Chloride Influx Aggravates Ca2+-Dependent AMPA Receptor-Mediated Motoneuron Death

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Journal of Neuroscience

• Publication date

  2003-06-15

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1523/JNEUROSCI.23-12-04942.2003PMID 12832516PMCID PMC6741175
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The AMPA receptor antagonist NBQX prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis.

  2003cited by this paper
• Molecular structure and physiological function of chloride channels.

  2002influential reference
• An α-mercaptoacrylic acid derivative (PD150606) inhibits selective motor neuron death via inhibition of kainate-induced Ca2+ influx and not via calpain inhibition

  2002cited by this paper
• GluR2-dependent properties of AMPA receptors determine the selective vulnerability of motor neurons to excitotoxicity.

  2002cited by this paper
• Na(+) entry through AMPA receptors results in voltage-gated k(+) channel blockade in cultured rat spinal cord motoneurons.

  2002cited by this paper
• Disruption of KCC2 reveals an essential role of K-Cl cotransport already in early synaptic inhibition.

  2001cited by this paper
• gamma-Aminobutyric acid(A) neurotransmission and cerebral ischemia.

  2001cited by this paper
• RPR 119990, a Novel α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Antagonist: Synthesis, Pharmacological Properties, and Activity in an Animal Model of Amyotrophic Lateral Sclerosis

  2001cited by this paper
• The KCl cotransporter, KCC2, is highly expressed in the vicinity of excitatory synapses in the rat hippocampus

  2001cited by this paper
• γ‐Aminobutyric acidA neurotransmission and cerebral ischemia

  2001cited by this paper
• Dendritic Spines Lost during Glutamate Receptor Activation Reemerge at Original Sites of Synaptic Contact

  2001cited by this paper
• Dehydroepiandrosterone sulfate is neuroprotective in a reversible spinal cord ischemia model: possible involvement of GABA(A) receptors.

  2000cited by this paper
• Different receptors mediate motor neuron death induced by short and long exposures to excitotoxicity.

  2000cited by this paper
• A role for sodium and chloride in kainic acid-induced beading of inhibitory interneuron dendrites.

  2000cited by this paper
• Ca(2+)-permeable AMPA receptors and selective vulnerability of motor neurons.

  2000cited by this paper
• Clomethiazole (ZENDRA, CMZ) improves hind limb motor function and reduces neuronal damage after severe spinal cord injury in rat

  1999cited by this paper
• The role of excitotoxicity in neurodegenerative disease: implications for therapy.

  1999cited by this paper
• The K+/Cl− co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation

  1999cited by this paper
• Regulation of intracellular chloride by cotransporters in developing lateral superior olive neurons.

  1999cited by this paper
• Neuronal Ca 2 +-activated Cl ÿ channels Ð homing in on an elusive channel species

  1999cited by this paper
• Regulation of Intracellular Chloride by Cotransporters in Developing Lateral Superior Olive Neurons

  1999cited by this paper
• Shift from depolarizing to hyperpolarizing glycine action in rat auditory neurones is due to age‐dependent Cl− regulation

  1999cited by this paper
• The role of excitotoxicity in neurodegenerative disease: implications for therapy.

  1999cited by this paper
• Activation of Excitatory Amino Acid Receptors in the Rat Hippocampal Slice Increases Intracellular Cl− and Cell Volume

  1998cited by this paper
• Nucleoside diphosphate kinase and Cl(-)-sensitive protein phosphorylation in apical membranes from ovine airway epithelium.

  1998cited by this paper
• Development of glycinergic synaptic transmission to rat brain stem motoneurons.

  1998cited by this paper
• Distinct roles for sodium, chloride, and calcium in excitotoxic dendritic injury and recovery.

  1998cited by this paper
• Glial cells potentiate kainate-induced neuronal death in a motoneuron-enriched spinal coculture system.

  1998cited by this paper
• Astrocytes regulate developmental changes in the chloride ion gradient of embryonic rat ventral spinal cord neurons in culture

  1998cited by this paper
• Modulating excitatory synaptic neurotransmission: potential treatment for neurological disease?

  1998cited by this paper
• Calcium‐activated chloride channels in bovine pulmonary artery endothelial cells.

  1997cited by this paper
• Membrane currents and the resting membrane potential in cultured bovine pulmonary artery endothelial cells.

  1996cited by this paper
• Motor Neurons Are Selectively Vulnerable to AMPA/Kainate Receptor-Mediated Injury In Vitro

  1996cited by this paper
• Perforated-patch recording with gramicidin avoids artifactual changes in intracellular chloride concentration.

  1995cited by this paper
• Gramicidin perforated patch-clamp technique reveals glycine-gated outward chloride current in dissociated nucleus solitarii neurons of the rat.

