CXCR4 Overexpression Is Associated with Poor Outcome in Females Diagnosed with Stage IV Non-small Cell Lung Cancer

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Journal of Thoracic Oncology

• Publication date

  2011-07-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1097/JTO.0b013e3182199a99PMID 21623238
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• References Subscriptions Permissions Email Alerts A Possible Role for CXCR4 and Its Ligand,

  2013cited by this paper
• The immunohistochemical overexpression of ribonucleotide reductase regulatory subunit M1 (RRM1) protein is a predictor of shorter survival to gemcitabine-based chemotherapy in advanced non-small cell lung cancer (NSCLC).

  2010cited by this paper
• Expression of the chemokine receptor CXCR4 correlates with a favorable prognosis in patients with adenocarcinoma of the lung.

  2010cited by this paper
• Screening for Epidermal Growth Factor Receptor Mutations in Lung Cancer

  2010cited by this paper
• Screening for epidermal growth factor receptor mutations in lung cancer.

  2009cited by this paper
• Sex-associated differences in non-small cell lung cancer in the new era: is gender an independent prognostic factor?

  2009cited by this paper
• CXCL12 and CXCR4 in adenocarcinoma of the lung: association with metastasis and survival.

  2009cited by this paper
• Positive feedback activation of estrogen receptors by the CXCL12-CXCR4 pathway.

  2009cited by this paper
• Nuclear expression of CXCR4 in tumor cells of non-small cell lung cancer is correlated with lymph node metastasis.

  2008cited by this paper
• Reassessment of CXCR4 Chemokine Receptor Expression in Human Normal and Neoplastic Tissues Using the Novel Rabbit Monoclonal Antibody UMB-2

  2008cited by this paper
• Stromal Cell–Derived Factor-1/Chemokine (C-X-C Motif) Ligand 12 Stimulates Human Hepatoma Cell Growth, Migration, and Invasion

  2007cited by this paper
• The pivotal role of CXCL12 (SDF-1)/CXCR4 axis in bone metastasis

  2007cited by this paper
• Mechanisms of regulation of CXCR4/SDF-1 (CXCL12)-dependent migration and homing in multiple myeloma.

  2007cited by this paper
• CXC chemokine receptor-4 antagonist blocks both growth of primary tumor and metastasis of head and neck cancer in xenograft mouse models.

  2007cited by this paper
• Women with pathologic stage I, II, and III non-small cell lung cancer have better survival than men.

  2006cited by this paper
• Survival Differences by Sex for Patients with Advanced Non-small Cell Lung Cancer on Eastern Cooperative Oncology Group Trial 1594

  2006cited by this paper
• DNA repair by ERCC1 in non-small-cell lung cancer and cisplatin-based adjuvant chemotherapy.

  2006cited by this paper
• Overexpression of CXCR4 Increases Migration and Proliferation of Human Adipose Tissue Stromal Cells

  2006cited by this paper
• Expression of chemokine CXCL12 and its receptor CXCR4 in human epithelial ovarian cancer: an independent prognostic factor for tumor progression.

  2006cited by this paper
• CD4+CXCR4highCD69+ T Cells Accumulate in Lung Adenocarcinoma

  2006cited by this paper
• Nuclear Estrogen Receptor β in Lung Cancer: Expression and Survival Differences by Sex

  2005cited by this paper
• Erlotinib in previously treated non-small-cell lung cancer.

  2005cited by this paper
• How do stem cells find their way home?

  2005cited by this paper
• Stromal cell derived factor-1: its influence on invasiveness and migration of breast cancer cells in vitro, and its association with prognosis and survival in human breast cancer

  2005cited by this paper
• Investigation of HER2 overexpression in non-small cell lung cancer.

  2005cited by this paper
• The Expression of Functional Chemokine Receptor CXCR4 Is Associated with the Metastatic Potential of Human Nasopharyngeal Carcinoma

  2005cited by this paper
• Vinorelbine plus cisplatin vs. observation in resected non-small-cell lung cancer.

