Biochemical and behavioral characterization of novel methylphenidate analogs.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Journal of Pharmacology and Experimental Therapeutics

• Publication date

  2002-05-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1124/JPET.301.2.527PMID 11961053
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The dopamine transporter and cocaine medication development: drug self-administration in nonhuman primates.

  2001cited by this paper
• Differential interaction of GBR 12909, a dopamine uptake inhibitor, with cocaine and methamphetamine in rats discriminating cocaine

  2001influential reference
• Laboratory measures of methylphenidate effects in cocaine-dependent patients receiving treatment.

  2000cited by this paper
• Synthesis and pharmacology of site-specific cocaine abuse treatment agents: 2-(aminomethyl)-3-phenylbicyclo[2.2.2]- and -[2.2.1]alkane dopamine uptake inhibitors.

  1999influential reference
• Behavioral and neurochemical effects of the dopamine transporter ligand 4-chlorobenztropine alone and in combination with cocaine in vivo.

  1999influential reference
• Asymmetric synthesis and pharmacology of methylphenidate and its para-substituted derivatives.

  1998cited by this paper
• Discriminative stimulus properties of cocaine: enhancement by monoamine reuptake blockers.

  1998cited by this paper
• Serotonergic mechanisms involved in the discriminative stimulus, reinforcing and subjective effects of cocaine

  1997cited by this paper
• Replacement medication for cocaine dependence: methylphenidate.

  1997cited by this paper
• Further evidence for a dopamine reuptake pharmacophore. The effect of N-methylation on Threo-methylphenidate and its analogs

  1997cited by this paper
• Synthesis and pharmacology of potential cocaine antagonists. 2. Structure-activity relationship studies of aromatic ring-substituted methylphenidate analogs.

  1996cited by this paper
• Affinities of methylphenidate derivatives for dopamine, norepinephrine and serotonin transporters.

  1996cited by this paper
• Structure−Activity Relationship Studies of Novel 4-[2-[Bis(4-fluorophenyl)methoxy]ethyl]-1-(3-phenylpropyl)piperidine Analogs: Synthesis and Biological Evaluation at the Dopamine and Serotonin Transporter Sites

  1996cited by this paper
• Place preference and microdialysis studies with two derivatives of methylphenidate.

  1996cited by this paper
• Translocation of dopamine and binding of 2 beta-carbomethoxy-3 beta-(4-fluorophenyl) tropane (WIN 35,428) measured under identical conditions in rat striatal synaptosomal preparations. Inhibition by various blockers.

  1995cited by this paper
• Can stimulant binding and dopamine transport be differentiated? Studies with GBR 12783 derivatives.

  1994cited by this paper
• Studies of the biogenic amine transporters. II. A brief study on the use of [3H]DA-uptake-inhibition to transporter-binding-inhibition ratios for the in vitro evaluation of putative cocaine antagonists.

  1993cited by this paper
• Methoxylation of cocaine reduces binding affinity and produces compounds of differential binding and dopamine uptake inhibitory activity: discovery of a weak cocaine "antagonist".

  1993cited by this paper
• Monoamine reuptake inhibitors enhance the discriminative state induced by cocaine in the rat

  1991cited by this paper
• Testing and evaluation of drugs of abuse

  1990cited by this paper
• Cocaine receptors on monoamine transporters and sodium channels.

  1988cited by this paper
• Cocaine receptors on monoamine transporters and sodium channels.

  1988cited by this paper
• Cocaine receptors on dopamine transporters are related to self-administration of cocaine.

  1987influential reference
• Selective labeling of serotonin uptake sites in rat brain by [3H]citalopram contrasted to labeling of multiple sites by [3H]imipramine.

  1987cited by this paper
• [3H]Threo‐(±)‐Methylphenidate Binding to 3,4‐Dihydroxyphenylethylamine Uptake Sites in Corpus Striatum: Correlation with the Stimulant Properties of Ritalinic Acid Esters

  1985cited by this paper
• Synthesis and pharmacology of hydroxylated metabolites of methylphenidate.

  1981cited by this paper
• Evaluation of the discriminative effects of morphine in the rat.

  1976cited by this paper
• Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction.

