Acute Hepatocyte Growth Factor Treatment Induces Long-Term Neuroprotection and Stroke Recovery via Mechanisms Involving Neural Precursor Cell Proliferation and Differentiation

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Journal of Cerebral Blood Flow and Metabolism

• Publication date

  2011-05-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1038/jcbfm.2010.211PMID 21119693PMCID PMC3099629
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Antiapoptotic and antiautophagic effects of glial cell line‐derived neurotrophic factor and hepatocyte growth factor after transient middle cerebral artery occlusion in rats

  2010cited by this paper
• Transplantation of TAT-Bcl-xL-transduced neural precursor cells: long-term neuroprotection after stroke.

  2010cited by this paper
• Implications of Vascular Endothelial Growth Factor for Postischemic Neurovascular Remodeling

  2009cited by this paper
• Hypoxic Preconditioning-Induced Cerebral Ischemic Tolerance: Role of Microvascular Sphingosine Kinase 2

  2009cited by this paper
• Adult neural stem cells in the mammalian central nervous system

  2009influential reference
• Endogenous Hepatocyte Growth Factor Is a Niche Signal for Subventricular Zone Neural Stem Cell Amplification and Self‐Renewal

  2009cited by this paper
• Diverse roles of matrix metalloproteinases and tissue inhibitors of metalloproteinases in neuroinflammation and cerebral ischemia.

  2009cited by this paper
• TAT-Bcl-x(L) improves survival of neuronal precursor cells in the lesioned striatum after focal cerebral ischemia.

  2009cited by this paper
• Neural stem/precursor cells for the treatment of ischemic stroke.

  2008cited by this paper
• Mesenchymal stem cells promote proliferation of endogenous neural stem cells and survival of newborn cells in a rat stroke model

  2008cited by this paper
• Mechanisms and functional implications of adult neurogenesis.

  2008cited by this paper
• Anti-VEGF receptor antagonist (VGA1155) reduces infarction in rat permanent focal brain ischemia.

  2008cited by this paper
• Early Beneficial Effect of Matrix Metalloproteinase Inhibition on Blood—Brain Barrier Permeability as Measured by Magnetic Resonance Imaging Countered by Impaired Long-Term Recovery after Stroke in Rat Brain

  2008cited by this paper
• Molecular targets in cerebral ischemia for developing novel therapeutics.

  2007cited by this paper
• [Relationship between cytokine concentration and activities of daily living in rehabilitation patients with stroke].

  2007cited by this paper
• Effects of hepatocyte growth factor on phosphorylation of extracellular signal-regulated kinase and hippocampal cell death in rats with transient forebrain ischemia.

  2006cited by this paper
• Subventricular Zone-Derived Neuroblasts Migrate and Differentiate into Mature Neurons in the Post-Stroke Adult Striatum

  2006cited by this paper
• HVJ-based non-viral gene transfer method: successful gene therapy using HGF and VEGF genes in experimental ischemia.

  2006cited by this paper
• Growth factors and stroke

  2006cited by this paper
• Hepatocyte growth factor attenuates cerebral ischemia-induced increase in permeability of the blood-brain barrier and decreases in expression of tight junctional proteins in cerebral vessels.

  2006cited by this paper
• The protective effect of hepatocyte growth factor against cell death in the hippocampus after transient forebrain ischemia is related to the improvement of apurinic/apyrimidinic endonuclease/redox factor-1 level and inhibition of NADPH oxidase activity.

  2006cited by this paper
• Prevention of Apoptosis-Inducing Factor Translocation is a Possible Mechanism for Protective Effects of Hepatocyte Growth Factor against Neuronal Cell Death in the Hippocampus after Transient Forebrain Ischemia

  2006cited by this paper
• Vascular endothelial growth factor improves recovery of sensorimotor and cognitive deficits after focal cerebral ischemia in the rat.

  2006cited by this paper
• D3 dopamine receptors do not regulate neurogenesis in the subventricular zone of adult mice.