  2005cited by this paper
• Differential Expression of CXCR4 Is Associated with the Metastatic Potential of Human Non–Small Cell Lung Cancer Cells

  2005cited by this paper
• Trafficking of Normal Stem Cells and Metastasis of Cancer Stem Cells Involve Similar Mechanisms: Pivotal Role of the SDF‐1–CXCR4 Axis

  2005cited by this paper
• Epidermal growth factor and hypoxia-induced expression of CXC chemokine receptor 4 on non-small cell lung cancer cells is regulated by the phosphatidylinositol 3-kinase/PTEN/AKT/mammalian target of rapamycin signaling pathway and activation of hypoxia inducible factor-1alpha.

  2005cited by this paper
• Estrogen receptor alpha and beta are prognostic factors in non-small cell lung cancer.

  2005cited by this paper
• Estrogen Receptor α and β are Prognostic Factors in Non–Small Cell Lung Cancer

  2005cited by this paper
• Epidermal Growth Factor and Hypoxia-induced Expression of CXC Chemokine Receptor 4 on Non-small Cell Lung Cancer Cells Is Regulated by the Phosphatidylinositol 3-Kinase/PTEN/AKT/Mammalian Target of Rapamycin Signaling Pathway and Activation of Hypoxia Inducible Factor-1α*

  2005cited by this paper
• Regulation of CXCR4-mediated chemotaxis and chemoinvasion of breast cancer cells

  2004cited by this paper
• Gender differences in non-small-cell lung cancer survival: an analysis of 4,618 patients diagnosed between 1997 and 2002.

  2004cited by this paper
• Anticancer drugs: To the rescue?

  2004cited by this paper
• CXCR4 Regulates Growth of Both Primary and Metastatic Breast Cancer

  2004cited by this paper
• CXCR4 antagonist inhibits stromal cell-derived factor 1-induced migration and invasion of human pancreatic cancer.

  2004cited by this paper
• EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy

  2004cited by this paper
• Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib.

  2004cited by this paper
• Chemokine receptor CXCR4 and early-stage non-small cell lung cancer: pattern of expression and correlation with outcome.

  2004cited by this paper
• Circulating CXCR4-positive stem/progenitor cells compete for SDF-1-positive niches in bone marrow, muscle and neural tissues: an alternative hypothesis to stem cell plasticity.

  2003cited by this paper
• The stromal derived factor-1/CXCL12-CXC chemokine receptor 4 biological axis in non-small cell lung cancer metastases.

  2003cited by this paper
• Chemokine signaling: rules of attraction.

  2003cited by this paper
• Molecular targeted agents in non-small-cell lung cancer.

  2003cited by this paper
• Chemokines, chemokine receptors and adhesion molecules on different human endothelia: discriminating the tissue‐specific functions that affect leucocyte migration

  2003cited by this paper
• The chemokine receptor CXCR4 is required for outgrowth of colon carcinoma micrometastases.

  2003cited by this paper
• Regression Modeling Strategies: With Applications to Linear Models, Logistic Regression, and Survival Analysis

  2003cited by this paper
• Testing Statistical Hypotheses of Equivalence

  2003cited by this paper
• Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: a randomized trial.

  2003cited by this paper
• Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer.

  2002cited by this paper
• Gender-dependent expression of alpha and beta estrogen receptors in human nontumor and tumor lung tissue.

  2002cited by this paper
• Phase III randomized trial comparing three platinum-based doublets in advanced non-small-cell lung cancer.

  2002cited by this paper
• Lung cancer in women: age, smoking, histology, performance status, stage, initial treatment and survival. Population-based study of 20 561 cases.

  2002cited by this paper
• Automated subcellular localization and quantification of protein expression in tissue microarrays

  2002cited by this paper
• Modeling Survival Data: Extending the Cox Model

  2002cited by this paper
• Involvement of chemokine receptors in breast cancer metastasis

  2001cited by this paper
• Sex-associated differences in survival of patients undergoing resection for lung cancer.

