Cytotoxic principles of Securinega virosa: virosecurinine and viroallosecurinine and related derivatives.

No abstract is available for this paper.

• Publication year

  1991

• Venue

  Journal of Pharmacy and Science

• Publication date

  1991-04-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1002/JPS.2600800408PMID 1865332
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Antitumor agents. 113. New 4 beta-arylamino derivatives of 4'-O-demethylepipodophyllotoxin and related compounds as potent inhibitors of human DNA topoisomerase II.

  1990cited by this paper
• The Cytotoxic Principles of Prunella vulgaris, Psychotria serpens, and Hyptis capitata: Ursolic Acid and Related Derivatives1

  1988cited by this paper
• Alkaloids from the leaves of Phyllanthus discoideus

  1988cited by this paper
• Antitumor activity of the isodon diterpenoids: Structural requirements for the activity

  1976cited by this paper
• Tumor inhibitors. LXXXI. Structure and partial synthesis of fabacein

  1973cited by this paper
• Cytotoxicity of sesquiterpene lactones.

  1971cited by this paper
• Some Observations on the Oxidation of Virosecurinine with Monoperphthalic Acid1,2

  1966cited by this paper
• Studies on the Alkaloids of Securinega virosa Pax. et Hoffm. IV.1 The Preferred Conformations of Allosecurinine (Phyllochrysine) and Dihydrosecurinine

  1964cited by this paper
• STRUCTURE AND STEREOCHEMISTRY OF NORSECURININE AND DIHYDRONORSECURININE.

  1964cited by this paper
• [DETERMINATION OF SECURININE AND ITS STEREOISOMERS IN PLANTS OF THE SECURINEGA SPECIES, AND ISOLATION OF VIROALLOSECURININE AND VIROSINE].

  1964cited by this paper
• Studies on the alkaloids of Securinega virosa Pax. et Hoffm.—I

  1963cited by this paper
• Studies on the alkaloids of Securinega virosa Pax. et Hoffom. I. Structure of virosecurinine.

  1963cited by this paper
• Studies on the Alkaloids of Securinega virosa Pax. et Hoffm. II.1 The Absolute Configuration of C-6 in Virosecurinine and the Stereochemical Interrelationship of Virosecurinine, Securinine, and Allosecurinine2

  1963cited by this paper

• A Review on the Ethnomedicinal Plants Used in Zimbabwe for the Treatment and Management of Skin Conditions: Perspectives on Pharmacological and Toxicological Evaluation

  2025cites this paper
• Traditional Uses, Pharmacology and Phytochemistry of the Medicinal Plant Flueggea virosa (Roxb. ex Willd.) Royle

  2024cites this paper
• Bioactivities and mechanism of action of securinega alkaloids derivatives reported prior to 2022.

  2023cites this paper
• Ethnobotanical Survey on Medicinal Plants Used in Burkina Faso in the Treatment of Breast Cancer, Phytochemistry and Antioxidant Activities: Euphorbia poissonii Pax and Flueggea virosa (Willd.) Voigt. (Euphorbiaceae)

  2022cites this paper
• Medicinal plants used for the management of respiratory diseases in Zimbabwe: Review and perspectives potential management of COVID-19

  2022cites this paper
• Securinine Induces Differentiation of Human Promyelocytic Leukemic HL-60 Cells through JNK-Mediated Signaling Pathway

  2021cites this paper
• Biologically active indolizidine alkaloids

  2020influential citation
• ETHNOBOTANICAL SURVEY OF MEDICINAL PLANTS USED IN THE TREATMENT OF CANCER IN DUTSIN-MA LOCAL GOVERNMENT AREA OF KATSINA STATE, NIGERIA

  2020cites this paper
• PHARMACOLOGICAL AND CHEMOTAXONOMIC ASPECT OF TERPENES IN SECURINEGA VIROSA

  2019cites this paper
• Bio-inspired Total Synthesis of Twelve Securinega Alkaloids: Structural Reassignments of (+)-Virosine B and (-)-Episecurinol A.

