Ethyl Pyruvate Attenuates Spinal Cord Ischemic Injury with a Wide Therapeutic Window through Inhibiting High-mobility Group Box 1 Release in Rabbits

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Anesthesiology

• Publication date

  2009-06-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1097/ALN.0b013e3181a160d6PMID 19417608
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Induction and subcellular localization of high‐mobility group box–1 (HMGB1) in the postischemic rat brain

  2008cited by this paper
• Trans-activator of Transcription-mediated Delivery of NEP1-40 Protein into Brain Has a Neuroprotective Effect against Focal Cerebral Ischemic Injury via Inhibition of Neuronal Apoptosis

  2008cited by this paper
• High mobility group box 1 protein is released by neural cells upon different stresses and worsens ischemic neurodegeneration in vitro and in vivo

  2007cited by this paper
• The Relationship between Apoptosis and High-Mobility Group Protein 1 Release from Murine Macrophages Stimulated with Lipopolysaccharide or Polyinosinic-Polycytidylic Acid1

  2007cited by this paper
• HMGB1, a novel inflammatory cytokine.

  2007cited by this paper
• Ethyl pyruvate induces necrosis-to-apoptosis switch and inhibits high mobility group box protein 1 release in A549 lung adenocarcinoma cells.

  2007cited by this paper
• HMGB1 as a potential therapeutic target.

  2007cited by this paper
• Anti‐high mobility group box 1 monoclonal antibody ameliorates brain infarction induced by transient ischemia in rats

  2007cited by this paper
• Ethyl pyruvate: a novel anti‐inflammatory agent

  2007cited by this paper
• HMGB1, a Novel Cytokine-Like Mediator Linking Acute Neuronal Death and Delayed Neuroinflammation in the Postischemic Brain

  2006cited by this paper
• Hyperbaric Oxygen Preconditioning Induces Tolerance against Spinal Cord Ischemia by Upregulation of Antioxidant Enzymes in Rabbits

  2006cited by this paper
• ELEVATED HIGH-MOBILITY GROUP BOX 1 LEVELS IN PATIENTS WITH CEREBRAL AND MYOCARDIAL ISCHEMIA

  2006cited by this paper
• Role of HMGB1 in apoptosis-mediated sepsis lethality.

  2006cited by this paper
• Methylprednisolone treatment in acute spinal cord injury: the myth challenged through a structured analysis of published literature.

  2006cited by this paper
• Inflammatory and Apoptotic Signaling after Spinal Cord Injury

  2006cited by this paper
• Inhibition of the Cerebral Ischemic Injury by Ethyl Pyruvate With a Wide Therapeutic Window

  2005cited by this paper
• Anti-inflammatory mechanism is involved in ethyl pyruvate-mediated efficacious neuroprotection in the postischemic brain.

  2005cited by this paper
• The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion

  2005cited by this paper
• The role of HMGB-1 on the development of necrosis during hepatic ischemia and hepatic ischemia/reperfusion injury in mice.

  2005cited by this paper
• Ethyl pyruvate enhances ATP levels, reduces oxidative stress and preserves cardiac function in a rat model of off-pump coronary bypass.

  2005cited by this paper
• Ethyl pyruvate preserves cardiac function and attenuates oxidative injury after prolonged myocardial ischemia.

  2004cited by this paper
• Inflammation and apoptosis: linked therapeutic targets in spinal cord injury.

  2004cited by this paper
• High mobility group protein 1 (HMGB1) quantified by ELISA with a monoclonal antibody that does not cross-react with HMGB2.

  2003cited by this paper
• Ethyl pyruvate: a novel anti-inflammatory agent.

  2003cited by this paper
• Thoracoabdominal Aortic Aneurysm Repair Mechanism of Complement Activation and Its Role in the Inflammatory Response After

  2003cited by this paper
• Ethyl Pyruvate Protects against Lethal Systemic Inflammation by Preventing HMGB1 Release

  2003cited by this paper
• Thoracoabdominal aneurysm surgery and the risk of paraplegia: contemporary practice and future directions.

  2002cited by this paper
• Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation

  2002cited by this paper
• Preconditioning with Hyperbaric Oxygen and Hyperoxia Induces Tolerance against Spinal Cord Ischemia in Rabbits

  2002cited by this paper
• Review of Current Evidence for Apoptosis After Spinal Cord Injury

  2000cited by this paper
• Apoptosis of motor neurons with induction of caspases in the spinal cord after ischemia.

