A Combination of Buprenorphine and Naltrexone Blocks Compulsive Cocaine Intake in Rodents Without Producing Dependence

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Science Translational Medicine

• Publication date

  2012-08-08

• Fields of study

  Medicine

• Identifiers
  DOI 10.1126/scitranslmed.3003948PMID 22875830PMCID PMC3448552
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Treatment of tobacco dependence.

  2011cited by this paper
• Buprenorphine and Opioid Antagonism, Tolerance, and Naltrexone-Precipitated Withdrawal

  2011cited by this paper
• Statement of the American Society of Addiction Medicine Consensus Panel on the Use of Buprenorphine in Office-Based Treatment of Opioid Addiction

  2011cited by this paper
• Abuse liability of intravenous buprenorphine/naloxone and buprenorphine alone in buprenorphine-maintained intravenous heroin abusers.

  2010cited by this paper
• The role of the dynorphin–κ opioid system in the reinforcing effects of drugs of abuse

  2010cited by this paper
• Inhibition of kappa opioid receptors attenuated increased cocaine intake in rats with extended access to cocaine

  2009influential reference
• Rats with Extended Access to Cocaine Exhibit Increased Stress Reactivity and Sensitivity to the Anxiolytic-Like Effects of the mGluR 2/3 Agonist LY379268 during Abstinence

  2008cited by this paper
• A role for brain stress systems in addiction.

  2008cited by this paper
• Addiction and the brain antireward system.

  2008cited by this paper
• Treatment of tobacco dependence.

  2008cited by this paper
• Stress-induced reinstatement of cocaine seeking is mediated by the kappa opioid system

  2008cited by this paper
• Anxiolytic-like effects of morphine and buprenorphine in the rat model of fear-potentiated startle: tolerance, cross-tolerance, and blockade by naloxone

  2008cited by this paper
• The kappa-opioid agonist U69,593 blocks cocaine-induced enhancement of brain stimulation reward.

  2008cited by this paper
• Striatal and ventral pallidum dynorphin concentrations are markedly increased in human chronic cocaine users.

  2008cited by this paper
• Alpha 1-noradrenergic system role in increased motivation for cocaine intake in rats with prolonged access.

  2008cited by this paper
• A stepped care strategy using buprenorphine and methadone versus conventional methadone maintenance in heroin dependence: a randomized controlled trial.

  2007cited by this paper
• Effects of Dose and Session Duration on Cocaine Self-Administration in Rats

  2007cited by this paper
• The effects of chronic buprenorphine on intake of heroin and cocaine in rats and its effects on nucleus accumbens dopamine levels during self-administration

  2006cited by this paper
• Pharmacological treatment of alcohol dependence: target symptoms and target mechanisms.

  2006cited by this paper
• Naltrexone and buprenorphine combination in the treatment of opioid dependence

  2006cited by this paper
• Rats Maintained Chronically on Buprenorphine Show Reduced Heroin and Cocaine Seeking in Tests of Extinction and Drug-Induced Reinstatement

  2005cited by this paper
• Interaction of μ‐opioid receptor agonists and antagonists with the analgesic effect of buprenorphine in mice

  2005cited by this paper
• Effects of buprenorphine on self-administration of cocaine and a nondrug reinforcer in rats

  2005cited by this paper
• Opiate antagonists reduce cocaine but not nicotine self-administration

  2005cited by this paper
• Randomized Trial of Buprenorphine for Treatment of Concurrent Opiate and Cocaine Dependence

  2004cited by this paper
• Heroin and cocaine intravenous self-administration in rats: Mediation by separate neural systems

  2004cited by this paper
• Drug Seeking Becomes Compulsive After Prolonged Cocaine Self-Administration

  2004cited by this paper
• Effects of kappa-opioid receptor ligands on intracranial self-stimulation in rats.

