Structural and functional comparison of HemN to other radical SAM enzymes

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Biological chemistry

• Publication date

  2005-10-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1515/BC.2005.113PMID 16218869
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Radical S-Adenosylmethionine Enzyme Coproporphyrinogen III Oxidase HemN

  2005cited by this paper
• Post-translational Formylglycine Modification of Bacterial Sulfatases by the Radical S-Adenosylmethionine Protein AtsB*

  2004cited by this paper
• Coenzyme B12-dependent enzymatic dehydration of 1,2-diols: simple reaction, complex mechanism!

  2004cited by this paper
• AdoMet radical proteins--from structure to evolution--alignment of divergent protein sequences reveals strong secondary structure element conservation.

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• MiaB Protein Is a Bifunctional Radical-S-Adenosylmethionine Enzyme Involved in Thiolation and Methylation of tRNA*

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• Lipoyl synthase requires two equivalents of S-adenosyl-L-methionine to synthesize one equivalent of lipoic acid.

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• S-adenosylmethionine radical enzymes.

  2004cited by this paper
• Crystal structure of the S-adenosylmethionine-dependent enzyme MoaA and its implications for molybdenum cofactor deficiency in humans.

  2004cited by this paper
• Role of the [2Fe-2S] cluster in recombinant Escherichia coli biotin synthase.

  2004cited by this paper
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  2004cited by this paper
• Crystal structure of coproporphyrinogen III oxidase reveals cofactor geometry of Radical SAM enzymes

  2003cited by this paper
• Identification of the 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase required for coenzyme F420 biosynthesis

  2003cited by this paper
• Bacterial heme biosynthesis and its biotechnological application

  2003cited by this paper
• Radical carbon skeleton rearrangements: catalysis by coenzyme B12-dependent mutases.

  2003cited by this paper
• S-Adenosylmethionine: a wolf in sheep's clothing, or a rich man's adenosylcobalamin?

  2003cited by this paper
• The generation of 5'-deoxyadenosyl radicals by adenosylmethionine-dependent radical enzymes.

  2003cited by this paper
• Introduction: Radical enzymology

  2003cited by this paper
• Thiamine biosynthesis in Escherichia coli: isolation and initial characterisation of the ThiGH complex

  2003cited by this paper
• Radical catalysis in coenzyme B12-dependent isomerization (eliminating) reactions.

  2003cited by this paper
• Very high-field EPR study of glycyl radical enzymes.

  2003influential reference
• Oxygen-dependent Coproporphyrinogen III Oxidase (HemF) from Escherichia coli Is Stimulated by Manganese*

  2003cited by this paper
• MiaB Protein from Thermotoga maritima

  2003cited by this paper
• MiaB Protein from Thermotoga maritima CHARACTERIZATION OF AN EXTREMELY THERMOPHILIC tRNA-METHYLTHIOTRANSFERASE*

  2003cited by this paper
• Reductive Cleavage of S-Adenosylmethionine by Biotin Synthase from Escherichia coli *

  2002cited by this paper
• Oxygen-independent Coproporphyrinogen-III Oxidase HemN from Escherichia coli *

  2002influential reference
• Direct H atom abstraction from spore photoproduct C-6 initiates DNA repair in the reaction catalyzed by spore photoproduct lyase: evidence for a reversibly generated adenosyl radical intermediate.

  2002cited by this paper
• Coenzyme B(12) dependent glutamate mutase.

  2002cited by this paper
• The [4Fe-4S](2+) cluster in reconstituted biotin synthase binds S-adenosyl-L-methionine.

  2002cited by this paper
• Electron-nuclear double resonance spectroscopic evidence that S-adenosylmethionine binds in contact with the catalytically active [4Fe-4S](+) cluster of pyruvate formate-lyase activating enzyme.

  2002cited by this paper
• Coordination of adenosylmethionine to a unique iron site of the [4Fe-4S] of pyruvate formate-lyase activating enzyme: a Mössbauer spectroscopic study.

  2002cited by this paper
• An anchoring role for FeS clusters: chelation of the amino acid moiety of S-adenosylmethionine to the unique iron site of the [4Fe-4S] cluster of pyruvate formate-lyase activating enzyme.

  2002cited by this paper
• The PyMOL Molecular Graphics System

  2002cited by this paper
• Adenosylmethionine-dependent iron-sulfur enzymes: versatile clusters in a radical new role

  2001cited by this paper
• Radical SAM, a novel protein superfamily linking unresolved steps in familiar biosynthetic pathways with radical mechanisms: functional characterization using new analysis and information visualization methods.

  2001influential reference
• Characterization of an allylic analogue of the 5'-deoxyadenosyl radical: an intermediate in the reaction of lysine 2,3-aminomutase.

  2001cited by this paper
• Activation of class III ribonucleotide reductase by flavodoxin: a protein radical-driven electron transfer to the iron-sulfur center.

