Solvent effects on environmentally coupled hydrogen tunnelling during catalysis by dihydrofolate reductase from Thermotoga maritima.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Chemistry

• Publication date

  2008-11-26

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1002/chem.200801804PMID 18924193
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Are environmentally coupled enzymatic hydrogen tunneling reactions influenced by changes in solution viscosity?

  2008cited by this paper
• Dynamic personalities of proteins

  2007cited by this paper
• Molecular dynamics simulation of thermal unfolding of Thermatoga maritima DHFR.

  2007cited by this paper
• Hydride transfer reaction catalyzed by hyperthermophilic dihydrofolate reductase is dominated by quantum mechanical tunneling and is promoted by both inter- and intramonomeric correlated motions.

  2006cited by this paper
• The Dynamic Energy Landscape of Dihydrofolate Reductase Catalysis

  2006cited by this paper
• Coupling of protein motions and hydrogen transfer during catalysis by Escherichia coli dihydrofolate reductase.

  2006cited by this paper
• Protein motions during catalysis by dihydrofolate reductases

  2006cited by this paper
• Biochemistry. Enzyme motions inside and out.

  2006cited by this paper
• Atomic Description of an Enzyme Reaction Dominated by Proton Tunneling

  2006cited by this paper
• Dynamical contributions to enzyme catalysis: critical tests of a popular hypothesis.

  2006cited by this paper
• Protein dynamics and catalysis: the problems of transition state theory and the subtlety of dynamic control

  2006cited by this paper
• Tunneling and dynamics in enzymatic hydride transfer.

  2006cited by this paper
• Enzyme Motions Inside and Out

  2006cited by this paper
• Relationship Between Enhancement of Electrostriction and Decrease of Activation Energy in Porcine Pancreatic Lipase Catalysis

  2005cited by this paper
• Tunneling and coupled motion in the Escherichia coli dihydrofolate reductase catalysis.

  2004cited by this paper
• Pivotal role of Gly 121 in dihydrofolate reductase from Escherichia coli: the altered structure of a mutant enzyme may form the basis of its diminished catalytic performance.

  2004cited by this paper
• Thermal-activated protein mobility and its correlation with catalysis in thermophilic alcohol dehydrogenase.

  2004cited by this paper
• Evidence for environmentally coupled hydrogen tunneling during dihydrofolate reductase catalysis.

  2003cited by this paper
• A Perspective on Enzyme Catalysis

  2003cited by this paper
• Hydride transfer during catalysis by dihydrofolate reductase from Thermotoga maritima.

  2003cited by this paper
• Effect of mutation on enzyme motion in dihydrofolate reductase.

  2003cited by this paper
• Slaving: Solvent fluctuations dominate protein dynamics and functions

  2002cited by this paper
• Environmentally coupled hydrogen tunneling

  2002cited by this paper
• Network of coupled promoting motions in enzyme catalysis

  2002cited by this paper
• Environmentally coupled hydrogen tunneling. Linking catalysis to dynamics.

  2002cited by this paper
• Effect of solution viscosity on intramolecular electron transfer in sulfite oxidase.

  2002cited by this paper
• Probes of hydrogen tunneling with horse liver alcohol dehydrogenase at subzero temperatures.

  2001cited by this paper
• Viscosity dependence of protein dynamics

  2001cited by this paper
• Protein Dynamics in Enzymatic Catalysis: Exploration of Dihydrofolate Reductase

  2000cited by this paper
• The crystal structure of dihydrofolate reductase from Thermotoga maritima: molecular features of thermostability.

  2000cited by this paper
• Enzyme dynamics and hydrogen tunnelling in a thermophilic alcohol dehydrogenase

  1999cited by this paper
• Distinction between the Influence of Dielectric Constant and of Methanol Concentration on Trypsin-Catalyzed Hydrolysis and Methanolysis

  1998cited by this paper
• Evidence for a functional role of the dynamics of glycine-121 of Escherichia coli dihydrofolate reductase obtained from kinetic analysis of a site-directed mutant.

  1997cited by this paper
• Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence.

  1997cited by this paper
• The reaction catalyzed by Escherichia coli aspartate aminotransferase has multiple partially rate-determining steps, while that catalyzed by the Y225F mutant is dominated by ketimine hydrolysis.

  1996cited by this paper
• Gating of photoinduced electron transfer from zinc cytochrome c and tin cytochrome c to plastocyanin. Effects of solution viscosity on rearrangement of the metalloprotein complex

  1993cited by this paper
• The control of protein stability and association by weak interactions with water: how do solvents affect these processes?

  1993cited by this paper
• Protein dynamics and solvation in aqueous and nonaqueous environments

  1993cited by this paper
• Hypersensitivity of an enzyme reaction to solvent water.

  1993cited by this paper
• The role of solvent viscosity in the dynamics of protein conformational changes.

