Pathophysiological Role of HERV-W in Schizophrenia.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  The Journal of Neuropsychiatry and Clinical Neurosciences

• Publication date

  2015-09-25

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1176/appi.neuropsych.15030059PMID 26404170
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• GABA abnormalities in schizophrenia: a methodological review of in vivo studies.

  2015cited by this paper
• Transcriptional Derepression of the ERVWE1 Locus following Influenza A Virus Infection

  2014cited by this paper
• Biological Insights From 108 Schizophrenia-Associated Genetic Loci

  2014cited by this paper
• Immunology of Schizophrenia

  2014cited by this paper
• Inflammation and the two-hit hypothesis of schizophrenia.

  2014cited by this paper
• Human Cytomegalovirus (HCMV) induces Human Endogenous Retrovirus (HERV) transcription

  2013cited by this paper
• GABBR1 has a HERV-W LTR in its regulatory region – a possible implication for schizophrenia

  2013cited by this paper
• ‘There and back again’: revisiting the pathophysiological roles of human endogenous retroviruses in the post-genomic era

  2013cited by this paper
• Human endogenous retrovirus type W (HERV-W) in schizophrenia: A new avenue of research at the gene–environment interface

  2013cited by this paper
• Viral infection, inflammation and schizophrenia.

  2013cited by this paper
• Maternal antibodies to infectious agents and risk for non-affective psychoses in the offspring--a matched case-control study.

  2012cited by this paper
• Human endogenous retroviruses: Their possible role in the molecular etiology of the schizophrenia

  2012cited by this paper
• Neurodevelopmental model of schizophrenia: update 2012

  2012cited by this paper
• The role of human endogenous retroviruses in the pathogenesis of autoimmune diseases

  2012cited by this paper
• Implication of the env gene of the human endogenous retrovirus W family in the expression of BDNF and DRD3 and development of recent-onset schizophrenia.

  2011cited by this paper
• Grey matter changes associated with host genetic variation and exposure to Herpes Simplex Virus 1 (HSV1) in first episode schizophrenia.

  2010cited by this paper
• The Human Endogenous Retrovirus Link between Genes and Environment in Multiple Sclerosis and in Multifactorial Diseases Associating Neuroinflammation

  2010cited by this paper
• Common variants conferring risk of schizophrenia: a pathway analysis of GWAS data.

  2010cited by this paper
• Similar immune profile in bipolar disorder and schizophrenia: selective increase in soluble tumor necrosis factor receptor I and von Willebrand factor.

  2009cited by this paper
• Reductions in frontal, temporal and parietal volume associated with the onset of psychosis.

  2008cited by this paper
• Schizophrenia, "just the facts" what we know in 2008. 2. Epidemiology and etiology.

  2008cited by this paper
• Rare chromosomal deletions and duplications increase risk of schizophrenia

  2008cited by this paper
• Maternal exposure to herpes simplex virus and risk of psychosis among adult offspring.

  2008cited by this paper
• Schizophrenia, "Just the Facts": what we know in 2008 part 1: overview.

  2008cited by this paper
• Endogenous retrovirus type W GAG and envelope protein antigenemia in serum of schizophrenic patients.

  2008cited by this paper
• Epigenetic control of fetal gene expression.

  2008cited by this paper
• Toxoplasma gondii as a risk factor for early-onset schizophrenia: analysis of filter paper blood samples obtained at birth.

  2007cited by this paper
• Elevated levels of human endogenous retrovirus‐W transcripts in blood cells from patients with first episode schizophrenia

  2007cited by this paper
• Review article: Epigenetic control of fetal gene expression

  2007cited by this paper
• Changes in region- and cell type-specific expression patterns of neutral amino acid transporter 1 (ASCT-1) in the anterior cingulate cortex and hippocampus in schizophrenia, bipolar disorder and major depression

  2007cited by this paper
• Obstetric conditions and risk of first admission with schizophrenia: a Danish national register based study.

  2007cited by this paper
• Duration of prodromal phase and severity of volumetric abnormalities in first-episode psychosis.

  2007cited by this paper
• Elevated levels of transcripts encoding a human retroviral envelope protein (syncytin) in muscles from patients with motor neuron disease

  2007cited by this paper
• Reduced expression of human endogenous retrovirus (HERV)-W GAG protein in the cingulate gyrus and hippocampus in schizophrenia, bipolar disorder, and depression

  2007cited by this paper
• Prenatal infectious and nutritional factors and risk of adult schizophrenia

  2007cited by this paper
• C-reactive protein is associated with the severity of cognitive impairment but not of psychiatric symptoms in individuals with schizophrenia.