  2004cited by this paper
• Effects of κ-opioid receptor ligands on intracranial self-stimulation in rats

  2004cited by this paper
• Antidepressant-Like Effects of κ-Opioid Receptor Antagonists in the Forced Swim Test in Rats

  2003cited by this paper
• Pharmacologic treatments for heroin and cocaine dependence.

  2003cited by this paper
• Effects of mixed-action kappa/mu opioids on cocaine self-administration and cocaine discrimination by rhesus monkeys.

  2003cited by this paper
• Effects of Mixed-Action κ/μ Opioids on Cocaine Self-Administration and Cocaine Discrimination by Rhesus Monkeys

  2003cited by this paper
• Effects of mu-opioid agonists on cocaine- and food-maintained responding and cocaine discrimination in rhesus monkeys: role of mu-agonist efficacy.

  2002cited by this paper
• Stress and cocaine addiction.

  2002cited by this paper
• Neurobiological evidence for hedonic allostasis associated with escalating cocaine use

  2002cited by this paper
• Opioid peptide receptor studies. 12. Buprenorphine is a potent and selective μ/κ antagonist in the [35S]‐GTP‐γ‐S functional binding assay

  1999cited by this paper
• Impulsivity resulting from frontostriatal dysfunction in drug abuse: implications for the control of behavior by reward-related stimuli

  1999cited by this paper
• Differential expression of response-disruptive and somatic indices of opiate withdrawal during the initiation and development of opiate dependence.

  1999cited by this paper
• Transition from moderate to excessive drug intake: change in hedonic set point.

  1998cited by this paper
• Regulation of cocaine reward by CREB.

  1998cited by this paper
• Effects of cyclazocine on cocaine self-administration in rats.

  1998cited by this paper
• Buprenorphine vs methadone maintenance treatment for concurrent opioid dependence and cocaine abuse.

  1997cited by this paper
• Drug abuse: hedonic homeostatic dysregulation.

  1997cited by this paper
• Combined effects of buprenorphine and a nondrug alternative reinforcer on IV cocaine self-administration in rats maintained under FR schedules

  1996cited by this paper
• The effects of eticlopride and naltrexone on responding maintained by food, cocaine, heroin and cocaine/heroin combinations in rats.

  1996cited by this paper
• Buprenorphine's physical dependence potential: antagonist-precipitated withdrawal in humans.

  1996cited by this paper
• Effects of methadone or buprenorphine maintenance on the subjective and reinforcing effects of intravenous cocaine in humans.

  1996cited by this paper
• In vivo apparent pA2 analysis for naltrexone antagonism of discriminative stimulus and analgesic effects of opiate agonists in rats.

  1994cited by this paper
• Repeated cocaine administration upregulates kappa and mu, but not delta, opioid receptors.

  1994cited by this paper
• Effects of buprenorphine and naltrexone on reinstatement of cocaine-reinforced responding in rats.

  1993cited by this paper
• Cocaine self-administration increases preprodynorphin, but not c-fos, mRNA in rat striatum.

  1993cited by this paper
• Molecular alterations in the neostriatum of human cocaine addicts

  1993cited by this paper
• Naltrexone–Buprenorphine Interactions: Effects on Cocaine Self-Administration

  1993cited by this paper
• Potential Involvement of Anxiety in the Neurobiology of Cocaine a

  1992cited by this paper
• The effects of chronic buprenorphine treatment on cocaine and food self-administration by rhesus monkeys.

  1992cited by this paper
• Intracerebroventricular naltrexone treatment attenuates acquisition of intravenous cocaine self-administration in rats.

  1991cited by this paper
• Current pharmacotherapies for opioid dependence.

  1990cited by this paper
• Effects of cocaine on extrapyramidal and limbic dynorphin systems.

  1990cited by this paper
• Opioid antagonist challenges in buprenorphine maintained patients.

  1990cited by this paper
• Buprenorphine and naltrexone effects on cocaine self-administration by rhesus monkeys.

  1990cited by this paper
• Buprenorphine suppresses cocaine self-administration in rhesus monkeys.

  1989cited by this paper
• Buprenorphine suppresses cocaine self-administration by rhesus monkeys.

