canadian Institutes of Health Research (MOP-15691), the University of Ottawa-Industry Grants Program, and the Ottawa Civic Hospital Foundation.

  2001cited by this paper
• Human ovarian cancer and cisplatin resistance: possible role of inhibitor of apoptosis proteins.

  2001cited by this paper
• Structural basis of IAP recognition by Smac/DIABLO

  2000cited by this paper
• Apoptosis and cancer chemotherapy

  2000cited by this paper
• Structural and biochemical basis of apoptotic activation by Smac/DIABLO

  2000cited by this paper
• The biochemistry of apoptosis

  2000cited by this paper
• IFN-alpha 2B enhances Th1 cytokine responses in bladder cancer patients receiving Mycobacterium bovis bacillus Calmette-Guérin immunotherapy.

  1999cited by this paper
• IAP family proteins--suppressors of apoptosis.

  1999influential reference
• Caspase-3 Is the Primary Activator of Apoptotic DNA Fragmentation via DNA Fragmentation Factor-45/Inhibitor of Caspase-activated DNase Inactivation*

  1999cited by this paper
• Mammalian caspases: structure, activation, substrates, and functions during apoptosis.

  1999cited by this paper
• Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes

  1996cited by this paper
• Apoptosis in the pathogenesis and treatment of disease

  1995cited by this paper
• Apoptosis and cancer chemotherapy.

  1994cited by this paper
• A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry.

  1991cited by this paper
• Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

  1980cited by this paper
• Apoptosis: A Basic Biological Phenomenon with Wide-ranging Implications in Tissue Kinetics

  1972cited by this paper
• Shrinkage necrosis: A distinct mode of cellular death

  1971cited by this paper

• IL-8 and PI3K pathway influence the susceptibility of TRAIL-sensitive colorectal cancer cells to TRAIL-induced cell death

  2024cites this paper
• Nano-TRAIL: a promising path to cancer therapy

  2023cites this paper
• Escaping cell death via TRAIL decoy receptors: a systematic review of their roles and expressions in colorectal cancer

  2022cites this paper
• BH3-mimetics: recent developments in cancer therapy

  2021cites this paper
• Targeting K-Ras and apoptosis-driven cellular transformation in cancer

  2021cites this paper
• Tumor necrosis factor‑related apoptosis‑inducing ligand as a therapeutic option in urothelial cancer cells with acquired resistance against first‑line chemotherapy.

  2020cites this paper
• Smac mimetics LCL161 and GDC-0152 inhibit osteosarcoma growth and metastasis in mice

  2019cites this paper
• Gemcitabine combined with an engineered oncolytic vaccinia virus exhibits a synergistic suppressive effect on the tumor growth of pancreatic cancer

  2018cites this paper
• IAPs and Resistance to Death Receptors in Cancer

  2017cites this paper
• Smac Mimetics to Therapeutically Target IAP Proteins in Cancer.

  2017cites this paper
• Therapeutic opportunities based on caspase modulation.

  2017cites this paper
• CF3DODA-Me induces apoptosis, degrades Sp1, and blocks the transformation phase of the blebbishield emergency program

  2017cites this paper
• Inducing death in tumor cells: roles of the inhibitor of apoptosis proteins

  2017cites this paper
• The Targeted SMAC Mimetic SW IV-134 is a strong enhancer of standard chemotherapy in pancreatic cancer

  2017cites this paper
• Do we have biomarkers to predict response to neoadjuvant and adjuvant chemotherapy and immunotherapy in bladder cancer?

  2017cites this paper
• BCG-unresponsive non-muscle-invasive bladder cancer: recommendations from the IBCG

  2017cites this paper
• Inhibitors of apoptosis: clinical implications in cancer

  2017cites this paper
• Silencing Livin induces apoptotic and autophagic cell death, increasing chemotherapeutic sensitivity to cisplatin of renal carcinoma cells

  2016cites this paper
• An inhibitor of apoptosis protein antagonist T-3256336 potentiates the antitumor efficacy of the Nedd8-activating enzyme inhibitor pevonedistat (TAK-924/MLN4924).

  2016cites this paper
• IAP antagonists sensitize murine osteosarcoma cells to killing by TNFα

  2016cites this paper
• Inhibitors of Apoptosis Proteins (IAPs) as Targets for Anti-Cancer Treatment

  2015cites this paper
• Smac mimetics as IAP antagonists.

  2015cites this paper
• Molecular Pathways Molecular Pathways : Targeting Death Receptors and Smac Mimetics

  2014cites this paper
• Trail Resistance Induces Epithelial-Mesenchymal Transition and Enhances Invasiveness by Suppressing PTEN via miR-221 in Breast Cancer

  2014cites this paper
• Bladder cancer stem cells: biological and therapeutic perspectives.

  2014cites this paper
• Conjugation to a SMAC mimetic potentiates sigma-2 ligand induced tumor cell death in ovarian cancer

  2014cites this paper
• PMN and anti-tumor immunity--the case of bladder cancer immunotherapy.

  2013cites this paper
• A Smac mimetic augments the response of urothelial cancer cells to gemcitabine and cisplatin

  2013cites this paper
• microRNA response elements-regulated TRAIL expression shows specific survival-suppressing activity on bladder cancer

  2013cites this paper
• Smac Mimetics in Combination with TRAIL Selectively Target Cancer Stem Cells in Nasopharyngeal Carcinoma

  2013cites this paper
• Targeting IAP proteins for therapeutic intervention in cancer

  2012cites this paper
• Nuclear cIAP1 overexpression is a tumor stage- and grade-independent predictor of poor prognosis in human bladder cancer patients.

  2012cites this paper
• p63 expression correlates with sensitivity to the Eg5 inhibitor AZD4877 in bladder cancer cells

  2012cites this paper
• Smac mimetic enables the anticancer action of BCG‐stimulated neutrophils through TNF‐α but not through TRAIL and FasL

  2012cites this paper
• TRAIL-mediated signaling in prostate, bladder and renal cancer

  2011cites this paper
• Apoptoseinduktion durch Taurolidin und rhTRAIL in humanen Ösophagus-Plattenepithelkarzinomzellen

  2011cites this paper
• IAP and death receptors-targeted therapies in bladder cancer

  2010cites this paper