From Art to Engineering? The Rise of In Vivo Mammalian Electrophysiology via Genetically Targeted Labeling and Nonlinear Imaging

A convergence of technical advancements in neuroscience has begun to transform mammalian electrophysiology from an art into a precise practice.

• Publication year

  2005

• Venue

  PLoS Biology

• Publication date

  2005-10-01

• Fields of study

  Biology, Medicine, Engineering, Art

• Identifiers
  DOI 10.1371/journal.pbio.0030355PMID 16207078PMCID 1250306
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Remote control of behavior through genetically targeted photostimulation of neurons.

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• A molecular and genetic arsenal for systems neuroscience.

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• Activation of cerebellar parallel fibers monitored in transgenic mice expressing a fluorescent Ca2+ indicator protein

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• Glycinergic neurons expressing enhanced green fluorescent protein in bacterial artificial chromosome transgenic mice

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• Detection of glutamate release from neurons by genetically encoded surface-displayed FRET nanosensors.

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• Large-scale genomic approaches to brain development and circuitry.

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• Genotype-environment interactions in mouse behavior: a way out of the problem.

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• Synaptic vesicle recycling studied in transgenic mice expressing synaptopHluorin

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• Light-activated ion channels for remote control of neuronal firing

  2004cited by this paper
• Monitoring Neural Activity and [Ca2+] with Genetically Encoded Ca2+ Indicators

  2004cited by this paper
• Expanded dynamic range of fluorescent indicators for Ca(2+) by circularly permuted yellow fluorescent proteins.

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• Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein

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• Ankyrin-based subcellular gradient of neurofascin, an immunoglobulin family protein, directs GABAergic innervation at purkinje axon initial segment.

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• Genetically Encoded Indicators of Cellular Calcium Dynamics Based on Troponin C and Green Fluorescent Protein*

  2004cited by this paper
• Neurotechnique In Vivo Imaging of Neuronal Activity by Targeted Expression of a Genetically Encoded Probe in the Mouse

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• Serial Block-Face Scanning Electron Microscopy to Reconstruct Three-Dimensional Tissue Nanostructure

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• Experience and Activity-Dependent Maturation of Perisomatic GABAergic Innervation in Primary Visual Cortex during a Postnatal Critical Period

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• Functional Fluorescent Ca2+ Indicator Proteins in Transgenic Mice under TET Control

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• Neurotechnique Targeted Whole-Cell Recordings in the Mammalian Brain In Vivo

  2003cited by this paper
• A gene expression atlas of the central nervous system based on bacterial artificial chromosomes

  2003cited by this paper
• Imagining imaging's future.

  2003cited by this paper
• Neurotechnique All-Optical Histology Using Ultrashort Laser Pulses

  2003cited by this paper
• Nonlinear magic: multiphoton microscopy in the biosciences

  2003cited by this paper
• Two-photon imaging to a depth of 1000 microm in living brains by use of a Ti:Al2O3 regenerative amplifier.

  2003cited by this paper
• Targeted whole-cell recordings in the mammalian brain in vivo.

  2003cited by this paper
• In Vivo Labeling of Parvalbumin-Positive Interneurons and Analysis of Electrical Coupling in Identified Neurons

  2002cited by this paper
• Selective photostimulation of genetically chARGed neurons.

  2002cited by this paper
• Adaptive filtering of vibrissa input in motor cortex of rat.

  2002cited by this paper
• Tuning FlaSh: redesign of the dynamics, voltage range, and color of the genetically encoded optical sensor of membrane potential.

  2002cited by this paper
• Transgenic mice expressing a pH and Cl– sensing yellow‐fluorescent protein under the control of a potassium channel promoter

  2002cited by this paper
• Discriminative whisking in the head-fixed rat: optoelectronic monitoring during tactile detection and discrimination tasks.

  2001cited by this paper
• A high signal-to-noise Ca2+ probe composed of a single green fluorescent protein

  2001cited by this paper
• A miniature head-mounted two-photon microscope. high-resolution brain imaging in freely moving animals.

  2001cited by this paper
• Two-photon microscopy in brain tissue: parameters influencing the imaging depth.

  2001cited by this paper
• Reducing the Environmental Sensitivity of Yellow Fluorescent Protein

  2001cited by this paper
• Circularly permuted green fluorescent proteins engineered to sense Ca2+

  2001cited by this paper
• Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP.