  2007cited by this paper
• Retrovirology BioMed Central

  2006cited by this paper
• Novel, replicated associations between dopamine D3 receptor gene polymorphisms and schizophrenia in two independent samples.

  2006cited by this paper
• Schizophrenia as an inflammation-mediated dysbalance of glutamatergic neurotransmission

  2006cited by this paper
• The Envelope Protein of a Human Endogenous Retrovirus-W Family Activates Innate Immunity through CD14/TLR4 and Promotes Th1-Like Responses1

  2006cited by this paper
• Altered placental syncytin and its receptor ASCT2 expression in placental development and pre‐eclampsia

  2006cited by this paper
• Transactivation of elements in the human endogenous retrovirus W family by viral infection

  2006cited by this paper
• The role of cytokines in mediating effects of prenatal infection on the fetus: implications for schizophrenia

  2006cited by this paper
• Deficit schizophrenia: association with serum antibodies to cytomegalovirus.

  2006cited by this paper
• Altered transcriptional activity of human endogenous retroviruses in neuroepithelial cells after infection with Toxoplasma gondii.

  2006cited by this paper
• Possible association between the gamma-aminobutyric acid type B receptor 1 (GABBR1) gene and schizophrenia.

  2005cited by this paper
• BDNF in schizophrenia, depression and corresponding animal models

  2005cited by this paper
• A Systematic Review of the Prevalence of Schizophrenia

  2005cited by this paper
• Age at onset of schizophrenia: interaction between brain-derived neurotrophic factor and dopamine D3 receptor gene variants

  2005cited by this paper
• Human endogenous retrovirus (HERV)-W ENV and GAG proteins: Physiological expression in human brain and pathophysiological modulation in multiple sclerosis lesions

  2005cited by this paper
• Human Endogenous Retrovirus Expression Profiles in Samples from Brains of Patients with Schizophrenia and Bipolar Disorders

  2005cited by this paper
• Size of burden of schizophrenia and psychotic disorders.

  2005cited by this paper
• The neurodevelopmental model of schizophrenia: update 2005

  2005cited by this paper
• Human endogenous retrovirus glycoprotein–mediated induction of redox reactants causes oligodendrocyte death and demyelination

  2004cited by this paper
• Serologic evidence of prenatal influenza in the etiology of schizophrenia.

  2004cited by this paper
• Antibodies to infectious agents in individuals with recent onset schizophrenia

  2004cited by this paper
• HERV-W-related RNA detected in plasma from individuals with recent-onset schizophrenia or schizoaffective disorder

  2004cited by this paper
• N-Linked Glycosylation and Sequence Changes in a Critical Negative Control Region of the ASCT1 and ASCT2 Neutral Amino Acid Transporters Determine Their Retroviral Receptor Functions

  2003cited by this paper
• Demystified . . . Human endogenous retroviruses

  2003cited by this paper
• A systematic review and meta-analysis of Northern Hemisphere season of birth studies in schizophrenia.

  2003cited by this paper
• Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway

  2003cited by this paper
• Processed pseudogenes of human endogenous retroviruses generated by LINEs: their integration, stability, and distribution.

  2002cited by this paper
• Epidemiology of schizophrenia

  2002cited by this paper
• The Sequence of the Human Genome

  2001cited by this paper
• The sequence of the human genome. Venter JC,∗ Adams MD, Myers EW, et al. Science 2001;291:1304–1351.

  2001cited by this paper
• Evidence of a dose-response relationship between urbanicity during upbringing and schizophrenia risk.

  2001cited by this paper
• The sequence of the human genome (abstract only)

  2001cited by this paper
• Multiple sclerosis retrovirus particles and recombinant envelope trigger an abnormal immune response in vitro, by inducing polyclonal Vbeta16 T-lymphocyte activation.

  2001cited by this paper
• Retroviral RNA identified in the cerebrospinal fluids and brains of individuals with schizophrenia

  2001cited by this paper
• Prenatal rubella, premorbid abnormalities, and adult schizophrenia

  2001cited by this paper
• Endogenous retroviruses in the human genome sequence

  2001cited by this paper
• A.E. Bennett Research Award. Prenatal rubella, premorbid abnormalities, and adult schizophrenia.