  1998cited by this paper

• Anti-HMGB1 Antibody Therapy Ameliorates Spinal Cord Ischemia–Reperfusion Injury in Rabbits

  2025cites this paper
• High Mobility Group Box 1 (HMGB1): Molecular Signaling and Potential Therapeutic Strategies

  2024cites this paper
• Hmgb1 Silencing in the Amygdala Inhibits Pain-Related Behaviors in a Rat Model of Neuropathic Pain

  2023cites this paper
• Protective role of ethyl pyruvate in spinal cord injury by inhibiting the high mobility group box-1/toll-like receptor4/nuclear factor-kappa B signaling pathway

  2022cites this paper
• Ethyl pyruvate: A newly discovered compound against ischemia-reperfusion injury in multiple organs.

  2021cites this paper
• HMGB1 released from nociceptors mediates inflammation

  2021cites this paper
• Ethyl pyruvate inhibits glioblastoma cells migration and invasion through modulation of NF-κB and ERK-mediated EMT

  2020cites this paper
• Ringer’s ethyl pyruvate solution attenuates hypoperfusion and renal injury after multivisceral ischemia–reperfusion in rabbits

  2020influential citation
• High Mobility Group Box-1 and Blood–Brain Barrier Disruption

  2020cites this paper
• HMGB1‐associated necroptosis and Kupffer cells M1 polarization underlies remote liver injury induced by intestinal ischemia/reperfusion in rats

  2020cites this paper
• [Effect and mechanism of glycyrrhizin on glial scar formation after spinal cord injury in rats].

  2020cites this paper
• Ethyl pyruvate protects against sepsis-associated encephalopathy through inhibiting the NLRP3 inflammasome

  2020cites this paper
• The effect of high mobility group box-1 protein on cerebral edema, blood-brain barrier, oxidative stress and apoptosis in an experimental traumatic brain injury model.

  2019cites this paper
• The Protective Effect of Curcumin on a Spinal Cord Ischemia-Reperfusion Injury Model.

  2017cites this paper
• Anti-inflammatory and anti-excitoxic effects of diethyl oxopropanamide, an ethyl pyruvate bioisoster, exert robust neuroprotective effects in the postischemic brain

  2017cites this paper
• Anti-encephalitogenic effects of ethyl pyruvate are reflected in the central nervous system and the gut.

  2017cites this paper
• High-Mobility Group Box 1 (HMGB1) Is Elevated Systemically in Persons with Acute or Chronic Traumatic Spinal Cord Injury

  2017cites this paper
• Tanshinone IIA Exerts an Antinociceptive Effect in Rats with Cancer-induced Bone Pain.

  2016cites this paper
• Hypoxic preconditioning increases the protective effect of bone marrow mesenchymal stem cells on spinal cord ischemia/reperfusion injury

  2016cites this paper
• Inhibiting High-Mobility Group Box 1 (HMGB1) Attenuates Inflammatory Cytokine Expression and Neurological Deficit in Ischemic Brain Injury Following Cardiac Arrest in Rats

  2016cites this paper
• Ethyl Pyruvate Combats Human Leukemia Cells but Spares Normal Blood Cells

  2016cites this paper
• Ethyl pyruvate modulates delayed paralysis following thoracic aortic ischemia reperfusion in mice.

  2016cites this paper
• Randomized Trial Tanshinone IIA Attenuates Chronic Pancreatitis-Induced Pain in Rats via Downregulation of HMGB 1 and TRL 4 Expression in the Spinal Cord

  2015cites this paper
• Tanshinone IIA Attenuates Chronic Pancreatitis-Induced Pain in Rats via Downregulation of HMGB1 and TRL4 Expression in the Spinal Cord.

  2015cites this paper
• Ethyl Pyruvate Inhibits HMGB1 Phosphorylation and Release by Chelating Calcium

  2015cites this paper
• Protective effects of ethyl pyruvate on sperm quality in cyclophosphamide treated mice

  2015cites this paper
• Role of high-mobility group box-1 in myocardial ischemia/reperfusion injury and the effect of ethyl pyruvate

  2015cites this paper
• HMGB1 in health and disease.

  2014cites this paper
• EVALUATION OF PROTECTIVE EFFECTS OF ETHYL PYRUVATE ON EMBYO DEVELOPING PROCESS IN IN VITRO FERTILIZATION (IVF) IN CYCLOPHOSPHAMIDE TREATED MICE

  2014cites this paper
• Receptor for Advanced Glycation End Products (RAGE) and Its Ligands: Focus on Spinal Cord Injury

  2014cites this paper
• Timing of xenon-induced delayed postconditioning to protect against spinal cord ischaemia-reperfusion injury in rats.