  2005cited by this paper
• Novel therapeutic strategy to treat brain ischemia : overexpression of hepatocyte growth factor gene reduced ischemic injury without cerebral edema in rat model

  2005cited by this paper
• Treatment of Stroke With Erythropoietin Enhances Neurogenesis and Angiogenesis and Improves Neurological Function in Rats

  2004cited by this paper
• Novel Therapeutic Strategy to Treat Brain Ischemia: Overexpression of Hepatocyte Growth Factor Gene Reduced Ischemic Injury Without Cerebral Edema in Rat Model

  2004cited by this paper
• Functional Recovery of Stroke Rats Induced by Granulocyte Colony-Stimulating Factor–Stimulated Stem Cells

  2004cited by this paper
• Hepatocyte growth factor promotes neuronal differentiation of neural stem cells derived from embryonic stem cells

  2004cited by this paper
• Treatment of Stroke With Erythropoietin Enhances Neurogenesis and Angiogenesis and Improves Neurological Function in Rats

  2004cited by this paper
• Induction of neurogenesis in the adult rat subventricular zone and neostriatum following dopamine D3 receptor stimulation

  2004cited by this paper
• Hepatocyte growth factor attenuates cerebral ischemia-induced learning dysfunction.

  2004cited by this paper
• Effect of Basic Fibroblast Growth Factor Treatment on Brain Progenitor Cells After Permanent Focal Ischemia in Rats

  2003cited by this paper
• Short‐term and long‐term survival of new neurons in the rat dentate gyrus

  2003cited by this paper
• Hepatocyte growth factor promotes proliferation and neuronal differentiation of neural stem cells from mouse embryos.

  2003cited by this paper
• VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia.

  2003cited by this paper
• Neuronal replacement from endogenous precursors in the adult brain after stroke

  2002cited by this paper
• Transient focal cerebral ischemia induces sensorimotor deficits in mice.

  2000cited by this paper
• Matrix metalloproteinases and TIMPs are associated with blood-brain barrier opening after reperfusion in rat brain.

  1998cited by this paper
• Protection of Hippocampal Neurons from Ischemia-Induced Delayed Neuronal Death by Hepatocyte Growth Factor: A Novel Neurotrophic Factor

  1998cited by this paper
• Expression of HGF and cMet in the developing and adult brain.

  1997cited by this paper
• Emerging multipotent aspects of hepatocyte growth factor.

  1996influential reference
• Localization and functional coupling of HGF and c-Met/HGF receptor in rat brain: implication as neurotrophic factor.

  1995cited by this paper
• Molecular cloning and expression of human hepatocyte growth factor

  1989cited by this paper

• Prototyping Minimal Extracellular Vesicle Mimetics Using Cell-Free Synthesis.

  2026cites this paper
• Hepatocyte Growth Factor/MET Activator Rescues Working Memory Deficits After Repeated Mild Traumatic Brain Injury

  2025cites this paper
• Unraveling the impact of human cerebrospinal fluid on human neural stem cell fate

  2025cites this paper
• Ischemia-reperfusion injury: molecular mechanisms and therapeutic targets

  2024cites this paper
• Peripheral inflammatory response in people after acute ischaemic stroke and isolated spontaneous cervical artery dissection

  2024cites this paper
• MET receptor tyrosine kinase promotes the generation of functional synapses in adult cortical circuits

  2024cites this paper
• Effects of an Angiotensin IV Analog on 3-Nitropropionic Acid-Induced Huntington’s Disease-Like Symptoms in Rats

  2024cites this paper
• Growth Factors and Their Application in the Therapy of Hereditary Neurodegenerative Diseases

  2024cites this paper
• Role of STAT3‐FOXO3 Signaling in the Modulation of Neuroplasticity by PD‐L1‐HGF‐Decorated Mesenchymal Stem Cell‐Derived Exosomes in a Murine Stroke Model

  2024cites this paper
• Naoxinqing tablet protects against cerebral ischemic/reperfusion injury by regulating ampkα/NAMPT/SIRT1/PGC-1α pathway.

  2023cites this paper
• Periplaneta Americana (L.) extract activates the ERK/CREB/BDNF pathway to promote post-stroke neuroregeneration and recovery of neurological functions in rats.