  2000cited by this paper
• Lung cancer in women: sex-associated differences in survival of patients undergoing resection for lung cancer.

  2000cited by this paper
• Chemokines: a new classification system and their role in immunity.

  2000cited by this paper
• Expression of stromal cell-derived factor 1 and CXCR4 ligand receptor system in pancreatic cancer: a possible role for tumor progression.

  2000cited by this paper
• The chemokine receptor CXCR4 is required for the retention of B lineage and granulocytic precursors within the bone marrow microenvironment.

  1999cited by this paper
• An application of changepoint methods in studying the effect of age on survival in breast cancer

  1999cited by this paper
• The α-Chemokine, Stromal Cell-derived Factor-1α, Binds to the Transmembrane G-protein-coupled CXCR-4 Receptor and Activates Multiple Signal Transduction Pathways*

  1998cited by this paper
• The Chemokine SDF-1 Is a Chemoattractant for Human CD34+ Hematopoietic Progenitor Cells and Provides a New Mechanism to Explain the Mobilization of CD34+ Progenitors to Peripheral Blood

  1997cited by this paper
• Steroid‐hormone receptors in cell lines and tumor biopsies of human lung cancer

  1996cited by this paper
• Interleukin-8 and related chemotactic cytokines--CXC and CC chemokines.

  1994cited by this paper
• Estrogen and progesterone receptors in bronchogenic carcinoma.

  1990cited by this paper
• Steroid receptors in human lung cancer.

  1985cited by this paper
• A new asymmetric measure of association for ordinal variables.

  1962cited by this paper

• CXCR4: A Promising Novel Strategy for Lung Cancer Treatment.

  2026cites this paper
• CXCR4-targeted therapy in lung cancer: plerixafor as a promising antimetastatic agent

  2025cites this paper
• G protein-coupled receptors as novel therapeutic targets in non-small-cell lung cancer

  2025cites this paper
• CXCR4/CXCL12 blockade therapy; a new horizon in TNBC therapy

  2025cites this paper
• Chemokine Receptors in Peripheral Blood Mononuclear Cells as Predictive Biomarkers for Immunotherapy Efficacy in Non-Small Cell Lung Cancer

  2025influential citation
• The role of SIK3 in HER2+ gastric cancer cells

  2024cites this paper
• The role of the CXCL12/CXCR4 axis in the immunotherapy of non-small cell lung cancer

  2024influential citation
• Genome-wide Detection of Chimeric Transcripts in Early-stage Non-small Cell Lung Cancer

  2023cites this paper
• Simultaneous activation of CXC chemokine receptor 4 and histamine receptor H1 enhances calcium signaling and cancer cell migration

  2023cites this paper
• Curcumin Disrupts a Positive Feedback Loop between ADMSCs and Cancer Cells in the Breast Tumor Microenvironment via the CXCL12/CXCR4 Axis

  2023cites this paper
• The role of PKC and PKD in CXCL12 and CXCL13 directed malignant melanoma and acute monocytic leukemic cancer cell migration.

  2023cites this paper
• LPA1-mediated inhibition of CXCR4 attenuates CXCL12-induced signaling and cell migration

  2023cites this paper
• The pathological role of C-X-C chemokine receptor type 4 (CXCR4) in colorectal cancer (CRC) progression; special focus on molecular mechanisms and possible therapeutics.

  2023cites this paper
• The clinicopathological and prognostic value of CXCR4 expression in patients with lung cancer: a meta-analysis

  2022influential citation
• Peripheral Blood Mononuclear Cells Predict Therapeutic Efficacy of Immunotherapy in NSCLC

  2022cites this paper
• Combination therapy with nivolumab (anti-PD-1 monoclonal antibody): A new era in tumor immunotherapy.

