Differential suppression of interferon-γ-induced Ia antigen expression on cultured rat astroglia and microglia by second messengers

The roles of intracellular second messengers in interferon-γ (IFN-γ)-induced Ia antigen (Ag) expression by astroglia and microglia were examined. Ia Ag on both glia types was induced by IFN-γ. Reagents known to increase intracellular cAMP or activate intracellular protein kinase C (PKC) reduced IFN-γ-induced Ia Ag expression by astroglia. In contrast, increasing intracellular cAMP had no suppressive effect on Ia Ag expression by microglia. These results indicate (1) cAMP and PKC negatively regulate IFN-γ-induced Ia expression on astroglia, and (2) Ia expression is regulated differentially in astroglia vs. microglia. These findings may explain the frequent observation of Ia+ microglia (or macrophages) but not astroglia in various neurodegenerative diseases.

• Publication year

  1990

• Venue

  Journal of Neuroimmunology

• Publication date

  1990-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/0165-5728(90)90164-IPMID 2170439PMCID 7119474
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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