PPARα mediates the hypolipidemic action of fibrates by antagonizing FoxO1

No abstract is available for this paper.

• Publication year

  2007

• Venue

  American Journal of Physiology-endocrinology and Metabolism

• Publication date

  2007-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1152/AJPENDO.00157.2006
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Effect of rosuvastatin on hepatic production of apolipoprotein B-containing lipoproteins in an animal model of insulin resistance and metabolic dyslipidemia.

  2006cited by this paper
• Targeting Foxo1 in Mice Using Antisense Oligonucleotide Improves Hepatic and Peripheral Insulin Action

  2006cited by this paper
• Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism.

  2006cited by this paper
• Aberrant Forkhead box O1 function is associated with impaired hepatic metabolism.

  2006cited by this paper
• Faculty Opinions recommendation of Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP.

  2005influential reference
• Intestinal lipoprotein overproduction, a newly recognized component of insulin resistance, is ameliorated by the insulin sensitizer rosiglitazone: studies in the fructose-fed Syrian golden hamster.

  2005cited by this paper
• Hyperlipidemic Effects of Dietary Saturated Fats Mediated through PGC-1 Coactivation of SREBP

  2005cited by this paper
• Non-alcoholic fatty liver and insulin resistance: a cause-effect relationship?

  2004cited by this paper
• Mechanism of Hepatic Insulin Resistance in Non-alcoholic Fatty Liver Disease*

  2004cited by this paper
• FoxOs at the crossroads of cellular metabolism, differentiation, and transformation.

  2004cited by this paper
• Foxo1 mediates insulin action on apoC-III and triglyceride metabolism.

  2004influential reference
• Fibrates for treatment of the metabolic syndrome

  2004cited by this paper
• Transgenic rescue of insulin receptor-deficient mice.

  2004cited by this paper
• Microsomal triglyceride transfer protein and its role in apoB-lipoprotein assembly Published, JLR Papers in Press, September 16, 2002. DOI 10.1194/jlr.R200014-JLR200

  2003cited by this paper
• PATHOPHYSIOLOGY OF TYPE 2 DIABETES

  2003cited by this paper
• Identification of hepatic transcriptional changes in insulin-resistant rats treated with peroxisome proliferator activated receptor-alpha agonists.

  2003influential reference
• Mechanisms of metabolic dyslipidemia in insulin resistant states: deregulation of hepatic and intestinal lipoprotein secretion.

  2003cited by this paper
• Convergence of peroxisome proliferator-activated receptor gamma and Foxo1 signaling pathways.

  2003cited by this paper
• Convergence of Peroxisome Proliferator-activated Receptor γ and Foxo1 Signaling Pathways*

  2003cited by this paper
• Inhibition of Foxo1 function is associated with improved fasting glycemia in diabetic mice.

  2003influential reference
• Fibrates in 2003: therapeutic action in atherogenic dyslipidaemia and future perspectives.

  2003cited by this paper
• The atherogenic lipoprotein profile associated with obesity and insulin resistance is largely attributable to intra-abdominal fat.

  2003cited by this paper
• Induction of endogenous genes by peroxisome proliferator activated receptor alpha ligands in a human kidney cell line and in vivo.

  2003cited by this paper
• The forkhead transcription factor Foxo1 regulates adipocyte differentiation.

  2003cited by this paper
• Markers of triglyceride-rich lipoprotein remnant metabolism in visceral obesity.

  2002cited by this paper
• Amelioration of high fructose-induced metabolic derangements by activation of PPARalpha.

  2002influential reference
• Basal insulin gene expression significantly improves conventional insulin therapy in type 1 diabetic rats.

  2002cited by this paper
• The mechanisms of action of PPARs.

  2002cited by this paper
• Regulation of insulin action and pancreatic β-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1

  2002cited by this paper
• Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men.

  2002cited by this paper
• Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes.

  2002cited by this paper
• Ameliorated Hepatic Insulin Resistance Is Associated with Normalization of Microsomal Triglyceride Transfer Protein Expression and Reduction in Very Low Density Lipoprotein Assembly and Secretion in the Fructose-fed Hamster*

  2002cited by this paper
• Pathogenesis of steatohepatitis.

