Persistence of antibodies to Borrelia burgdorferi in dogs of New York and Connecticut.

Multiple blood samples were obtained from privately owned dogs living in tick-infested areas of New York (Westchester County) and Connecticut, where Lyme disease in human beings has been reported. Of the 175 dogs examined, 127 (72.6%) had limb/joint disorder, whereas the remaining 48 dogs were considered healthy. Results of analysis of 419 serum samples revealed IgM antibody to Borrelia burgdorferi in healthy and lame dogs during all seasons. Prevalence of seropositivity was significantly (P less than 0.01) greater, using a polyvalent ELISA (89.5%) than using a class-specific ELISA for IGM antibody (57.8%). Mean antibody titers obtained by use of polyvalent ELISA were likewise higher than IgM titers. Analysis of paired serum samples from dogs with limb/joint disorder indicated that 118 (92.9%) remained positive for IgM or IgG antibodies when retested weeks or months after initial testing. In 48 dogs without history of joint involvement or other signs of disease, 43 (89.6%) had antibody to B burgdorferi 2 or more times. Serotest results also revealed little or no change in antibody titer for lame dogs given antibiotics or for healthy dogs 2 or more months after initial sample collection.

• Publication year

  1990

• Venue

  Journal of the American Veterinary Medical Association

• Publication date

  1990-04-01

• Fields of study

  Medicine, Environmental Science

• Identifiers
  DOI 10.2460/javma.1990.196.07.1064PMID 2329074
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Enzyme-linked immunosorbent assays for Lyme disease: reactivity of subunits of Borrelia burgdorferi.

  1989cited by this paper
• Clinical and serologic evaluations of induced Borrelia burgdorferi infection in dogs.

  1988cited by this paper
• Immunoblot analysis of immunoglobulin G response to the Lyme disease agent (Borrelia burgdorferi) in experimentally and naturally exposed dogs

  1988cited by this paper
• Heterogeneity in immunoblot patterns obtained by using four strains of Borrelia burgdorferi and sera from naturally exposed dogs

  1988cited by this paper
• Measurement of antibodies to the Borrelia burgdorferi flagellum improves serodiagnosis in Lyme disease

  1988cited by this paper
• Comparison of immunoblotting and indirect enzyme-linked immunosorbent assay using different antigen preparations for diagnosing early Lyme disease.

  1988cited by this paper
• Clinical and serologic studies of canine borreliosis.

  1987cited by this paper
• Isolation of antigenic components from the Lyme disease spirochete: their role in early diagnosis.

  1987cited by this paper
• Antigens of Borrelia burgdorferi recognized during Lyme disease. Appearance of a new immunoglobulin M response and expansion of the immunoglobulin G response late in the illness.

  1986cited by this paper
• Longitudinal assessment of the clinical and epidemiological features of Lyme disease in a defined population.

  1986cited by this paper
• Immunochemical and immunological analysis of European Borrelia burgdorferi strains.

  1986cited by this paper
• Natural exposure of Wisconsin dogs to the Lyme disease spirochete (Borrelia burgdorferi).

  1986cited by this paper
• Borreliosis in dogs from southern Connecticut.

  1985cited by this paper
• Arthritis caused by Borrelia burgdorferi in dogs.

  1985cited by this paper
• Diagnosing early Lyme disease.

  1985cited by this paper
• Comparison of an indirect fluorescent-antibody test with an enzyme-linked immunosorbent assay for serological studies of Lyme disease

  1984cited by this paper
• Spirochete-associated arthritis (Lyme disease) in a dog.

  1984cited by this paper
• The spirochetal etiology of Lyme disease.

  1983cited by this paper
• Lyme arthritis: correlation of serum and cryoglobulin IgM with activity, and serum IgG with remission.

  1979cited by this paper

• Clinical presentation, diagnostic findings, and outcome in dogs with presumptive primary and reactive immune-mediated polyarthritis in France.

  2025cites this paper
• Clinical canine Borrelia burgdorferi (sensu lato) infections are associated with highly elevated total IgG ELISA titers and convalescent Th2 immune responses

  2025cites this paper
• Immune-mediated polyarthritis : pathophysiology and classification

  2018cites this paper
• Update on Canine and Feline Blood Donor Screening for Blood‐Borne Pathogens

  2016cites this paper
• Identification of host blood-meal sources and Borrelia in field-collected Ixodes ricinus ticks in north-western Poland.

  2015cites this paper
• Comparison of different diagnostic assays for the detection of Borrelia burgdorferi-specific antibodies in dogs.

  2014cites this paper
• Primeiro relato de soroprevalência de borreliose canina em uma cidade localizada a uma altitude média na região tropical (Medellín, Colombia)

  2014cites this paper
• First report of canine borreliosis seroprevalence in a middle-altitude tropical urban area (Medellín-Colombia)

  2014cites this paper
• Lyme nephritis.

  2013cites this paper
• Prävalenz, Diagnostik und Bedeutung von Borrelia burgdorferi und Anaplasma phagozytophilum bei Hunden im

  2013cites this paper
• Synovial Lesions in Experimental Canine Lyme Borreliosis

  2012cites this paper
• Molecular and pathological investigations of the central nervous system in Borrelia burgdorferi–infected dogs

  2011cites this paper
• Follow-up of Bernese Mountain dogs and other dogs with serologically diagnosed Borrelia burgdorferi infection: What happens to seropositive animals?

