Glioma-induced inhibition of caspase-3 in microglia promotes a tumor-supportive phenotype

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Nature Immunology

• Publication date

  2016-09-12

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/ni.3545PMID 27618552
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2016cited by this paper
• Epidemiology of gliomas.

  2015cited by this paper
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  2015cited by this paper
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  2015cited by this paper
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  2014cited by this paper
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  2013cited by this paper
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  2013cited by this paper
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  2013cited by this paper
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  2013cited by this paper
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  2012cited by this paper
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  2012cited by this paper
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  2011cited by this paper
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  2011cited by this paper
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  2011cited by this paper
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  2011cited by this paper
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  2011cited by this paper
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  2011cited by this paper
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  2011cited by this paper
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  2010cited by this paper
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  2010cited by this paper
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  2010cited by this paper
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  2009cited by this paper
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  2008cited by this paper
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  2001cited by this paper
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  2001cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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