Angiotensin II-induced Akt activation is mediated by metabolites of arachidonic acid generated by CaMKII-stimulated Ca2(+)-dependent phospholipase A2.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  American Journal of Physiology. Heart and Circulatory Physiology

• Publication date

  2005-05-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1152/AJPHEART.00571.2004PMID 15637121
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• P-450 metabolites of arachidonic acid in the control of cardiovascular function.

  2002influential reference
• Aminoglycosides increase intracellular calcium levels and ERK activity in proximal tubular OK cells expressing the extracellular calcium-sensing receptor.

  2002cited by this paper
• 12(S)-HETE, pleiotropic functions, multiple signaling pathways.

  2002cited by this paper
• 20-HETE contributes to the acute fall in cerebral blood flow after subarachnoid hemorrhage in the rat.

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• 5(S)-Hydroxyeicosatetraenoic Acid Stimulates DNA Synthesis in Human Microvascular Endothelial Cells via Activation of Jak/STAT and Phosphatidylinositol 3-Kinase/Akt Signaling, Leading to Induction of Expression of Basic Fibroblast Growth Factor 2*

  2002cited by this paper
• A pyrrolidine-based specific inhibitor of cytosolic phospholipase A(2)alpha blocks arachidonic acid release in a variety of mammalian cells.

  2001cited by this paper
• Angiotensin receptors: signaling, vascular pathophysiology, and interactions with ceramide.

  2001cited by this paper
• Cytochrome P450 Epoxygenase Metabolism of Arachidonic Acid Inhibits Apoptosis

  2001cited by this paper
• Differential ANG II-induced growth activation pathways in mesenteric artery smooth muscle cells from SHR.

  2001cited by this paper
• HET0016, a potent and selective inhibitor of 20‐HETE synthesizing enzyme

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• Angiotensin II activates Akt/protein kinase B by an arachidonic acid/redox‐dependent pathway and independent of phosphoinositide 3‐kinase

  2001influential reference
• Adrenomedullin Induces Endothelium-Dependent Vasorelaxation via the Phosphatidylinositol 3-Kinase/Akt-Dependent Pathway in Rat Aorta

  2001cited by this paper
• Functional Interaction of Calcium-/Calmodulin-dependent Protein Kinase II and Cytosolic Phospholipase A2 *

  2001cited by this paper
• Role of c-Src in the regulation of vascular contraction and Ca2+ signaling by angiotensin II in human vascular smooth muscle cells

  2001cited by this paper
• Pyrrolidine inhibitors of human cytosolic phospholipase A(2).

  2000cited by this paper
• Activation of Akt/protein kinase B after stimulation with angiotensin II in vascular smooth muscle cells.

  1999cited by this paper
• Activation of Akt/protein kinase B after stimulation with angiotensin II in vascular smooth muscle cells.

  1999cited by this paper
• Arachidonic Acid Metabolites Mediate Angiotensin II-Induced NADH/NADPH Oxidase Activity and Hypertrophy in Vascular Smooth Muscle Cells

  1999cited by this paper
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  1999cited by this paper
• Reactive Oxygen Species Mediate the Activation of Akt/Protein Kinase B by Angiotensin II in Vascular Smooth Muscle Cells*

  1999cited by this paper
• AT1 calcium signaling in renal vascular smooth muscle cells.

  1999cited by this paper
• Regulation of arachidonic acid release and cytosolic Phospholipase A2 activation

  1999cited by this paper
• Elevated Myocardial Cytosolic Calcium Impairs Insulin-Like Growth Factor-1-Stimulated Protein Synthesis in Chronic Renal Failure

  1999cited by this paper
• Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation.

  1998cited by this paper
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  1998cited by this paper
• Role of NADH/NADPH oxidase-derived H2O2 in angiotensin II-induced vascular hypertrophy.

  1998cited by this paper
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  1998cited by this paper
• Cytochrome P-450 metabolites mediate norepinephrine-induced mitogenic signaling.

  1998cited by this paper
• Phosphatidylinositol 3-kinase-mediated endocytosis of renal Na+, K+-ATPase alpha subunit in response to dopamine.

  1998cited by this paper
• Mechanism of activation and function of protein kinase B.

  1998cited by this paper
• 20-Hydroxyeicosatetraenoic acid mediates calcium/calmodulin-dependent protein kinase II-induced mitogen-activated protein kinase activation in vascular smooth muscle cells.

  1998cited by this paper
• Cytosolic 85-kDa Phospholipase A2-mediated Release of Arachidonic Acid Is Critical for Proliferation of Vascular Smooth Muscle Cells*

  1997cited by this paper
• A role for Ca2+/calmodulin-dependent protein kinase II in the mitogen-activated protein kinase signaling cascade of cultured rat aortic vascular smooth muscle cells.

  1997cited by this paper
• Calcium/Calmodulin-dependent Protein Kinase IIα Mediates Activation of Mitogen-activated Protein Kinase and Cytosolic Phospholipase A2 in Norepinephrine-induced Arachidonic Acid Release in Rabbit Aortic Smooth Muscle Cells*

  1996cited by this paper
• Mechanisms of ANG II-induced mitogenic responses: role of 12-lipoxygenase and biphasic MAP kinase.

  1996cited by this paper
• Requirement for Generation of H2O2 for Platelet-Derived Growth Factor Signal Transduction

  1995influential reference
• Phosphorylation and activation of Ca(2+)-calmodulin-dependent protein kinase IV by Ca(2+)-calmodulin-dependent protein kinase Ia kinase. Phosphorylation of threonine 196 is essential for activation.

  1995cited by this paper
• Angiotensin II stimulates phosphorylation of high-molecular-mass cytosolic phospholipase A2 in vascular smooth-muscle cells.

  1994cited by this paper
• Effects of 17-octadecynoic acid, a suicide-substrate inhibitor of cytochrome P450 fatty acid omega-hydroxylase, on renal function in rats.

  1994cited by this paper
• Effects of reactive oxygen species on arachidonic acid metabolism in rabbit platelets.

  1993cited by this paper
• Early and late effects of angiotensin-II on Ca2+ fluxes in bovine adrenal zona glomerulosa cells.

  1993cited by this paper
• Enhanced synthesis of epoxyeicosatrienoic acids by cholesterol-fed rabbit aorta.

  1991cited by this paper
• Vascular Smooth Muscle: A Review of the Molecular Basis of Contractility*

  1991cited by this paper
• Synthesis of lipoxygenase and epoxygenase products of arachidonic acid by normal and stenosed canine coronary arteries.

  1990cited by this paper
• Regulation of intracellular Ca2+ levels in cultured vascular smooth muscle cells. Reduction of Ca2+ by atriopeptin and 8-bromo-cyclic GMP is mediated by cyclic GMP-dependent protein kinase.

  1989cited by this paper
• Inhibitors of cytochrome P-450-dependent arachidonic acid metabolism.

  1988cited by this paper
• Biphasic effect of oxygen radicals on prostaglandin production by rat mesangial cells.

  1987cited by this paper
• Regulation of the induction of a cytochrome P-450 prostaglandin omega-hydroxylase by pregnancy in rabbit lung.

  1987cited by this paper
• The renin-angiotensin system and long-term regulation of arterial pressure.

  1986cited by this paper
• A new generation of Ca2+ indicators with greatly improved fluorescence properties.

  1985cited by this paper

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