  2009cites this paper
• Serological investigations towards borreliosis in populations of dogs in Lublin District

  2008cites this paper
• ACVIM small animal consensus statement on Lyme disease in dogs: diagnosis, treatment, and prevention.

  2006cites this paper
• Zu Vorkommen und Häufigkeit von Glomerulonephritis und Antikörpern gegen Borrelia burgdorferi beim Berner Sennenhund

  2005cites this paper
• Canine and Feline Blood Donor Screening for Infectious Disease

  2005cites this paper
• Suppurative, nonseptic polyarthropathy in dogs.

  2005cites this paper
• Experimental infection of dogs with Borrelia burgdorferi sensu stricto using Ixodes scapularis ticks artificially infected by capillary feeding

  2004cites this paper
• Freqüência de anticorpos contra Borrelia burgdorferi em cães na região metropolitana do Rio de Janeiro

  2004cites this paper
• cães na região metropolitana do Rio de Janeiro cães na região metropolitana do Rio de Janeiro cães na região metropolitana do Rio de Janeiro cães na região metropolitana do Rio de Janeiro

  2004cites this paper
• Canine borreliosis.

  2003cites this paper
• Lyme borreliosis.

  2003cites this paper
• Use of a C6 ELISA test to evaluate the efficacy of a whole-cell bacterin for the prevention of naturally transmitted canine Borrelia burgdorferi infection.

  2002cites this paper
• Utility of an in-office C6 ELISA test kit for determination of infection status of dogs naturally exposed to Borrelia burgdorferi.

  2002cites this paper
• Assessing the association between the geographic distribution of deer ticks and seropositivity rates to various tick-transmitted disease organisms in dogs.

  2001cites this paper
• Reactivity of dog sera to whole-cell or recombinant antigens of Borrelia burgdorferi by ELISA and immunoblot analysis.

  2001cites this paper
• Familial glomerulonephropathy in a litter of beagles.

  2000cites this paper
• Borrelioses, agentes e vetores

  2000cites this paper
• A serological study of cohorts of young dogs, naturally exposed to Ixodes ricinus ticks, indicates seasonal reinfection by Borrelia burgdorferi sensu lato.

  1999cites this paper
• Ticks and antibodies to Borrelia burgdorferi from mammals at Cape Hatteras, NC and Assateague Island, MD and VA.

  1999cites this paper
• COHORTS OF YOUNG DOGS, NATURALLY EXPOSED TO IXODES RICINUS TICKS, INDICATES SEASONAL REINFECTION BY BORRELIA BURGDORFERI SENSU LATO.

  1999cites this paper
• Antibodies to Ehrlichia equi in dogs from the northeastern United States.

  1997cites this paper
• Seroprevalence of Borrelia burgdorferi in dogs in Alabama, USA.

  1997cites this paper
• Serologic diagnosis of canine and equine borreliosis: use of recombinant antigens in enzyme-linked immunosorbent assays

  1997cites this paper
• Lyme disease: laboratory diagnosis of infected and vaccinated symptomatic dogs.

  1996cites this paper
• Serologic responses of dogs naturally exposed to or vaccinated against Borrelia burgdorferi infection.

  1995cites this paper
• Evaluation of an enzyme-linked immunosorbent assay that uses the 41-kd flagellin as the antigen for detection of antibodies to Borrelia burgdorferi in cattle.

  1994cites this paper
• Natural infections with Borrelia spirochetes in two dogs from Florida

  1994cites this paper
• Serologic evidence of canine and equine ehrlichiosis in northeastern United States

  1993cites this paper
• Pilot survey for Lyme disease antibodies in Brisbane dogs.

  1993cites this paper
• Association between clinical lameness and Borrelia burgdorferi antibody in dairy cows.

  1993cites this paper
• Performance of a Borrelia burgdorferi bacterin in borreliosis-endemic areas.

  1993cites this paper
• Canine exposure to Borrelia burgdorferi and prevalence of Ixodes dammini (Acari: Ixodidae) on deer as a measure of Lyme disease risk in the northeastern United States.

  1993cites this paper
• The distribution of canine exposure to Borrelia burgdorferi in a Lyme-Disease endemic area.

  1993cites this paper
• Examination of Koch's postulates for Borrelia burgdorferi as the causative agent of limb/joint dysfunction in dogs with borreliosis.

  1992cites this paper
• Lyme borreliosis in cattle and horses: a review of the literature.

  1992cites this paper
• Questions "push" for vaccination against Borrelia burgdorferi infection.

  1992cites this paper
• Relationship between development of antibodies to Borrelia burgdorferi in dogs and the subsequent development of limb/joint borreliosis.

  1992cites this paper
• Dogs as sentinels for Lyme disease in Massachusetts.

  1991cites this paper
• Tick parasitism and antibodies to Borrelia burgdorferi in cats.

  1990cites this paper
• Lyme borreliosis in domestic animals.

  1989cites this paper