  1994cited by this paper
• Glycine response in acutely dissociated ventromedial hypothalamic neuron of the rat: new approach with gramicidin perforated patch-clamp technique.

  1994cited by this paper
• A novel chloride-dependent GTP-utilizing protein kinase in plasma membranes from human respiratory epithelium.

  1994cited by this paper
• Glycine responses in rat CNS neurons studied with gramicidin perforated patch recording.

  1994cited by this paper
• Effect of gamma-aminobutyric acid modulation on neuronal ischemia in rabbits.

  1994cited by this paper
• Excitatory amino acids as a final common pathway for neurologic disorders.

  1994cited by this paper
• gamma-Aminobutyric acidA receptor regulation by a chloride-dependent kinase and a sodium-dependent phosphatase.

  1993cited by this paper
• Oxidative stress, glutamate, and neurodegenerative disorders.

  1993cited by this paper
• A chloride channel widely expressed in epithelial and non-epithelial cells

  1992cited by this paper
• Chloride transport blockers prevent N-methyl-D-aspartate receptor-channel complex activation.

  1992cited by this paper
• Altered glutamatergic mechanisms and selective motor neuron degeneration in amyotrophic lateral sclerosis: possible role of glycine.

  1991cited by this paper
• Light microscopic and ultrastructural analysis of GABA‐immunoreactive profiles in the monkey spinal cord

  1990cited by this paper
• Blockade of desensitization augments quisqualate excitotoxicity in hippocampal neurons.

  1990cited by this paper
• Changes in extracellular amino acid neurotransmitters produced by focal cerebral ischemia.

  1990cited by this paper
• Ionic dependence of glutamate neurotoxicity

  1987cited by this paper
• Delayed neurotoxicity of excitatory amino acids in vitro.

  1987cited by this paper
• Anatomical distribution and ultrastructural organization of the GABAergic system in the rat spinal cord. An immunocytochemical study using anti-GABA antibodies.

  1987cited by this paper
• Regulation of hormone-sensitive GTP-dependent regulatory proteins by chloride.

  1987cited by this paper
• Voltage-clamp analysis of a Ca2+- and voltage-dependent chloride conductance in cultured mouse spinal neurons.

  1986cited by this paper
• A Ca-dependent Cl− conductance in cultured mouse spinal neurones

  1984cited by this paper
• Effects of Anoxia on the Stimulated Release of Amino Acid Neurotransmitters in the Cerebellum In Vitro

  1983cited by this paper
• Alterations of putative neurotransmitters and enzymes during ischemia in gerbil cerebral cortex.

  1978cited by this paper
• Glycine-specific synapses in rat spinal cord. Identification by electron microscope autoradiography

  1976cited by this paper
• Identification by Electron Microscope Autoradiography

  1976cited by this paper

• Roles of GABAA receptor α5 subunit on locomotion and working memory in transient forebrain ischemia in mice.

  2020cites this paper
• LRRC8A-dependent volume-regulated anion channels contribute to ischemia-induced brain injury and glutamatergic input to hippocampal neurons.

  2020cites this paper
• L'implication de l'ubiquiline-2 dans l'agrégation de TDP-43 et la pathogénèse de la sclérose latérale amyotrophique

  2019cites this paper
• Interferon‐γ Receptor 1 and GluR1 upregulated in motor neurons of symptomatic hSOD1G93A mice

  2018cites this paper
• What Is Being Trained? How Divergent Forms of Plasticity Compete To Shape Locomotor Recovery after Spinal Cord Injury

  2017cites this paper
• DNA strand breaks and TDP-43 mislocation are absent in the murine hSOD1G93A model of amyotrophic lateral sclerosis in vivo and in vitro

  2017cites this paper
• Imaging of glial cell morphology, SOD1 distribution and elemental composition in the brainstem and hippocampus of the ALS hSOD1G93A rat.

  2017cites this paper
• Sigma 1 receptor activation modifies intracellular calcium exchange in the G93AhSOD1 ALS model.

  2017influential citation
• NSAIDs modulate GABA-activated currents via Ca2+-activated Cl− channels in rat dorsal root ganglion neurons

  2016cites this paper
• Novel computer vision algorithm for the reliable analysis of organelle morphology in whole cell 3D images--A pilot study for the quantitative evaluation of mitochondrial fragmentation in amyotrophic lateral sclerosis.

  2015cites this paper
• Endoplasmic reticulum stress is accompanied by activation of NF-κB in amyotrophic lateral sclerosis.

  2014cites this paper
• Degenerative processes in organotypic spinal slices: challenging pre-motor network with stress conditions

  2014cites this paper
• The neurotrophic properties of progranulin depend on the granulin E domain but do not require sortilin binding.