  1992cited by this paper
• Solvent dielectric effects on protein dynamics.

  1992cited by this paper
• Inhibition of cytochrome-P450 reductase by polyols has an electrostatic nature.

  1992cited by this paper
• The solvent effects on the kinetics of bacterial formate dehydrogenase reaction.

  1990cited by this paper
• Kinetics of the lactate dehydrogenase reaction in high-viscosity media.

  1989cited by this paper
• Construction and evaluation of the kinetic scheme associated with dihydrofolate reductase from Escherichia coli.

  1987cited by this paper
• Investigation of diffusion-limited rates of chymotrypsin reactions by viscosity variation.

  1982cited by this paper
• Stereochemistry of reduction of folic acid using dihydrofolate reductase

  1979cited by this paper
• Viscosity-dependent structural fluctuations in enzyme catalysis.

  1979cited by this paper
• The chemical kinetics of the enolase reaction with special reference to the use of mixed solvents.

  1957cited by this paper
• Brownian motion in a field of force and the diffusion model of chemical reactions

  1940cited by this paper

• Structural Effects on the Hydride-Tunneling Kinetic Isotope Effects of NADH/NAD+ Model Reactions: Relating to the Donor–Acceptor Distances

  2025cites this paper
• Glycerol-slaved 1H-1H NMR cross-relaxation in quasi-native lysozyme.

  2024cites this paper
• of folate by dihydrofolate reductase from

  2023cites this paper
• Correlation of temperature dependence of hydride kinetic isotope effects with donor-acceptor distances in two solvents of different polarities.

  2023cites this paper
• Cryo‐kinetics Reveal Dynamic Effects on the Chemistry of Human Dihydrofolate Reductase

  2021cites this paper
• Mechanisms of Viscous Media Effects on Elementary Steps of Bacterial Bioluminescent Reaction

  2021cites this paper
• Temperature, Dynamics, and Enzyme-Catalyzed Reaction Rates.

  2020cites this paper
• What are the signatures of tunnelling in enzyme-catalysed reactions?

  2019cites this paper
• On Protein Preferential Solvation in Water:Glycerol Mixtures.

  2019cites this paper
• Probing the basis of catalysis of dihydrofolate reductase

  2018cites this paper
• Reduction of Folate by Dihydrofolate Reductase from Thermotoga maritima.

  2017cites this paper
• Minimization of dynamic effects in the evolution of dihydrofolate reductase

  2016cites this paper
• Solvent-Slaved Motions in the Hydride Tunneling Reaction Catalyzed by Human Glycolate Oxidase

  2016cites this paper
• Protein motions, dynamic effects and thermal stability in dihydrofolate reductase from the hyperthermophile thermotoga maritima

  2015cites this paper
• Protein motions and dynamic effects in enzyme catalysis.

  2015cites this paper
• Viscosity Dependence of Some Protein and Enzyme Reaction Rates: Seventy-Five Years after Kramers.

  2015cites this paper
• Thermal Adaptation of Dihydrofolate Reductase from the Moderate Thermophile Geobacillus stearothermophilus

  2014cites this paper
• Different Dynamical Effects in Mesophilic and Hyperthermophilic Dihydrofolate Reductases

  2014cites this paper
• Internal friction in enzyme reactions

  2013cites this paper
• Effects of Temperature on the Kinetic Isotope Effects for Proton and Hydride Transfers in the Active Site Variant of Choline Oxidase Ser101Ala

  2013influential citation
• Evidence that a 'dynamic knockout' in Escherichia coli dihydrofolate reductase does not affect the chemical step of catalysis.

  2012cites this paper
• Effect of pH on Hydride Transfer by Escherichia coli Dihydrofolate Reductase

  2011cites this paper
• The Role of Large-Scale Motions in Catalysis by Dihydrofolate Reductase

  2011cites this paper
• Solvent effects on catalysis by Escherichia coli dihydrofolate reductase.

  2010cites this paper
• The temperature dependence of the kinetic isotope effects of dihydrofolate reductase from Thermotoga maritima is influenced by intersubunit interactions.

  2010cites this paper
• Update 1 of: Tunneling and dynamics in enzymatic hydride transfer.

  2010cites this paper
• Coupled motions in enzyme catalysis.

  2010cites this paper
• Different reaction mechanisms for mesophilic and thermophilic dihydrofolate reductases.

  2009cites this paper
• Solvent-slaved protein motions accompany proton but not hydride tunneling in light-activated protochlorophyllide oxidoreductase.

  2009cites this paper
• Effect of dimerization on the stability and catalytic activity of dihydrofolate reductase from the hyperthermophile Thermotoga maritima.

  2009cites this paper
• The Role of Arginine 28 in Catalysis by Dihydrofolate Reductase from the Hyperthermophile Thermotoga maritima

  2009cites this paper
• Probing coupled motions in enzymatic hydrogen tunnelling reactions.

  2009cites this paper