Mild impairment of learning and memory in mice overexpressing the mSim2 gene located on chromosome 16: an animal model of Down's syndrome.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Human Molecular Genetics

• Publication date

  1999-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/HMG/8.8.1409PMID 10400987
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Molecular Cloning: A Laboratory Manual

  2001cited by this paper
• Down syndrome and mouse models.

  1998cited by this paper
• Ts1Cje, a partial trisomy 16 mouse model for Down syndrome, exhibits learning and behavioral abnormalities.

  1998cited by this paper
• Control of cell lineage-specific development and transcription by bHLH-PAS proteins.

  1998cited by this paper
• Impaired spatial working and reference memory in segmental trisomy (Ts65Dn) mice.

  1998cited by this paper
• Animal models in the study of the biological function of genes on human chromosome 21 and their role in the pathophysiology of Down syndrome.

  1997influential reference
• Oxidative stress mediates impairment of muscle function in transgenic mice with elevated level of wild-type Cu/Zn superoxide dismutase.

  1997cited by this paper
• The murine Sim-2 gene product inhibits transcription by active repression and functional interference

  1997cited by this paper
• Functional screening of 2 Mb of human chromosome 21q22.2 in transgenic mice implicates minibrain in learning defects associated with Down syndrome

  1997cited by this paper
• cDNA cloning of a murine homologue of Drosophila single-minded, its mRNA expression in mouse development, and chromosome localization.

  1996cited by this paper
• Down's syndrome-like skeletal abnormalities in Ets2 transgenic mice

  1996cited by this paper
• Expression patterns of two murine homologs of Drosophila single-minded suggest possible roles in embryonic patterning and in the pathogenesis of Down syndrome.

  1996cited by this paper
• Constitutive overexpression of Cu/Zn superoxide dismutase exacerbates kainic acid-induced apoptosis of transgenic-Cu/Zn superoxide dismutase neurons.

  1996cited by this paper
• Characterization of msim, a murine homologue of the Drosophila sim transcription factor.

  1996cited by this paper
• The mammalian single-minded (SIM) gene: mouse cDNA structure and diencephalic expression indicate a candidate gene for Down syndrome.

  1996cited by this paper
• Two new members of the murine Sim gene family are transcriptional repressors and show different expression patterns during mouse embryogenesis

  1996cited by this paper
• Physical mapping of the holoprosencephaly critical region in 21q22.3, exclusion of SIM2 as a candidate gene for holoprosencephaly, and mapping of SIM2 to a region of chromosome 21 important for Down syndrome.

  1995cited by this paper
• Down syndrome-critical region contains a gene homologous to Drosophila sim expressed during rat and human central nervous system development.

  1995cited by this paper
• Single–minded and Down syndrome?

  1995cited by this paper
• A mouse model for Down syndrome exhibits learning and behaviour deficits

  1995cited by this paper
• Thymic abnormalities and enhanced apoptosis of thymocytes and bone marrow cells in transgenic mice overexpressing Cu/Zn‐superoxide dismutase: implications for Down syndrome.

  1995cited by this paper
• Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein.

  1994cited by this paper
• Behavioral impairment in radial-arm maze learning and acetylcholine content of the hippocampus and cerebral cortex in aged mice.

  1994cited by this paper
• Physical mapping of chromosome 21.

  1993cited by this paper
• Modality-specific retrograde amnesia of fear.

  1992cited by this paper
• Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning.

  1992cited by this paper
• The Drosophila single-minded gene encodes a helix-loop-helix protein that acts as a master regulator of CNS midline development.

  1991cited by this paper
• The single-minded gene of Drosophila is required for the expression of genes important for the development of CNS midline cells.

  1990cited by this paper
• Exploration of mice in a black and white test box: validation as a model of anxiety.

  1989cited by this paper
• Expression vector system based on the chicken beta-actin promoter directs efficient production of interleukin-5.

