GILT expression in B cells diminishes cathepsin S steady‐state protein expression and activity

No abstract is available for this paper.

• Publication year

  2013

• Venue

  European Journal of Immunology

• Publication date

  2013-01-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/eji.201242379PMID 23012103PMCID PMC3706190
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Therapeutic dosing of an orally active, selective cathepsin S inhibitor suppresses disease in models of autoimmunity.

  2011cited by this paper
• GILT modulates CD4+ T cell tolerance to the melanocyte differentiation antigen tyrosinase-related protein 1

  2011cited by this paper
• Comparative Quantitative Mass Spectrometry Analysis of MHC Class II-Associated Peptides Reveals a Role of GILT in Formation of Self-Peptide Repertoire

  2010cited by this paper
• Defective Cross-Presentation of Viral Antigens in GILT-Free Mice

  2010cited by this paper
• GILT Accelerates Autoimmunity to the Melanoma Antigen Tyrosinase-Related Protein 1

  2010cited by this paper
• Gamma-IFN-inducible-lysosomal thiol reductase modulates acidic proteases and HLA class II antigen processing in melanoma

  2008cited by this paper
• MHC class II molecules on the move for successful antigen presentation

  2008cited by this paper
• Target Peptide Sequence within Infectious Human Immunodeficiency Virus Type 1 Does Not Ensure Envelope-Specific T-Helper Cell Reactivation: Influences of Cysteine Protease and Gamma Interferon-Induced Thiol Reductase Activities

  2008cited by this paper
• Expression Patterns of H 2O in Mouse B Cells and Dendritic Cells Correlate with Cell Function 1

  2007cited by this paper
• Expression Patterns of H2-O in Mouse B Cells and Dendritic Cells Correlate with Cell Function1

  2007cited by this paper
• Functional Requirements for the Lysosomal Thiol Reductase GILT in MHC Class II-Restricted Antigen Processing1

  2006cited by this paper
• Toll-dependent selection of microbial antigens for presentation by dendritic cells

  2006cited by this paper
• A guided tour into subcellular colocalization analysis in light microscopy

  2006cited by this paper
• Ectopic Expression of HLA-DO in Mouse Dendritic Cells Diminishes MHC Class II Antigen Presentation1

  2004cited by this paper
• The Protease Inhibitor Cystatin C Is Differentially Expressed among Dendritic Cell Populations, but Does Not Control Antigen Presentation 1

  2003cited by this paper
• Activation of Lysosomal Function During Dendritic Cell Maturation

  2003cited by this paper
• Cathepsin S inhibitor prevents autoantigen presentation and autoimmunity.

  2002cited by this paper
• Structure of a Cys25-->Ser mutant of human cathepsin S.

  2002cited by this paper
• Analysis of Protease Activity in Live Antigen-presenting Cells Shows Regulation of the Phagosomal Proteolytic Contents During Dendritic Cell Activation

  2002cited by this paper
• Absence of γ-Interferon–inducible Lysosomal Thiol Reductase in Melanomas Disrupts T Cell Recognition of Select Immunodominant Epitopes

  2002cited by this paper
• Cathepsin S Regulates the Expression of Cathepsin L and the Turnover of γ-Interferon-inducible Lysosomal Thiol Reductase in B Lymphocytes*

  2001cited by this paper
• Defective Antigen Processing in GILT-Free Mice

  2001cited by this paper
• Gamma-interferon-inducible lysosomal thiol reductase (GILT). Maturation, activity, and mechanism of action.

  2000cited by this paper
• Enzymatic reduction of disulfide bonds in lysosomes: characterization of a gamma-interferon-inducible lysosomal thiol reductase (GILT).

  2000cited by this paper
• Cathepsin S required for normal MHC class II peptide loading and germinal center development.

  1999cited by this paper
• Impaired invariant chain degradation and antigen presentation and diminished collagen-induced arthritis in cathepsin S null mice.

  1999cited by this paper
• Cathepsin S activity regulates antigen presentation and immunity.

  1998cited by this paper
• Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation.

  1998cited by this paper
• Developmental regulation of invariant chain proteolysis controls MHC class II trafficking in mouse dendritic cells.

  1998cited by this paper
• Intracellular formation and cell surface expression of a complex of an intact lysosomal protein and MHC class II molecules.

  1998cited by this paper
• Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus.

  1998cited by this paper
• Negative regulation by HLA-DO of MHC class II-restricted antigen processing.

  1997cited by this paper
• Degradation of Mouse Invariant Chain: Roles of Cathepsins S and D and the Influence of Major Histocompatibility Complex Polymorphism

  1997cited by this paper
• HLA-DM Interactions with Intermediates in HLA-DR Maturation and a Role for HLA-DM in Stabilizing Empty HLA-DR Molecules

  1996cited by this paper
• Essential role for cathepsin S in MHC class II-associated invariant chain processing and peptide loading.

