VprBP binds full‐length RAG1 and is required for B‐cell development and V(D)J recombination fidelity

No abstract is available for this paper.

• Publication year

  2011

• Venue

  EMBO Journal

• Publication date

  2011-12-13

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/emboj.2011.455PMID 22157821PMCID PMC3280554
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2010influential reference
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  2008influential reference
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  2008influential reference
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  2007influential reference
• Investigating the human immunodeficiency virus type 1-infected monocyte-derived macrophage secretome.

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  2000cited by this paper
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  1996cited by this paper
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  1996cited by this paper
• A zinc-binding domain involved in the dimerization of RAG1.

  1996cited by this paper
• Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice.

  1994cited by this paper
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• Expression and V(D)J recombination activity of mutated RAG-1 proteins.

  1993cited by this paper
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  1993cited by this paper
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  1992cited by this paper
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  1992cited by this paper
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  1992cited by this paper
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  1991cited by this paper
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  1989cited by this paper
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  1987cited by this paper
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  1977cited by this paper

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