  2002cited by this paper
• Management of dyslipidemia.

  2002cited by this paper
• Diabetes mellitus, obesity, and hepatic steatosis.

  2002cited by this paper
• Amelioration of high fructose-induced matabolic derangements by activation of PPARα

  2002cited by this paper
• Accumulation of Triglyceride-Rich Lipoprotein in Subjects With Abdominal Obesity: The Biguanides and the Prevention of the Risk of Obesity (BIGPRO) 1 Study

  2001cited by this paper
• Peroxisome proliferator-activated receptor subtype-specific regulation of hepatic and peripheral gene expression in the Zucker diabetic fatty rat.

  2001cited by this paper
• Regulation of lipid metabolism and gene expression by fenofibrate in hamsters.

  2001cited by this paper
• A potent PPARalpha agonist stimulates mitochondrial fatty acid beta-oxidation in liver and skeletal muscle.

  2001influential reference
• A potent PPARα agonist stimulates mitochondrial fatty acid β-oxidation in liver and skeletal muscle

  2001cited by this paper
• Management of dyslipidemia.

  2001cited by this paper
• Apolipoproteins C-I and C-III as important modulators of lipoprotein metabolism

  2001cited by this paper
• The hypolipidemic action of bezafibrate therapy in hypertriglyceridemia is mediated by upregulation of lipoprotein lipase: no effects on VLDL substrate affinity to lipolysis or LDL receptor binding.

  2000cited by this paper
• The Insulin Resistance Syndrome: Impact on Lipoprotein Metabolism and Atherothrombosis

  2000cited by this paper
• Differential regulation of gene expression by insulin and IGF‐1 receptors correlates with phosphorylation of a single amino acid residue in the forkhead transcription factor FKHR

  2000cited by this paper
• Cell Culture Conditions Determine Apolipoprotein CIII Secretion and Regulation by Fibrates in Human Hepatoma HepG2 Cells

  1999cited by this paper
• Insulin resistance in obesity: metabolic mechanisms and measurement methods.

  1998cited by this paper
• Insulin sensitivity indices calculated from basal and OGTT-induced insulin, glucose, and FFA levels.

  1998cited by this paper
• Overview of fenofibrate.

  1998cited by this paper
• DNA binding preferences of PPAR alpha/RXR alpha heterodimers.

  1997cited by this paper
• DNA Binding Preferences of PPARα/RXRα Heterodimers

  1997cited by this paper
• Alterations in Lipoprotein Metabolism in Peroxisome Proliferator-activated Receptor α-deficient Mice*

  1997cited by this paper
• Hypolipidemic activity of select fibrates correlates to changes in hepatic apolipoprotein C-III expression: a potential physiologic basis for their mode of action.

  1995cited by this paper
• Fibrates downregulate apolipoprotein C-III expression independent of induction of peroxisomal acyl coenzyme A oxidase. A potential mechanism for the hypolipidemic action of fibrates.

  1995cited by this paper
• Inhibition of lipoprotein lipase activity by synthetic peptides of apolipoprotein C-III.

  1992cited by this paper
• Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man

  1985cited by this paper
• Modulation of lipoprotein lipase activity by apolipoproteins. Effect of apolipoprotein C-III.

  1985cited by this paper
• Effect of serum and C‐apoproteins from very low density lipoproteins on human postheparin plasma hepatic lipase

  1976cited by this paper

• Orchestration of Gut–Liver-Associated Transcription Factors in MAFLD: From Cross-Organ Interactions to Therapeutic Innovation

  2025cites this paper
• Telmisartan reverses hepatic steatosis via PCK1 upregulation: A novel PPAR-independent mechanism in experimental models of MASLD

  2025cites this paper
• FTO inhibition mitigates high-fat diet-induced metabolic disturbances and cognitive decline in SAMP8 mice

  2025cites this paper
• L-carnitine attenuates autophagic flux, apoptosis, and necroptosis in rats with dexamethasone-induced non-alcoholic steatohepatitis

  2024cites this paper
• Determination of in vitro immunotoxic potencies of a series of perfluoralkylsubstances (PFASs) in human Namalwa B lymphocyte and human Jurkat T lymphocyte cells

  2024cites this paper
• Adipose Tissue Protects against Hepatic Steatosis in Male Rats Fed a High-Fat Diet plus Liquid Fructose: Sex-Related Differences

  2023cites this paper
• FOXO1 represses PPARα-Mediated induction of FGF21 gene expression.