  2014cites this paper
• Ethyl pyruvate ameliorates 3-nitropropionic acid-induced striatal toxicity through anti-neuronal cell death and anti-inflammatory mechanisms.

  2014cites this paper
• Ethyl pyruvate inhibits HMGB1 phosphorylation and secretion in activated microglia and in the postischemic brain.

  2014cites this paper
• Improvement of Hypoxia–Ischemia-Induced White Matter Injury in Immature Rat Brain by Ethyl Pyruvate

  2013cites this paper
• Effects of ethyl pyruvate administration on female rats' pyramidal cells of cornu ammonis after brain ischemia: a stereological and histopathological study

  2013cites this paper
• Beneficial effects of hydrogen-rich saline against spinal cord ischemia-reperfusion injury in rabbits.

  2013cites this paper
• Targeted delivery of neurogenin-2 protein in the treatment for cerebral ischemia-reperfusion injury.

  2013cites this paper
• HMGB1 Contributes to Regeneration After Spinal Cord Injury in Adult Zebrafish

  2013cites this paper
• Effect of Ethyl Pyruvate on Paclitaxel-Induced Neuropathic Pain in Rats

  2013cites this paper
• Ethyl pyruvate protects against lipopolysaccharide‐induced white matter injury in the developing rat brain

  2013cites this paper
• Ischemic postconditioning protects the spinal cord from ischemia-reperfusion injury via modulation of redox signaling.

  2013cites this paper
• Ethyl pyruvate ameliorates intracerebral hemorrhage-induced brain injury through anti-cell death and anti-inflammatory mechanisms.

  2013cites this paper
• Neuroprotective effects of alpha-ketoglutarate and ethyl pyruvate against motor dysfunction and oxidative changes caused by repeated 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine exposure in mice

  2013cites this paper
• Ethyl pyruvate attenuates formalin-induced inflammatory nociception by inhibiting neuronal ERK phosphorylation

  2012cites this paper
• Effects of Ethyl Pyruvate on Allodynia, TNF-α Expression, and Apoptosis in the Dorsal Root Ganglion after Spinal Nerve Ligation Injury

  2012cites this paper
• HMGB1 in renal ischemic injury.

  2012cites this paper
• Neuroprotective effects of allicin on spinal cord ischemia-reperfusion injury via improvement of mitochondrial function in rabbits.

  2012cites this paper
• Multiple roles of HMGB1 in clinical and experimental arthritides

  2012cites this paper
• Role of high mobility group box 1 (HMGB1) in wound healing.

  2012cites this paper
• HMGB1 in Development and Diseases of the Central Nervous System

  2012cites this paper
• HMGB1 as a therapeutic target in spinal cord injury: A hypothesis for novel therapy development.

  2011cites this paper
• Oxidative stress in spinal cord injury and antioxidant-based intervention

  2011cites this paper
• Comparison of carbamylated erythropoietin-FC fusion protein and recombinant human erythropoietin during porcine aortic balloon occlusion-induced spinal cord ischemia/reperfusion injury

  2011cites this paper
• Beneficial effects of hydrogen gas against spinal cord ischemia-reperfusion injury in rabbits.

  2011cites this paper
• Sevoflurane postconditioning attenuates spinal cord reperfusion injury through free radicals-mediated up-regulation of antioxidant enzymes in rabbits.

  2011cites this paper
• HMGB1 is a therapeutic target for sterile inflammation and infection.

  2011cites this paper
• Glycyrrhizin attenuates rat ischemic spinal cord injury by suppressing inflammatory cytokines and HMGB1

  2011cites this paper
• High-Mobility Group Box 1, Oxidative Stress, and Disease

  2011cites this paper
• Spinal high-mobility group box 1 contributes to mechanical allodynia in a rat model of bone cancer pain.

  2010cites this paper
• Ethyl pyruvate has a neuroprotective effect through activation of extracellular signal-regulated kinase in Parkinson's disease model.

  2010cites this paper
• The biochemical basis for the anti-inflammatory and cytoprotective actions of ethyl pyruvate and related compounds.

  2010cites this paper
• High mobility group box 1 protein as a potential drug target for infection- and injury-elicited inflammation.

  2010cites this paper
• Pyruvate: immunonutritional effects on neutrophil intracellular amino or alpha-keto acid profiles and reactive oxygen species production

  2010influential citation
• Comparison of the effect of mexiletine and methylprednisolone on neural function and histopathological damage after transient spinal cord ischemia in rabbits.

  2010cites this paper
• Beneficial effects of sodium or ethyl pyruvate after traumatic brain injury in the rat.

  2010cites this paper
• Autophagy inhibition in combination cancer treatment.

  2009cites this paper