  2001cited by this paper
• Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis

  2000cited by this paper
• Endogenous retroviruses and schizophrenia.

  2000cited by this paper
• Molecular investigations implicate human endogenous retroviruses as mediators of anti-retroviral antibodies in autoimmune rheumatic disease.

  1999cited by this paper
• Phylogeny of a Novel Family of Human Endogenous Retrovirus Sequences, HERV-W, in Humans and Other Primates

  1999cited by this paper
• Molecular Characterization and Placental Expression of HERV-W, a New Human Endogenous Retrovirus Family

  1999cited by this paper
• Molecular characterization of a MSRV-like sequence identified by RDA from monozygotic twin pairs discordant for schizophrenia.

  1999cited by this paper
• Molecular identification of a novel retrovirus repeatedly isolated from patients with multiple sclerosis. The Collaborative Research Group on Multiple Sclerosis.

  1997cited by this paper
• Herpes simplex virus ICP0 and ICP4 immediate early proteins strongly enhance expression of a retrovirus harboured by a leptomeningeal cell line from a patient with multiple sclerosis.

  1993cited by this paper
• Isolation of retrovirus from patients with multiple sclerosis

  1991cited by this paper
• Isolation of retrovirus from patients with multiple sclerosis.

  1991cited by this paper
• Schizophrenia, just the facts. What do we know, how well do we know it?

  1988cited by this paper
• A Re-Evaluation of the Viral Hypothesis: Is Psychosis the Result of Retroviral Integration at a Site Close to the Cerebral Dominance Gene?

  1984cited by this paper

• ERVWE1 Impairs Mitochondrial Homeostasis and Promotes Neuronal Apoptosis via the miR-27b-3p/BNIP3 Axis in Schizophrenia.

  2026cites this paper
• HERV-W Env Induces Neuron Pyroptosis via the NLRP3–CASP1–GSDMD Pathway in Recent-Onset Schizophrenia

  2025cites this paper
• Unravelling the Viral Hypothesis of Schizophrenia: A Comprehensive Review of Mechanisms and Evidence

  2025cites this paper
• Human endogenous retrovirus W family envelope protein (ERVWE1) regulates macroautophagy activation and micromitophagy inhibition via NOXA1 in schizophrenia

  2025cites this paper
• Mechanistic regulation of HERV activation in tumors and implications for translational research in oncology

  2024cites this paper
• Transcription of Endogenous Retroviruses: Broad and Precise Mechanisms of Control

  2024cites this paper
• Integrating human endogenous retroviruses into transcriptome-wide association studies highlights novel risk factors for major psychiatric conditions

  2024cites this paper
• Beyond pathogens: the intriguing genetic legacy of endogenous retroviruses in host physiology

  2024cites this paper
• Local Hormones and Neurolipidomics in schizophrenia

  2023cites this paper
• Schizophrenia as metabolic disease. What are the causes?

  2023cites this paper
• Viral Infections and Schizophrenia: A Comprehensive Review

  2023cites this paper
• Role of Increased Syncytin-1 Expression in Pathogenesis of Anti-N-Methyl-d-Aspartate Receptor Encephalitis

  2022cites this paper
• The role of virome in the gastrointestinal tract and beyond

  2022cites this paper
• Association between Prenatal Viral Infections and the Occurrence of Schizophrenia in Adulthood

  2022cites this paper
• İnsan Endojen Retrovirüslerin Kanserle Olan İlişkisinin İncelenmesi

  2021cites this paper
• Human Endogenous Retroviruses as Biomedicine Markers

  2021cites this paper
• The "Missing Heritability"-Problem in Psychiatry: Is the interaction of Genetics, Epigenetics and Transposable Elements a potential solution?

  2021cites this paper
• Transposable elements in brain health and disease.

  2020cites this paper
• The Association between Plasma ERVWE1 Concentrations and Affective Symptoms during Pregnancy: Is This a Friendly Alien?

  2020cites this paper
• P.202 The association between ERV-WE1 plasma concentrations and mental health during pregnancy: is this a benevolent parasite?

  2020cites this paper
• Human Endogenous Retroviruses Type W ( HERV-W ) : an Epiphenomenon or the Missing Link in Schizophrenia ?

  2017influential citation
• The benefits of integration.

  2016cites this paper
• Evidence of extensive non-allelic gene conversion among LTR elements in the human genome

  2016cites this paper