ERO1-independent production of H2O2 within the endoplasmic reticulum fuels Prdx4-mediated oxidative protein folding

Tasuku Konno,Eduardo Pinho Melo,C. Lopes,I. Mehmeti,S. Lenzen,D. Ron,E. Avezov

Published 2015 in Journal of Cell Biology

ABSTRACT

Tracking the kinetics of equilibration of H2O2 between compartments reveals unexpected isolation of the endoplasmic reticulum and hints at a hitherto unsuspected local source of peroxide.

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