  1989cited by this paper
• Expression vector system based on the chicken β-actin promoter directs efficient production of interleukin-5

  1989cited by this paper
• Current Protocols in Molecular Biology (New York: Greene Publishing Associates and Wiley-Interscience). Host-Range Shuttle System for Gene Insertion into the Chromosomes of Gram-negative Bacteria.

  1988cited by this paper
• The Drosophila single-minded gene encodes a nuclear protein with sequence similarity to the per gene product.

  1988cited by this paper
• Place navigation impaired in rats with hippocampal lesions

  1982cited by this paper
• The Hippocampus as a Cognitive Map

  1980cited by this paper
• Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.

  1979cited by this paper
• Control of Cell Lineage-specific Development and Transcription by Bhlh–pas Proteins

  year unknowncited by this paper

• The role of bHLH-PAS transcription factors in endoplasmic reticulum stress

  2025cites this paper
• Characterization of functionally deficient SIM2 variants found in patients with neurological phenotypes

  2022cites this paper
• The accumulation of copper in the brain of Down syndrome promotes oxidative stress: possible mechanism underlying cognitive impairment

  2022cites this paper
• Single-minded 2 is required for left-right asymmetric stomach morphogenesis.

  2021cites this paper
• Combinatorial Gene Effects on the Neural Progenitor Pool in Down Syndrome

  2017cites this paper
• Mental Retardation and Human Chromosome 21 Gene Overdosage : From Functional Genomics and Molecular Mechanisms Towards Prevention and Treatment of the Neuropathogenesis of Down Syndrome

  2017cites this paper
• Characterising impaired synaptic plasticity and network function in a mouse model of Alzheimer’s Disease in Down Syndrome

  2017cites this paper
• Early growth response‐1‐mediated down‐regulation of drebrin correlates with loss of dendritic spines

  2017cites this paper
• Genómica del síndrome de Down

  2016cites this paper
• HSA21 Single-Minded 2 (Sim2) Binding Sites Co-Localize with Super-Enhancers and Pioneer Transcription Factors in Pluripotent Mouse ES Cells

  2015cites this paper
• FROM TRAIT TO GENE AND BACK : A GENERAL OUTLINE

  2014cites this paper
• SIM2 maintains innate host defense of the small intestine.

  2014cites this paper
• Characterization of human variants in obesity-related SIM1 protein identifies a hot-spot for dimerization with the partner protein ARNT2.

  2014cites this paper
• Monozygotic twins with trisomy 21 and partial agenesis of the corpus callosum.

  2013cites this paper
• Sim2 prevents entry into the myogenic program by repressing MyoD transcription during limb embryonic myogenesis

  2012cites this paper
• A novel binding protein of single-minded 2: the mitotic arrest-deficient protein MAD2B

  2012cites this paper
• Sonic Hedgehog pathway impairment in Neural Precursor Cells of the Ts65Dn mouse, an animal model of Down syndrome

  2012cites this paper
• The in vivo Down syndrome genomic library in mouse.

  2012cites this paper
• A de novo duplication of chromosome 21q22.11→qter associated with Down syndrome: prenatal diagnosis, molecular cytogenetic characterization and fetal ultrasound findings.

  2011cites this paper
• The Role of the Transcription Factor SIM2 in Prostate Cancer

  2011cites this paper
• Identification of downstream target genes and analysis of obesity-related variants of the bHLH/PAS transcription factor single-minded 1.

  2011cites this paper
• Down syndrome: searching for the genetic culprits

  2011cites this paper
• Characterization of PTZ-Induced Seizure Susceptibility in a Down Syndrome Mouse Model That Overexpresses CSTB

  2011cites this paper
• Variants in RET associated with Hirschsprung's disease affect binding of transcription factors and gene expression.

  2011cites this paper
• Mental Retardation and Human Chromosome 21 Gene Overdosage: From Functional Genomics and Molecular Mechanisms Towards Prevention and Treatment of the Neuropathogenesis of Down Syndrome

  2011cites this paper
• Alterations of brain circuits in Down syndrome murine models.