  1996cited by this paper
• T cell recognition of major histocompatibility complex class II complexes with invariant chain processing intermediates

  1995cited by this paper
• HLA-DM induces CLIP dissociation from MHC class II alpha beta dimers and facilitates peptide loading.

  1995cited by this paper
• The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3

  1995cited by this paper
• Isolation and characterization of the intracellular MHC class II compartment

  1994cited by this paper
• Antigen processing and class II MHC peptide-loading compartments in human B-lymphoblastoid cells

  1994cited by this paper
• The CLIP region of invariant chain plays a critical role in regulating major histocompatibility complex class II folding, transport, and peptide occupancy

  1994cited by this paper
• Endosomal aspartic proteinases are required for invariant-chain processing.

  1994cited by this paper
• Inhibition of endosomal proteolytic activity by leupeptin blocks surface expression of MHC class II molecules and their conversion to SDS resistance alpha beta heterodimers in endosomes.

  1992cited by this paper
• Dynamics of three-dimensional replication patterns during the S-phase, analysed by double labelling of DNA and confocal microscopy.

  1992cited by this paper
• Invariant chain can function as a chaperone protein for class II major histocompatibility complex molecules.

  1992cited by this paper
• The generation of immunogenic peptides can be selectively increased or decreased by proteolytic enzyme inhibitors.

  1991cited by this paper
• MHC class II-associated invariant chain contains a sorting signal for endosomal compartments.

  1990cited by this paper
• Intracellular transport of class II MHC molecules directed by invariant chain

  1990cited by this paper
• Cloning and characterization of a mouse cysteine proteinase.

  1986cited by this paper

• Interferon-gamma-inducible protein 30 prevents IFN-γ-receptor 1 degradation to maintain PD-L1 and MHC-II levels in metastatic melanoma.

  2026cites this paper
• Neutrophil-Derived Proteases in Lung Inflammation: Old Players and New Prospects

  2024cites this paper
• Compensational role between cathepsins.

  2024cites this paper
• Antibacterial responses and functional characterization of the interferon gamma inducible lysosomal thiol reductase (GILT) protein in Chinese mitten crab (Eriocheir sinensis).

  2022cites this paper
• Prognostic value of gamma‐interferon‐inducible lysosomal thiol reductase expression in female patients diagnosed with breast cancer

  2021cites this paper
• Alterations in Lysosome Homeostasis in Lipid-Related Disorders: Impact on Metabolic Tissues and Immune Cells

  2021influential citation
• Therapeutic potential of targeting cathepsin S in pulmonary fibrosis.

  2021cites this paper
• Cathepsin S: investigating an old player in lung disease pathogenesis, comorbidities, and potential therapeutics

  2020cites this paper
• B and T Cells Driving Multiple Sclerosis: Identity, Mechanisms and Potential Triggers

  2020cites this paper
• Cysteine Cathepsins in Tumor-Associated Immune Cells

  2019cites this paper
• High GILT Expression and an Active and Intact MHC Class II Antigen Presentation Pathway Are Associated with Improved Survival in Melanoma

  2019cites this paper
• GILT restricts the cellular entry mediated by the envelope glycoproteins of SARS-CoV, Ebola virus and Lassa fever virus

  2019cites this paper
• Lentivirus mediated γ-interferon-inducible lysosomal thiol reductase (GILT) knockdown suppresses human glioma U373MG cell proliferation.

  2019cites this paper
• Microglia express gamma-interferon-inducible lysosomal thiol reductase in the brains of Alzheimer's disease and Nasu-Hakola disease.

  2018cites this paper
• The Other Function: Class II-Restricted Antigen Presentation by B Cells

  2017cites this paper
• Diverse cellular and organismal functions of the lysosomal thiol reductase GILT.

  2015cites this paper
• Conformational instability governed by disulfide bonds partitions the dominant from subdominant helper T-cell responses specific for HIV-1 envelope glycoprotein gp120.

  2015cites this paper
• Elevation of c-MYC Disrupts HLA Class II–Mediated Immune Recognition of Human B Cell Tumors

  2015cites this paper
• Cell Tumors Mediated Immune Recognition of Human B - Elevation of c-MYC Disrupts HLA Class II

  2015cites this paper
• Investigating Thiol-Dependent Processes in the Phagosome of Macrophages

  2014cites this paper
• Chemical biology of antigen presentation by MHC molecules.

  2014cites this paper
• γ-Interferon-inducible Lysosomal Thiol Reductase (GILT) Maintains Phagosomal Proteolysis in Alternatively Activated Macrophages*

  2014cites this paper
• Proteases: Essential Actors in Processing Antigens and Intracellular Toll-Like Receptors

  2013cites this paper
• Inhibition of Cathepsin S Produces Neuroprotective Effects after Traumatic Brain Injury in Mice

  2013cites this paper