  2001cited by this paper
• Activation of class III ribonucleotide reductase from E. coli. The electron transfer from the iron-sulfur center to S-adenosylmethionine.

  2001cited by this paper
• Spectroscopic changes during a single turnover of biotin synthase: destruction of a [2Fe-2S] cluster accompanies sulfur insertion.

  2001cited by this paper
• Terminal steps of haem biosynthesis.

  2001cited by this paper
• The [4Fe-4S]1+ Cluster of Pyruvate Formate-Lyase Activating Enzyme Generates the Glycyl Radical on Pyruvate Formate-Lyase: EPR-Detected Single Turnover

  2000cited by this paper
• Direct FeS cluster involvement in generation of a radical in lysine 2,3-aminomutase.

  2000cited by this paper
• The Activating Component of the Anaerobic Ribonucleotide Reductase from Escherichia coli

  2000cited by this paper
• Escherichia coli LipA is a lipoyl synthase: in vitro biosynthesis of lipoylated pyruvate dehydrogenase complex from octanoyl-acyl carrier protein.

  2000cited by this paper
• Radical mechanisms in adenosylmethionine- and adenosylcobalamin-dependent enzymatic reactions.

  2000cited by this paper
• Biotin Synthase Mechanism: Evidence for Hydrogen Transfer from the Substrate into Deoxyadenosine

  1999cited by this paper
• Spectroscopic Evidence for the Participation of an Allylic Analogue of the 5‘-Deoxyadenosyl Radical in the Reaction of Lysine 2,3-Aminomutase

  1999cited by this paper
• Transcriptional Control of Bacillus subtilis hemN and hemZ

  1999cited by this paper
• Reconstitution and Characterization of the Polynuclear Iron-Sulfur Cluster in Pyruvate Formate-lyase-activating Enzyme

  1998cited by this paper
• Spore Photoproduct Lyase from Bacillus subtilis Spores Is a Novel Iron-Sulfur DNA Repair Enzyme Which Shares Features with Proteins such as Class III Anaerobic Ribonucleotide Reductases and Pyruvate-Formate Lyases

  1998cited by this paper
• Detection of a new substrate-derived radical during inactivation of ribonucleotide reductase from Escherichia coli by gemcitabine 5'-diphosphate.

  1998cited by this paper
• The role and source of 5′‐deoxyadenosyl radical in a carbon skeleton rearrangement catalyzed by a plant enzyme

  1998cited by this paper
• Activation of the Anaerobic Ribonucleotide Reductase fromEscherichia coli

  1997cited by this paper
• The Alcaligenes eutrophus hemN gene encoding the oxygen-independent coproporphyrinogen III oxidase, is required for heme biosynthesis during anaerobic growth

  1997cited by this paper
• Biotin synthase, a new member of the family of enzymes which uses S-adenosylmethionine as a source of deoxyadenosyl radical.

  1997cited by this paper
• Activation of the anaerobic ribonucleotide reductase from Escherichia coli. The essential role of the iron-sulfur center for S-adenosylmethionine reduction.

  1997cited by this paper
• Biotin Synthase from Escherichiacoli, an Investigation of the Low Molecular Weight and Protein Components Required for Activity inVitro(*)

  1995cited by this paper
• Cloning and characterization of the Escherichia coli hemN gene encoding the oxygen-independent coproporphyrinogen III oxidase

  1995cited by this paper
• Cloning, DNA sequence, and complementation analysis of the Salmonella typhimurium hemN gene encoding a putative oxygen-independent coproporphyrinogen III oxidase

  1994cited by this paper
• A putative anaerobic coproporphyrinogen III oxidase in Rhodobacter sphaeroides. I. Molecular cloning, transposon mutagenesis and sequence analysis of the gene

  1992cited by this paper
• An organic radical in the lysine 2,3-aminomutase reaction.

  1992cited by this paper
• Structure of a substrate radical intermediate in the reaction of lysine 2,3-aminomutase.

  1992cited by this paper
• Enzymic Reaction Selectivity by Negative Catalysis or How Do Enzymes Deal with Highly Reactive Intermediates

  1990cited by this paper
• Enzymatic Reaction Selectivity by Negative Catalysis or How Do Enzymes Deal with Highly Reactive Intermediates

  1990cited by this paper
• The role of S-adenosylmethionine in the lysine 2,3-aminomutase reaction.

  1987cited by this paper
• Anaerobic and aerobic coproporphyrinogen III oxidases of Rhodopseudomonas spheroides. Mechanism and stereochemistry of vinyl group formation.

  1983cited by this paper
• Protoporphyrin formation in Rhizobium japonicum

  1983cited by this paper
• Synthetic and biosynthetic studies of porphyrins, Part IV. Further studies of the conversion of corporporhyrinogen-III to protoporphyrin-IX: mass spectrometric investigations of the incubation of specifically deuteriated coproporhyringen-III with chicken red cell haemolysates.

