Cdc42 controls the dilation of the exocytotic fusion pore by regulating membrane tension

M. Bretou,O. Jouannot,I. Fanget,Paolo Pierobon,N. Larochette,P. Gestraud,M. Guillon,V. Emiliani,S. Gasman,C. Desnos,A. Lennon-Duménil,F. Darchen,W. Bement

Published 2014 in Molecular Biology of the Cell

ABSTRACT

On exocytosis, membrane fusion starts with the formation of a narrow fusion pore that must expand to allow the release of secretory compounds. The GTPase Cdc42 promotes fusion pore dilation in neuroendocrine cells by controlling membrane tension.

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