  2019cites this paper
• Ethnobotanical study of medicinal plants from Ghana; confirmation of ethnobotanical uses, and review of biological and toxicological studies on medicinal plants used in Apra Hills Sacred Grove

  2018cites this paper
• Taxonomy , phytochemistry , pharmacology and traditional uses of Flueggea virosa ( Roxb . ex Willd . ) Royle : A Review

  2018cites this paper
• Securinine disturbs redox homeostasis and elicits oxidative stress-mediated apoptosis via targeting thioredoxin reductase.

  2017cites this paper
• Synthesis and Antiproliferative and Metabolic Evaluations of Novel Securinine Derivatives.

  2016cites this paper
• Synthesis and biological evaluation of new securinine analogues as potential anticancer agents.

  2016cites this paper
• Flueggether A and Virosinine A, Anti-HIV Alkaloids from Flueggea virosa.

  2015cites this paper
• Total Synthesis of (−)-Secu’amamine A Exploiting Type II Anion Relay Chemistry

  2015cites this paper
• Securinega virosa ( Euphorbiaceae ) root bark extract inhibits glioblastoma multiforme cell survival in vitro

  2015influential citation
• From monomer to tetramer and beyond: the intriguing chemistry of Securinega alkaloids from Flueggea virosa

  2013cites this paper
• Fluevirosines A-C: a biogenesis inspired example in the discovery of new bioactive scaffolds from Flueggea virosa.

  2013cites this paper
• Enantioselective total synthesis of virosaine A and bubbialidine.

  2013cites this paper
• An efficient approach to the securinega alkaloids empowered by cooperative N-heterocyclic carbene/Lewis acid catalysis.

  2013cites this paper
• Virosaines A and B, two new birdcage-shaped Securinega alkaloids with an unprecedented skeleton from Flueggea virosa.

  2012cites this paper
• Unexpected ring contraction and oxidation rearrangement reactions of securinine

  2012cites this paper
• Development of an efficient synthetic strategy for bioactive alkaloids possessing a spirocyclic ring system

  2010cites this paper
• Enantioselective approach to Securinega alkaloids. Total synthesis of securinine and (-)-norsecurinine.

  2009cites this paper
• New Phenolic Glycosides from Securinega virosa and Their Antioxidant Activity

  2009cites this paper
• Total synthesis of the Securinega alkaloids.

  2009cites this paper
• Identification and antiproliferative activity evaluation of a series of triterpenoids isolated from Flueggea virosa (Roxb. ex Willd.).

  2009cites this paper
• Preliminary studies on anti-inflammatory and analgesic activities of Securinega virosa (Euphorbiaceae) in experimental animal models

  2008cites this paper
• Suffruticosine, a Novel Octacyclic Alkaloid with an Unprecedented Skeleton from Securinega suffruticosa (Pall.) Rehd.

  2008cites this paper
• Two New Alkaloids from Flueggea virosa

  2008cites this paper
• Antimalarial activity of crude extracts from nine African medicinal plants.

  2008cites this paper
• Callus of Securinega suffruticosa , a cell line accumulates dextro Securinega alkaloids

  2007cites this paper
• Flueggenines A and B, two novel C,C-linked dimeric indolizidine alkaloids from Flueggea virosa.

  2006cites this paper
• Alkaloids from the Root of Flueggea Virosa

  2006cites this paper
• An effective enantioselective approach to the securinega alkaloids: total synthesis of (-)-norsecurinine.

  2005cites this paper
• First total synthesis of (+)-viroallosecurinine

  2004cites this paper
• Trypanocidal activity of bergenin, the major constituent of Flueggea virosa, on Trypanosoma brucei.

  2004cites this paper
• Some Pharmacological Properties of An Aqueous Extract of Securinega Virosa Roots

  2000cites this paper
• Dammarane Triterpenes from the Leaves of Securinega melanthesoides

  1998cites this paper
• Biological screening of traditional medicinal plants from Papua New Guinea.

  1995cites this paper
• Natural products as anticancer agents.

  1994cites this paper
• Antineoplastic Alkaloids From Chinese Medicinal Plants and Their Analogs

  1994cites this paper
• Muscarine, oxazole, imidazole, thiazole, and peptide alkaloids, and other miscellaneous alkaloids.

  1994cites this paper
• Muscarine, oxazole, thiazole, imidazole and peptide alkaloids and other miscellaneous alkaloids.

  1992cites this paper