  2023cites this paper
• Current, emerging, and potential therapies for non-alcoholic steatohepatitis

  2023cites this paper
• The hepatoprotective effects of n3-polyunsaturated fatty acids against non-alcoholic fatty liver disease in diabetic rats through the FOXO1/PPARα/GABARAPL1 signalling pathway.

  2022cites this paper
• Hepatic IGF2/H19 Epigenetic Alteration Induced Glucose Intolerance in Gestational Diabetes Mellitus Offspring via FoxO1 Mediation

  2022cites this paper
• Ethnic differences in ApoC-III concentration and the risk of cardiovascular disease: No evidence for the cardioprotective role of rare/loss of function APOC3 variants in non-Europeans

  2022cites this paper
• Bempedoic acid as a PPARα activator: New perspectives for hepatic steatosis treatment in a female rat experimental model

  2022cites this paper
• Bempedoic acid as a PPARα activator: new perspectives for hepatic steatosis treatment in a female rat experimental model.

  2021cites this paper
• Dietary Supplementation of Olive Mill Waste Water Polyphenols in Rabbits: Evaluation of the Potential Effects on Hepatic Apoptosis, Inflammation and Metabolism through RT-qPCR Approach

  2021cites this paper
• FOXO transcription factor family in cancer and metastasis

  2020cites this paper
• Effects of a Low Dose of Caffeine Alone or as Part of a Green Coffee Extract, in a Rat Dietary Model of Lean Non-Alcoholic Fatty Liver Disease without Inflammation

  2020cites this paper
• Tissue-Specific Metabolic Regulation of FOXO-Binding Protein: FOXO Does Not Act Alone

  2020cites this paper
• The forkhead box O family in insulin action and lipid metabolism

  2020cites this paper
• Down-regulation of MicroRNA-592 in obesity contributes to hyperglycemia and insulin resistance

  2019cites this paper
• Rosa rugosa flavonoids exhibited PPARα agonist-like effects on genetic severe hypertriglyceridemia of mice.

  2019cites this paper
• Chronic fructose intake does not induce liver steatosis and inflammation in female Sprague–Dawley rats, but causes hypertriglyceridemia related to decreased VLDL receptor expression

  2019cites this paper
• Adrenoceptor‐related decrease in serum triglycerides is independent of PPARα activation

  2019cites this paper
• Biochemistry and Molecular Biology of Mechanisms of Action of Fibrates – An Overview

  2019cites this paper
• Lactobacillus helveticus-MIKI-020 enhances hepatic FGF21 expression and decreases the core body temperature during sleep in mice

  2019cites this paper
• The olive constituent oleuropein, as a PPARα agonist, markedly reduces serum triglycerides.

  2018cites this paper
• FOXO family in regulating cancer and metabolism.

  2018cites this paper
• Molecular Actions of PPARα in Lipid Metabolism and Inflammation.

  2018cites this paper
• FAM3B (PANDER) functions as a co‐activator of FOXO1 to promote gluconeogenesis in hepatocytes

  2018cites this paper
• Hepatic transcriptome analysis from HFD-fed mice defines a long noncoding RNA regulating cellular cholesterol levels

  2018cites this paper
• Forkhead Box O (FoxO) Transcription Factors in Autophagy, Metabolic Health, and Tissue Homeostasis

  2018cites this paper
• Effects of altered photoperiod on circadian clock and lipid metabolism in rats

  2017cites this paper
• Chronic activation of PPARα with fenofibrate reduces autophagic proteins in the liver of mice independent of FGF21

  2017cites this paper
• Liquid fructose in Western-diet-fed mice impairs liver insulin signaling and causes cholesterol and triglyceride loading without changing calorie intake and body weight.

  2017cites this paper
• Antiplatelet activity of drugs used in hypertension, dyslipidemia and diabetes: Additional benefit in cardiovascular diseases prevention.