  1989cited by this paper
• Nor-binaltorphimine, a highly selective kappa-opioid antagonist in analgesic and receptor binding assays.

  1988cited by this paper
• Psychotomimesis mediated by kappa opiate receptors

  1986cited by this paper
• Buprenorphine : characteristics of binding sites in the rat central nervous system.

  1981cited by this paper
• In vivo RECEPTOR BINDING OF THE OPIATE PARTIAL AGONIST, BUPRENORPHINE, CORRELATED WITH ITS AGONISTIC AND ANTAGONISTIC ACTIONS

  1981cited by this paper
• Buprenorphine suppresses heroin use by heroin addicts.

  1980cited by this paper
• Development and maintenance of morphine tolerance and dependence in the rat by scheduled access to morphine drinking solutions.

  1978influential reference

• Docking 14 million virtual isoquinuclidines against the mu and kappa opioid receptors reveals dual antagonists-inverse agonists with reduced withdrawal effects

  2025cites this paper
• Docking 14 Million Virtual Isoquinuclidines against the μ and κ Opioid Receptors Reveals Dual Antagonists–Inverse Agonists with Reduced Withdrawal Effects

  2025cites this paper
• Comorbid alcohol use disorder and post-traumatic stress disorder: A proof-of-concept randomized placebo-controlled trial with buprenorphine and naltrexone combination treatment.

  2023cites this paper
• PPL-138 (BU10038): A bifunctional NOP/mu partial agonist that reduces cocaine self-administration in rats.

  2022cites this paper
• Pharmacological Treatments for Cocaine Craving: What Is the Way Forward? A Systematic Review

  2022cites this paper
• Nalmefene, a Mu Opioid Receptor Antagonist/Kappa Opioid Receptor Partial Agonist, Potentiates Cocaine Motivation But Not Intake with Extended Access Self-Administration in Adult Male Mice.

  2021cites this paper
• Can pharmacotherapy improve treatment outcomes in people with co-occurring major depressive and cocaine use disorders?

  2021cites this paper
• The Buprenorphine Analogue BU10119 Attenuates Drug-Primed and Stress-Induced Cocaine Reinstatement in Mice

  2021cites this paper
• Translational value of non-human primates in opioid research.

  2021cites this paper
• Animal Models of the Behavioral Symptoms of Substance Use Disorders.

  2020cites this paper
• Improving translation of animal models of addiction and relapse by reverse translation

  2020cites this paper
• Improving translation of animal models of addiction and relapse by reverse translation

  2020cites this paper
• NOP-Related Mechanisms in Substance Use Disorders.

  2019cites this paper
• The Rise and Fall of Kappa-Opioid Receptors in Drug Abuse Research.

  2019cites this paper
• Naloxone reversed cognitive impairments induced by repeated morphine under heavy perceptual load in the 5‐choice serial reaction time task

  2019cites this paper
• Modulation of drug choice by extended drug access and withdrawal in rhesus monkeys: Implications for negative reinforcement as a driver of addiction and target for medications development

  2018cites this paper
• Knockdown of hypocretin attenuates extended access of cocaine self-administration in rats

  2018cites this paper
• Buprenorphine requires concomitant activation of NOP and MOP receptors to reduce cocaine consumption

  2018influential citation
• Buprenorphine Added on Brief Cognitive Behavioral Therapy for Treatment of Methamphetamine Use Disorder

  2018cites this paper
• Cebranopadol, a Mixed Opioid Agonist, Reduces Cocaine Self-administration through Nociceptin Opioid and Mu Opioid Receptors

  2017cites this paper
• Cebranopadol Blocks the Escalation of Cocaine Intake and Conditioned Reinstatement of Cocaine Seeking in Rats

  2017influential citation
• Pharmacological Treatments for Alcohol–Cocaine Interactions: A Preclinical Focus

  2017cites this paper
• Insights from Preclinical Choice Models on Treating Drug Addiction.