  2000cited by this paper
• Germ Line Transformation of Mammals by Pronuclear Microinjection

  2000cited by this paper
• Dynamic and quantitative Ca2+ measurements using improved cameleons.

  1999cited by this paper
• Human theta oscillations exhibit task dependence during virtual maze navigation

  1999cited by this paper
• Task-related Theta Activity from Intracranial Recordings During Virtual Maze Navigation

  1999cited by this paper
• Circular permutation and receptor insertion within green fluorescent proteins.

  1999cited by this paper
• Visualizing secretion and synaptic transmission with pH-sensitive green fluorescent proteins

  1998cited by this paper
• The green fluorescent protein.

  1998cited by this paper
• In vivo dendritic calcium dynamics in neocortical pyramidal neurons

  1997influential reference
• Photon Upmanship : Techreview Why Multiphoton Imaging Is More than a Gimmick

  1997cited by this paper
• Photon upmanship: why multiphoton imaging is more than a gimmick.

  1997cited by this paper
• A genetically encoded optical probe of membrane voltage.

  1997cited by this paper
• Homologous recombination based modification in Esherichia coli and germline transmission in transgenic mice of a bacterial artificial chromsome

  1997cited by this paper
• Fluorescent indicators for Ca2+based on green fluorescent proteins and calmodulin

  1997cited by this paper
• Direct cortical representation of drawing.

  1994cited by this paper
• Anatomical and functional imaging of neurons using 2-photon laser scanning microscopy.

  1994cited by this paper
• Primary structure of the Aequorea victoria green-fluorescent protein.

  1992cited by this paper
• Hypothalamic neuron involvement in integration of reward, aversion, and cue signals.

  1986cited by this paper
• Latency variability and the identification of antidromically activated neurons in mammalian brain

  1978cited by this paper

• Functional integration of new neurons into adult cortical circuits

  2017cites this paper
• Functional and oxygen‐metabolic photoacoustic microscopy of the awake mouse brain

  2017cites this paper
• Time to wake up: Studying neurovascular coupling and brain-wide circuit function in the un-anesthetized animal

  2016cites this paper
• Neuron Primer Analysis of Neuronal Spike Trains , Deconstructed

  2016cites this paper
• Analysis of Neuronal Spike Trains, Deconstructed.

  2016cites this paper
• New steps toward understanding the regulation of photosystem i biogenesis in chlamydomonas reinhardtii

  2016cites this paper
• Protein-based calcium sensors

  2015cites this paper
• Primer : The deconstruction of neuronal spike trains

  2015cites this paper
• Prospect for feedback guided surgery with ultra-short pulsed laser light.

  2012cites this paper
• Neuronal Basis of Non-Invasive Functional Imaging: From Microscopic Neurovascular Dynamics to BOLD fMRI

  2012cites this paper
• Towards an understanding of human alpha-7 nicotinic acetylcholine receptor selectivity: the creation and characterization of a soluble ligand binding domain template

  2011cites this paper
• Characterizing Ligand-Gated Ion Channel Receptors with Genetically Encoded Ca++ Sensors

  2011cites this paper
• Transfection via whole-cell recording in vivo: bridging single-cell physiology, genetics and connectomics

  2011cites this paper
• Building a zoo of mice for genetic analyses: A comprehensive protocol for the rapid generation of BAC transgenic mice

  2010cites this paper
• Imaging Neural Circuits Via Two-Photon-Excited Fluorescence And Second Harmonic Generation Microscopy

  2009cites this paper
• MRI studies of appetite centre function in rodents

  2009cites this paper
• Topology, dynamics, and control in cortical blood flow elucidated with optical techniques

  2009cites this paper
• BAC Use in the Study of the CNS

  2009cites this paper
• Chapter 10. In vivo measurements of blood flow and glial cell function with two-photon laser-scanning microscopy.

  2008cites this paper
• In Vivo Measurements of Blood Flow and Glial Cell Function with Two-Photon Laser-Scanning Microscopy

  2008cites this paper
• Fluorescence Changes of Genetic Calcium Indicators and OGB-1 Correlated with Neural Activity and Calcium In Vivo and In Vitro

  2008cites this paper
• Genetically encoded calcium indicators.

  2008cites this paper
• Seeing the Brain in Action: How Multiphoton Imaging Has Advanced Our Understanding of Neuronal Function

  2008cites this paper
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• Imaging large-scale neural activity with cellular resolution in awake, mobile mice.

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