The neurogene BTG2TIS21/PC3 is transactivated by ΔNp73α via p53 specifically in neuroblastoma cells

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Journal of Cell Science

• Publication date

  2005-03-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1242/jcs.01704
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• DeltaNp73beta is active in transactivation and growth suppression.

  2004cited by this paper
• ΔNp73β Is Active in Transactivation and Growth Suppression

  2004cited by this paper
• Differential response of p53 target genes to p73 overexpression in SH-SY5Y neuroblastoma cell line

  2004influential reference
• BTG2 antiproliferative protein interacts with the human CCR4 complex existing in vivo in three cell-cycle-regulated forms

  2003cited by this paper
• p73α expression induces both accumulation and activation of wt-p53 independent of the p73α transcriptional activity

  2003influential reference
• When p53 needs p73 to be functional - forced p73 expression induces nuclear accumulation of endogenous p53 protein.

  2003cited by this paper
• TP53 family members and human cancers

  2003cited by this paper
• DeltaN-p73alpha accumulates in human neuroblastic tumors.

  2002cited by this paper
• On the shoulders of giants: p63, p73 and the rise of p53.

  2002cited by this paper
• BTG2TIS21/PC3 induces neuronal differentiation and prevents apoptosis of terminally differentiated PC12 cells

  2002cited by this paper
• Accumulation of an inactive form of p53 protein in cells treated with TNFα

  2002cited by this paper
• BTG2(TIS21/PC3) induces neuronal differentiation and prevents apoptosis of terminally differentiated PC12 cells.

  2002cited by this paper
• The human BTG 2 / TIS 21 / PC 3 gene : genomic structure , transcriptional regulation and evaluation as a candidate tumor suppressor gene

  2002influential reference
• Autoinhibitory Regulation of p73 by ΔNp73 To Modulate Cell Survival and Death through a p73-Specific Target Element within the ΔNp73 Promoter

  2002cited by this paper
• p53 induces the expression of its antagonist p73ΔN, establishing an autoregulatory feedback loop

  2002cited by this paper
• ΔNp73, A Dominant-Negative Inhibitor of Wild-type p53 and TAp73, Is Up-regulated in Human Tumors

  2002cited by this paper
• Expression of B-cell translocation gene 2 protein in normal human tissues.

  2002cited by this paper
• The human BTG2/TIS21/PC3 gene: genomic structure, transcriptional regulation and evaluation as a candidate tumor suppressor gene.

  2002cited by this paper
• Expression of ΔNp73 is a molecular marker for adverse outcome in neuroblastoma patients

  2002cited by this paper
• DN-p73 is activated after DNA damage in a p53-dependent manner to regulate p53-induced cell cycle arrest

  2002cited by this paper
• Transactivation-deficient Delta TA-p73 inhibits p53 by direct competition for DNA binding: implications for tumorigenesis.

  2002cited by this paper
• Transactivation-deficient p73α (p73Δexon2) inhibits apoptosis and competes with p53

  2001cited by this paper
• The gene PC3(TIS21/BTG2), prototype member of the PC3/BTG/TOB family: regulator in control of cell growth, differentiation, and DNA repair?

  2001cited by this paper
• Reciprocal down-regulation of p53 and SOD2 gene expression–implication in p53 mediated apoptosis

  2001influential reference
• The gene PC3TIS21/BTG2, prototype member of the PC3/BTG/TOB family: Regulator in control of cell growth, differentiation, and DNA repair?

  2001cited by this paper
• Transactivation-deficient p73alpha (p73Deltaexon2) inhibits apoptosis and competes with p53.

  2001cited by this paper
• Transcriptional Repression by p53 through Direct Binding to a Novel DNA Element* 210

  2001cited by this paper
• Human and Mouse Fas (APO-1/CD95) Death Receptor Genes Each Contain a p53-responsive Element That Is Activated by p53 Mutants Unable to Induce Apoptosis*

  2000cited by this paper
• MDM2 Suppresses p73 Function without Promoting p73 Degradation

  1999cited by this paper
• p73 and p63 Are Homotetramers Capable of Weak Heterotypic Interactions with Each Other but Not with p53*

  1999cited by this paper
• Solution structure of a conserved C‐terminal domain of p73 with structural homology to the SAM domain

  1999cited by this paper
• The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage

  1999cited by this paper
• Deletion of the COOH-terminal region of p73alpha enhances both its transactivation function and DNA-binding activity but inhibits induction of apoptosis in mammalian cells.