  1980cited by this paper
• Coproporphyrinogenase activities in extracts of Rhodopseudomonas spheroides and Chromatium strain D.

  1972cited by this paper
• Coproporphyrinogenase activity in extracts from Rhodopseudomonas spheroides.

  1969cited by this paper

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  2022cites this paper
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  2021cites this paper
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  2020cites this paper
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  2019cites this paper
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  2019cites this paper
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  2018cites this paper
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  2018cites this paper
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  2017cites this paper
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  2017cites this paper
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  2015cites this paper
• Primary Amine Oxidase of Escherichia coli Is a Metabolic Enzyme that Can Use a Human Leukocyte Molecule as a Substrate

  2015cites this paper
• Discovery of Multiple Modified F430 Coenzymes in Methanogens and Anaerobic Methanotrophic Archaea Suggests Possible New Roles for F430 in Nature

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• Radical S-Adenosylmethionine (SAM) Enzymes in Cofactor Biosynthesis: A Treasure Trove of Complex Organic Radical Rearrangement Reactions*

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• Characterisation of Desulfovibrio vulgaris haem b synthase, a radical SAM family member.

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• Coping with anoxia: a comprehensive proteomic and transcriptomic survey of denitrification.

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• Revealing nature's synthetic potential through the study of ribosomal natural product biosynthesis.

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• Comparative and Functional Genomics of Anoxygenic Green Bacteria from the Taxa Chlorobi , Chloroflexi , and Acidobacteria

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• The radical SAM enzyme AlbA catalyzes thioether bond formation in subtilosin A.

  2012cites this paper
• Covalent intermediate in the catalytic mechanism of the radical S-adenosyl-L-methionine methyl synthase RlmN trapped by mutagenesis.

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• Radical SAM enzymes involved in the biosynthesis of purine-based natural products.

  2012cites this paper
• Structural insights into radical generation by the radical SAM superfamily.

  2011cites this paper
• Pyruvate is the source of the two carbons that are required for formation of the imidazoline ring of 4-demethylwyosine.

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• Investigating the biosynthesis of heam d1 in pseudomonas aeruginosa: a cofactor for dissimilatory nitrite reductase.

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• RlmN and Cfr are radical SAM enzymes involved in methylation of ribosomal RNA.

  2010cites this paper
• Anaerobic sulfatase‐maturating enzyme – A mechanistic link with glycyl radical‐activating enzymes?

  2010cites this paper
• Acinetobacter ADP1 as a system for in vivo identification of bacterial coproporphyrinogen III oxidases

  2010cites this paper
• The tetrapyrrole biosynthetic pathway and its regulation in Rhodobacter capsulatus.

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• Crystal Structure of the Nitrogenase-like Dark Operative Protochlorophyllide Oxidoreductase Catalytic Complex (ChlN/ChlB)2*♦

  2010cites this paper
• Structural and Biochemical Investigation of the Escherichia coli Oxygen Independent Coproporphyrinogen III Oxidase (HemN) and its Substrate

  2009cites this paper
• Chapter 7 – Hydrogenases, Hydrogen Production, and Anoxia

  2009cites this paper
• Structural insight into the assembly of iron-sulfur clusters and their function in radical generation

  2008cites this paper
• The Radical SAM Superfamily.

  2008cites this paper
• Anaerobic Sulfatase-maturating Enzymes, First Dual Substrate Radical S-Adenosylmethionine Enzymes*

  2008cites this paper
• Biosynthesis and Insertion of the Molybdenum Cofactor

  2008cites this paper
• The biochemistry of heme biosynthesis.

  2008cites this paper
• The Radical SAM Superfamily

  2008cites this paper
• Cysteine Desulfurase-Mediated Sulfur Donation Pathways in Plants and Phototrophic Bacteria

  2008cites this paper
• Structure/function relationships of [NiFe]- and [FeFe]-hydrogenases.

  2007cites this paper
• S-adenosylmethionine as an oxidant: the radical SAM superfamily.

  2007cites this paper
• Binding energy in the one-electron reductive cleavage of S-adenosylmethionine in lysine 2,3-aminomutase, a radical SAM enzyme.

  2007cites this paper
• Substrate recognition, protein dynamics, and iron-sulfur cluster in Pseudomonas aeruginosa adenosine 5'-phosphosulfate reductase.

  2006cites this paper
• Functional genomic analysis of alkaloid biosynthesis in Hyoscyamus niger reveals a cytochrome P450 involved in littorine rearrangement.

  2006cites this paper
• Free radical mechanisms in enzymology.

  2006cites this paper
• The Elongator subunit Elp3 contains a Fe4S4 cluster and binds S‐adenosylmethionine

  2006cites this paper
• Maturation of hydrogenases.

  2006cites this paper