  2011cites this paper
• Putting the Brakes on Proliferation Gene Dosage Effects on Hippocampal Neurogenesis in the Ts65Dn Mouse Model of Down Syndrome

  2011cites this paper
• Combinatorial Gene Effects on the Neural Progenitor Pool in Down Syndrome

  2011cites this paper
• Gene regulatory and pro-tumourigenic mechanisms of the bHLH-PAS transcription factor SIM2s.

  2010cites this paper
• Generation of a panel of antibodies against proteins encoded on human chromosome 21

  2010cites this paper
• Down syndrome and the molecular pathogenesis resulting from trisomy of human chromosome 21

  2010influential citation
• Intensity matters : effects of prenatal stress on the developing brain / Richelle Mychasiuk

  2010cites this paper
• Identification of the Transcription Factor Single-Minded Homologue 2 as a Potential Biomarker and Immunotherapy Target in Prostate Cancer

  2009cites this paper
• Functional Characterization of Basic Helix-Loop-Helix-PAS Type Transcription Factor NXF in Vivo

  2009cites this paper
• Looking for Biomarkers for Prostate Cancer Early Detection

  2009cites this paper
• Regulation of Mammary Lactogenic Differentiation by Singleminded-2s

  2009cites this paper
• Possible association of Down syndrome and exstrophy–epispadias complex: report of two new cases and review of the literature

  2009cites this paper
• Sim1 and Sim2 expression during chick and mouse limb development.

  2009cites this paper
• Cancer Therapy: Preclinical Identification of the Transcription Factor Single-Minded Homologue 2 as a Potential Biomarker and Immunotherapy Target in Prostate Cancer

  2009cites this paper
• Mental retardation and associated neurological dysfunctions in Down syndrome: a consequence of dysregulation in critical chromosome 21 genes and associated molecular pathways.

  2008cites this paper
• Modifications du transcriptome au cours du développement postnatal du cervelet dans un modèle murin de Trisomie 21

  2008cites this paper
• The bHLH/Per-Arnt-Sim transcription factor SIM2 regulates muscle transcript myomesin2 via a novel, non-canonical E-box sequence

  2008cites this paper
• Synaptic and cognitive abnormalities in mouse models of down syndrome: Exploring genotype‐phenotype relationships

  2007influential citation
• Mental retardation in Down syndrome: from gene dosage imbalance to molecular and cellular mechanisms.

  2007cites this paper
• Trisomy for the Down syndrome 'critical region' is necessary but not sufficient for brain phenotypes of trisomic mice.

  2007cites this paper
• Mice lacking alpha1,3-fucosyltransferase IX demonstrate disappearance of Lewis x structure in brain and increased anxiety-like behaviors.

  2007cites this paper
• The power of comparative and developmental studies for mouse models of Down syndrome

  2007cites this paper
• Using mouse models to explore genotype-phenotype relationship in Down syndrome.

  2007cites this paper
• Effect of mouse Sim2 gene on the cell cycle of PC12 cells

  2006cites this paper
• Mouse Models of Cognitive Disorders in Trisomy 21: A Review

  2006cites this paper
• Down Syndrome, Molecular Genetics of

  2006cites this paper
• The proteins of human chromosome 21

  2006cites this paper
• Inhibition of breast cancer growth and invasion by single-minded 2s.

  2006cites this paper
• DYRK1A BAC transgenic mice show altered synaptic plasticity with learning and memory defects.

  2006cites this paper
• Effects of overexpression of Sim2 on spatial memory and expression of synapsin I in rat hippocampus

  2006cites this paper
• Gene-Dosage Effect on Chromosome 21 Transcriptome in Trisomy 21: Implication in Down Syndrome Cognitive Disorders

  2006cites this paper
• C21orf5, a new member of Dopey family involved in morphogenesis, could participate in neurological alterations and mental retardation in Down syndrome.