  2017cites this paper
• The Addition of Liquid Fructose to a Western-Type Diet in LDL-R−/− Mice Induces Liver Inflammation and Fibrogenesis Markers without Disrupting Insulin Receptor Signalling after an Insulin Challenge

  2017influential citation
• CREBH mediates metabolic inflammation to hepatic VLDL overproduction and hyperlipoproteinemia

  2017cites this paper
• APOC3 Protein Is Not a Predisposing Factor for Fat-induced Nonalcoholic Fatty Liver Disease in Mice*

  2017cites this paper
• Aberrant expression of microRNA induced by high-fructose diet: implications in the pathogenesis of hyperlipidemia and hepatic insulin resistance.

  2017cites this paper
• Non-alcoholic steatohepatitis: emerging molecular targets and therapeutic strategies

  2016cites this paper
• FoxO1: A Conductor of Insulin Signaling to Glucose and Lipid Metabolism

  2016cites this paper
• FoxO1 Plays an Important Role in Regulating β-Cell Compensation for Insulin Resistance in Male Mice.

  2016cites this paper
• Metformin improves lipid metabolism disorders through reducing the expression of microsomal triglyceride transfer protein in OLETF rats.

  2016cites this paper
• Forkhead box transcription factor 1: role in the pathogenesis of diabetic cardiomyopathy

  2016cites this paper
• Betaine increases the butyrylcholinesterase activity in rat plasma.

  2016cites this paper
• Long-term fructose consumption prolongs hepatic stearoyl-CoA desaturase 1 activity independent of upstream regulation in rats.

  2016cites this paper
• Linking diet to acne metabolomics, inflammation, and comedogenesis: an update

  2015cites this paper
• Peroxisome proliferator-activated receptorβ/δ activation is essential for modulating p-Foxo1/Foxo1 status in functional insulin-positive cell differentiation

  2015cites this paper
• Molecular mechanism of PPARα action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease.

  2015cites this paper
• Toward a Mechanistic Understanding of Hepatic Insulin Action and Resistance

  2014cites this paper
• Fructose intake and circulating triglycerides: An examination of the role of APOC3

  2014cites this paper
• Production and Metabolism of Triglyceride-Rich Lipoproteins in Both the Normal and Diabetic States

  2014cites this paper
• Mechanism of antiplatelet action of hypolipidemic, antidiabetic and antihypertensive drugs by PPAR activation: PPAR agonists: new antiplatelet agents.

  2014cites this paper
• Fructose-Induced Hypertriglyceridemia: A Review

  2014cites this paper
• The Effect of FoxO1 on Glycemic Control and Skeletal Muscle Glucose Uptake and Lipid Metabolism

  2014cites this paper
• Hepatic mitochondrial and ER stress induced by defective PPARα signaling in the pathogenesis of hepatic steatosis.

  2014cites this paper
• Fructose: It’s “Alcohol Without the Buzz”

  2013influential citation
• The PPARα agonist fenofibrate suppresses B-cell lymphoma in mice by modulating lipid metabolism☆☆☆

  2013cites this paper
• ATF4 Protein Deficiency Protects against High Fructose-induced Hypertriglyceridemia in Mice*

  2013cites this paper
• Quercetin Preserves β-Cell Mass and Function in Fructose-Induced Hyperinsulinemia through Modulating Pancreatic Akt/FoxO1 Activation

  2013influential citation
• Consumo elevado de fructosa y su posible influencia sobre el metabolismo lipídico

  2012cites this paper
• FOXO1 involvement in insulin resistance-related pro-inflammatory cytokine production in hepatocytes

  2012cites this paper
• Effects of Teucrium polium Ethyl acetate Extract on Serum, Liver and Muscle Triglyceride Content of Sucrose-Induced Insulin Resistance in Rat

  2012cites this paper
• Some observations on experimental model for inducing diabetes in mice and rats.

  2012cites this paper
• Treatment with Ginger Ameliorates Fructose-Induced Fatty Liver and Hypertriglyceridemia in Rats: Modulation of the Hepatic Carbohydrate Response Element-Binding Protein-Mediated Pathway

  2012cites this paper
• Lipoprotein Lipase in the Arterial Wall: Regulation by Dietary Fatty Acids

  2011cites this paper
• Regulation of FoxO transcription factors by acetylation and protein-protein interactions.

