Design, synthesis, and functional evaluation of leukocyte function associated antigen-1 antagonists in early and late stages of cancer development.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Journal of Medicinal Chemistry

• Publication date

  2013-01-22

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1021/jm3016848PMID 23339734
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Three-dimensional growth as multicellular spheroid activates the proangiogenic phenotype of colorectal carcinoma cells via LFA-1-dependent VEGF: implications on hepatic micrometastasis

  2008cited by this paper
• Inhibitors targeting the LFA-1/ICAM-1 cell-adhesion interaction: design and mechanism of action.

  2008cited by this paper
• The NMR structure and dynamics of the two-domain tick carboxypeptidase inhibitor reveal flexibility in its free form and stiffness upon binding to human carboxypeptidase B.

  2008cited by this paper
• Protein–protein recognition and interaction hot spots in an antigen–antibody complex: Free energy decomposition identifies “efficient amino acids”

  2007cited by this paper
• Comparative normal mode analysis of LFA-1 integrin I-domains.

  2007cited by this paper
• ICAM‐1 Peptide Inhibitors of T‐cell Adhesion bind to the allosteric site of LFA‐1. An NMR Characterization

  2007cited by this paper
• Competition between intercellular adhesion molecule‐1 and a small‐molecule antagonist for a common binding site on the αl subunit of lymphocyte function‐associated antigen‐1

  2006cited by this paper
• On the affinity regulation of the metal-ion-dependent adhesion sites in integrins.

  2006cited by this paper
• Dynamic control of allosteric antagonism of leukocyte function antigen‐1 and intercellular adhesion molecule‐1 interaction

  2006cited by this paper
• Targeting leukocyte integrins in human diseases

  2005cited by this paper
• Application of stereocontrolled stepwise [3+2] cycloadditions to the preparation of inhibitors of alpha4beta1-integrin-mediated hepatic melanoma metastasis.

  2005cited by this paper
• Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis.

  2005cited by this paper
• Rolling Adhesion through an Extended Conformation of Integrin αLβ2 and Relation to α I and β I-like Domain Interaction

  2004cited by this paper
• Expression of Cell Adhesion Molecules, their Ligands and Tumour Necrosis Factor α in the Liver of Patients with Metastatic Gastrointestinal Carcinomas

  2004cited by this paper
• Rolling adhesion through an extended conformation of integrin alphaLbeta2 and relation to alpha I and beta I-like domain interaction.

  2004cited by this paper
• Activation of integrin beta-subunit I-like domains by one-turn C-terminal alpha-helix deletions.

  2004cited by this paper
• Vascular endothelial growth factor: basic science and clinical progress.

  2004cited by this paper
• Activation of integrin β-subunit I-like domains by one-turn C-terminal α-helix deletions

  2004cited by this paper
• HADDOCK: a protein-protein docking approach based on biochemical or biophysical information.

  2003cited by this paper
• Small molecule integrin antagonists that bind to the beta2 subunit I-like domain and activate signals in one direction and block them in the other.

  2003cited by this paper
• Integrin avidity regulation: are changes in affinity and conformation underemphasized?

  2003cited by this paper
• Structures of the L I Domain and Its Complex with ICAM-1 Reveal a Shape-Shifting Pathway for Integrin Regulation

  2003cited by this paper
• Evaluation of malignancy using Ki-67 labeling index for gastric stromal tumor

  2003cited by this paper
• Regulation of B16F1 melanoma cell metastasis by inducible functions of the hepatic microvasculature.

  2002cited by this paper
• Small Molecule Inhibitors Induce Conformational Changes in the I Domain and the I-like Domain of Lymphocyte Function-associated Antigen-1

  2002cited by this paper
• Transition From Rolling to Firm Adhesion Is Regulated by the Conformation of the I Domain of the Integrin Lymphocyte Function-associated Antigen-1*

  2002cited by this paper
• Generation of an LFA-1 antagonist by the transfer of the ICAM-1 immunoregulatory epitope to a small molecule.

  2002cited by this paper
• Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings.

  2001cited by this paper
• Reversibly locking a protein fold in an active conformation with a disulfide bond: Integrin αL I domains with high affinity and antagonist activity in vivo

  2001cited by this paper
• Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site

  2001cited by this paper
• Hydrogen peroxide mediates vascular cell adhesion molecule‐1 expression from interleukin‐18–activated hepatic sinusoidal endothelium: Implications for circulating cancer cell arrest in the murine liver

  2001cited by this paper
• An isolated, surface-expressed I domain of the integrin αLβ2 is sufficient for strong adhesive function when locked in the open conformation with a disulfide bond

  2001cited by this paper
• Locking in alternate conformations of the integrin αLβ2 I domain with disulfide bonds reveals functional relationships among integrin domains

  2001cited by this paper
• Free energy calculations on dimer stability of the HIV protease using molecular dynamics and a continuum solvent model.

  2000cited by this paper
• Chemokines trigger immediate beta2 integrin affinity and mobility changes: differential regulation and roles in lymphocyte arrest under flow.

  2000cited by this paper
• NMR and mutagenesis evidence for an I domain allosteric site that regulates lymphocyte function-associated antigen 1 ligand binding.

  2000cited by this paper
• Vascular endothelial growth factor (VEGF) stimulates monocyte migration through endothelial monolayers via increased integrin expression.