  2013cites this paper
• Monocyte Chemoattractant Protein-1 upregulates GABA-induced current: evidence of modified GABAA subunit composition in cortical neurons from the G93A mouse model of Amyotrophic Lateral Sclerosis.

  2013cites this paper
• Overexpression of human mutated G93A SOD1 changes dynamics of the ER mitochondria calcium cycle specifically in mouse embryonic motor neurons.

  2013cites this paper
• Genetic ablation of phospholipase C delta 1 increases survival in SOD1(G93A) mice.

  2013cites this paper
• Dantrolene is neuroprotective in vitro, but does not affect survival in SOD1(G⁹³A) mice.

  2012cites this paper
• The unfolded protein response in models of human mutant G93A amyotrophic lateral sclerosis

  2012cites this paper
• Transient increase in neuronal chloride concentration by neuroactive aminoacids released from glioma cells

  2012influential citation
• SOD1 and TDP-43 animal models of amyotrophic lateral sclerosis: recent advances in understanding disease toward the development of clinical treatments

  2011cites this paper
• Glutamate pathway implication in amyotrophic lateral sclerosis: what is the signal in the noise?

  2010cites this paper
• Amyotrophic lateral sclerosis and excitotoxicity: from pathological mechanism to therapeutic target.

  2010cites this paper
• Downregulation of the Potassium Chloride Cotransporter KCC2 in Vulnerable Motoneurons in the SOD1-G93A Mouse Model of Amyotrophic Lateral Sclerosis

  2010cites this paper
• Molecular and cellular mechanisms of excitotoxic neuronal death

  2010cites this paper
• Differential contribution of the Na+‐K+‐2Cl− cotransporter NKCC1 to chloride handling in rat embryonic dorsal root ganglion neurons and motor neurons

  2009cites this paper
• Decreased chloride levels of cerebrospinal fluid in patients with amyotrophic lateral sclerosis.

  2009influential citation
• Inhibitory synaptic transmission in striatal neurons after transient cerebral ischemia

  2009cites this paper
• Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival

  2008cites this paper
• GABAA receptors present higher affinity and modified subunit composition in spinal motor neurons from a genetic model of amyotrophic lateral sclerosis

  2008cites this paper
• Ivermectin inhibits AMPA receptor-mediated excitotoxicity in cultured motor neurons and extends the life span of a transgenic mouse model of amyotrophic lateral sclerosis.

  2007cites this paper
• Roles of Volume-Sensitive Chloride Channel in Excitotoxic Neuronal Injury

  2007cites this paper
• Astrocytes regulate GluR2 expression in motor neurons and their vulnerability to excitotoxicity

  2007cites this paper
• Disruption of ionic and cell volume homeostasis in cerebral ischemia: The perfect storm.

  2007cites this paper
• Survey of ALS‐associated factors potentially promoting Ca2+ overload of motor neurons

  2007cites this paper
• Role of mitochondria in kainate-induced fast Ca2+ transients in cultured spinal motor neurons.

  2007cites this paper
• The role of excitotoxicity in the pathogenesis of amyotrophic lateral sclerosis.

  2006cites this paper
• Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy

  2006cites this paper
• Excitotoxicity and Amyotrophic Lateral Sclerosis

  2006cites this paper
• Characterization of changes in synaptic strength in the CA1 region of the hippocampus by the analysis of miniature synaptic currents

  2005cites this paper
• Excitotoxic death induced by released glutamate in depolarized primary cultures of mouse cerebellar granule cells is dependent on GABAA receptors and niflumic acid‐sensitive chloride channels

  2005influential citation
• Cytoskeletal dynamics in and traumatic injury of cerebellar and hippocampal neurons

  2005cites this paper
• Rat embryonic motoneurons in long-term co-culture with Schwann cells--a system to investigate motoneuron diseases on a cellular level in vitro.

  2005cites this paper
• Excitotoxicity and ALS: What is unique about the AMPA receptors expressed on spinal motor neurons?

  2005cites this paper
• GluR2 Deficiency Accelerates Motor Neuron Degeneration in a Mouse Model of Amyotrophic Lateral Sclerosis

  2005cites this paper
• Synaptic signaling between neurons and glia

  2004cites this paper
• Glutamate‐induced elevations in intracellular chloride concentration in hippocampal cell cultures derived from EYFP‐expressing mice

  2004cites this paper
• Increased GABAergic function in mouse models of Huntington's disease: Reversal by BDNF

  2004cites this paper
• Synaptic signaling between GABAergic interneurons and oligodendrocyte precursor cells in the hippocampus

  2004cites this paper
• Long-lasting changes in GABA responsiveness in cultured neurons.

  2004cites this paper
• Spinal myoclonus responsive to topiramate

  2004cites this paper