  1999cited by this paper
• Interaction of c-Abl and p73α and their collaboration to induce apoptosis

  1999cited by this paper
• Identification of a transactivation activity in the COOH-terminal region of p73 which is impaired in the naturally occurring mutants found in human neuroblastomas.

  1999influential reference
• Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis.

  1999cited by this paper
• Two new p73 splice variants, gamma and delta, with different transcriptional activity.

  1998cited by this paper
• Regulation of p53 downstream genes.

  1998cited by this paper
• p73 is a human p53-related protein that can induce apoptosis

  1997cited by this paper
• Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers.

  1997cited by this paper
• p73 is a simian [correction of human] p53-related protein that can induce apoptosis.

  1997cited by this paper
• Identification of BTG2, an antiproliferative p53–dependent component of the DNA damage cellular response pathway

  1996cited by this paper
• Developmental expression of PC3 gene is correlated with neuronal cell birthday.

  1994cited by this paper
• Coactivation of the MDR1 and MYCN genes in human neuroblastoma cells during the metastatic process in the nude mouse.

  1994cited by this paper
• Molecular cloning of PC3, a putatively secreted protein whose mRNA is induced by nerve growth factor and depolarization.

  1991cited by this paper
• The Gene PC 3 TIS 21 / BTG 2 , Prototype Member of the PC 3 / BTG / TOB Family : Regulator in Control of Cell Growth , Differentiation , and DNA Repair ?

  year unknowncited by this paper

• Keratinocytes in atopic dermatitis express abundant ΔNp73 regulating thymic stromal lymphopoietin production via NF-κB.

  2017cites this paper
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  2017cites this paper
• Distinct TP73–DAPK2–ATG5 pathway involvement in ATO‐mediated cell death versus ATRA‐mediated autophagy responses in APL

  2017cites this paper
• DEC1 Coordinates with HDAC8 to Differentially Regulate TAp73 and ΔNp73 Expression

  2014cites this paper
• TAp73 Protein Stability Is Controlled by Histone Deacetylase 1 via Regulation of Hsp90 Chaperone Function*

  2013cites this paper
• Role of P73 and P53 in the biology of neural stem cells and in the architecture of the neurogenic niches in mouse brain

  2013cites this paper
• BTG2 overexpression increases the radiosensitivity of breast cancer cells in vitro and in vivo.

  2012cites this paper
• Induction of the small heat shock protein αB-crystallin by genotoxic stress is mediated by p53 and p73

  2010cites this paper
• Analysis of the intracellular localization of p73 N-terminal protein isoforms TAp73 and ∆Np73 in medulloblastoma cell lines

  2010cites this paper
• Dysregulation of Platelet-Derived Growth Factor β-Receptor Expression by ΔNp73 in Neuroblastoma

  2009cites this paper
• p73 Plays a Role in Erythroid Differentiation through GATA1 Induction*

  2009cites this paper
• p73α isoforms drive opposite transcriptional and post-transcriptional regulation of MYCN expression in neuroblastoma cells

  2008cites this paper
• PU.1 binding to the p53 family of tumor suppressors impairs their transcriptional activity

  2008cites this paper
• ΔNp73 Modulates Nerve Growth Factor-Mediated Neuronal Differentiation through Repression of TrkA

  2007cites this paper
• Expression of C-terminal deleted p53 isoforms in neuroblastoma

  2006cites this paper
• TIS21/BTG2/PC3 as a link between ageing and cancer: cell cycle regulator and endogenous cell death molecule

  2006cites this paper
• p53 isoforms can regulate p53 transcriptional activity.

  2005cites this paper
• Differential regulation of p 73 variants in response to cisplatin treatment in SH-SY 5 Y neuroblastoma cells

  year unknowncites this paper