  2000cited by this paper
• NMR solution structure of the inserted domain of human leukocyte function associated antigen-1.

  2000cited by this paper
• Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain.

  1999cited by this paper
• CD44 stimulation induces integrin-mediated adhesion of colon cancer cell lines to endothelial cells by up-regulation of integrins and c-Met and activation of integrins.

  1999cited by this paper
• Dissemination of T cell lymphoma to target organs: a post-homing event implicating ICAM-1 and matrix metalloproteinases.

  1999cited by this paper
• A dimeric crystal structure for the N-terminal two domains of intercellular adhesion molecule-1.

  1998cited by this paper
• Leukocyte adhesion: CD11/CD18 integrins and intercellular adhesion molecules.

  1997cited by this paper
• Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

  1997cited by this paper
• Establishment and Characterization of Human Gastric Carcinoma Lines with High Metastatic Potential in the Liver: Changes in Integrin Expression Associated with the Ability to Metastasize in the Liver of Nude Mice

  1996cited by this paper
• Enhanced metastatic ability of TNF-alpha-treated malignant melanoma cells is reduced by intercellular adhesion molecule-1 (ICAM-1, CD54) antisense oligonucleotides.

  1994cited by this paper
• Interleukin-1 receptor blockade reduces the number and size of murine B16 melanoma hepatic metastases.

  1994cited by this paper
• Monoclonal antibodies to lymphocyte function-associated antigen-1 inhibit invasion of human lymphoma and metastasis of murine lymphoma

  1993cited by this paper
• CHARMM: A program for macromolecular energy, minimization, and dynamics calculations

  1983cited by this paper

• Mechanism-guided rational design of anti-neuroinflammatory keratin-derived protein for spinal cord injury repair

  2025cites this paper
• Pyrrolidine/Azepane Ring Expansion via Intramolecular Ullmann-Type Annulation/Rearrangement Cascade: Synthesis of Highly Functionalized 1H-Benzazepines.

  2023cites this paper
• Organocatalytic Asymmetric Domino [3+2]-Cycloaddition-Acyl Transfer Reaction between Azomethine Ylides and α-Nitro-α,β-Unsaturated Ketones.

  2023cites this paper
• Enantioselective Synthesis and Biological Evaluation of Pyrrolidines Bearing Quaternary Stereogenic Centers.

  2023cites this paper
• Denture Adhesive Containing Microparticles for Delivery of Miconazole: In Vivo Toxicity

  2022cites this paper
• Enantioselective 1,3-Dipolar Cycloaddition Using (Z)-α-Amidonitroalkenes as a Key Step to the Access to Chiral cis-3,4-Diaminopyrrolidines

  2022cites this paper
• CCR7 in Blood Cancers – Review of Its Pathophysiological Roles and the Potential as a Therapeutic Target

  2021cites this paper
• Nitroprolinates as Nucleophiles in Michael‐type Additions and Acylations. Synthesis of Enantiomerically Enriched Fused Amino‐pyrrolidino‐[1,2‐a]pyrazinones and ‐diketopiperazines

  2020cites this paper
• Lovastatin inhibits Toll-like receptor 4 signaling in microglia by targeting its co-receptor myeloid differentiation protein 2 and attenuates neuropathic pain.

  2019cites this paper
• Cell Adhesion Molecules and Their Roles and Regulation in the Immune and Tumor Microenvironment

  2019cites this paper
• Application of 1,3‐Dipolar Reactions between Azomethine Ylides and Alkenes to the Synthesis of Catalysts and Biologically Active Compounds

  2018cites this paper
• Diastereoselective [3 + 2] vs [4 + 2] Cycloadditions of Nitroprolinates with α,β-Unsaturated Aldehydes and Electrophilic Alkenes: An Example of Total Periselectivity.

  2017cites this paper
• Role of LFA-1 and ICAM-1 in Cancer

  2017cites this paper
• Two-State Reactivity of Histone Demethylases Containing Jumonji-C Active Sites: Different Mechanisms for Different Methylation Degrees.

  2017cites this paper
• Molecular mechanism of Gαi activation by non-GPCR proteins with a Gα-Binding and Activating motif

  2017cites this paper
• Tumor infiltrating lymphocytes need LFA-1 to adhere to target cells

  2017cites this paper
• Unusual Amino Acids in Medicinal Chemistry.

  2016cites this paper
• Enantioselective Synthesis of Polysubstituted Spiro-nitroprolinates Mediated by a (R,R)-Me-DuPhos·AgF-Catalyzed 1,3-Dipolar Cycloaddition.

  2016cites this paper
• Advances in NMR Methods To Map Allosteric Sites: From Models to Translation.

  2016cites this paper
• Synthesis of Chromen[4,3‐b]pyrrolidines by Intramolecular 1,3‐Dipolar Cycloadditions of Azomethine Ylides: An Experimental and Computational Assessment of the Origin of Stereocontrol

  2015cites this paper
• Protein-protein interactions as drug targets.

  2015cites this paper
• Efficient Diastereo‐ and Enantioselective Synthesis of exo‐Nitroprolinates by 1,3‐Dipolar Cycloadditions Catalyzed by Chiral Phosphoramidite⋅Silver(I) Complexes

  2014cites this paper
• Asymmetric 1,3-dipolar cycloadditons of stabilized azomethine ylides with nitroalkenes.

  2014cites this paper