  2017cites this paper
• Hypocretin Neurotransmission Within the Central Amygdala Mediates Escalated Cocaine Self-administration and Stress-Induced Reinstatement in Rats.

  2017cites this paper
• Knockdown of Hypocretin/Orexin Attenuates Extended-Access Cocaine Self-Administration in Rats

  2017cites this paper
• Utility of Nonhuman Primates in Substance Use Disorders Research.

  2017cites this paper
• Naltrexone HCI/bupropion HCI for chronic weight management in obese adults: patient selection and perspectives

  2016cites this paper
• Kappa‐Opioid Antagonists for Psychiatric Disorders: From Bench to Clinical Trials

  2016cites this paper
• Buprenorphine + naloxone plus naltrexone for the treatment of cocaine dependence: the Cocaine Use Reduction with Buprenorphine (CURB) study.

  2016cites this paper
• Effects of the kappa opioid receptor antagonist nor‐binaltorphimine (nor‐BNI) on cocaine versus food choice and extended‐access cocaine intake in rhesus monkeys

  2016cites this paper
• Nociceptin receptor activation does not alter acquisition, expression, extinction and reinstatement of conditioned cocaine preference in mice.

  2016cites this paper
• Systemic Delivery of a Brain-Penetrant TrkB Antagonist Reduces Cocaine Self-Administration and Normalizes TrkB Signaling in the Nucleus Accumbens and Prefrontal Cortex

  2016cites this paper
• Combination of Levo-Tetrahydropalmatine and Low Dose Naltrexone: A Promising Treatment for Prevention of Cocaine Relapse

  2016cites this paper
• Synthesis and characterization of a dual kappa-delta opioid receptor agonist analgesic blocking cocaine reward behavior.

  2015cites this paper
• Pharmacological Treatment of Substance Abuse Disorders

  2015cites this paper
• The opioid receptors as targets for drug abuse medication

  2015cites this paper
• The biology of Nociceptin/Orphanin FQ (N/OFQ) related to obesity, stress, anxiety, mood, and drug dependence.

  2014cites this paper
• Experiments with cocaine and heroin addicts--are they predictive?

  2014cites this paper
• The effects of amphetamine, butorphanol, and their combination on cocaine self-administration.

  2014cites this paper
• Mixed κ/μ partial opioid agonists as potential treatments for cocaine dependence.

  2014cites this paper
• Self-Administration of Ethanol, Cocaine, or Nicotine Does Not Decrease the Soma Size of Ventral Tegmental Area Dopamine Neurons

  2014cites this paper
• Novel approaches for the treatment of psychostimulant and opioid abuse – focus on opioid receptor-based therapies

  2014cites this paper
• A non‐rewarding, non‐aversive buprenorphine/naltrexone combination attenuates drug‐primed reinstatement to cocaine and morphine in rats in a conditioned place preference paradigm

  2014cites this paper
• Cocaine use reduction with buprenorphine (CURB): rationale, design, and methodology.

  2013cites this paper
• Buprenorphine and related orvinols

  2013cites this paper
• Substance use disorders: psychoneuroimmunological mechanisms and new targets for therapy.

  2013cites this paper
• Endogenous opiates and behavior: 2012.

  2013cites this paper
• The macrocyclic tetrapeptide [D‐Trp]CJ‐15,208 produces short‐acting κ opioid receptor antagonism in the CNS after oral administration

  2013cites this paper
• Kappa opioid receptor-mediated dysregulation of gamma-aminobutyric acidergic transmission in the central amygdala in cocaine addiction.

  2013cites this paper
• Synthesis and biological evaluation of dynorphin analogs and, Caco-2 permeability of opioid macrocyclic tetrapeptides

  2013cites this paper
• Opus: University of Bath Online Publication Store a Non-rewarding, Non-aversive Buprenorphine/naltrexone Combination Attenuates Drug- Primed Reinstatement to Cocaine and Morphine in Rats in a Conditioned Place Preference Paradigm

  year unknowninfluential citation