Genetically engineered murine models of prostate cancer: insights into mechanisms of tumorigenesis and potential utility.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Future Oncology

• Publication date

  2005-11-24

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1517/14796694.1.3.351PMID 16556009
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• A probasin-large T antigen transgenic mouse line develops prostate adenocarcinoma and neuroendocrine carcinoma with metastatic potential.

  2001influential reference
• Estrogen Imprinting of the Developing Prostate Gland Is Mediated through Stromal Estrogen Receptor α Studies with αERKO and βERKO Mice

  2001cited by this paper
• Modeling prostate cancer in the mouse.

  2001cited by this paper
• Role of fibroblast growth factor receptor signaling in prostate cancer cell survival.

  2001cited by this paper
• Prostatic neoplasia in transgenic mice with prostate‐directed overexpression of the c‐myc oncoprotein

  2000cited by this paper
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  2000cited by this paper
• Chemoprevention of prostate carcinogenesis by alpha-difluoromethylornithine in TRAMP mice.

  2000cited by this paper
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  2000cited by this paper
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• Identification of c-myc responsive genes using rat cDNA microarray.

  2000cited by this paper
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  2000cited by this paper
• Pathologic progression of autochthonous prostate cancer in the TRAMP model

  1999cited by this paper
• Roles for Nkx3.1 in prostate development and cancer.

  1999cited by this paper
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  1999cited by this paper
• MYC oncogenes and human neoplastic disease

  1999cited by this paper
• Adoptive immunotherapy prevents prostate cancer in a transgenic animal model

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• Gene therapy of cancer: activation of nucleoside prodrugs with E. coli purine nucleoside phosphorylase.

  1999cited by this paper
• Effects of pituitary hormones on the prostate

  1999cited by this paper
• A transgenic mouse model of metastatic prostate cancer originating from neuroendocrine cells.

  1998cited by this paper
• The heparan sulfate-fibroblast growth factor family: diversity of structure and function.

  1998cited by this paper
• Generation and reproductive phenotypes of mice lacking estrogen receptor beta.

  1998cited by this paper
• Pten is essential for embryonic development and tumour suppression

  1998cited by this paper
• Development, progression, and androgen-dependence of prostate tumors in probasin-large T antigen transgenic mice: a model for prostate cancer.

  1998cited by this paper
• Expression of early growth response genes in human prostate cancer.

  1998cited by this paper
• Detection of chromosomal anomalies and c-myc gene amplification in the cribriform pattern of prostatic intraepithelial neoplasia and carcinoma by fluorescence in situ hybridization.

  1997cited by this paper
• PTEN, a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer

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  1997cited by this paper
• Detection of c-myc oncogene amplification and chromosomal anomalies in metastatic prostatic carcinoma by fluorescence in situ hybridization.

  1997cited by this paper
• Prostate-specific and Androgen-dependent Expression of a Novel Homeobox Gene*

  1996cited by this paper
• Progression of prostatic intraepithelial neoplasia to invasive carcinoma in C3(1)/SV40 large T antigen transgenic mice: histopathological and molecular biological alterations.

  1996cited by this paper
• CD28/B7 system of T cell costimulation.

  1996cited by this paper
• A decade of molecular biology of retinoic acid receptors

  1996cited by this paper
• Cyclin‐dependent kinases and pRb: regulators of the proliferation‐differentiation switch

  1995cited by this paper
• Prostate cancer in a transgenic mouse.

  1995cited by this paper
• Retinoblastoma gene mutations in primary human prostate cancer

  1995cited by this paper
• Allelic loss of the retinoblastoma gene in primary human prostatic adenocarcinomas

  1995cited by this paper
• The retinoblastoma protein and cell cycle control.

  1995cited by this paper
• Effect of prolactin on the prostate

  1994cited by this paper
• Normal and abnormal development of the male urogenital tract. Role of androgens, mesenchymal-epithelial interactions, and growth factors.

  1992cited by this paper
• The FGF family of growth factors and oncogenes.

  1992cited by this paper
• Restriction of neuroblastoma to the prostate gland in transgenic mice

  1991cited by this paper
• CTLA-4 is a second receptor for the B cell activation antigen B7

  1991cited by this paper
• Suppression of tumorigenicity of human prostate carcinoma cells by replacing a mutated RB gene.

  1990cited by this paper
• Expression of basic fibroblast growth factor mRNA in benign prostatic hyperplasia and prostatic carcinoma

  1988cited by this paper
• Expression of the c-myc protooncogene in human prostatic carcinoma and benign prostatic hyperplasia.

  1986cited by this paper
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  year unknowncited by this paper

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  2008cites this paper
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