  2023cites this paper
• The Case for a Novel Therapeutic Approach to Dementia: Small Molecule Hepatocyte Growth Factor (HGF/MET) Positive Modulators

  2023cites this paper
• Neuroprotective Effects of Quercetin on Ischemic Stroke: A Literature Review

  2022cites this paper
• Fosgonimeton, a Novel Positive Modulator of the HGF/MET System, Promotes Neurotrophic and Procognitive Effects in Models of Dementia

  2022cites this paper
• Therapeutic Factors in Ischemic Stroke Control

  2022cites this paper
• Post‐ischemic protection of hepatocyte growth factor requires the type II transmembrane serine protease matriptase—A reciprocal regulation of the two for neuroprotection in stroke brain

  2022cites this paper
• Reduced HGF/MET Signaling May Contribute to the Synaptic Pathology in an Alzheimer's Disease Mouse Model

  2022influential citation
• Alterations of inflammatory cytokines in super-acute stroke patients and the potential pathogenesis.

  2022cites this paper
• Notoginsenoside R1 Improves Cerebral Ischemia/Reperfusion Injury by Promoting Neurogenesis via the BDNF/Akt/CREB Pathway

  2021cites this paper
• Agonistic analog of growth hormone–releasing hormone promotes neurofunctional recovery and neural regeneration in ischemic stroke

  2021cites this paper
• Extracellular vesicles from hypoxia-preconditioned microglia promote angiogenesis and repress apoptosis in stroke mice via the TGF-β/Smad2/3 pathway

  2021cites this paper
• HGF and MET: From Brain Development to Neurological Disorders

  2021cites this paper
• Inhibition of Fatty Acid Synthesis Aggravates Brain Injury, Reduces Blood-Brain Barrier Integrity and Impairs Neurological Recovery in a Murine Stroke Model

  2021cites this paper
• Effects of an evidence-based nursing intervention on neurological function and serum inflammatory cytokines in patients with acute cerebral infarction: A randomized controlled trial

  2021cites this paper
• Bone marrow mesenchymal stem cells overexpressing hepatocyte growth factor ameliorate hypoxic–ischemic brain damage in neonatal rats

  2021cites this paper
• Paradoxical role of hepatocyte growth factor in ischemic stroke: stroke risk/stroke recovery

  2021cites this paper
• Lithium enhances post-stroke blood-brain barrier integrity, activates the MAPK/ERK1/2 pathway and alters immune cell migration in mice.

  2020cites this paper
• The incremental prognostic value of sIL-2R and HGF in acute ischemic stroke

  2020cites this paper
• Neural Progenitor Cell-Derived Extracellular Vesicles Enhance Blood-Brain Barrier Integrity by NF-κB (Nuclear Factor-κB)-Dependent Regulation of ABCB1 (ATP-Binding Cassette Transporter B1) in Stroke Mice

  2020cites this paper
• Hepatocyte growth factor protects PC12 cells against OGD/R-induced injury by reducing iron

  2020cites this paper
• Novel neuroprotective tetramethylpyrazine analog T-006 promotes neurogenesis and neurological restoration in a rat model of stroke

  2019cites this paper
• Post-acute delivery of NMDA or GABAA α5 receptor antagonists promotes neurological recovery and peri-infarct brain remodeling after transient focal cerebral ischemia in mice

  2019cites this paper
• Tetramethylpyrazine nitrone activates the BDNF/Akt/CREB pathway to promote post‐ischaemic neuroregeneration and recovery of neurological functions in rats

  2018cites this paper
• Plasmid-based gene therapy with hepatocyte growth factor stimulates peripheral nerve regeneration after traumatic injury.

  2018cites this paper
• Increase in Blood Levels of Growth Factors Involved in the Neuroplasticity Process by Using an Extremely Low Frequency Electromagnetic Field in Post-stroke Patients

  2018cites this paper
• Enriched Environment Elicits Proangiogenic Mechanisms After Focal Cerebral Ischemia

  2018cites this paper
• The pericyte secretome: Potential impact on regeneration.

  2018cites this paper
• Neuroprotective Agents: An Overview on the General Modes of Action

  2017cites this paper
• Neuronal Regeneration by Using Endogenous Stem Cells and DDS Technology

  2017cites this paper
• Identification of neuronal and angiogenic growth factors in an in vitro blood-brain barrier model system: Relevance in barrier integrity and tight junction formation and complexity.

  2017cites this paper
• Vertebrate Neural Stem Cells: Development, Plasticity, and Regeneration.

