Alteration in the surface morphology of synchronized B-16 melanoma cell during the cell cycle.

B-16 melanoma cells were synchronized for G1-S periods by mitotic shake-off and S-G2 periods by thymidine block. The surface morphology of the B-16 melanoma at low density partially confluent culures revealed that, as in other cell systems investigated, the surface morphology could be correlated with four periods to cell cycle: G1, S, G2 and M. G1 cells were rounded and possessed microvilli, blebs and ruffles (late G1). During S period, blebs and microvilli diminished and disappeared, but ruffles were more evident. Late G2 cells acquired microvilli, surface blebs, and extended filopodia and began to thicken and round themselves for mitosis.

• Publication year

  1975

• Venue

  Acta Dermato-Venereologica

• Publication date

  1975-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.2340/000155555331336PMID 52966
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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