5-HT3 antagonists derived from aminopyridazine-type muscarinic M1 agonists.

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Journal of Medicinal Chemistry

• Publication date

  1998-01-29

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1021/JM9705418PMID 9464362
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• SR 46559A: a novel and potent muscarinic compound with no cholinergic syndrome

  2005cited by this paper
• Electrophysiological consequences of ligand binding to the desensitized 5‐HT3 receptor in mammalian NG108‐15 cells.

  1996cited by this paper
• The 5-HT3 receptor channel.

  1995cited by this paper
• Subpopulations of neonatal rat sensory neurons express functional neurotransmitter receptors which elevate intracellular calcium.

  1994cited by this paper
• Aminopyridazines--an alternative route to potent muscarinic agonists with no cholinergic syndrome.

  1993cited by this paper
• Activation and desensitization of the 5‐HT3 receptor in a rat glioma x mouse neuroblastoma hybrid cell.

  1991cited by this paper
• Properties of 5‐hydroxytryptamine3 receptor‐gated currents in adult rat dorsal root ganglion neurones

  1991cited by this paper
• Novel 5-HT3 antagonists. Indole oxadiazoles.

  1991cited by this paper
• Optically active benzamides as predictive tools for mapping the dopamine D2 receptor.

  1990cited by this paper
• Conformation-activity relationship study of 5-HT3 receptor antagonists and a definition of a model for this receptor site.

  1990cited by this paper
• [3H]-BRL 43694 (Granisetron), a specific ligand for 5-HT3 binding sites in rat brain cortical membranes.

  1989cited by this paper
• Selective and functional 5-hydroxytryptamine3 receptor antagonism by BRL 43694 (granisetron).

  1989cited by this paper
• 'Concentration‐clamp' study of gamma‐aminobutyric‐acid‐induced chloride current kinetics in frog sensory neurones.

  1986cited by this paper
• Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

  1981cited by this paper

• Diverse pharmacological potential of pyridazine analogs against various diseases.

  2023cites this paper
• Design and Synthesis of 1,2-Bis(hydroxymethyl)pyrrolo[2,1- a]phthalazine Hybrids as Potent Anticancer Agents that Inhibit Angiogenesis and Induce DNA Interstrand Cross-links.

  2019cites this paper
• COPD: preclinical models and emerging therapeutic targets

  2019cites this paper
• Synthesis and biological evaluation of 3-amino-, 3-alkoxy- and 3-aryloxy-6-(hetero)arylpyridazines as potent antitumor agents.

  2019cites this paper
• A novel method for heterocyclic amide–thioamide transformations

  2017cites this paper
• 1-Piperazinylphthalazines as potential VEGFR-2 inhibitors and anticancer agents: Synthesis and in vitro biological evaluation.

  2016cites this paper
• Tests for Anxiolytic Activity

  2015cites this paper
• Structure-activity relationship studies of SEN12333 analogues: determination of the optimal requirements for binding affinities at α7 nAChRs through incorporation of known structural motifs.

  2015cites this paper
• ZrOCl2.8H2O as a green and efficient catalyst for the expeditious synthesis of substituted 3-arylpyrimido(4,5-c)pyridazines in water

  2015cites this paper
• Design and validation of a homogeneous time-resolved fluorescence cell-based assay targeting the ligand-gated ion channel 5-HT3A.

  2015cites this paper
• Preparation of differentially substituted 3,6-diaminopyridazines under mild conditions

  2014cites this paper
• Access to 4-alkylaminopyridazine derivatives via nitrogen-assisted regioselective Pd-catalyzed reactions.

  2014cites this paper
• Microwave-enhanced synthesis of 2,3,6-trisubstituted pyridazines: application to four-step synthesis of gabazine (SR-95531).

  2010cites this paper
• New pyridazinone derivatives with vasorelaxant and platelet antiaggregatory activities.

  2010cites this paper
• Synthesis and in‐vitro Cytotoxic Evaluation of Novel Pyridazin‐4‐one Derivatives

  2010cites this paper
• Synthesis and Antibacterial Activity of Some Glucosyl- and Ribosyl-Pyridazin-3-ones

  2009cites this paper
• 1-amino-4-benzylphthalazines as orally bioavailable smoothened antagonists with antitumor activity.

  2009cites this paper
• Microwave-enhanced efficient synthesis of diversified 3,6-disubstituted pyridazines.

  2007cites this paper
• 3.40 – Chemogenomics

  2007cites this paper
• Synthesis of regiospecifically polysubstituted pyridazinones

  2007cites this paper
• 1 Chemogenomics in Drug Discovery

  2006cites this paper
• Microwave-assisted cyclic amidine synthesis using TiCl4.

  2006cites this paper
• Chemogenomics in drug discovery.

  2006cites this paper
• Annulation of primary amines to piperazines and diazaspirocycles utilizing alpha-methyl benzyl resin.

  2006cites this paper
• Use of 4-bromo pyridazine 3,6-dione for building 3-amino pyridazine libraries

  2006cites this paper
• Antagonists du receptor histamine H3

  2006cites this paper
• Composés actives sur le recepteur histamine H3

  2006cites this paper
• Sequential regio and chemoselective cross-coupling reactions by means of O6-tri-isopropylsulfonate of 4-bromo-pyridazine 3,6-dione

  2006cites this paper
• A Synthon Approach to Spiro Compounds

  2006cites this paper
• A Convenient access to thienyl‐substituted phthalazines

  2005cites this paper
• Novel pyridazino[4,3-b]indoles with dual inhibitory activity against Mycobacterium tuberculosis and monoamine oxidase.

  2004cites this paper
• The solid-phase synthesis and use of N-monosubstituted piperazines in chemical library synthesis.

  2003cites this paper
• Derives de phenylpyridazine utilises en tant que ligands pour des recepteurs gaba

  2003cites this paper
• The 5-HT(3) and nACh ionotropic receptors: a perspective from the computational chemistry point of view.

  2002cites this paper
• Synthesis and muscarinic activities of O-[(benzyl- or benzoyl-pyrazolyl)propynyl]-oximes of N-methylpiperidinone, 3-tropinone, and 3-quinuclidinone.

  2002cites this paper
• 5-HT(3)R binding of lerisetron: an interdisciplinary approach to drug-Receptor interactions.

  2001cites this paper
• Physiologically active compounds interacting with serotonin (5-hydroxytryptamine) receptors

  2001cites this paper
• Synthesis of new bridged tetrahydro-β-carbolines and spiro-fused quinuclidines

  2001cites this paper
• Toward general methods of targeted library design: topomer shape similarity searching with diverse structures as queries.

  2000cites this paper
• RECENT ADVANCES IN THE CHEMISTRY OF PYRIDAZINES

  2000cites this paper
• Glycinergic potentiation by some 5-HT(3) receptor antagonists: insight into selectivity.

  2000cites this paper
• Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 2. Molecular basis of the intrinsic efficacy of arylpiperazine derivatives at the central 5-HT3 receptors.

  1999cites this paper
• Search for new lead compounds: The example of the chemical and pharmacological dissection of aminopyridazines

  1998cites this paper
• Arylpiperazines with serotonin-3 antagonist activity: a comparative molecular field analysis.

  1998cites this paper
• Psychotropic and neurotropic activity

  1997cites this paper