  2022cites this paper
• CXCR4 expression in lung carcinogenesis: Evaluating gender-specific differences in survival outcomes based on CXCR4 expression in early stage non-small cell lung cancer patients

  2021influential citation
• Role of CXCR4 as a Prognostic Biomarker Associated With the Tumor Immune Microenvironment in Gastric Cancer

  2021cites this paper
• Plasma exo-hsa_circRNA_0056616: A potential biomarker for lymph node metastasis in lung adenocarcinoma

  2020cites this paper
• Chemokines and Bone.

  2020cites this paper
• The prevalence and prognostic significance of estrogen receptor beta expression in non-small cell lung cancer

  2020cites this paper
• CXC Chemokine Receptor 4 Antagonist Functionalized Renal Clearable Manganese-Doped Iron Oxide Nanoparticles for Active-Tumor-Targeting Magnetic Resonance Imaging-Guided Bio-Photothermal Therapy.

  2019cites this paper
• CXCR4 Accelerates Osteoclastogenesis Induced by Non-Small Cell Lung Carcinoma Cells Through Self-Potentiation and VCAM1 Secretion

  2018cites this paper
• Lung cancer in Spanish women: The WORLD07 project

  2018cites this paper
• CXCR4 Based Therapeutics for Non-Small Cell Lung Cancer (NSCLC)

  2018cites this paper
• Correlation of High-Risk Soft Tissue Sarcoma Biomarker Expression Patterns with Outcome following Neoadjuvant Chemoradiation

  2018cites this paper
• Somatostatin and CXCR4 expression patterns in adenocarcinoma and squamous cell carcinoma of the lung relative to small cell lung cancer

  2018cites this paper
• Expression of the DNA repair gene MLH1 correlates with survival in patients who have resected pancreatic cancer and have received adjuvant chemoradiation: NRG Oncology RTOG Study 9704

  2018cites this paper
• SDF-1 / CXCR 4 as prognostic markers for postoperative radiochemotherapy in head and neck cancer

  2018cites this paper
• Characterisation of targeted imaging and theranostic agents for cancer and fibrosis

  2018cites this paper
• Cav3.1 overexpression is associated with negative characteristics and prognosis in non-small cell lung cancer

  2018cites this paper
• The prognostic value of CXC chemokine receptor 4 in non-small cell lung cancer : a meta-analysis

  2017cites this paper
• Loss of tumour-specific ATM protein expression is an independent prognostic factor in early resected NSCLC

  2017cites this paper
• Screening of cancer tissue arrays identifies CXCR4 on adrenocortical carcinoma: correlates with expression and quantification on metastases using 64Cu-plerixafor PET

  2017cites this paper
• SDF-1/CXCR4 expression in head and neck cancer and outcome after postoperative radiochemotherapy

  2017cites this paper
• Emerging roles of the CXCL12/CXCR4 axis in pancreatic cancer progression and therapy☆

  2017cites this paper
• Targeting the CXCR4/CXCL12 axis with the peptide antagonist E5 to inhibit breast tumor progression

  2017cites this paper
• Primary treatment for oropharyngeal squamous cell carcinoma in Alberta, Canada: A population‐based study

  2017cites this paper
• Analysis of the prognostic role of an immune checkpoint score in resected non-small cell lung cancer patients

  2017cites this paper
• Lung Cancer in Women with a Family History of Cancer: The Spanish Female-specific Database WORLD07.

  2016cites this paper
• Expression of PD-L1 Identifies a Subgroup of More Aggressive Non-Small Cell Carcinomas of the Lung

  2016cites this paper
• Oncogenic roles and drug target of CXCR4/CXCL12 axis in lung cancer and cancer stem cell

  2016cites this paper
• mir-1-mediated paracrine effect of cancer-associated fibroblasts on lung cancer cell proliferation and chemoresistance.

  2016cites this paper
• Drug-resistant CXCR4-positive cells have the molecular characteristics of EMT in NSCLC.