  2005cites this paper
• Animal Models of Neurological Disorders

  2005cites this paper
• Spatial and temporal localization during embryonic and fetal human development of the transcription factor SIM2 in brain regions altered in Down syndrome

  2005cites this paper
• Molecular aspects of Down syndrome.

  2005cites this paper
• FunctionalSIM 2 in the Noncoding Sequences Conserved in a Limited Number of Mammals data

  2004cites this paper
• Noncoding sequences conserved in a limited number of mammals in the SIM2 interval are frequently functional.

  2004cites this paper
• Identification of a Novel Basic Helix-Loop-Helix-PAS Factor, NXF, Reveals a Sim2 Competitive, Positive Regulatory Role in Dendritic-Cytoskeleton Modulator Drebrin Gene Expression

  2004cites this paper
• Genetic Dissection of Learning and Memory in Mice

  2004cites this paper
• Sim2 contributes to neuroendocrine hormone gene expression in the anterior hypothalamus.

  2004cites this paper
• Aberrant protein expression of transcription factors BACH1 and ERG, both encoded on chromosome 21, in brains of patients with Down syndrome and Alzheimer's disease.

  2003cites this paper
• A new mouse model for Down syndrome.

  2003cites this paper
• Advances in Down Syndrome Research

  2003cites this paper
• Overexpression of transcription factor BACH1 in fetal Down syndrome brain.

  2003cites this paper
• Hormones, Obesity, Learning, and Breathing — the Many Functions of Mammalian Single-Minded Genes

  2003cites this paper
• Differential Activities of Murine Single Minded 1 (SIM1) and SIM2 on a Hypoxic Response Element

  2002cites this paper
• Sim2 Mutants Have Developmental Defects Not Overlapping with Those of Sim1 Mutants

  2002cites this paper
• Sim 2 Mutants Have Developmental Defects Not Overlapping with Those of Sim 1 Mutants

  2002cites this paper
• Drosophila single-minded represses gene transcription by activating the expression of repressive factors.

  2001cites this paper
• [The structure and physiological function of bHLH-PAS transcription factors].

  2001cites this paper
• Mice containing a human chromosome 21 model behavioral impairment and cardiac anomalies of Down's syndrome.

  2001cites this paper
• Murine models for Down syndrome.

  2001cites this paper
• Behavioural profiling of a murine Charcot–Marie–Tooth disease type 1A model

  2001cites this paper
• Molecular neuropathology of transgenic mouse models of Down syndrome.

  2001cites this paper
• Molecular mechanisms of human single-minded 2 (SIM2) gene expression: identification of a promoter site in the SIM2 genomic sequence.

  2001cites this paper
• The Genetics of Cognitive Processes: Candidate Genes in Humans and Animals

  2001cites this paper
• Applications of the Morris water maze in the study of learning and memory.

  2001cites this paper
• Specific impairment of cardiogenesis in mouse ES cells containing a human chromosome 21.

  2000cites this paper
• Behavioral phenotype of individuals with Down syndrome.

  2000cites this paper
• Mice trisomic for a bacterial artificial chromosome with the single-minded 2 gene (Sim2) show phenotypes similar to some of those present in the partial trisomy 16 mouse models of Down syndrome.

  2000cites this paper
• Isolation of two novel genes, DSCR5 and DSCR6, from Down syndrome critical region on human chromosome 21q22.2.

  2000cites this paper
• Overexpression of mSim2 gene in the zona limitans of the diencephalon of segmental trisomy 16 Ts1Cje fetuses, a mouse model for trisomy 21: a novel whole-mount based RNA hybridization study.

  2000cites this paper
• Muscle weakness, hyperactivity, and impairment in fear conditioning in tau-deficient mice.

  2000cites this paper
• (Over)correction of FMR1 deficiency with YAC transgenics: behavioral and physical features.

  2000cites this paper