The crystal structure of human α‐amino‐β‐carboxymuconate‐ε‐semialdehyde decarboxylase in complex with 1,3‐dihydroxyacetonephosphate suggests a regulatory link between NAD synthesis and glycolysis

No abstract is available for this paper.

• Publication year

  2009

• Venue

  The FEBS Journal

• Publication date

  2009-11-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1111/j.1742-4658.2009.07372.xPMID 19843166
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Production of l-tryptophan-derived catabolites in hepatocytes from streptozotocin-induced diabetic rats

  2009cited by this paper
• Effect of indoleamine dioxygenase-1 deficiency and kynurenine pathway inhibition on murine cerebral malaria.

  2009cited by this paper
• Enzymology of mammalian NAD metabolism in health and disease.

  2008cited by this paper
• Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme.

  2007cited by this paper
• Detection of transient intermediates in the metal-dependent nonoxidative decarboxylation catalyzed by alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase.

  2007cited by this paper
• NAD+ metabolism in health and disease.

  2007cited by this paper
• Tissue expression and biochemical characterization of human 2‐amino 3‐carboxymuconate 6‐semialdehyde decarboxylase, a key enzyme in tryptophan catabolism

  2007cited by this paper
• Characterization of the Kynurenine Pathway in Human Neurons

  2007cited by this paper
• Crystal structure of alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase: insight into the active site and catalytic mechanism of a novel decarboxylation reaction.

  2006cited by this paper
• α-Amino-β-carboxymuconic-ε-semialdehyde Decarboxylase (ACMSD) Is a New Member of the Amidohydrolase Superfamily†

  2006cited by this paper
• Immunopathogenesis of cerebral malaria.

  2006cited by this paper
• Transition metal-catalyzed nonoxidative decarboxylation reactions.

  2006cited by this paper
• Alpha-amino-beta-carboxymuconic-epsilon-semialdehyde decarboxylase (ACMSD) is a new member of the amidohydrolase superfamily.

  2006cited by this paper
• Regulation of mouse hepatic alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase, a key enzyme in the tryptophan-nicotinamide adenine dinucleotide pathway, by hepatocyte nuclear factor 4alpha and peroxisome proliferator-activated receptor alpha.

  2006cited by this paper
• Regulation of Mouse Hepatic α-Amino-β-Carboxymuconate-ϵ-Semialdehyde Decarboxylase, a Key Enzyme in the Tryptophan-Nicotinamide Adenine Dinucleotide Pathway, by Hepatocyte Nuclear Factor 4α and Peroxisome Proliferator-Activated Receptor α

  2006cited by this paper
• Prolonged Survival of a Murine Model of Cerebral Malaria by Kynurenine Pathway Inhibition

  2005cited by this paper
• Tryptophan Catabolism: Identification and Characterization of a New Degradative Pathway

  2005cited by this paper
• Structural and catalytic diversity within the amidohydrolase superfamily.

  2005cited by this paper
• Kinetic and spectroscopic characterization of ACMSD from Pseudomonas fluorescens reveals a pentacoordinate mononuclear metallocofactor.

  2005cited by this paper
• The kynurenine pathway of tryptophan degradation as a drug target.

  2004cited by this paper
• The new life of a centenarian: signalling functions of NAD(P).

  2004cited by this paper
• Metabolites of the kynurenine pathway of tryptophan metabolism in the cerebrospinal fluid of Malawian children with malaria.

  2003cited by this paper
• Tryptophan Metabolites and Brain Disorders

  2003cited by this paper
• Prokaryotic Homologs of the Eukaryotic 3-Hydroxyanthranilate 3,4-Dioxygenase and 2-Amino-3-Carboxymuconate-6-Semialdehyde Decarboxylase in the 2-Nitrobenzoate Degradation Pathway of Pseudomonas fluorescens Strain KU-7

  2003cited by this paper
• Macrophage activating properties of the tryptophan catabolite picolinic acid.

  2003cited by this paper
• Identification and Expression of a cDNA Encoding Human α-Amino-β-carboxymuconate-ε-semialdehyde Decarboxylase (ACMSD)

  2002cited by this paper
• Identification and expression of alpha cDNA encoding human 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (ACMSD): a key enzyme for the tryptophan-niacine pathway and quinolinate hypothesis.

  2002cited by this paper
• Expression of rat hepatic 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase is affected by a high protein diet and by streptozotocin-induced diabetes.

  2002cited by this paper
• The PyMOL Molecular Graphics System

  2002cited by this paper
• Endogenous kynurenines as targets for drug discovery and development

  2002cited by this paper
• Identification and expression of a cDNA encoding human alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD). A key enzyme for the tryptophan-niacine pathway and "quinolinate hypothesis".

  2002cited by this paper
• Implementation of molecular replacement in AMoRe.

  2001cited by this paper
• Is ischemia involved in the pathogenesis of murine cerebral malaria?

  2001cited by this paper
• Antiviral, cytotoxic and apoptotic activities of picolinic acid on human immunodeficiency virus-1 and human herpes simplex virus-2 infected cells.

  2001cited by this paper
• Apoptosis Induced by Niacin-Related Compounds in K562 Cells but not in Normal Human Lymphocytes

  2000cited by this paper
• Tryptophan metabolism and brain function: focus on kynurenine and other indole metabolites.

  1999cited by this paper
• Automated protein model building combined with iterative structure refinement

  1999cited by this paper
• Peroxisome-proliferator regulates key enzymes of the tryptophan-NAD+ pathway.