  2016cites this paper
• Expression of the CXCR4 ligand SDF-1/CXCL12 is prognostically important for adenocarcinoma and large cell carcinoma of the lung

  2016cites this paper
• Pancreatic Cancer Invasion of the Lymphatic Vasculature and Contributions of the Tumor Microenvironment: Roles for E-selectin and CXCR4

  2016cites this paper
• Importance of CXCL12 and CXCR4 in radiotherapy of head and neck cancer, considering the association with HPV-infection

  2015cites this paper
• HuR-targeted nanotherapy in combination with AMD3100 suppresses CXCR4 expression, cell growth, migration, and invasion in lung cancer

  2015cites this paper
• The Intricate Role of CXCR 4 in Cancer

  2015cites this paper
• Positron Emission Tomographic Imaging of CXCR4 in Cancer: Challenges and Promises

  2015cites this paper
• Chemokine receptor CXCR4 expression and lung cancer prognosis: a meta-analysis.

  2015cites this paper
• a meta-analysis for cXcr 4 as a prognostic marker and potential drug target in non-small cell lung cancer

  2015cites this paper
• Low ATM protein expression in malignant tumor as well as cancer-associated stroma are independent prognostic factors in a retrospective study of early-stage hormone-negative breast cancer

  2015cites this paper
• Inverse expression of somatostatin and CXCR4 chemokine receptors in gastroenteropancreatic neuroendocrine neoplasms of different malignancy

  2015cites this paper
• Role of Chemokines in Non-Small Cell Lung Cancer: Angiogenesis and Inflammation

  2015cites this paper
• Clinicopathological significance of CXCR 4 in non-small cell lung cancer

  2015cites this paper
• Clinicopathological significance of CXCR4 in non-small cell lung cancer

  2015cites this paper
• Elevated expression of CXCR4 and correlation with clinicopathological features and prognosis of non-small cell lung cancer patients: a meta-analysis.

  2015cites this paper
• IL-24 Inhibits Lung Cancer Cell Migration and Invasion by Disrupting The SDF-1/CXCR4 Signaling Axis

  2015cites this paper
• Expression of CXCR4 and non-small cell lung cancer prognosis: a meta-analysis.

  2015cites this paper
• Chemokines and Bone

  2015cites this paper
• A meta-analysis for CXCR4 as a prognostic marker and potential drug target in non-small cell lung cancer

  2015cites this paper
• Differential expression and prognostic value of the chemokine receptor CXCR4 in bronchopulmonary neuroendocrine neoplasms

  2014cites this paper
• Targeting chemokine receptor CXCR4 for treatment of HIV-1 infection, tumor progression, and metastasis.

  2014cites this paper
• The intricate role of CXCR4 in cancer.

  2014cites this paper
• CXCR4 over-expression and survival in cancer: A system review and meta-analysis

  2014cites this paper
• Interaction of the chemokines I-TAC (CXCL11) and SDF-1 (CXCL12) in the regulation of tumor angiogenesis of colorectal cancer

  2014cites this paper
• Quantification of ER/PR expression in ovarian low-grade serous carcinoma.

  2013cites this paper
• A Method for Biomarker Directed Survival Prediction in Advanced Non-Small-Cell Lung Cancer Patients Treated with Carboplatin-Based Therapy

  2013cites this paper
• CXCR4/CXCL12 Axis in Non Small Cell Lung Cancer (NSCLC) Pathologic Roles and Therapeutic Potential

  2013cites this paper
• The role of the CXCR4/CXCL12 axis and its clinical implications in gastric cancer.

  2012cites this paper
• Basal Ki67 expression measured by digital image analysis is optimal for prognostication in oral squamous cell carcinoma.

  2012cites this paper
• Chemokine Regulation of Cell Trafficking in Lung Cancer Metastasis

  2012cites this paper
• Emodin inhibits invasion and migration of prostate and lung cancer cells by downregulating the expression of chemokine receptor CXCR4

  2012cites this paper
• Imaging agents for the chemokine receptor 4 (CXCR4).

  2012cites this paper