TGFbeta1 induces epithelial-mesenchymal transition, but not myofibroblast transdifferentiation of human kidney tubular epithelial cells in primary culture.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  International journal of experimental pathology (Print)

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 16709228PMCID PMC2517360
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Epithelial to mesenchymal transition in renal fibrogenesis: pathologic significance, molecular mechanism, and therapeutic intervention.

  2004cited by this paper
• Role of connective tissue growth factor in renal tubular epithelial-myofibroblast transdifferentiation and extracellular matrix accumulation in vitro.

  2004cited by this paper
• Combinatorial signaling pathways determine fibroblast proliferation and myofibroblast differentiation

  2004cited by this paper
• Smad3 as a mediator of the fibrotic response

  2004cited by this paper
• Integration of TGF-beta/Smad and Jagged1/Notch signalling in epithelial-to-mesenchymal transition.

  2004cited by this paper
• Identifying the molecular phenotype of renal progenitor cells.

  2004cited by this paper
• The role of epithelial-to-mesenchymal transition in renal fibrosis

  2004cited by this paper
• Epithelial to Mesenchymal Transition in Madin-Darby Canine Kidney Cells Is Accompanied by Down-regulation of Smad3 Expression, Leading to Resistance to Transforming Growth Factor-β-induced Growth Arrest*

  2003cited by this paper
• TGF-beta1-mediated alterations of renal proximal tubular epithelial cell phenotype.

  2003cited by this paper
• Tubular epithelial-myofibroblast transdifferentiation mechanisms in proximal tubule cells

  2003cited by this paper
• Epithelial-mesenchymal transition of tubular epithelial cells in human renal biopsies.

  2002cited by this paper
• Evidence that fibroblasts derive from epithelium during tissue fibrosis.

  2002cited by this paper
• Interstitial expression of alpha-SMA: an early marker of chronic renal allograft dysfunction.

  2002cited by this paper
• How cells change their phenotype

  2002cited by this paper
• Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis.

  2001cited by this paper
• Advanced glycation end products cause epithelial-myofibroblast transdifferentiation via the receptor for advanced glycation end products (RAGE).

  2001cited by this paper
• Tubular phenotypic change in progressive tubulointerstitial fibrosis in human glomerulonephritis.

  2001cited by this paper
• Microenvironment and stem properties of bone marrow‐derived mesenchymal cells

  2001cited by this paper
• Quantitation of TGF-beta1 mRNA in porcine mesangial cells by comparative kinetic RT/PCR: comparison with ribonuclease protection assay and in situ hybridization.

  2001cited by this paper
• Role of myofibroblasts during normal tissue repair and excessive scarring: interest of their assessment in nephropathies.

  2000cited by this paper
• Identification of Connective Tissue Growth Factor as a Target of WT1 Transcriptional Regulation*

  2000cited by this paper
• Transdifferentiation of Distal but Not Proximal Tubular Epithelial Cells from Human Kidney in Culture

  1999cited by this paper
• Renal Tubular Cells Cultured from Genetically Modified Animals

  1999cited by this paper
• Immunohistochemical localization of connective tissue growth factor (CTGF) in the mouse embryo between days 7.5 and 14.5 of gestation.

  1999cited by this paper
• Transforming growth factor-beta regulates tubular epithelial-myofibroblast transdifferentiation in vitro.

  1999cited by this paper
• Tubular epithelial-myofibroblast transdifferentiation in progressive tubulointerstitial fibrosis in 5/6 nephrectomized rats.

  1998cited by this paper
• Vimentin expression and distal tubular damage in the rat kidney.

  1996cited by this paper
• Cadherin 11 expression marks the mesenchymal phenotype: towards new functions for cadherins?

  1995cited by this paper
• Identification and characterization of a fibroblast marker: FSP1

  1995cited by this paper
• Renal allograft rejection: expression and function of VCAM‐1 on tubular epithelial cells

  1993cited by this paper
• Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts

  1993cited by this paper
• The activated mesangial cell: a glomerular "myofibroblast"?

  1992cited by this paper
• The consequences for renal function of widening of the interstitium and changes in the tubular epithelium of the renal cortex and outer medulla in various renal diseases.

  1992cited by this paper

• Modulation of cancer-associated fibroblasts by nanodelivery system to enhance efficacy of tumor therapy.