  1999cited by this paper
• Refinement of macromolecular structures by the maximum-likelihood method.

  1997cited by this paper
• NAD+ biosynthesis and metabolic fluxes of tryptophan in hepatocytes isolated from rats fed a clofibrate-containing diet.

  1996cited by this paper
• The CCP4 suite: programs for protein crystallography.

  1994cited by this paper
• Picolinic acid blocks the neurotoxic but not the neuroexcitant properties of quinolinic acid in the rat brain: evidence from turning behaviour and tyrosine hydroxylase immunohistochemistry.

  1994cited by this paper
• PROCHECK: a program to check the stereochemical quality of protein structures

  1993cited by this paper
• Assessment of Phase Accuracy by Cross Validation: the Free R Value. Methods and Applications

  1993cited by this paper
• Assessment of phase accuracy by cross validation: the free R value. Methods and applications.

  1993cited by this paper
• Improved methods for building protein models in electron density maps and the location of errors in these models.

  1991cited by this paper
• Utilization of tryptophan, nicotinamide and nicotinic acid as precursors for nicotinamide nucleotide synthesis in isolated rat liver cells

  1988cited by this paper
• Quinolinic acid: an endogenous metabolite that produces axon-sparing lesions in rat brain.

  1983cited by this paper
• Nicotinic Acid Biosynthesis: Control by an Enzyme that Competes with a Spontaneous Reaction

  1964cited by this paper
• Biological Crystallography Integration of Macromolecular Diffraction Data

  year unknowncited by this paper

• Therapeutic Potential of ACMSD Inhibitors in NAD+ Deficient Diseases

  2025cites this paper
• α-Amino-β-carboxymuconate-ε-semialdehyde decarboxylase catalyzes enol/keto tautomerization of oxaloacetate

  2024cites this paper
• Identifying genetic susceptibility to Aspergillus fumigatus infection using collaborative cross mice and RNA‐Seq approach

  2024cites this paper
• Metabolic Alterations in NADSYN1-Deficient Cells

  2023cites this paper
• Kynurenine Pathway Regulation at Its Critical Junctions with Fluctuation of Tryptophan

  2023cites this paper
• Structural Basis of Human Dimeric α-Amino-β-Carboxymuconate-ε-Semialdehyde Decarboxylase Inhibition With TES-1025

  2022cites this paper
• Improved tolerance of recombinant Chlamydomonas rainhardtii with putative 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase from Pyropia yezoensis to nitrogen starvation

  2021cites this paper
• Kynurenines in the Pathogenesis of Multiple Sclerosis: Therapeutic Perspectives

  2020cites this paper
• Diflunisal Derivatives as Modulators of ACMS Decarboxylase Targeting the Tryptophan-Kynurenine Pathway.

  2020cites this paper
• The IDO Metabolic Trap Hypothesis for the Etiology of ME/CFS

  2019cites this paper
• Structure based mimicking of Phthalic acid esters (PAEs) and inhibition of hACMSD, an important enzyme of the tryptophan kynurenine metabolism pathway.

  2018influential citation
• α-Amino-β-carboxymuconate-ε-semialdehyde Decarboxylase (ACMSD) Inhibitors as Novel Modulators of De Novo Nicotinamide Adenine Dinucleotide (NAD+) Biosynthesis.

  2018cites this paper
• The kynurenine pathway and the brain: Challenges, controversies and promises.

  2017cites this paper
• Kynurenine pathway metabolites and enzymes involved in redox reactions.

  2017cites this paper
• Origen y consecuencias de la inflamación en depresión

  2017cites this paper
• A Novel p.Glu298Lys Mutation in the ACMSD Gene in Sporadic Parkinson’s Disease

  2017cites this paper
• Overview of the role of vitamins and minerals on the kynurenine pathway in health and disease.

  2016cites this paper
• An enzyme in the kynurenine pathway that governs vulnerability to suicidal behavior by regulating excitotoxicity and neuroinflammation

  2016cites this paper
• Assessment of potential antibacterial drug targets

  2016cites this paper
• Etude de la voie des kynurénines dans l'obésité humaine

  2015cites this paper
• Crystal structure of human nicotinic acid phosphoribosyltransferase

  2015cites this paper
• Human α‐amino‐β‐carboxymuconate‐ε‐semialdehyde decarboxylase (ACMSD): A structural and mechanistic unveiling

  2015cites this paper
• Mechanism of Cisplatin-Induced Cytotoxicity Is Correlated to Impaired Metabolism Due to Mitochondrial ROS Generation

  2015cites this paper
• Enzymes in COG2159 of the Amidohydrolase Superfamily: Structure and Mechanism of 5-Carboxyvanillate Decarboxylase (LIGW)

  2015influential citation
• Kynurenines with Neuroactive and Redox Properties: Relevance to Aging and Brain Diseases

  2014cites this paper
• Structures of bacterial kynurenine formamidase reveal a crowded binuclear zinc catalytic site primed to generate a potent nucleophile

  2014cites this paper
• Crystal structures of isoorotate decarboxylases reveal a novel catalytic mechanism of 5-carboxyl-uracil decarboxylation and shed light on the search for DNA decarboxylase

  2013cites this paper
• Genome-Wide Association Study for Type 2 Diabetes in Indians Identifies a New Susceptibility Locus at 2q21

  2013cites this paper
• The Power of Two

  2013cites this paper
• Evidence for a dual role of an active site histidine in α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase.

  2012cites this paper
• Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies.

  2011cites this paper