  2011cites this paper
• Gut-liver interaction in triglyceride-rich lipoprotein metabolism.

  2011influential citation
• The complex biology of FOXO.

  2011cites this paper
• Development of a sensitive ELISA to quantify apolipoprotein CIII in nonhuman primate serum

  2011cites this paper
• Transcriptional Activation of Apolipoprotein CIII Expression by Glucose May Contribute to Diabetic Dyslipidemia

  2011cites this paper
• Liver AMP/ATP ratio and fructokinase expression are related to gender differences in AMPK activity and glucose intolerance in rats ingesting liquid fructose.

  2011cites this paper
• Fructose: metabolic, hedonic, and societal parallels with ethanol.

  2010cites this paper
• Nuclear receptors and hepatic lipidogenic enzyme response to a dyslipidemic sucrose-rich diet and its reversal by fish oil n-3 polyunsaturated fatty acids.

  2010cites this paper
• Homozygosity for the patatin‐like phospholipase‐3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease

  2010cites this paper
• Peroxisome Proliferator-Activated Receptor Alpha Target Genes

  2010cites this paper
• FoxO1 links hepatic insulin action to endoplasmic reticulum stress.

  2010cites this paper
• Factors modulating fibrates response: therapeutic implications and alternative strategies.

  2009cites this paper
• FoxO1 and hepatic lipid metabolism

  2009cites this paper
• New metabolites of fenofibrate in Sprague–Dawley rats by UPLC-ESI-QTOF-MS-based metabolomics coupled with LC-MS/MS

  2009cites this paper
• Regulation von FoxO-Transkriptionsfaktoren durch Umweltnoxen: Einfluss von Metallionen und polyzyklischen aromatischen Kohlenwasserstoffen

  2009cites this paper
• Activación de PP2A y alteraciones metabólicas inducidas por la ingestión de fructosa en forma líquida

  2009cites this paper
• Replacing dietary glucose with fructose increases ChREBP activity and SREBP-1 protein in rat liver nucleus.

  2009cites this paper
• Role of dietary carbohydrates and macronutrients in the pathogenesis of nonalcoholic fatty liver disease

  2008cites this paper
• Modulación del PPARα por agentes farmacológicos y naturales y sus implicaciones metabólicas

  2008cites this paper
• Diabetic dyslipidemia and atherosclerosis: Evidence from clinical trials

  2008cites this paper
• Metabolic (In)Flexibility of the Diabetic Heart

  2008cites this paper
• FOXO-binding partners: it takes two to tango

  2008cites this paper
• Adiponectin Reduces Plasma Triglyceride by Increasing VLDL Triglyceride Catabolism

  2008cites this paper
• Apolipoprotein CIII Links Hyperlipidemia With Vascular Endothelial Cell Dysfunction

  2008cites this paper
• The role of FoxO in the regulation of metabolism

  2008cites this paper
• Proteomic analysis of fructose-induced fatty liver in hamsters.

  2008influential citation
• FoxO1 mediates insulin-dependent regulation of hepatic VLDL production in mice.

  2008cites this paper
• Suppressor of cytokine signaling‐3 (SOCS‐3) and a deficit of serine/threonine (Ser/Thr) phosphoproteins involved in leptin transduction mediate the effect of fructose on rat liver lipid metabolism

  2008cites this paper
• Diabetic dyslipidemia and atherosclerosis: Evidence from clinical trials

  2007cites this paper
• PPARα and dyslipidemia

  2007cites this paper
• High-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol, apoproteins and a case of a drug trial that did not fulfil expectations.

  2007cites this paper
• Increased Expression and Activity of the Transcription Factor FOXO1 in Nonalcoholic Steatohepatitis

  2007cites this paper
• Aberrant Forkhead box O1 function is associated with impaired hepatic metabolism.

  2006cites this paper
• Fructose Intake and Circulating Triglycerides: an Examination of the Role of Apoc 3

  year unknowncites this paper
• Review Article Peroxisome Proliferator Activated Receptors and Lipoprotein Metabolism

  year unknowncites this paper