  2023cites this paper
• Liquiritin inhibits TGF-β1-induced epithelial mesenchymal transition and extracellular matrix deposition in human renal proximal tubular epithelial cells by suppressing the MAPK signaling

  2023cites this paper
• Tacrolimus Induces Fibroblast to Myofibroblast Transition via a TGFβ-Dependent Mechanism to Contribute to Renal Fibrosis.

  2023cites this paper
• Role of extracellular matrix components and structure in new renal models in vitro

  2022cites this paper
• Cancer-Associated Fibroblast Heterogeneity, Activation and Function: Implications for Prostate Cancer

  2022cites this paper
• Establishment of a Nanopatterned Renal Disease Model by Mimicking the Physical and Chemical Cues of a Diseased Mesangial Cell Microenvironment.

  2021cites this paper
• MiR-27b-3p inhibits the progression of renal fibrosis via suppressing STAT1

  2021influential citation
• Peri-renal adipose inflammation contributes to renal dysfunction in a non-obese prediabetic rat model: Role of anti-diabetic drugs.

  2021cites this paper
• The Role of Cancer-Associated Fibroblasts in Tumor Progression

  2021cites this paper
• Thrombospondin-1: A Key Protein That Induces Fibrosis in Diabetic Complications

  2020cites this paper
• Praliciguat inhibits progression of diabetic nephropathy in ZSF1 rats and suppresses inflammation and apoptosis in human renal proximal tubular cells.

  2020cites this paper
• Transforming growth factor β signaling pathway: A promising therapeutic target for cancer

  2019cites this paper
• miR-130a-3p inhibition protects against renal fibrosis in vitro via the TGF-β1/Smad pathway by targeting SnoN.

  2019cites this paper
• Metabolomics Study of Metabolic Changes in Renal Cells in Response to High-Glucose Exposure Based on Liquid or Gas Chromatography Coupled With Mass Spectrometry

  2019cites this paper
• TGF-β1 up-regulates cadherin-11 expression through Snail: A potential mechanism for human trophoblast cell differentiation.

  2018cites this paper
• Functional Role of Non-Coding RNAs during Epithelial-To-Mesenchymal Transition

  2018cites this paper
• Human Organ Culture: Updating the Approach to Bridge the Gap from In Vitro to In Vivo in Inflammation, Cancer, and Stem Cell Biology

  2017cites this paper
• An immunofluorescence assay for extracellular matrix components highlights the role of epithelial cells in producing a stable, fibrillar extracellular matrix

  2017cites this paper
• Epithelial contribution to the profibrotic stiff microenvironment and myofibroblast population in lung fibrosis

  2017cites this paper
• Effects of aristolochic acid I and/or hypokalemia on tubular damage in C57BL/6 rat with aristolochic acid nephropathy

  2017cites this paper
• Cancer cells remodel themselves and vasculature to overcome the endothelial barrier.

  2016cites this paper
• Keratins are novel markers of renal epithelial cell injury.

  2016cites this paper
• Tacrolimus Modulates TGF-β Signaling to Induce Epithelial-Mesenchymal Transition in Human Renal Proximal Tubule Epithelial Cells

  2016cites this paper
• Development of an In Vitro Assay to Evaluate Contractile Function of Mesenchymal Cells that Underwent Epithelial-Mesenchymal Transition.

  2016cites this paper
• Spontaneous calcification process in primary renal cells from a medullary sponge kidney patient harbouring a GDNF mutation

  2015influential citation
• Epigenetic repression of Krüppel-like factor 4 through Dnmt1 contributes to EMT in renal fibrosis

  2015cites this paper
• Macrophages During the Fibrotic Process: M2 as Friend and Foe

  2015cites this paper
• Involvement of orphan nuclear receptor COUP-TFII in cadherin-6 and cadherin-11 regulation: implications in development and cancer.

  2015cites this paper
• Regulation of the anti-tumour immune response by cancer-associated fibroblasts.