  2016cites this paper
• Method parameters’ impact on mortality and variability in mouse stroke experiments: a meta-analysis

  2016cites this paper
• Treadmill exercise ameliorates ischemia-induced brain edema while suppressing Na⁺/H⁺ exchanger 1 expression.

  2016cites this paper
• Ischemic Post-Conditioning Induces Post-Stroke Neuroprotection via Hsp70-Mediated Proteasome Inhibition and Facilitates Neural Progenitor Cell Transplantation

  2016cites this paper
• The hepatocyte growth factor isoform NK2 activates motogenesis and survival but not proliferation due to lack of Akt activation.

  2016cites this paper
• Systemic Proteasome Inhibition Induces Sustained Post-stroke Neurological Recovery and Neuroprotection via Mechanisms Involving Reversal of Peripheral Immunosuppression and Preservation of Blood–Brain–Barrier Integrity

  2015cites this paper
• Sustained Functional Improvement by Hepatocyte Growth Factor-Like Small Molecule BB3 after Focal Cerebral Ischemia in Rats and Mice

  2015cites this paper
• Protective effects of HGF gene-expressing human mesenchymal stem cells in acetaminophen-treated hepatocytes

  2015cites this paper
• The development of small molecule angiotensin IV analogs to treat Alzheimer's and Parkinson's diseases.

  2015cites this paper
• Pharmacological Agents in Post Stroke Recovery

  2014cites this paper
• Biotherapies dans l'accident vasculaire cerebral

  2014cites this paper
• Typical and Atypical Stem Cell Niches of the Adult Nervous System in Health and Inflammatory Brain and Spinal Cord Diseases

  2014cites this paper
• Biotherapies in stroke.

  2014cites this paper
• Restorative Therapy in Stroke

  2014cites this paper
• High concentration but low activity of hepatocyte growth factor in periodontitis.

  2014cites this paper
• The Procognitive and Synaptogenic Effects of Angiotensin IV–Derived Peptides Are Dependent on Activation of the Hepatocyte Growth Factor/c-Met System

  2014cites this paper
• Matriptase is required for the active form of hepatocyte growth factor induced Met, focal adhesion kinase and protein kinase B activation on neural stem/progenitor cell motility.

  2014cites this paper
• Neural stem cell survival factors.

  2013cites this paper
• MicroRNA-124 protects against focal cerebral ischemia via mechanisms involving Usp14-dependent REST degradation

  2013cites this paper
• Angiogenic cytokines in renovascular disease: do they have potential for therapeutic use?

  2013cites this paper
• TAT-Hsp70 Induces Neuroprotection Against Stroke Via Anti-Inflammatory Actions Providing Appropriate Cellular Microenvironment for Transplantation of Neural Precursor Cells

  2013cites this paper
• Transforming growth factor-β1 selectively inhibits hepatocyte growth factor expression via a micro-RNA-199–dependent posttranscriptional mechanism

  2013cites this paper
• Differences in the expression of hepatocyte growth factor in acute and chronic bowel inflammation—Implications for diagnosis? *

  2013cites this paper
• A methachromatic-based experimental model for identification of bowel as the focus of an acute inflammation

  2013cites this paper
• Neuroprotective Effect of Human Placenta-Derived Cell Treatment of Stroke in Rats

  2013cites this paper
• Immunological Profile of Silent Brain Infarction and Lacunar Stroke

  2013cites this paper
• Growth Factors Released from Gelatin Hydrogel Microspheres Increase New Neurons in the Adult Mouse Brain

  2012cites this paper
• Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation.

  2012cites this paper
• Neural Stem Cells in the Adult Brain: From Benchside to Clinic

  2012cites this paper
• The novel proteasome inhibitor BSc2118 protects against cerebral ischaemia through HIF1A accumulation and enhanced angioneurogenesis.

  2012cites this paper
• VEGF-induced angiogenesis in the ischemic brain: effect of hyperlipidemia

  2012cites this paper
• Stimulation of Plasticity and Functional Recovery After Stroke - Cell-based and Pharmacological Therapy

  2011cites this paper
• Regulation of blood-brain barrier tightness and polarity following ischemic stroke

  2010cites this paper