Maintenance of hyporesponsiveness to antigen by a distinct subclass of T lymphocytes.

Immunization with increasing doses of SRBC, in excess of 10(8), results in a progressive decline in the anti-SRBC PFC response. This hyporesponsive state is antigen specific and is reflected in a decrease of both T helper and B antibody-forming activity. We asked whether the apparent defect of T helper activity reflected a) an absence of alphaSRBC helper T cell activity, or b) the presence of SRBC-specific suppressor T cells within the hyporesponsive population. Our results indicate that at least a portion of hyporesponsiveness noted after antigen exposure to large doses of antigen can be ascribed to specific suppressor T cell activation. Fractionation of the suppressive T cell population using Ly antiserum showed that specific suppressive activity was mediated by a subclass of T cells (Ly2+), distinct from that committed to express helper function (Ly1).

• Publication year

  1976

• Venue

  Journal of Immunology

• Publication date

  1976-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.117.6.2209PMID 62809
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Separation of helper T cells from suppressor T cells expressing different Ly components. II. Activation by antigen: after immunization, antigen-specific suppressor and helper activities are mediated by distinct T-cell subclasses

  1976cited by this paper
• Evidence for specific suppression in the maintenance of immunologic tolerance

  1975cited by this paper
• Feedback induction of suppressor T-cell activity

  1975cited by this paper
• SELECTIVE ROLES OF THYMUS-DERIVED LYMPHOCYTES IN THE ANTIBODY RESPONSE

  1974cited by this paper
• IMMUNE RESPONSES IN VITRO

  1971cited by this paper
• Cell interactions in the induction of tolerance: the role of thymic lymphocytes.

  1970cited by this paper
• IMMUNIZATION OF DISSOCIATED SPLEEN CELL CULTURES FROM NORMAL MICE

  1967cited by this paper
• ANTIBODY SYNTHESIS AT THE CELLULAR LEVEL

  1966cited by this paper

• HISTAMINE 2-RECEPTOR-MEDIATED IMMUNOMODULATION IN THE MOUSE. II. I M M U N O M O D U L A T I O N BY THE H2 ANTAGONIST METIAMIDE

  2002cites this paper
• Effect of thymostimulin in models of cell-mediated and humoral autoreactivity and on T-dependent suppression.

  1987cites this paper
• CONSEQUENCES OF PRENATAL EXPOSURE TO MATERNAL ALLOANTIGENS *

  1982cites this paper
• Enhancement of immune responses and possible inhibition of suppressor cells by aclacinomycin A.

  1981cites this paper
• Reduced immunological responsiveness induced by oral immunization in nude mice.

  1980cites this paper
• Effect of cytotoxic agents on suppressor cells in mice.

  1980cites this paper
• Histamine 2-receptor-mediated immunomodulation in the mouse. II. Immunomodulation by the H2 antagonist metiamide.

  1980cites this paper
• T cell independent induction of antigen specific suppression of the antibody response

  1979cites this paper
• Histamine 2 receptor-mediated immunomodulation in the mouse. I. Immunomodulation by the H2 agonist tolazoline.

  1979cites this paper
• Studies on the mechanism of suppression by T cells in an adoptive secondary response.

  1979cites this paper
• Murine lymphocyte surface antigens.

  1979cites this paper
• Regulation of the Immune Response

  1978cites this paper
• Immunoregulatory circuits among T-cell sets. II. Physiologic role of feedback inhibition in vivo: absence in NZB mice

  1978cites this paper
• Expression of Ly 1, Ly 2, Thy 1, and TL differentiation antigens on mouse T-cell tumors

  1978cites this paper
• Ly phenotype and mechanism of action of mouse neonatal suppressor T cells

  1977cites this paper
• Suppressor T cells in low zone tolerance II. Characterization of suppressor T and amplifier cells by physical and serological methods

  1977cites this paper