  1973cited by this paper

• Comprehensive metabolic investigation of dopamine reuptake inhibitor HDMP-28 in equine liver microsomes and Cunninghamella elegans for doping control.

  2024cites this paper
• The Tungsten-Promoted Synthesis of Piperidyl-Modified erythro-Methylphenidate Derivatives

  2023cites this paper
• Methylphenidate Analogues as a New Class of Potential Disease-Modifying Agents for Parkinson’s Disease: Evidence from Cell Models and Alpha-Synuclein Transgenic Mice

  2022cites this paper
• Analytically Confirmed Intoxication by 4-Fluoromethylphenidate, an Analog of Methylphenidate.

  2019cites this paper
• Novel Psychoactive Drugs

  2019cites this paper
• Use of cognitive enhancers: methylphenidate and analogs.

  2019cites this paper
• In Vitro Neurochemical Assessment of Methylphenidate and Its “Legal High” Analogs 3,4-CTMP and Ethylphenidate in Rat Nucleus Accumbens and Bed Nucleus of the Stria Terminalis

  2018cites this paper
• Analytical characterization and pharmacological evaluation of the new psychoactive substance 4-fluoromethylphenidate (4F-MPH) and differentiation between the (±)-threo and (±)-erythro diastereomers.

  2017cites this paper
• Analysis of six 'neuro-enhancing' phenidate analogs.

  2017cites this paper
• Mechanisms of amphetamine action illuminated through optical monitoring of dopamine synaptic vesicles in Drosophila brain

  2016cites this paper
• Classics in Chemical Neuroscience: Methylphenidate.

  2016cites this paper
• action illuminated through optical monitoring of synaptic vesicles in Drosophila brain.

  2016cites this paper
• An overview of emerging and new psychoactive substances in the United Kingdom.

  2016cites this paper
• Influence of sensitization on the discriminative stimulus effects of methylphenidate in mice

  2014cites this paper
• Dopamine reuptake transporter (DAT) "inverse agonism"--a novel hypothesis to explain the enigmatic pharmacology of cocaine.

  2014cites this paper
• Characterization of four new designer drugs, 5-chloro-NNEI, NNEI indazole analog, α-PHPP and α-POP, with 11 newly distributed designer drugs in illegal products.

  2014cites this paper
• Acute and chronic methylphenidate alters prefrontal cortex neuronal activity recorded from freely behaving rats.

  2012cites this paper
• Agents in Development for the Management of Cocaine Abuse

  2012cites this paper
• The discriminative stimulus properties of methylphenidate in C57BL/6J mice

  2011cites this paper
• Ligand and structure based studies on methylphenidate analogues

  2010cites this paper
• Quantitative structure-activity relationship studies of threo-methylphenidate analogs.

  2010cites this paper
• Use of stimulants to treat cocaine and methamphetamine abuse

  2008cites this paper
• Differential pharmacokinetics and pharmacodynamics of methylphenidate enantiomers: does chirality matter?

  2008cites this paper
• Agonist treatment for stimulant abuse and dependence

  2007cites this paper
• Synthesis and pharmacology of site-specific cocaine abuse treatment agents: restricted rotation analogues of methylphenidate.

  2007cites this paper
• Methylphenidate and its Isomers

  2006cites this paper
• Ligand-based design of dopamine reuptake inhibitors : fuzzy relational clustering and 2-D and 3-D QSAR modleing

  2006cites this paper
• Methylphenidate analogs with behavioral differences interact differently with arginine residues on the dopamine transporter in rat striatum

  2005influential citation
• Caffeine induces differential cross tolerance to the amphetamine-like discriminative stimulus effects of dopaminergic agonists.

  2005cites this paper
• Conformational analysis of methylphenidate: comparison of molecular orbital and molecular mechanics methods

  2004cites this paper
• Dysfunctions in Dopamine Systems and ADHD: Evidence From Animals and Modeling

  2004cites this paper
• Synthesis and pharmacology of site specific cocaine abuse treatment agents: 8-substituted isotropane (3-azabicyclo[3.2.1]octane) dopamine uptake inhibitors.

  2003cites this paper
• Dopamine transporter as target for drug development of cocaine dependence medications.

  2003cites this paper