Study of viral pathogenesis in humanized mice

Jenna M Gaska,A. Ploss

Published 2015 in Current Opinion in Virology

ABSTRACT

Highlights • Many human pathogens have a narrow host range.• Engraftment of human tissues into mice can render animals susceptible to infection.• Genetic humanization has yielded mice with inheritable susceptible to viral infection.• Additional refinements are needed to improve the utility of humanized mice.

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