  2014cites this paper
• Preservation of Kidneys by Machine Perfusion Influences Gene Expression and May Limit Ischemia/Reperfusion Injury

  2014cites this paper
• Regulation of basal cell plasticity : implications for airway epithelial remodeling in asthma

  2014cites this paper
• Valproic acid suppresses cervical cancer tumor progression possibly via activating Notch1 signaling and enhances receptor-targeted cancer chemotherapeutic via activating somatostatin receptor type II

  2013cites this paper
• PKH(high) cells within clonal human nephrospheres provide a purified adult renal stem cell population.

  2013cites this paper
• Activation of Smad‐mediated TGF‐β signaling triggers epithelial–mesenchymal transitions in murine cloned corneal progenitor cells

  2013cites this paper
• Inhibitory effect of bone morphogenetic protein-7 on hepatic fibrosis in rats.

  2013cites this paper
• Epithelial-to-mesenchymal transition in fibrosis: collagen type I expression is highly upregulated after EMT, but does not contribute to collagen deposition.

  2013cites this paper
• Direct transcriptional reprogramming of adult cells to embryonic nephron progenitors.

  2013cites this paper
• Cancer Stem Cells, EMT, and Developmental Pathway Activation in Pancreatic Tumors

  2012cites this paper
• Tumor necrosis factor superfamily member LIGHT induces epithelial-mesenchymal transition in A549 human alveolar epithelial cells.

  2012cites this paper
• Cadherin‐11 contributes to pulmonary fibrosis: potential role in TGF‐β production and epithelial to mesenchymal transition

  2012cites this paper
• Distinct Mesenchymal Alterations in N-Cadherin and E-Cadherin Positive Primary Renal Epithelial Cells

  2012cites this paper
• Bleomycin‐induced lung injury in mice investigated by MRI: Model assessment for target analysis

  2012cites this paper
• Oxidative damage and TGF‐β differentially induce lung epithelial cell sonic hedgehog and tenascin‐C expression: implications for the regulation of lung remodelling in idiopathic interstitial lung disease

  2011influential citation
• Scar wars: mapping the fate of epithelial-mesenchymal-myofibroblast transition.

  2011cites this paper
• Oxidative stress and renal interstitial fibrosis in patients after renal transplantation: current state of knowledge.

  2011cites this paper
• Study of growth factors and receptors in carcinoma ex pleomorphic adenoma.

  2010cites this paper
• Primary cell cultures from human renal cortex and renal-cell carcinoma evidence a differential expression of two spliced isoforms of Annexin A3.

  2010cites this paper
• Cancer associated fibroblasts (CAFs) in tumor microenvironment.

  2010cites this paper
• Osteopontin and cadherin 11 are novel mediators and drug targets for chronic lung diseases

  2010influential citation
• Characterization of connective tissue growth factor expression in primary cultures of human tubular epithelial cells: modulation by hypoxia.

  2010cites this paper
• Induction of epithelial-mesenchymal transition in primary airway epithelial cells from patients with asthma by transforming growth factor-beta1.

  2009cites this paper
• Urinary connective tissue growth factor increases far earlier than histopathological damage and functional deterioration in early chronic renal allograft injury

  2009cites this paper
• Myeloma light chains induce epithelial-mesenchymal transition in human renal proximal tubule epithelial cells.

  2008cites this paper
• Regulation of cadherin-11 by GSK3 and TGFβ1 in cancer cells

  2008cites this paper
• Origin of renal myofibroblasts in the model of unilateral ureter obstruction in the rat

  2008cites this paper
• Inhibition of renal rho kinase attenuates ischemia/reperfusion-induced injury.

  2008cites this paper
• Aristolochic acid induces proximal tubule apoptosis and epithelial to mesenchymal transformation.

  2008cites this paper
• Renal interstitial cells, proteinuria and progression of lupus nephritis: new frontiers for old factors

  2008cites this paper
• Cholangiocytes with mesenchymal features contribute to progressive hepatic fibrosis of the polycystic kidney rat.

  2007cites this paper
• Cadherin-9 Is a Novel Cell Surface Marker for the Heterogeneous Pool of Renal Fibroblasts

  2007cites this paper
• Insulin-like growth factor-1 sustains stem cell mediated renal repair.

  2007cites this paper
• Genes involved in TGFβ1-driven epithelial-mesenchymal transition of renal epithelial cells are topologically related in the human interactome map

  2007influential citation
• Novel aspects of renal tubulointerstitial fibrosis

  2006cites this paper